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| 1 | Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy:A single center report of 8 cases显示文摘This article describes cases of anti-tumor necrosis factor(TNF)-α-induced autoimmune hepatitis and evaluates the outcome of these patients in relation to their immunosuppressive strategy. A retrospective analysis of medical records was performed in our center, in order to detect cases of autoimmune hepatitis(AIH) associated with anti-TNF biologic agents. We describe and analyze eight cases of AIH following anti-TNF therapy, 7 with infliximab and 1 with adalimumab. A distinction should be made between induction of autoimmunity and clinically evident autoimmune disease. Liver biopsy is useful in detecting the role of the TNF-α antagonist in the development of AIH. The lack of relapse after discontinuing immunosuppressive therapy favors, as in this case series, an immune-mediated drug reaction as most patients with AIH have a relapse after treatment is suspended. Although AIH related to anti-TNF therapy is rare, a baseline immunological panel along with liver function tests should be performed in all patients with autoimmune disease before starting biologics. | Susana Rodrigues Susana Lopes Fernando Magro Hélder Cardoso Ana Maria Horta e Vale Margarida Marques Eva Mariz Miguel Bernardes Joanne Lopes Fátima Carneiro Guilherme Macedo | 2015 | World Journal of Gastroenterology2015，21，24： | 9 |
| 2 | Management of autoimmune hepatitis:Focus on pharmacologic treatments beyond corticosteroids显示文摘In autoimmune hepatitis, patients who are intolerant or with toxicity experience, non-responders, relapsers or refractory are challenging. Non-standard drugs are being tried to preemptively avoid corticosteroid-related side effects. Prognosis and quality of life of life rely on treatment optimization. Recently, emergence of powerful immunosuppressive agents, mainly from liver transplantation, challenged the supremacy of the corticosteroid regime and promise greater immunosuppression than conventional medications, offer site-specific actions and satisfactory patient tolerance. Successes in experimental models of related diseases have primed these molecular interventions. We performed a literature review on alternative treatments. Azatioprine intolerance is the principal indication for mycophenolate use butit can be used as a front-line therapy. Cyclosporine A and tacrolimus have been tested for non-responders or relapsers. Rituximab may be used as salvage therapy. Anti-tumor necrosis factor-alpha agents may be used for incomplete responses or non-responders. Methotrexate is possibly an alternative for induction of remission and maintenance in refractory patients. Cyclophosphamide has been included in the induction regimen with corticosteroids. Ursodeoxycholic acid action is mainly immunomodulatory. Non-standard treatments are coming slowly to the attention, but its use should be cautious performed by experienced centers. | Marta Casal Moura Rodrigo Liberal Hélder Cardoso Ana Maria Horta e Vale Guilherme Macedo | 2014 | World Journal of Hepatology2014，6，6： | 2 |
| 3 | Somatic Embryogenesis in Iberian Grapevine (Vitis vinifera) Cultivars Using Carpels as Initial Explants: Protocol Establishment and Histological Evaluation显示文摘Trincadeira and Aragonez are two important grapevine cultivars in the Iberian Peninsula, used for high quality red wines production. Both cultivars are strongly affected by fungal diseases, with consequent high loses on plant productivity and fruit quality. A successful protocol for plant regeneration via somatic embryogenesis (SE) was established for both cultivars allowing further plant improvement based on gene transfer technology. Several factors were evaluated during the three different phases which characterize an SE plant regeneration protocol. The culture room temperature during the induction phase, a parameter usually accepted as standard by most researchers, proved in these trials to significantly affect the embryo induction rates. Concerning embryo conversion, it was specially affected by the embryo developmental stage, by the intensity and duration of the chilling treatment and by the supplementation of conversion culture medium with activated charcoal. The responses obtained, both for induction and conversion, proved to be highly genotype dependent. Calli structure, as well as embryo integrity, was histologically observed, allowing to characterize embryonic and non-embryonic masses and to identify abnormalities on embryo development. | Hélia Guerra Cardoso Maria Catarina Campos Maria Salomé Pais Augusto Peixe | 2019 | Journal of Agricultural Science and Technology(B)2019，9，1： | 2 |
| 4 | Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor显示文摘 | Wu Y Sun H Basta-Pljakic J Cardoso L Kennedy OD Jasper H Domene H Karabatas L Guida C Schaffler MB Rosen CJ Yakar S | | 0，，： | 1 |
| 5 | The mixing of liquids by a plume of low-Reynolds number bubbles显示文摘 | Cardoso SSS | 2000 | Chemical Engineering Science2000，55，14： | 1 |
| 6 | Uniform flow in a smooth open channel显示文摘 | Cardoso A H Graf W H Gust G | 1989 | Journal of Hydraulic Engineering ASCE1989，27，5： | 1 |
| 7 | Plantain and ba- nana starches:granule structural characteristics explain the differences in their starch degradation patterns 显示文摘 | Soares C A Peroni-Okita F H G Cardoso M B | 2011 | J Agric Food Chem2011，59，12： | 1 |
| 8 | Equivariant Adaptive Source Separation显示文摘 | Cardoso J F Laheld B H | 1994 | IEEE Transaction on Signal Processing (S1053-587X)1994，44，12： | 1 |
| 9 | DNA methylation,nuclear structure,gene expression and cancer显示文摘 | Leonhardt H Cardoso MC | 2000 | J Cell Biochem Suppl2000，135，： | 1 |
| 10 | Blind separation of multi-dimensional components via subspace decomposition: performance analysis 显示文摘 | LAHAT D CARDOSO J F MESSER H | 2014 | IEEE Transactions on Signal Processing2014，62，11： | 1 |
| 11 | Equivariant Adaptive Source Separation 显示文摘 | Cardoso J F Laheld B H | 1996 | IEEE Trans Signal Processing1996，44，： | 1 |
| 12 | Coaching leadership: Leaders' and followers' perception assessment questionnaires in nursing显示文摘 | Cardoso M LAP Ramos L H D'Innocenzo M | 2014 | Einstein (Sa: 0 Paulo)2014，12，： | 1 |
| 13 | Equivariant Adap- tive Source Separation显示文摘 | CARDOSO J F LAHELD B H | 1996 | IEEE Transactions on Signal Processing1996，44，12： | 1 |
| 14 | Cell cy- cle markers for live cell analyses 显示文摘 | Easwaran H P Leonhardt H Cardoso M C | 2005 | Cell Cycle2005，4，3： | 1 |
| 15 | Ethanol tolerance of sugar transport, and the rectification of stuck wine fermentations显示文摘 | Santos J Sousa M J Cardoso H Inficio J | 2008 | Microbiology2008，154，： | 1 |
| 16 | Nutritional requirement of digestible tryptophan for white-egg layers of 60 to 76 weeks of age 显示文摘 | CARDOSO A S COSTA F G P DA SILVA J H V | 2014 | The Journal of Applied Poultry Research2014，23，4： | 1 |
| 17 | Friedel-Crafts acylaiton of anisole with acetic anhydride over silica-supported hetempolyphostungstic acid (HPW/SiO2 )显示文摘 | CARDOSO L A M ALVES W It GONZAGA A R E AGUIAR L M G ANDRADE H M C | 2004 | J Mol Catal A2004，209，12： | 1 |
| 18 | Equivariant adaptive source separation显示文摘 | Cardoso J F Laheld B H | 1996 | IEEE Transactions on Signal Processing1996，44，12： | 1 |
| 19 | Application of Neural-network Modules to Electric Power System Fault Section Estimation显示文摘 | Cardoso G Rolim J G Zum H H | | 0，，03： | 1 |
| 20 | Equivariant adaptive source separation显示文摘 | Cardoso J F Laheld B H | 1996 | IEEE Transactions on Signal Process1996，44，12： | 1 |
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