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| 1 | Microarray,SAGE and their applications to cardiovascular diseases显示文摘The wealth of DNA data generated by the human genome project coupling with recently invented high-throughput gene expression profiling techniques has dramatically sped up the process for biomedical researchers on elucidating the role of genes in human diseases. One powerful method to reveal insight into gene functions is the systematic analysis of gene expression. Two popular high-throughput gene expression technologies, microarray and Serial Analysis of Gene Expression (SAGE) are capable of producing large amounts of gene expression data with the potential of providing novel insights into fundamental disease processes, especially complex syndromes such as cardiovascular disease, whose etiologies are due to multiple genetic factors and their interplay with the environment. Microarray and SAGE have already been used to examine gene expression patterns of cell-culture, animal and human tissues models of cardiovascular diseases. In this review, we will first give a brief introduction of microarray and SAGE technologies and point out their limitations. We will then discuss the major discoveries and the new biological insightsthat have emerged from their applications to cardiovascular diseases. Finally we will touch upon potential challenges and future developments in this area. | SHUI QING YE, TERA LAVOIE, DAVID C USHER, LI Q. ZHANG1 Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21224, USA2Department of Biological Science, University of Delaware, Newark, DE 19716, USA | 2002 | Cell Research2002，12，2： | 5 |
| 2 | Improving the quality of transitional care for persons with complex care needs 显示文摘 | Coleman EA Boult C American Geriatrics Society Health Care Systems Committee | 2003 | J Am Geriatr Soc2003，51，4： | 1 |
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| 4 | Estimating the willingness to pay for drug abuse treatment: a pilot study 显示文摘 | Zarkin AG Cares S C Bala M V | 2000 | Journal of Substance Abuse Treatment2000，18，： | 1 |
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| 6 | Identification of phthalate esters in the serum of young Puerto Riean girls with premature breast development 显示文摘 | Colon I Care D Bourdony C J Rosario O | 2000 | Environ Health Perspect2000，108，9： | 1 |
| 7 | Improving the quality of transitional care for persons with complex care needs 显示文摘 | Coleman E A Boult C American Geriatrics Society Health Care Systems Committee | 2003 | J Am Geriatr Soc2003，51，4： | 1 |
| 8 | Elastic-plastic indentation stress fields using the finite-element method 显示文摘 | Care G Fischer-Cripps A C | 1997 | Journal Of Materials Science1997，32，： | 1 |
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| 10 | Attenuation of proinflammatory response by recombinant human IL - 10 in human endotox- emia:effeet of timing of recombinant human IL - 10 administration 显示文摘 | Pajkrt D Camoglio L Tiel -van Buul M C de Bruin K Cutler D L Affrime M B Rikken G van der Poll T ten Care J W van Deventer S J | 1997 | Journal of immunolo- gy1997，158，8： | 1 |
| 11 | regu- lar follow-up in patients with heart failure 显示文摘 | LOPEZ C C FALCES S C CUB/Q D et aL Randomized clini- cal trial of a postdischarge pharmaceutical care program vs | 2006 | Farm Hosp2006，306，： | 1 |
| 12 | Improving the quality of transitional care for persons with complex care needs 显示文摘 | Coleman EA Boult C American Geriatrics Society Health Care Systems Committee | 2003 | J Am Gefiatr Soc2003，51，4： | 1 |
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| 14 | Nanoscale metallic iron for environmental remediation: prospects and limitations显示文摘 | Noubactep C Care S Crane R | 2012 | Water Air Soil Pollut2012，223，3： | 1 |
| 15 | An Accurate and Versatile Lattice Closure Scheme for Lattice Boltzmann Equation Fluids under External Forces显示文摘 | Hollis A P Halliday I Care C M | | 0，，17： | 1 |
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| 17 | Characterization of the aromatic profile for the authentication and differentiation of typical Italian dry-sausages显示文摘 | Bianchi F Cantoni C Cared M | 2007 | Talanta2007，72，： | 1 |
| 18 | Lattice Boltzmann scheme for modeling liquid-crystal dynamics:Zenithal bistable device in the presence of defect motion显示文摘 | Spencer T J Care C M | 2006 | Physical Review E2006，74，06： | 1 |
| 19 | Cardiologic diagnosis of pulmonary em-bolism:echocardiography显示文摘 | Care rj S Tfifiro MP Zito C | 2000 | Minerva Cardioangiol2000，48，121： | 1 |
| 20 | Fluoride mechanisms显示文摘 | Ten- Care JM Van Loveren C | 1999 | Dent Clin North Am1999，43，4： | 1 |
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