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| 1 | Role of pentoxifylline in non-alcoholic fatty liver disease in high-fat diet-induced obesity in mice显示文摘AIM:To study pentoxifylline effects in liver and adipose tissue inflammation in obese mice induced by high-fat diet(HFD).METHODS: Male swiss mice(6-wk old) were fed a highfat diet(HFD; 60% kcal from fat) or AIN-93(control diet; 15% kcal from fat) for 12 wk and received pentoxifylline intraperitoneally(100 mg/kg per day) for the last 14 d. Glucose homeostasis was evaluated by measurements of basal glucose blood levels and insulin tolerance test two days before the end of the protocol. Final body weight was assessed. Epididymal adipose tissue was collected and weighted for adiposity evaluation. Liver and adipose tissue biopsies were homogenized in solubilization buffer and cytokines were measured in supernatant by enzyme immunoassay or multiplex kit, respectively. Hepatic histopathologic analyses were performed in sections of paraformaldehyde-fixed, paraffin-embedded liver specimens stained with hematoxylin-eosin by an independent pathologist. Steatosis(macrovesicular and microvesicular), ballooning degeneration and inflammation were histopathologically determined. Triglycerides measurements were performed after lipid extraction in liver tissue. RESULTS: Pentoxifylline treatment reduced microsteatosis and tumor necrosis factor(TNF)-α in liver(156.3 ± 17.2 and 62.6 ± 7.6 pg/mL of TNF-α for non-treated and treated obese mice, respectively; P < 0.05). Serum aspartate aminotransferase levels were also reduced(23.2 ± 6.9 and 12.1 ± 1.6 U/L for nontreated and treated obese mice, respectively; P < 0.05) but had no effect on glucose homeostasis. In obese adipose tissue, pentoxifylline reduced TNF-α(106.1 ± 17.6 and 51.1 ± 9.6 pg/mL for non-treated and treated obese mice, respectively; P < 0.05) and interleukin-6(340.8 ± 51.3 and 166.6 ± 22.5 pg/mL for non-treated and treated obese mice, respectively; P < 0.05) levels; however, leptin(8.1 ± 0.7 and 23.1 ± 2.9 ng/mL for non-treated and treated lean mice, respectively; P < 0.05) and plasminogen activator inhibitor-1(600.2 ± 32.3 and 1508.6 ± 210.4 pg/mL for non-treated and treated lean mice, respectively; P < 0.05) levels increased in lean adipose tissue. TNF-α level in the liver of lean mice also increased(29.6 ± 6.6 and 75.4 ± 12.6 pg/mL for non-treated and treated lean mice, respectively; P < 0.05) while triglycerides presented a tendency to reduction.CONCLUSION: Pentoxifylline was beneficial in obese mice improving liver and adipose tissue inflammation. Unexpectedly, pentoxifylline increased pro-inflammatory markers in the liver and adipose tissue of lean mice. | Simone Coghetto Acedo Cintia Rabelo e Paiva Caria érica Martins Ferreira Gotardo José Aires Pereira José Pedrazzoli Marcelo Lima Ribeiro Alessandra Gambero | 2015 | World Journal of Hepatology2015，7，24： | 2 |
| 2 | Human leukocyte antigen DQ2/8 prevalence in non-celiac patients with gastrointestinal diseases显示文摘AIM: To investigate the prevalence of human leukocyte antigen (HLA) DQ2/8 alleles in Southern Italians with liver and gastrointestinal (GI) diseases outside of celiac disease. METHODS: HLA DQ2/8 status was assessed in 443 patients from three ambulatory gastroenterology clinics in Southern Italy (University of Federico Ⅱ, Naples, Loreto Crispi Hospital, Ruggi D'Aragona Hospital, Salerno). Patients were grouped based on disease status [pre-post transplant liver disease, esophageal/gastric organic and functional diseases, irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD)] and DQ2/8 alleles, which correspond to a celiac disease genetic risk gradient. Subject allele frequencies were compared to healthy Italian controls. RESULTS: One hundred and ninety-six out of four hundred and forty-three (44.2%) subjects, median age 56 years and 42.6% female, were DQ2/8 positive. When stratifying by disease we found that 86/188 (45.7%) patients with liver disease were HLA DQ2/8 positive, 39/73 (53.4%) with functional upper GI diseases and 19/41 (46.3%) with organic upper GI diseases were positive. Furthermore, 38/105 (36.2%) patients with IBS and 14/36 (38.9%) with IBD were HLA DQ2/8 positive (P = 0.21). Compared to healthy controls those with functional upper GI diseases disorders had a 1.8 times higher odds of DQ2/8 positivity. Those with liver disease had 1.3 times the odds, albeit not statistically significant, ofDQ2/8 positivity. Both those with IBS and IBD had a lower odds of DQ2/8 positivity compared to healthy controls. CONCLUSION: The proportion of individuals HLA DQ2/8 positive is higher in those with liver/upper functional GI disease and lower in IBS/IBD as compared to general population estimates. | Daniel DiGiacomo Antonella Santonicola Fabiana Zingone Edoardo Troncone Maria Cristina Caria Patrizia Borgheresi Gianpaolo Parrilli Carolina Ciacci | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 3 | Transfer of Tn5385, a composite,multiresistance chromosomal element from Enterococcus faecalis 显示文摘 | Rice LB Carias LL | 1998 | J Bacteriol1998，180，3： | 1 |
| 4 | Neurotoxic effect of lead at low concentrations 显示文摘 | Mameli O Caria M A Melis F | 2001 | Brain Res Bull2001，55，2： | 1 |
| 5 | Gatabolic eventc in osteoarthritis cartilage显示文摘 | Blanco Caria F G | 1999 | Osteoarthritis Cartilage1999，7，3： | 1 |
| 6 | Assessing RET/PTC in thyroid nodule fine-needle aspirates: the FISH point of view 显示文摘 | Caria P Dettori T Frau DV | 2013 | Endocr Relat Cancer2013，20，4： | 1 |
| 7 | The potential clinical utility of serum α - tryptase levels显示文摘 | Carias K Amaout R | 1999 | J Allergy Clin Immunol1999，103，6： | 1 |
| 8 | Intensity-Modulated Radiotherapy in the Treatment of Oropharyngeal Cancer: An Update of the Memorial Sloan-Kettering Cancer Center Experience显示文摘 | Jeremy Setton Nicola Caria Jonathan Romanyshyn Lawrence Koutcher Suzanne L. Wolden Michael J. Zelefsky Nicholas Rowan Eric J. Sherman Matthew G. Fury David G. Pfister Richard J. Wong Jatin P. Shah Dennis H. Kraus Weiji Shi Zhigang Zhang Karen D. Schupak D | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，： | 1 |
| 9 | Potential for broad-scale transmission of Ebola virus disease during the West Africa crisis:lessons for the Global Health security agenda显示文摘Background:The 2014-2016 Ebola crisis in West Africa had approximately eight times as many reported deaths as the sum of all previous Ebola outbreaks.The outbreak magnitude and occurrence of multiple Ebola cases in at least seven countries beyond Liberia,Sierra Leone,and Guinea,hinted at the possibility of broad-scale transmission of Ebola.Main text:Using a modeling tool developed by the US Centers for Disease Control and Prevention during the Ebola outbreak,we estimated the number of Ebola cases that might have occurred had the disease spread beyond the three countries in West Africa to cities in other countries at high risk for disease transmission(based on late 2014 air travel patterns).We estimated Ebola cases in three scenarios:a delayed response,a Liberia-like response,and a fast response scenario.Based on our estimates of the number of Ebola cases that could have occurred had Ebola spread to other countries beyond the West African foci,we emphasize the need for improved levels of preparedness and response to public health threats,which is the goal of the Global Health Security Agenda.Our estimates suggest that Ebola could have potentially spread widely beyond the West Africa foci,had local and international health workers and organizations not committed to a major response effort.Our results underscore the importance of rapid detection and initiation of an effective,organized response,and the challenges faced by countries with limited public health systems.Actionable lessons for strengthening local public health systems in countries at high risk of disease transmission include increasing health personnel,bolstering primary and critical healthcare facilities,developing public health infrastructure(e.g.laboratory capacity),and improving disease surveillance.With stronger local public health systems infectious disease outbreaks would still occur,but their rapid escalation would be considerably less likely,minimizing the impact of public health threats such as Ebola.Conclusions:The Ebola outbreak could have potentially spread to other countries,where limited public health surveillance and response capabilities may have resulted in additional foci.Health security requires robust local health systems that can rapidly detect and effectively respond to an infectious disease outbreak. | Eduardo A.Undurraga Cristina Carias Martin I.Meltzer Emily B.Kahn | 2017 | Infectious Diseases of Poverty2017，6，1： | 1 |
| 10 | Role of class A penicillin-binding proteins in the expression of beta-lactam resistance in Enterococcus faecium 显示文摘 | Rice L B Carias L L Rudin S | 2009 | Bacteriology2009，191，11： | 1 |
| 11 | Biological assessment of porous-implant hydroxyapatite combined with periosteal grafting in maxillary defects显示文摘 | Caria PH Kawachi EY Bertran CA | 2007 | J Oral Maxillofac Surg2007，65，5： | 1 |
| 12 | Chronic stroke recovery after combined BCI training and physiotherapy:a case report显示文摘 | Caria A Weber C Br(o)tz D | 2011 | Psychophysiology2011，48，4： | 1 |
| 13 | A potential virulence gene,hylEfm,predominates in Enterococcus faecium of clinical ori-gin显示文摘 | Rice LB Carias L Rudin S | 2003 | J Infect Dis2003，187，3： | 1 |
| 14 | Mutiple sclerosis recurrence risk for siblings in an isolated population of central Sandinia,Italy显示文摘 | Montomoli C Prokopenko I Caria A | 2002 | Genet Epidemiol2002，22，3： | 1 |
| 15 | Regulation of anterior insular cortex activity u sing real-time fMRI 显示文摘 | Caria A | 2007 | Neurolmage2007，35，3： | 1 |
| 16 | Chronic stroke recovery after combined BCI training and physiotherapy:a case report显示文摘 | Caria A Weber C Br?tz D | 2011 | Psychophysiology2011，48，4： | 1 |
| 17 | Methotrexate as a possible trigger of macrophage activation syndrome in systemic juvenile idiopathic arthrkis显示文摘 | Ravelli A Caria MC Buratti S | 2001 | J Rheumatol2001，28，4： | 1 |
| 18 | Characterization of the Influence of Semen-Derived Enhancer of Virus Infection on the Interaction of HIV-1 with Female Reproductive Tract Tissues显示文摘 | Allen SA Carias AM Anderson MR | 2015 | J Virol2015，89，： | 1 |
| 19 | Autonmoic nervous system activity and life threatening arrhythmias in experimental epilepsy显示文摘 | MAMELI O CARIA MA MELIS F | 2001 | Seizure2001，10，： | 1 |
| 20 | Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus显示文摘 | I. Raz M. Hanefeld L. Xu C. Caria D. Williams-Herman H. Khatami | 2006 | Diabetologia2006，，11： | 1 |
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