|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Liver disease in pregnancy显示文摘Liver diseases in pregnancy may be categorized into liver disorders that occur only in the setting of pregnancy and liver diseases that occur coincidentally with pregnancy. Hyperemesis gravidarum, preeclampsia/eclampsia, syndrome of hemolysis, elevated liver tests and low platelets (HELLP), acute fatty liver of pregnancy, and intrahepatic cholestasis of pregnancy are pregnancy-specific disorders that may cause elevations in liver tests and hepatic dysfunction. Chronic liver diseases, including cholestatic liver disease, autoimmune hepatitis, Wilson disease, and viral hepatitis may also be seen in pregnancy. Management of liver disease in pregnancy requires collaboration between obstetricians and gastroenterologists/hepatologists. Treatment of pregnancy-specific liver disorders usually involves delivery of the fetus and supportive care, whereas management of chronic liver disease in pregnancy is directed toward optimizing control of the liver disorder. Cirrhosis in the setting of pregnancy is less commonly observed but offers unique challenges for patients and practitioners. This article reviews the epidemiology, pathophysiology, diagnosis, and management of liver diseases seen in pregnancy. | Noel M Lee Carla W Brady | 2009 | World Journal of Gastroenterology2009，15，8： | 13 |
| 2 | Cancer stem cell plasticity and tumor hierarchy显示文摘The origins of the complex process of intratumoral heterogeneity have been highly debated and different cellular mechanisms have been hypothesized to account for the diversity within a tumor. The clonal evolution and cancer stem cell(CSC) models have been proposed as drivers of this heterogeneity. However, the concept of cancer stem cell plasticity and bidirectional conversion between stem and non-stem cells has added additional complexity to these highly studied paradigms and may help explain the tumor heterogeneity observed in solid tumors. The process of cancer stem cell plasticity in which cancer cel s harbor the dynamic ability of shifting from a non-CSC state to a CSC state and vice versa may be modulated by specific microenvironmental signals and cellular interactions arising in the tumor niche. In addition to promoting CSC plasticity, these interactions may contribute to the cellular transformation of tumor cells and affect response to chemotherapeutic and radiation treatments by providing CSCs protection from these agents. Herein, we review the literature in support of this dynamic CSC state, discuss the effectors of plasticity, and examine their role in the development and treatment of cancer. | Marina Carla Cabrera Robert E Hollingsworth Elaine M Hurt | 2015 | World Journal of Stem Cells2015，7，1： | 8 |
| 3 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 4 | Lack of microRNA‐101 causes E‐cadherin functional deregulation through EZH2 up‐regulation in intestinal gastric cancer显示文摘 | Joana Carvalho Nicole C van Grieken Patricia M Pereira Sónia Sousa Marianne Tijssen Tineke E Buffart Bego?a Diosdado Heike Grabsch Manuel AS Santos Gerrit Meijer Raquel Seruca Beatriz Carvalho Carla Oliveira | 2012 | J Pathol2012，，1： | 3 |
| 5 | Effect of epidural analgesia on labor and delivery: a retrospective study显示文摘 | Sandro Gerli Alessandro Favilli Marta M Acanfora Vittorio Bini Carla Giorgini Gian Carlo Di Renzo | 2011 | Journal of Maternal-Fetal and Neonatal Medicine2011，，3： | 2 |
| 6 | Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel显示文摘Background Antiplatelet agents reduce recurrence after cerebral ischaemia but are not effective in all patients,in part because of treatment resistance.The primary aim was to assess the proportion of patients who are insensitive to clopidogrel.The secondary aim was to assess the association between insensitivity to clopidogrel and recurrent cerebrovascular events.Methods Following written informed consent,independent patients with a recent non-cardioembolic ischaemic stroke or transient ischaemic attack,and taking clopidogrel,were enrolled.Platelet function was assessed with remote measurement of surface expression of P-selectin(CD62P)using commercial kits sensitive to aspirin or clopidogrel.Participants’general practitioners provided details on recurrent vascular events at least 90 days later.Data are mean(SD)and median[IQR].Resistance was defined as:aspirin median fluorescence(MF)>500 units,clopidogrel MF>860 units.Non-parametric descriptors and tests were used.Results 63 patients were recruited:mean age 64(13.7)years,women 47%.At baseline,59(95%)patients were taking clopidogrel alone with 3(5%)on combined clopidogrel and aspirin.Assessment of platelet surface P-selectin revealed:aspirin test 528[317,834],>50054.8%;clopidogrel test 429[303,656],>86011.3%.No participants on aspirin and clopidogrel showed aspirin resistance.Thirteen(20.6%)patients had a recurrent cerebrovascular event;those with an ischaemic stroke had a non-significantly higher baseline P-selectin using the clopidogrel test as compared with those with no recurrence:626[380,801]versus 406[265,609],p=0.08.Conclusions Remote measurement of platelet function assessed using the platelet surface expression of P-selectin is feasible.11%of patients taking clopidogrel showed resistance.No significant associations were noted between clopidogrel resistance and recurrent ischaemic events. | Jason Philip Appleton Carla Richardson Natalia Dovlatova Jane May Nikola Sprigg Stan Heptinstall Philip M Bath | 2021 | Stroke & Vascular Neurology2021，6，1： | 2 |
| 7 | Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia显示文摘 | Francielle Tramontini Gomes de Sousa Cardozo Carla Maísa Camelini Alessandra Mascarello Márcio José Rossi Ricardo José Nunes Célia Regina Monte Barardi Margarida Matos de Mendon?a Cláudia Maria Oliveira Sim?es | 2011 | Antiviral Research2011，，1： | 2 |
| 8 | Volume visaalization and exploration through flexible transfer function design显示文摘 | Francisco de M Pinto Carla M D S Freitas | 2008 | Computers & Graphics2008，，32： | 1 |
| 9 | A simple two-phase route to silver nanoparticles/polyaniline structures显示文摘 | MARCELA M ERYZA G CARLA D | 2006 | J Phys Chem B2006，110，17： | 1 |
| 10 | Vicenin-2,a potential anti-inflammatory constituent of Urtica circularis显示文摘 | Carla M Roberto D Cristina A l | 2011 | J Nat Prod2011，74，6： | 1 |
| 11 | Passive UHF RFID Tag for Airport Suitcase Tracking and Identification 显示文摘 | CARLA R M JORGE R C CARLOS A F | 2011 | IEEE Antennas and Wireless Propagation Letters2011，10，： | 1 |
| 12 | Accessing gelling ability of vegetable proteins using rheological and fluorescence techniques显示文摘 | Ana Paula Batista Carla A M Portugal Isabel Sousa | 2005 | International Journal of Biological Macromolecules2005，36，： | 1 |
| 13 | Obstructive Sleep Apnea in a Clinical Series of Adult Epilepsy Patients显示文摘 | Raffaele M Michele T Carla A | 2003 | Epilepsy2003，44，6： | 1 |
| 14 | Molecular genetics of heat tolerance and heat shock proteins in cereals显示文摘 | Elena M Natalya K Carla P | 2002 | Plant Molec- ular Biology2002，48，： | 1 |
| 15 | Development of a fluorescent - Bead - Based multiplex immunoassay to determine immunoglobulin G subclass responses to Neisseria meningitidis serogroup A and C polysaccharides 显示文摘 | Richarda M de Voer Fiona RM van der Klis Carla WAM Engels et al | 2008 | Clin Vaccine Immunol2008，15，8： | 1 |
| 16 | Rewarding the consumer for curbing the evasion of commodity taxes?显示文摘 | Carla M | 2009 | FinanzArchiv: Public Finance Analysis2009，65，38： | 1 |
| 17 | Towards the bio-production of trans-carveol and carvone from limonene:induction after cell growth on limonene and toluene显示文摘 | Carla C C R de carvalho M Manuela R da Fonseca | | 0，，： | 1 |
| 18 | Classi- fication of Brazilian honeys by physical and chemical analyti- cal methods and low field nuclear magnetic resonance (LFIH NMR) 显示文摘 | Roberta de O R R Eliane T M Carla da S C | 2014 | LWT- Food Science and Technology2014，55，： | 1 |
| 19 | Kimura?s Disease: Case Report and Review of the Literature显示文摘 | Carla M Hobeika Tan-Lucien H Mohammed Gregory L Johnson Keith Hansen | 2005 | Journal of Thoracic Imaging2005，，4： | 1 |
| 20 | Chromosomal inversion polymorphisms and adaptation 显示文摘 | Ary A Carla M Andrew R | 2004 | Trends in Ecology & Evolution2004，19，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员