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| 1 | 变性梯度凝胶电泳(DGGE)在微生物生态学中的应用显示文摘由于从环境样品中分离和培养细菌的困难 ,分子生物学方法已发展用来描述和鉴定微生物群落。近年来基于 DNA方法的群落分析得到了迅速的发展 ,如 PCR扩增技术 ,克隆文库法 ,荧光原位杂交法 ,限制性酶切片段长度多态性法 ,变性和温度梯度凝胶电泳法。DGGE已广泛用于分析自然环境中细菌、蓝细菌 ,古菌、微微型真核生物、真核生物和病毒群落的生物多样性。这一技术能够提供群落中优势种类信息和同时分析多个样品。具有可重复和容易操作等特点 ,适合于调查种群的时空变化 ,并且可通过对切下的带进行序列分析或与特异性探针杂交分析鉴定群落成员。DGGE分析微生物群落的一般步骤如下 :一是核酸的提取 ,二是 1 6Sr RNA,1 8S r RNA或功能基因如可容性甲烷加单氧酶羟化酶基因 ( mmo X)和氨加单氧酶 α-亚单位基因 ( amo A)片段的扩增 ,三是通过DGGE分析 PCR产物。DGGE使用具有化学变性剂梯度的聚丙烯酰胺凝胶 ,该凝胶能够有区别的解链PCR扩增产物。由 PCR产生的不同的 DNA片段长度相同但核苷酸序列不同。因此不同的双链 DNA片段由于沿着化学梯度的不同解链行为将在凝胶的不同位置上停止迁移 [5] 。 DNA解链行为的不同导致一个凝胶带图案 ,该图案是微生物群落中主要种类的一个轮廓。 DGGE使用所有生物中保守的基因? | 马悦欣 Carola Holmstrm Jeremy Webb Staffan Kjelleberg | 2003 | 生态学报2003，23，8： | 100 |
| 2 | 前交叉韧带解剖重建理念与方法显示文摘前交叉韧带(Anterior Cruciate Ligament,ACL)解剖重建技术是基于ACL解剖理论发展起来的一项手术技术。ACL解剖重建是根据ACL的解剖特点进行功能重建,恢复ACL原有的尺寸、韧带胶原走行方向和止点位置。解剖重建不仅包括双束和单束重建,而且包括以此理论为基础的ACL重建术后的翻修与加固。本文对ACL的解剖重建技术进行介绍,针对在关节镜下如何观察原ACL的止点位置,测量止点长宽,选择骨道位置,如何利用影像学进行评价进行了详细的阐述和解释,并介绍了该技术目前的临床评价结果。同时,本文对ACL解剖重建和传统'经典'重建方法的区别进行了重点说明与解释,为提高国内医师对ACL解剖重建技术的认识提供参考和帮助。 | 周敬滨 Zachary Working Carola F.van Eck Freddie H.Fu | 2011 | 中国运动医学杂志2011，30，6： | 34 |
| 3 | Multiple checkpoints keep follicular helper T cells under control to prevent autoimmunity显示文摘Follicular helper T(Tfh)cells select mutated B cells in germinal centres,which can then differentiate into long-lived high affinity memory B cells and plasma cells.Tfh cells are regulated by a unique molecular programme orchestrated by the transcriptional repressor Bcl6.This transcription factor turns down expression of multiple genes,including transcriptional regulators of other T helper lineages and a vast amount of microRNAs.This enables Tfh cells to express a suite of chemokine receptors,stimulatory ligands and cytokines that enable migration into B-cell follicles,and provision of effective help to B cells.Not surprisingly,dysregulation of this powerful helper subset can lead to a range of autoantibody-mediated diseases;indeed,aberrant accumulation of Tfh cells has been linked with systemic lupus erythematosus,Sjogren’s disease and autoimmune arthritis.Here we dissect multiple checkpoints that operate throughout Tfh cell development and maturation to maintain immunological tolerance while mounting robust and long-lasting antibody responses. | Di Yu Carola G Vinuesa | 2010 | Cellular & Molecular Immunology2010，7，3： | 16 |
| 4 | Climate Change, Risk and Grain Yields in China显示文摘Adopting Just and Pope (1978, 1979) style yield functions, this paper proposes a method to analyze the impacts of regional climate change on grain production in China. We find that changes in climate will affect grain production in North and South China differently. Specifically, it emerges that a 1℃ increase in annual average temperature could reduce national grain output by 1.45% (1.74% reduction in North China and 1.19% reduction in South China), while an increase in total annual precipitation of around 100 mm could increase national grain output by 1.31% (3.0% increase in North China and 0.59% reduction in South China). | Rainer Holst Xiaohua Yu Carola Grün | 2013 | Journal of Integrative Agriculture2013，12，7： | 14 |
| 5 | 抗血管生成因子Angiostatin与Endostatin作用下肿瘤血管生成的二维数值模拟显示文摘目的数值模拟抗血管生成因子Angiostatin和Endostatin对肿瘤血管生成的影响。方法建立肿瘤内外血管生成的二维离散数学模型。模型耦合两种抗血管生成因子Angiostatin和Endostatin的抑制效应,数值模拟在促血管生成因子诱导下肿瘤微血管网生成,讨论血管生成抑制因子的影响。结果抗血管生成因子Angiostatin对肿瘤内外血管网络生成的速度和成熟度有抑制作用。抗血管生成因子Angiostatin和Endostatin耦合作用时,在肿瘤血管生成的早期有明显的抑制效应;在肿瘤血管生成的中后期,它们可以降低肿瘤血管化程度。结论本文模型能够较好的模拟抗血管生成因子Angiostatin和Endostatin对内皮细胞迁移和增殖的抑制作用。 | 赵改平 高昊 吴洁 许世雄 Collins MW LONG Quan Carola Koenig Padhani AR | 2006 | 医用生物力学2006，21，4： | 10 |
| 6 | Gastrointestinal neuromuscular apparatus: An underestimated target of gut microbiota显示文摘Over the last few years, the importance of the resident intestinal microbiota in the pathogenesis of several gastrointestinal diseases has been largely investigated. Growing evidence suggest that microbiota can influence gastrointestinal motility. The current working hypothesis is that dysbiosis-driven mucosal alterations induce the production of several inflammatory/immune mediators which affect gut neuro-muscular functions. Besides these indirect mucosal-mediated effects, the present review highlights that recent evidence suggests that microbiota can directly affect enteric nerves and smooth muscle cells functions through its metabolic products or bacterial molecular components translocated from the intestinal lumen. Tolllike receptors, the bacterial recognition receptors, are expressed both on enteric nerves and smooth muscle and are emerging as potential mediators between microbiota and the enteric neuromuscular apparatus. Furthermore, the ongoing studies on probiotics support the hypothesis that the neuromuscular apparatus may represent a target of intervention, thus opening new physiopathological and therapeutic scenarios. | Michele Pier Luca Guarino Michele Cicala Lorenza Putignani Carola Severi | 2016 | World Journal of Gastroenterology2016，22，45： | 8 |
| 7 | 美国及欧洲的医疗卫生服务体系现状分析显示文摘介绍了英国、德国和美国近年来的医疗卫生体系、医疗费用筹集制度、医疗保险覆盖程度、卫生服务提供情况和医疗管理体制现状,重点论述了各医疗卫生体系存在的问题和目前的改革措施,提出医疗卫生改革的基本原则,以期为我国的医疗体制改革提供借鉴。 | Carola Fink-Anthe | 2009 | 中华医院管理杂志2009，25，9： | 7 |
| 8 | Expression of HER2 and bradykinin B_1 receptors in precursor lesions of gallbladder carcinoma显示文摘AIM:To determine the expression of HER2 and bradykinin B 1 receptors(B 1 R) in the two pathogenic models of gallbladder cancer:the metaplasia-dysplasia-carcinoma and the adenoma-carcinoma pathways.METHODS:Receptor proteins were visualized by immunohistochemistry on 5-μm sections of paraffin-embedded tissue.Expression of both receptors was studied in biopsy samples from 92 patients(6 males and 86 females;age ranging from 28 to 86 years,mean 56 years).High HER2 expression in specimens was additionally investigated by fluorescence in situ hybridiza-tion.Cell proliferation in each sample was assessed by using the Ki-67 proliferation marker.RESULTS:HER2 receptor protein was absent in adenomas and in normal gallbladder epithelium.On the contrary,there was intense staining for HER2 on the basolateral membrane of epithelial cells of intestinal metaplasia(22/24;91.7%) and carcinoma in situ(9/10;90%),the lesions that displayed a significantly high proliferation index.Protein up-regulation of HER2 in the epithelium with metaplasia or carcinoma in situ was not accompanied by HER2 gene amplification.A similar result was observed in invasive carcinomas(0/12).The B 1 R distribution pattern mirrored that of HER2 except that B 1 R was additionally observed in the adenomas.The B 1 R appeared either as cytoplasmic dots or labeling on the apical cell membrane of the cells composing the epithelia with intestinal metaplasia(24/24;100%) and carcinoma in situ(10/10;100%) and in the epithelial cells of adenomas.In contrast,both HER2(4/12;33%) and B 1 R(1/12;8.3%) showed a low expression in invasive gallbladder carcinomas.CONCLUSION:The up-regulation of HER2 and B1R in precursor lesions of gallbladder carcinoma suggests cross-talk between these two receptors that may be of importance in the modulation of cell proliferation in gallbladder carcinogenesis. | Cesar Toledo Carola E Matus Ximena Barraza Pamela Arroyo Pamela Ehrenfeld Carlos D Figueroa Kanti D Bhoola Maeva del Pozo Maria T Poblete | 2012 | World Journal of Gastroenterology2012，18，11： | 6 |
| 9 | Common features between neoplastic and preneoplastic lesions of the biliary tract and the pancreas显示文摘the bile duct system and pancreas show many similarities due to their anatomical proximity and common embryological origin.Consequently,preneoplastic and neoplastic lesions of the bile duct and pancreas share analogies in terms of molecular,histological and pathophysiological features.Intraepithelial neoplasms are reported in biliary tract,as biliary intraepithelial neoplasm(BilIN),and in pancreas,as pancreatic intraepithelial neoplasm(PanIN).Both can evolve to invasive carcinomas,respectively cholangiocarcinoma(CCA)and pancreatic ductal adenocarcinoma(PDAC).Intraductal papillary neoplasms arise in biliary tract and pancreas.Intraductal papillary neoplasm of the biliary tract(IPNB)share common histologic and phenotypic features such as pancreatobiliary,gastric,intestinal and oncocytic types,and biological behavior with the pancreatic counterpart,the intraductal papillary mucinous neoplasm of the pancreas(IPMN).All these neoplastic lesions exhibit similar immunohistochemical phenotypes,suggesting a common carcinogenic process.Indeed,CCA and PDAC display similar clinic-pathological features as growth pattern,poor response to conventional chemotherapy and radiotherapy and,as a consequence,an unfavorable prognosis.The objective of this review is to discuss similarities and differences between the neoplastic lesions of the pancreas and biliary tract with potential implications on a common origin from similar stem/progenitor cells. | Piera Zaccari Vincenzo Cardinale Carola Severi Federica Pedica Guido Carpino Eugenio Gaudio Claudio Doglioni Maria Chiara Petrone Domenico Alvaro Paolo Giorgio Arcidiacono Gabriele Capurso | 2019 | World Journal of Gastroenterology2019，25，31： | 6 |
| 10 | Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation显示文摘AIM To investigate the relation of two different mutations to the outcome of partial external biliary diversion(PEBD)in severe bile salt export pump(BSEP) deficiency.METHODS Mutations in the gene encoding BSEP leading to severe BSEP deficiency in two unrelated patients were identified by genomic sequencing. Native liver biopsies and transiently transfected human embryonic kidney(HEK) 293 cells expressing either wild-type or mutated BSEP were subjected to immunofluorescence analysis to assess BSEP transporter localization. Bile acid profiles of patient and control bile samples were generated by ultra-performance liquid chromatographytandem mass spectrometry. Wild-type and mutant BSEP transport of [~3H]-labeled taurocholate(TC) and taurochenodeoxycholate(TCDC) was assessed by vesicular transport assays.RESULTS A girl(at 2 mo) presented with pruritus, jaundice and elevated serum bile salts(BS). PEBD stabilized liver function and prevented liver transplantation. She was heterozygous for the BSEP deletion p.T919 del and the nonsense mutation p.R1235 X. At the age of 17 years relative amounts of conjugated BS in her bile were normal, while total BS were less than 3% as compared to controls. An unrelated boy(age 1.5 years) presenting with severe pruritus and elevated serum BS was heterozygous for the same nonsense and another missense mutation, p.G1032 R. PEBD failed to alleviate pruritus, eventually necessitating liver transplantation. BS concentration in bile was about 5% of controls. BS were mainly unconjugated with an unusual low amount of chenodeoxycholate derivatives(< 5%). The patients' native liver biopsies showed canalicular BSEP expression. Both BSEP p.T919 del and p.G1032 R were localized in the plasma membrane in HEK293 cells. In vitro transport assays showed drastic reduction of transport by both mutations. Using purified recombinant BSEP as quantifiable reference, per-molecule transport rates for TC and TCDC were determined to be 3 and 2 BS molecules per wild-type BSEP transporter per minute, respectively.CONCLUSION In summary, our findings suggest that residual function of BSEP as well as substrate specificity influence the therapeutic effectiveness of PEBD in progressive familial intrahepatic cholestasis type 2(PFIC-2). | Philipp Ellinger Jan Stindt Carola Droge Katharina Sattler Claudia Stross Stefanie Kluge Diran Herebian Sander HJ Smits Martin Burdelski Sebastian Schulz-Jürgensen Antje Ballauff Jan Schulte am Esch Ertan Mayatepek Dieter Haussinger Ralf Kubitz Lutz Schmitt | 2017 | World Journal of Gastroenterology2017，23，29： | 4 |
| 11 | Proton pump inhibitors and dysbiosis: Current knowledge and aspects to be clarified显示文摘Proton pump inhibitors (PPIs) are common medications within the practice of gastroenterology. These drugs, which act through the irreversible inhibition of the hydrogen/potassium pump (H+/K+-ATPase pump) in the gastric parietal cells, are used in the treatment of several acid-related disorders. PPIs are generally well tolerated but, through the long-term reduction of gastric acid secretion, can increase the risk of an imbalance in gut microbiota composition (i.e., dysbiosis). The gut microbiota is a complex ecosystem in which microbes coexist and interact with the human host. Indeed, the resident gut bacteria are needed for multiple vital functions, such as nutrient and drug metabolism, the production of energy, defense against pathogens, the modulation of the immune system and support of the integrity of the gut mucosal barrier. The bacteria are collected in communities that vary in density and composition within each segment of the gastrointestinal (GI) tract. Therefore, every change in the gut ecosystem has been connected to an increased susceptibility or exacerbation of various GI disorders. The aim of this review is to summarize the recently available data on PPI-related microbiota alterations in each segment of the GI tract and to analyze the possible involvement of PPIs in the pathogenesis of several specific GI diseases. | Giovanni Bruno Piera Zaccari Giulia Rocco Giulia Scalese Cristina Panetta Barbara Porowska Stefano Pontone Carola Severi | 2019 | World Journal of Gastroenterology2019，25，22： | 4 |
| 12 | Numerical simulation of blood flow and interstitial fluid pressure in solid tumor microcirculation based on tumor-induced angiogenesis显示文摘A coupled intravascular transvascular 空隙的液体流动模型被开发在稳固的肿瘤学习血流动和空隙的液体压力的分布微循环基于一个导致肿瘤的微脉管的网络。这从 2D 被产生肿瘤 angiogenesis 的九点的分离数学模型并且包含二个父母容器。通过微脉管的网络的血流动和在肿瘤纸巾的空隙的液体流动被扩大 Poiseuille 的法律和 Darcy 的法律执行分别地, transvascular 流动被欧椋鸟的法律描述;脉管的渗透和空隙的水力的传导性的效果也被考虑。模拟结果在肿瘤的里面上预言异构的血供应,空隙的高血压和低传送对流,它与生理的观察事实一致。这些结果可以为肿瘤和进一步临床的研究的 anti-angiogenesis 处理提供有益的信息。 | Gaiping Zhao Jie Wu Shixiong Xu M. W. Collins Quan Long Carola S. Konig Yuping Jiang Jian Wang A. R. Padhani | 2007 | Acta Mechanica Sinica2007，23，5： | 4 |
| 13 | Dietary inclusion of a partially defatted black soldier fly(Hermetia illucens)larva meal in low fishmeal-based diets for rainbow trout(Oncorhynchus mykiss)显示文摘Background:Recent investigations highlighted that Hermetia illucens(BSF)larva meal can be a valuable alternative protein source for aquafeed production.In this study,in substitution of fishmeal,we used increasing inclusion levels of a partially defatted BSF larva meal in low fishmeal-based diets for rainbow trout(Oncorhynchus mykiss Walbaum)and we evaluated the related implications in terms of growth performance,physical characteristics,proximate and fatty acid(FA)compositions of the fillets,gut and liver histology,and diet digestibility.In a 131-day trial,576 fish(100.1±9.29 g)were randomly allotted to 24 tanks(24 fish/tank,4 replicates/treatment).Six experimental diets were produced to have partial replacement of fishmeal(0,10%,20%,30%,40%and 50%)by increasing levels of BSF meal(0%[BSF0],3%[BSF3],6%[BSF6],9%[BSF9],12%[BSF12]and 15%[BSF15]on as fed basis,respectively).Results:No differences were observed among the treatments for all the considered growth performance parameters.The viscero and hepato-somatic indexes showed significant differences among the treatments,with the highest values observed in the BSF15 group.No differences were recorded in terms of fillet’s physical characteristics,dry matter(DM),crude protein(CP)and ether extract(EE)contents.Total saturated and monounsaturated FA increased,while polyunsaturated FA(particularly n-3 FA)decreased while increasing the HI meal inclusion in the diet.Histopathology of liver and gut was not affected,whereas,in posterior gut,villi were higher in BSF6 and BSF9 compared to BSF3 fish.The apparent digestibility of DM,CP,EE and gross energy did not vary among the treatments.Conclusions:These results suggest that a partially defatted BSF meal could be included up to 15%in low fishmeal-based diets for rainbow trout with no adverse effects on growth performance,fillet’s physical characteristics,gut and liver health,and diet digestibility.On the contrary,the fillet FA composition worsened while increasing the level of BSF meal in the diet. | Christian Caimi Ilaria Biasato Giulia Chemello Sara Bellezza Oddon Carola Lussiana Vanda Maria Malfatto Maria Teresa Capucchio Elena Colombino Achille Schiavone Francesco Gai Angela Trocino Alberto Brugiapaglia Manuela Renna Laura Gasco | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 3 |
| 14 | Helicobacter pylori infection in obesity and its clinical outcome after bariatric surgery显示文摘The present review summarizes the prevalence and active clinical problems in obese patients with Helicobacter pylori(H.pylori)infection,as well as the outcomes after bariatric surgery in this patient population.The involvement of H.pylori in the pathophysiology of obesity is still debated.It may be that the infection is protective against obesity,because of the gastritis-induced decrease in production and secretion of the orexigenic hormone ghrelin.However,recent epidemiological studies have failed to show an association between H.pylori infection and reduced body mass index.H.pylori infection might represent a limiting factor in the access to bariatric bypass surgery,even if highquality evidence indicating the advantages of preoperative H.pylori screening and eradication is lacking.The clinical management of infection is complicated by the lower eradication rates with standard therapeutic regimens reported in obese patients than in the normalweight population.Prospective clinical studies to ameliorate both H.pylori eradication rates and control the clinical outcomes of H.pylori infection after different bariatric procedures are warranted. | Marilia Carabotti Chiara D'Ercole Angelo Iossa Enrico Corazziari Gianfranco Silecchia Carola Severi | 2014 | World Journal of Gastroenterology2014，20，3： | 3 |
| 15 | Recurrence rates after endoscopic resection of large colorectal polyps:A systematic review and meta-analysis显示文摘BACKGROUND Complete polyp resection is the main goal of endoscopic removal of large colonic polyps.Resection techniques have evolved in recent years and endoscopic submucosal dissection(ESD),endoscopic mucosal resection(EMR)with margin ablation,cold snare polypectomy(CSP),cold EMR,and underwater EMR have been introduced.Yet,efficacy of these techniques with regard to local recurrence rates(LRRs)vs traditional hot snare polypectomy and standard EMR remains unclear.AIM To analyze LRR of large colonic polyps in a systematic review and meta-analysis.METHODS MEDLINE,EMBASE,EBM Reviews,and CINAHL were searched for prospective studies reporting LRR or incomplete resection rate(IRR)after colonic polypectomy of polyps≥10 mm,published between January 2011 and July 2021.Primary outcome was LRR for polyps≥10 mm.RESULTS Six thousand nine hundred and twenty-eight publications were identified,of which 34 prospective studies were included.LRR for polyps≥10 mm at up to 12 mo’follow-up was 11.0%(95%CI,7.1%-14.8%;15 studies;4904 polyps).ESD(1.7%;95%CI,0%-3.4%;3 studies,221 polyps)and endoscopic mucosal resection with margin ablation(3.3%;95%CI,2.2%-4.5%;2 studies,947 polyps)significantly reduced LRR vs standard EMR without(15.2%;95%CI,12.5%-18.0%;4 studies,650 polyps)or with unsystematic margin ablation(16.5%;95%CI,15.2%-17.8%;6 studies,3031 polyps).CONCLUSION LRR is significantly lower after ESD or EMR with routine margin ablation;thus,these techniques should be considered standard for endoscopic removal of large colorectal polyps.Other techniques,such as CSP,cold EMR,and underwater EMR require further evaluation in prospective studies before their routine implementation in clinical practice can be recommended. | Carola Rotermund Roupen Djinbachian Mahsa Taghiakbari Markus D Enderle Axel Eickhoff Daniel von Renteln | 2022 | World Journal of Gastroenterology2022，28，29： | 3 |
| 16 | Hydroxyethylstarch revisited for acute brain injury treatment显示文摘Infusion of the colloid hydroxyethylstarch has been used for volume substitution to maintain hemodynamics and microcirculation after e.g., severe blood loss.In the last decade it was revealed that hydroxyethylstarch can aggravate acute kidney injury, especially in septic patients.Because of the serious risk for critically ill patients, the administration of hydroxyethylstarch was restricted for clinical use.Animal studies and recently published in vitro experiments showed that hydroxyethylstarch might exert protective effects on the blood-brain barrier.Since the prevention of blood-brain barrier disruption was shown to go along with the reduction of brain damage after several kinds of insults, we revisit the topic hydroxyethylstarch and discuss a possible niche for the application of hydroxyethylstarch in acute brain injury treatment. | Martin A.Schick Malgorzata Burek Carola Y.Forster Michiaki Nagai Christian Wunder Winfried Neuhaus | 2021 | Neural Regeneration Research2021，16，7： | 2 |
| 17 | 实体肿瘤血管任意方向生成的二维数值模拟显示文摘目的二维数值生成实体肿瘤任意方向生长的血管网,为研究实体肿瘤内血液动力学、药物输运以及抗血管生成提供更趋真实的微血管网络结构。方法将新生血管芽尖的内皮细胞迁移方向由先前模型的上、下、左、右四个方向扩展为任意方向,建立相应的二维离散模型,数值模拟实体肿瘤微脉管系统的生成过程,比较模拟结果与相关实验数据的符合程度。结果对盲肠肿瘤微血管网进行数值模拟,与改进前的模型和其他模型比较,本模型生成的肿瘤微血管网结构特征,如血管的走向、扭曲、分叉与融合等,更接近生理实际,与实验观测图像的相似度更高。结论该模型可模拟实体肿瘤的微血管网生成,为肿瘤内血液微循环、药物传递以及抗血管生成的理论研究提供较为接近实际的微血管网络结构。 | 吴洁 许世雄 龙泉 Collins MW Carola Koenig 赵改平 蒋雨平 Padhani AR | 2007 | 医用生物力学2007，22，1： | 2 |
| 18 | Infrared thermography of the udder surface of dairy cattle: Characteristics, methods, and correlation with rectal temperature显示文摘 | Moritz Metzner Carola Sauter-Louis Andrea Seemueller Wolfram Petzl Wolfgang Klee | 2013 | The Veterinary Journal2013，，： | 2 |
| 19 | Ag-Zn粉末的机械合金化和随后的热处理(英文)显示文摘研究了在机械合金化过程中Ag和Zn以及随后的热处理中的显微组织演变。机械合金化在SPEX8000D铣床中进行。采用X射线衍射(XRD)﹑透射电子显微镜(TEM)和扫描电子显微镜(SEM)观察样品的显微组织。使用差示扫描量热计(DSC)研究样品的热性能。结果表明,在合金化初期的碾磨过程中能观察到ε,β,β′,α固溶体和剩余的Zn。随后,ε,β,β′和Zn相消失,α固溶体中的Zn浓度剧烈升高。在碾磨7.2ks后,机械合金化过程达到稳定状态。在此期间,α固溶体的组分和晶粒尺寸保持不变。后续热处理表明α固溶体也能够通过机械合金化结合热处理得到。最后,为了得到α固溶体,根据碾磨和热处理过程中样品的微观组织演变,提出一个最佳的工艺路线。 | Danny GUZMN Oscar RIVERA Claudio AGUILAR Stella ORDOEZ Carola MARTíNEZ Daniel SERAFINI Paula ROJAS | 2013 | Transactions of Nonferrous Metals Society of China2013，23，7： | 2 |
| 20 | Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus显示文摘 | NicholasSimpson Paul A.Gatenby AnastasiaWilson ShreyaMalik David A.Fulcher Stuart G.Tangye HarinderManku Timothy J.Vyse GiovannaRoncador Gavin A.Huttley Christopher C.Goodnow Carola G.Vinuesa Matthew C.Cook | 2009 | Arthritis & Rheumatism2009，，1： | 2 |
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