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| 1 | Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro显示文摘Sertoli 房间紧密的连接(TJ ) 是血睾丸障碍的关键部件,在它扣押开发在生精的小管以内经历精子发生的细菌房间的地方。神经质地调整的 claudin-11 是在不孕涉及障碍功能和它的鼠科的猛烈结果的批评 transmembrane 蛋白质。我们试图估计份量上到 TJ 功能的 claudin-11 的贡献的意义在 vitro,使用调停 siRNA 的基因 silencing。我们也进行了 occludin 的贡献的分析, TJ 的另一内在的 transmembrane 蛋白质。claudin-11 或 occludin 的 Silencing 在一个不成熟的老鼠 Sertoli 房间文化模型用 siRNA 被进行。Transepithelial 电的抵抗被用来在整个文化估计份量上 TJ 功能。在 siRNA 处理以后的二天,房间为对 mRNA 的 RT-PCR 评价为连接蛋白质或 lyzed 的 immunocytochemical 本地化被修理表示。claudin-11, occludin,或两个的 Silencing 在 55% 的 TJ 功能导致了重要减少(P <0.01 ) , 51%(P <0.01 ) ,并且 62%(P <0.01 ) 分别地。数据在到 Sertoli 房间 TJ 的指向的蛋白质的本地化是有在 mRNA 表示和显著减小的重要减少的伴随物。我们提供 claudin-11 显著地贡献的量的证据(P <0.01 ) 到 Sertoli 房间 TJ 在 vitro 工作。有趣地, occludin,神经质地在不孕被调整然而并非含有直到迟了的成人生活,也是一重要(P <0.01 ) 贡献者到障碍功能。我们的数据与一致在清楚地为这些表明一个角色的 vivo 研究,在维持正常 TJ 障碍的蛋白质组织并且工作。 | Mark J McCabe Caroline FH Foo Marcel E Dinger Peter M Smooker Peter G Stanton | 2016 | Asian Journal of Andrology2016，18，4： | 7 |
| 2 | Nerve Growth Factor and Artemin Are Paracrine Mediators of Pancreatic Neuropathy in Pancreatic Adenocarcinoma显示文摘 | Güralp O. Ceyhan Karl-Herbert Sch?fer Annika G. Kerscher Ulrich Rauch Ihsan Ekin Demir Mustafa Kadihasanoglu Carolin B?hm Michael W. Müller Markus W. Büchler Nathalia A. Giese Mert Erkan Helmut Friess | 2010 | Annals of Surgery2010，，5： | 2 |
| 3 | maternal and child undemutrition: Consequcnces for adult health and human capital 显示文摘 | CESAR G V LINDA A CAROLINE F | 2008 | The lancet2008，371，9607： | 1 |
| 4 | Physiologic cardiac hypertrophy during pregnancy involves a change in gene expression regulating cardiac metabolism 显示文摘 | JEFFREY G W CAROLINE O THOMAS H H | 2006 | FASEB J2006，20，8： | 1 |
| 5 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 6 | Effect of surfactants on the functional properties of gelatin-based edible films显示文摘 | CAROLINE A CARVALHO R TOMAS G G | 2011 | Journal of Food Engineering2011，103，2： | 1 |
| 7 | Tenderness-An enzymatic view显示文摘 | Caroline M K Paul L S Ronald G B | 2010 | Meat Science2010，84，： | 1 |
| 8 | The Termination of Inter-firm Relationships 显示文摘 | CAROLINE G SHEELAGH M | 2001 | Journal of Business & Industrial Marketing2001，16，2： | 1 |
| 9 | Patient reported outcome measures following specialistnurse - led clinics in preparation for breast reconstructionsurger显示文摘 | Caroline LE Osbome Fiona G Court Joseph MO Donoghue | 2010 | The Breast2010，19，： | 1 |
| 10 | Interactions between earthworms and arsenic in the soil environment :a review显示文摘 | Caroline J L Trevor G P Andrew A M | 2003 | Environ Pollut2003，124，： | 1 |
| 11 | Matrix - corn - prehensive in - house validation and robustness check of a confirm - atory method for the determination off our nitrofuran me- tabolites in poultry muscle and shrimp by LC - MS/MS 显示文摘 | Claudia B Petra G Carolin S | 2007 | J Chrom B2007，856，： | 1 |
| 12 | The tRNA function of SsrA controlling repression of bacteriophage Mu prophage显示文摘 | Caroline R Johnnes G Ariane T | 2001 | PNAS2001，98，10： | 1 |
| 13 | Costs And Benefits of Health Information Technology:New Trends From The Literature显示文摘 | Caroline G Ali T Margaret M | 2009 | Health Affairs2009，28，2： | 1 |
| 14 | Conditional economic incentives for reducing HIV risk behaviors:integration of psychology and behavioral economics显示文摘 | Don Operario Caroline Kuo Sandra G | 2013 | Health Psychology2013，32，： | 1 |
| 15 | Hepatitis B virus hepatotropism is mediated by specific receptor recognition in the liver and not restricted to susceptible hosts显示文摘 | Alexa Schieck Andreas Schulze Caroline G?hler Thomas Müller Uwe Haberkorn Alexander Alexandrov Stephan Urban Walter Mier | 2013 | Hepatology2013，，1： | 1 |
| 16 | Solving Real Car Sequencing Problems with Ant Colony Optimization显示文摘 | Caroline G Marc G Wilson L P | 2005 | European Journal of Operation Research2005，166，3： | 1 |
| 17 | Integration ofhigh and very high-resolution seismic reflection profiles tostudy Upper Quaternary deposits of a coastal area in thewestern Gulf of Lions,SW France显示文摘 | CAROLINE L MICHEL T BERNARD G | 2005 | Marine GeophysicalResearches2005，26，： | 1 |
| 18 | Pareto memetic algorithm for multiple objective optimiza- tion with an industrial applieation 显示文摘 | Arnaud Z Caroline G Marc G | 2008 | Journal of Heuristics2008，14，4： | 1 |
| 19 | DHA-induced stress response in human colon cancer cells – Focus on oxidative stress and autophagy显示文摘 | Kristine Pettersen Vivi Talstad Monsen Caroline Hild Hakv?g Pettersen Hilde Bremseth Overland Grete Pettersen Helle Samdal Almaz Nigatu Tesfahun Anne G?ril Lundemo Geir Bj?rk?y Svanhild Sch?nberg | 2015 | Free Radical Biology and Medicine2015，，： | 1 |
| 20 | Effect of surfactants on thefunctional properties of gelatin - based edible films 显示文摘 | Caroline A Carvalho R TomasG G | 2011 | Journal offood engineering2011，103，2： | 1 |
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