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| 1 | Effect of alcohol consumption on liver stiffness measured by transient elastography显示文摘AIM:To determine the evolution of transient elastography(TE) in patients with alcoholic liver disease according to alcohol cessation or continuation.METHODS:We retrospectively selected in our local database all patients who had two TE between June 2005 and November 2010 with chronic alcohol excessive consumption and excluded those with associated cause of liver disease.TE was performed at least one week apart by senior operator.TE examinations with less than ten successful measures or with an interquartile range above 30% were excluded.We retrospectively reviewed file of all patients to include only patient followed up by trained addictologist and for which definite information on alcohol consumption was available.Concomitant biological parameters [aspartate amino transferase(AST),alanine amino transferase and gamma-glutamyl transpeptidase(GGT)] within 4 wk of initial and final TE were recorded.Putative fibrosis score according to initial and final TE were determined with available cut-off for alcoholic liver disease and hepatitis C.Initial and final putative fibrosis score were compared according to alcohol consumption during follow-up.RESULTS:During the study period 572 patients had TE examination for alcoholic liver disease and 79 of them had at least two examinations.Thirty-seven patients met our criteria with a median follow-up of 32.5 wk.At the end of the study,13(35%) were abstinent,and 24(65%) relapsers.Eight patients had liver biopsy during follow-up.TE decreased significantly during follow-up in 85% of abstinent patients [median(range):-4.9(-6.1,-1.9)],leading to a modification of the putative fibrosis stage in 28%-71% of patient according to different cut-off value.In relapsers TE increased in 45% and decreased in 54% of patient.There was no statistical difference between initial and final TE in relapsers.In the overall population,using 22.6 kPa as cut-off for cirrhosis,4 patients had cirrhosis at initial TE and 3 patients had cirrhosis at final TE.Using 19.5 kPa as cut-off for cirrhosis,7 patients had cirrhosis at initial TE and 5 patients had cirrhosis at final TE.Using 12.5 kPa as cut-off for cirrhosis,16 patients had cirrhosis at initial TE and 15 patients had cirrhosis at final TE.Evolution of biological data was in accordance with the relapse or abstinent status:abstinence ratio(duration of abstinence/duration follow-up) was correlated with AST ratio(r =-0.465,P = 0.007) and GGT ratio(r =-0.662,P<0.0001).GGT was correlated with initial(r = 0.488,P = 0.002) and final TE(r = 0.49,P<0.005).Final TE was correlated with AST(r = 0.362,P<0.05).Correlation between TE ratio and AST ratio(r = 0.44,P = 0.01) revealed that TE varied proportionally to AST for all patients irrespective of their alcohol status.The same relationship was observed between TE ratio and GGT ratio(r = 0.65,P<0.0001).Evolution of TE was significantly correlated with the ratio of time of abstinence to observation time(r =-0.387,P = 0.016) and the evolution of liver enzymes.CONCLUSION:TE significantly decreased with abstinence.Results of TE in alcoholic liver disease cannot be interpreted without taking into account alcohol consumption and liver enzymes. | Edouard Bardou-Jacquet Ludivine Legros Draman Soro Marianne Latournerie Anne Guillygomarc'h Caroline Le Lan Pierre Brissot Dominique Guyader Romain Moirand | 2013 | World Journal of Gastroenterology2013，19，4： | 20 |
| 2 | Long-term results of endoscopic balloon dilatation of lower gastrointestinal tract strictures in Crohn's disease:A prospective study显示文摘AIM:To examine the long-term results of endoscopic treatment in a prospective study conducted over a period of 10 years,1997 to January 2007.METHODS:A total of 25 patients(20 female and five male:aged 18-75 years),with at least one symptom of stricture not passable with the standard colonoscope and with a confirmed scarred Crohn's stricture of the lower gastrointestinal tract,were included in the study.The main symptom was abdominal pain.The endoscopic balloon dilatation was performed with an 18 mm balloon under endoscopic and radiological control.RESULTS:Eleven strictures were located in the colon,13 at the anastomosis after ileocecal resection,three at the Bauhin valve and four in the ileum.Four patients had two strictures and one patient had three strictures.Of the 31 strictures,in 30 was balloon dilatation successful in a single endoscopic session,so that eventually the strictures could be passed easily with the standard colonoscope.In one patient with a long stricture of the ileum involving the Bauhin valve and an additional stricture of the ileum which were 15 cm apart,sufficient dilatation was not possible.This patient therefore required surgery.Improvement of abdominal symptoms was achieved in all cases which had technically successful balloon dilatation,althoughin one case perforation occurred after dilatation of a recurrent stricture.Available follow-up was in the range of 54-118 mo(mean of 81 mo).The relapse rate over this period was 46%,but 64% of relapsing strictures could be successfully dilated again.Only in four patients was surgery required during this follow-up period.CONCLUSION:We conclude from these initial results that endoscopic balloon dilatation,especially for short strictures in Crohn's disease,can be performed with reliable success.Perforation is a rare complication.It is our opinion that in the long-term,the relapse rate is probably higher than after surgery,but usually a second endoscopic treatment can be performed successfully,leading to a considerable success rate of the endoscopic procedure. | Klaus Stienecker Daniel Gleichmann Ulrike Neumayer H Joachim Glaser Carolin Tonus | 2009 | World Journal of Gastroenterology2009，15，21： | 9 |
| 3 | Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial显示文摘 | Caroline AH Klazen Paul NM Lohle Jolanda de Vries Frits H Jansen Alexander V Tielbeek Marion C Blonk Alexander Venmans Willem Jan J van Rooij Marinus C Schoemaker Job R Juttmann Tjoen H Lo Harald JJ Verhaar Yolanda van der Graaf Kaspar J van Everdingen Al | 2010 | 2010 (9746)2010，，9746： | 2 |
| 4 | Intravitreal triamcinolone for refractory diabetic macular edema显示文摘 | Adam Martidis Jay S Duker Paul B Greenberg Adam H Rogers Carmen A Puliafito Elias Reichel Caroline Baumal | 2002 | Ophthalmology2002，，5： | 2 |
| 5 | Silk-based biomaterials 显示文摘 | Gregory H Frank D Caroline J | 2003 | Biomaterials2003，24，3： | 1 |
| 6 | Silk-based biomaterials显示文摘 | Gregory H Altman Frank Diaz Caroline Jakuba Tara Calabro Rebecca L Horan Jingsong Chen Helen Lu John Richmond David L Kaplan | 2002 | Biomaterials2002，，3： | 1 |
| 7 | Concrete structures strengthened with near-surface mounted reinforcement of CFRP显示文摘 | TALJSTEN B CAROLIN A NORDIN H | 2002 | Advances in Structural Engineering2002，6，3： | 1 |
| 8 | Generating receptive endometrium in Asherman's syndrome显示文摘 | Caroline E Q David H | 2011 | J Hum Reprod Sci2011，4，1： | 1 |
| 9 | Physiologic cardiac hypertrophy during pregnancy involves a change in gene expression regulating cardiac metabolism 显示文摘 | JEFFREY G W CAROLINE O THOMAS H H | 2006 | FASEB J2006，20，8： | 1 |
| 10 | Comparative biomechanical testing of anterior and posterior stabilization procedures 显示文摘 | Christian HF Christof H Caroline H | 2005 | Spine2005，30，13： | 1 |
| 11 | Social anxiety and coping strategies in the eating disorders显示文摘 | Hendrik H Fiona W Caroline M | 2003 | Eating Behaviors2003，4，： | 1 |
| 12 | Agrobacterium-mediated transformation as a tool for functional genomics in fungi 显示文摘 | Caroline B M Paul J J H Cees A M | 2005 | Current Genetics2005，48，： | 1 |
| 13 | Sizing gaseous emboli using doppler embolic signal intensity显示文摘 | Caroline B James P David H | | 0，，05： | 1 |
| 14 | Antioxidant activity of yoghurt peptides:Part l-in vitro assays and evaluationin x-3 enriched milk显示文摘 | K H Sabeena Farvin Caroline P Baron Nina Skall Nielsen | 2010 | Food Chemistry2010，123，： | 1 |
| 15 | Deployable structures in nature: examples, analysis and realization 显示文摘 | Caroline H Eyal K Ariel H | 2004 | Journal of the International Association for Shell and Spatial Structures2004，45，3： | 1 |
| 16 | Investigation into the effects of temperature and stirring rate on the solid-phase extraction of diuron from water using a C18 extraction disk显示文摘 | Caroline E Green Michael H Abraham | 2000 | Journal of Chromatography A2000，885，： | 1 |
| 17 | Attraction of colorado potato beetle to herbivore-damaged plants during herbivory and after its termination 显示文摘 | Caroline J B Dicke M Visser J H Maarten A P | 1997 | Journal of Chemical Ecology1997，23，4： | 1 |
| 18 | Somatic embryogenesis and shoot regeneration from excised adventitious roots of the rootstock Rosa hybrida L. ‘Moneyway’显示文摘 | Theo P. M. Salm Caroline J. G. Toorn Charlotte H. H?nisch Hans J. M. Dons | 1996 | Plant Cell Reports1996，，7： | 1 |
| 19 | Generating receptive endometrium in Asherman's syndrome显示文摘 | Caroline EG David H | 2011 | J Hum Reprod Sci2011，4，1： | 1 |
| 20 | The development and application of a diatom-based quantitative Reconstruction technique in forensic science显示文摘 | Benjamin P Steve B Caroline H | 2006 | J Forensic Sci2006，3，51： | 1 |
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