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| 1 | Liver transplantation: Current status and challenges显示文摘Great progress has been made in the field of liver transplantation over the past two decades. This progress, however, also brings up the next set of challenges: First, organ shortage remains a major limitation, and accounts for a large proportion of wait list mortality. While living donation has successfully increased the total number of liver transplants done in Asian countries, the total number of such transplants has been stagnant in the western hemisphere. As such, there has been a significant effort over the past decade to increase the existing deceased donor pool. This effort has resulted in a greater use of liver allografts following donation after cardiac death(DCD) along with marginal and extended criteria donors. Improved understanding of the pathophysiology of liver allografts procured after circulatory arrest has not only resulted in better selection and management of DCD donors, but has also helped in the development of mechanical perfusion strategies. Early outcomes demonstrating the clinical applicability of both hypothermic and normothermic perfusion and its potential to impact patient survival and allograft function have generated much interest. Second, long-term outcomes of liver transplant recipients have not improved significantly, as recipients continue to succumb to complications of long-term immunosuppression, such as infection, malignancy and renal failure. Furthermore, recent evidence suggests that chronic immune-mediated injury to the liver may also impact graft function. | Caroline C Jadlowiec Timucin Taner | 2016 | World Journal of Gastroenterology2016，22，18： | 23 |
| 2 | Use of antibiotics in broiler production:Global impacts and alternatives显示文摘Antibiotics are used to fight bacterial infections.However, a selective pressure gave rise to bacteria resistant to antibiotics.This leaves scientists worried about the danger to human and animal health.Some strategies can be borrowed to reduce the use of antibiotics in chicken farms.Much research has been carried out to look for natural agents with similar beneficial effects of growth promoters.The aim of these alternatives is to maintain a low mortality rate, a good level of animal yield while preserving environment and consumer health.Among these, the most popular are probiotics, prebiotics, enzymes,organic acids, immunostimulants, bacteriocins, bacteriophages, phytogenic feed additives, phytoncides,nanoparticles and essential oils. | Youcef Mehdi Marie-Pierre Létourneau-Montminy Marie-Lou Gaucher Younes Chorfi Gayatri Suresh Tarek Rouissi Satinder Kaur Brar Caroline Cté Antonio Avalos Ramirez Stéphane Godbout | 2018 | Animal Nutrition2018，，2： | 19 |
| 3 | Revisiting the liver’s role in transplant alloimmunity显示文摘The transplanted liver can modulate the recipient immune system to induce tolerance after transplantation.This phenomenon was observed nearly five decades ago.Subsequently,the liver’s role in multivisceral transplantation was recognized,as it has a protective role in preventing rejection of simultaneously transplanted solid organs such as kidney and heart.The liver has a unique architecture and is home to many cells involved in immunity and inflammation.After transplantation,these cells migrate from the liver into the recipient.Early studies identified chimerism as an important mechanism by which the liver modulates the human immune system.Recent studies on human T-cell subtypes,cytokine expression,and gene expression in the allograft have expanded our knowledge on the potential mechanisms underlying immunomodulation.In this article,we discuss the privileged state of liver transplantation compared to other solid organ transplantation,the liver allograft’s role in multivisceral transplantation,various cells in the liver involved in immune responses,and the potential mechanisms underlying immunomodulation of host alloresponses. | Nitin Abrol Caroline C Jadlowiec Timucin Taner | 2019 | World Journal of Gastroenterology2019，25，25： | 2 |
| 4 | Gut microbiota disturbance during antibiotic therapy: a multi-omic approach显示文摘 | Ana Elena Pérez-Cobas María José Gosalbes Anette Friedrichs Henrik Knecht Alejandro Artacho Kathleen Eismann Wolfgang Otto David Rojo Rafael Bargiela Martin von Bergen Sven C Neulinger Carolin D?umer Femke-Anouska Heinsen Amparo Latorre Coral Barbas Jana | 2013 | Gut2013，，11： | 2 |
| 5 | Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial显示文摘 | Caroline AH Klazen Paul NM Lohle Jolanda de Vries Frits H Jansen Alexander V Tielbeek Marion C Blonk Alexander Venmans Willem Jan J van Rooij Marinus C Schoemaker Job R Juttmann Tjoen H Lo Harald JJ Verhaar Yolanda van der Graaf Kaspar J van Everdingen Al | 2010 | 2010 (9746)2010，，9746： | 2 |
| 6 | Development of chlorine dioxide related by-product models for drinking water treatment显示文摘 | Caroline K Robert C Anderews B | 2002 | Water Res2002，36，1： | 1 |
| 7 | Stroke subtype classification to mechanism-specific and undetermined categories by TOAST,ASCO,and Causative Classification System显示文摘 | Michael M Caroline AD Orla C | 2010 | Stroke2010，41，8： | 1 |
| 8 | Studies of microstructural and mechanical properties of Nylon/glass composite显示文摘 | Cartledge Caroline A B | 1999 | Journal of Materials Science1999，34，： | 1 |
| 9 | Rapid uptake of 15N-ammonium and glycine- 13C, 15N by arbuscular and ericoid mycorrhizal plants native to a Northern California coastal pygmy forest显示文摘 | Kai C R Caroline S 13 | 2007 | Soil Biology and Biochemistry2007，39，10： | 1 |
| 10 | Development of chlorine dioxide-related by-product models for drinking water treatment显示文摘 | Caroline Korn Robert C Andrews | 2002 | Water Res2002，，36： | 1 |
| 11 | Retinoids in chemoprevention and differention therapy显示文摘 | Laura A Hansen Caroline C Sigman Fausto Andreola | 2000 | Carcinogenesis2000，21，7： | 1 |
| 12 | Mutagenic activity promoted by amentoflavone and methanolic extract of Byrsonima crassa Niedenzu显示文摘 | Cássia Regina Primila Cardoso Ilce Mara de Syllos Cólus Caroline Cristiane Bernardi Miriam Sannomiya Wagner Vilegas Eliana Aparecida Varanda | 2006 | Toxicology2006，，1： | 1 |
| 13 | A link between chemokine levels and disease severity in human African trypanosomiasis显示文摘 | Bertrand C Caroline B Ge'de'on | 2006 | Intern J Parasitol2006，36，： | 1 |
| 14 | Multilocus genotypes and DNA fingerprints do not predict variation in azole resistance among clinical isolates of Candida albicans显示文摘 | Leah E C Caroline S Richard C S | 1999 | Antimicrob Agents Chemother1999，43，： | 1 |
| 15 | Development of chlorine dioxide related by-product models for drinking water treatment显示文摘 | ROBERT C ANDREWS B | 2002 | Water Research2002，36，： | 1 |
| 16 | HLA-B * 5703 independently associated with HIV-1 disease progression in Rwandan women显示文摘 | Caroline C Tang J Rivers C | 1999 | AIDS1999，13，： | 1 |
| 17 | Recombinant tissue-type plasminogen activator therapy of thrombosis in 16 neonates显示文摘 | Caroline F Odile C Didier P | 1998 | Pediatrics1998，133，1： | 1 |
| 18 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 19 | Synthesis of new lichen xanthones显示文摘 | John A E Caroline E C Hui J | 1992 | Aust J Chem1992，45，5： | 1 |
| 20 | Exceptionally high levels of CA125 due to endometriosis显示文摘 | Caroline C Bashir T | 2002 | J Obstet Gynaecol2002，22，3： | 1 |
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