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| 1 | Tight junction disruption: Helicobacter pylori and dysregulation of the gastric mucosal barrier显示文摘Long-term chronic infection with Helicobacter pylori(H. pylori) is a risk factor for gastric cancer development. In the multi-step process that leads to gastric cancer,tight junction dysfunction is thought to occur and serve as a risk factor by permitting the permeation of luminal contents across an otherwise tight mucosa. Mechanisms that regulate tight junction function and structure in the normal stomach,or dysfunction in the infected stomach,however,are largely unknown. Although conventional tight junction components are expressed in gastric epithelial cells,claudins regulate paracellular permeability and are likely the target of inflammation or H. pylori itself. There are 27 different claudin molecules,each with unique properties that render the mucosa an intact barrier that is permselective in a way that is consistent with cell physiology. Understanding the architecture of tight junctions in the normal stomach and then changes that occur during infection is important but challenging,because most of the reports that catalog claudin expression in gastric cancer pathogenesis are contradictory. Furthermore,the role of H. pylori virulence factors,such as cytotoxin-associated gene A and vacoulating cytotoxin,in regulating tight junction dysfunction during infection is inconsistent in different gastric cell lines and in vivo,likely because non-gastric epithelial cell cultures were initially used to unravel the details of their effects on the stomach. Hampering further study,as well,is the relative lack of cultured cell models that have tight junction claudins that are consistent with native tissues. This summary will review the current state of knowledge about gastric tight junctions,normally and in H. pylori infection,and make predictions about the consequences of claudin reorganization during H. pylori infection. | Tyler J Caron Kathleen E Scott James G Fox Susan J Hagen | 2015 | World Journal of Gastroenterology2015，21，40： | 7 |
| 2 | Response of bacterioplankton and phytoplankton to organic carbon and inorganic nutrient additions in contrasting oceanic ecosystems显示文摘 | Caron D A Lira E L Sanders R W | 2000 | Aquatic Microbial Ecology2000，22，： | 1 |
| 3 | Comparison of terrestrial DTV transmission system: The ATSC 8-VSB, the DVB-T COFDM and the ISDB-T BST-OFDM 显示文摘 | Wu Y Pliszka E Caron B | 2000 | IEEE TransBroadcasting2000，46，2： | 1 |
| 4 | Sharps injuries in UK health carc:a review of inju'y rates, viral transmission and potential efficacy of safety devices 显示文摘 | Alexander E Caron P | 2006 | Occupational Medicine2006，56，8： | 1 |
| 5 | Genetic heterogeneity of hepatitis E virus in Darfur, Sudan, and neighboring Chad显示文摘 | Nicand E Armstrong G L Enouf V Guthmann J P Guerin J P Caron M Nizou J Y Andraghetti R | 2005 | Med Virol2005，，7： | 1 |
| 6 | GPS/IMU data fusion using multi sensor Kalman filtering:introduction of contextual aspects显示文摘 | CARON F DUFLOS E POMORSKI D | 2006 | Information Fusion2006，，7： | 1 |
| 7 | Evaluation of the prophy- lactie use of mitomycin-C to inhibit haze formation after photore- fractive keralectomy 显示文摘 | Carones F Vigo L Scandola E | 2002 | Cataract Refraet Surg2002，28，： | 1 |
| 8 | Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases显示文摘 | Caron E Hall A | 1998 | Science1998，282，5394： | 1 |
| 9 | Different anthracycline derivates for reducing cardiotoxicity in cancer patients显示文摘 | van-Dalen E C Michiels E M Caron H N | 2006 | Cochrane Database Syst Rev2006，12，5： | 1 |
| 10 | Scraping and mitomycin C to treat haze and regression after photorefractive keratectomy formyopia显示文摘 | Vigo L Scandola E Carones F | 2003 | J Cataract Refract Surg2003，19，4： | 1 |
| 11 | Laser in situ keratomileusis for hyperopia and hyperopic and mixed astigmatism with LADARVision using 7 to 10 mm ablation diameters显示文摘 | Carones F Vigo L Scandola E | 2003 | J Refract Surg2003，19，： | 1 |
| 12 | The global monsoon as seen through the divergent atmospheric circulation显示文摘 | Trenberth K E Stepaniak D P Caron J M | | 0，，： | 1 |
| 13 | Evaluation of the prophylactic llse of mitomycin-C to inhibit haze formation after photofracfive keratectomy显示文摘 | Carones F Vigo L Scandoh E | 2002 | Cataract Refract Surg2002，28，： | 1 |
| 14 | GPS/IMU data fusion using multisensory Kalman filtering:introduction of contextual aspects显示文摘 | Caron F Dufls E Pomorski D | 2006 | Information Fusion2006，7，： | 1 |
| 15 | Laser in situ keratomileusis for hypero- pia and hyperopic and mixed astigmatism with LADARVision using 7 to 10-mm ablation diameters显示文摘 | Carones F Vigo L Scandola E | 2003 | J Refract Surg2003，19，5： | 1 |
| 16 | Picoplankton and nanoplankton and their trophic coupling in the surface waters of the Sargasso Sea south of Bermuda 显示文摘 | Caron D A Peele E R Lim E L | 1999 | Limnol Oceanogr1999，44，： | 1 |
| 17 | Evaluation of the prophylactic use of mitomycin-c to inhibit haze formation after photore fractive keratectomy 显示文摘 | Carones F Vigo L Scandola E | 2002 | J Cataract Refract Surg2002，28，： | 1 |
| 18 | Responses of bacterioplankton and phytoplankton to organic carbon and inorganic nutrient additions in contrasting oceanic ecosystems 显示文摘 | DAVID A CARON E L L ROBERT W | 2000 | Aquatic Microbial Ecology2000，22，2： | 1 |
| 19 | The atmospheric energy budget and implications for surface fluxes and ocean heat transports显示文摘 | Trenberth K E Caron J M Stepaniak D P | 2001 | Cli- mate Dynamics2001，17，： | 1 |
| 20 | Subversion of actin dynamics by EPEC and EHEC显示文摘 | Caron E Crepin V F Simpson N | 2006 | Curr Opin Microbiol2006，9，1： | 1 |
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