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| 1 | Clinical epidemiology of chronic viral hepatitis B:A Tuscany real-world large-scale cohort study显示文摘AIM To build a regional database of chronic patients to define the clinical epidemiology of hepatitis B virus(HBV)-infected patients in the Tuscan public health care system.METHODS This study used a cross-sectional cohort design. We evaluated chronic viral hepatitis patients with HBV referred to the outpatient services of 16 hospital units. Information in the case report forms included main demographic data, blood chemistry data, viral hepatitis markers, instrumental evaluations, and eligibility for treatment or ongoing therapy and liver transplantation. RESULTS Of 4015 chronic viral hepatitis patients, 1096(27.3%) were HBV infected. The case report form was correctly completed for only 833 patients(64% males, 36% females; mean age 50.1 ± 15.4). Of these HBV-infected patients, 73% were Caucasian, 21% Asian, 4% Central African, 1% North African and 1% American. Stratifying patients by age and nationality, we found that 21.7% of HBV-infected patients were aged < 34 years(only 2.8% were Italian). The most represented routes of transmission were nosocomial/dental procedures(23%), mother-to-child(17%) and sexual transmission(12%). The most represented HBV genotypes were D(72%) and A(14%). Of the patients, 24.7% of patients were HBe Ag positive, and 75.3% were HBe Ag negative. Of the HBV patients 7% were anti-HDV positive. In the whole cohort, 26.9% were cirrhotic(35.8% aged < 45 years), and 47% were eligible for or currently undergoing treatment, of whom 41.9 % were cirrhotic. CONCLUSION Only 27.3% of chronic viral hepatitis patients were HBV infected. Our results provide evidence of HBV infection in people aged < 34 years, especially in the foreign population not protected by vaccination. In our cohort of patients, liver cirrhosis was also found in young adults. | Cristina Stasi Caterina Silvestri Roberto Berni Maurizia Rossana Brunetto Anna Linda Zignego Cristina Orsini Stefano Milani Liana Ricciardi Andrea De Luca Pierluigi Blanc Cesira Nencioni Donatella Aquilini Alessandro Bartoloni Giampaolo Bresci Santino Marchi Franco Filipponi Piero Colombatto Paolo Forte Andrea Galli Sauro Luchi Silvia Chigiotti Alessandro Nerli Giampaolo Corti Rodolfo Sacco Paola Carrai Angelo Ricchiuti Massimo Giusti Paolo Almi Andrea Cozzi Silvia Carloppi Giacomo Laffi Fabio Voller Francesco Cipriani | 2018 | World Journal of Hepatology2018，10，5： | 3 |
| 2 | Use of Octogenarian Donors for Liver Transplantation: A Survival Analysis显示文摘 | D. Ghinolfi J. Marti P. De Simone Q. Lai D. Pezzati L. Coletti D. Tartaglia G. Catalano G. Tincani P. Carrai D. Campani M. Miccoli G. Biancofiore F. Filipponi | 2014 | American Journal of Transplantation2014，，9： | 2 |
| 3 | Efficacy and Safety of Combination Therapy With Everolimus and Sorafenib for Recurrence of Hepatocellular Carcinoma After Liver Transplantation显示文摘 | P. De Simone L. Crocetti D. Pezzati I. Bargellini D. Ghinolfi P. Carrai G. Leonardi C. Della Pina D. Cioni L. Pollina D. Campani C. Bartolozzi R. Lencioni F. Filipponi | 2014 | Transplantation Proceedings2014，，1： | 2 |
| 4 | Modified RECIST to assess tumor response after Transarterial Chemoembolization of Hepatocellular Carcinoma: CT-pathologic correlation in 178 liver explants显示文摘 | Irene Bargellini Elena Bozzi Daniela Campani Paola Carrai Paolo De Simone Luca Pollina Roberto Cioni Franco Filipponi Carlo Bartolozzi | 2012 | European Journal of Radiology2012，，： | 1 |
| 5 | Increase in Tannin Consumption by Sifaka (Propithecus ver- reauxi verreauxi) Females during the Birth Season: a Case for Self-Medication in Prosimians? 显示文摘 | CARRAI V BORGOGNINI-TARLI S M HUFFMAN M A | 2003 | Primates2003，44，1： | 1 |
| 6 | The role of early electroclinical assessment in improving the evaluation of patients with disorders of 显示文摘 | Amantini A Carrai R Fossi S | 2011 | Funct Neurol2011，26，1： | 1 |
| 7 | Biomechanical and electromyographic assessment of spastic hypertonus in motor complete traumatic spinal cord-injured individuals 显示文摘 | Grippo A Carrai R Hawamdeh Z | 2011 | Spinal Cord2011，49，1： | 1 |
| 8 | The role of early electro- clinical assessment in improving the evaluation of patients with disorders off 显示文摘 | Amantini A Carrai R Fossi S | 2011 | Funct Neurol2011，26，1： | 1 |
| 9 | Prognostic value of somato- sensory evoked potentials in comatose children: a systematic literature review显示文摘 | Carrai R Grippo A Loft S | 2010 | Intensive Care Med2010，36，7： | 1 |
| 10 | Neurophysiological monito- ring in adult and pediatric intensive care显示文摘 | Amantini A Carrai R Lori S | 2012 | Minerva Anestesiol2012，78，9： | 1 |
| 11 | A Modified Retinex for Image Contrast Enhancement and Dynamics Control显示文摘 | G Orsini G Ramponi P Carrai | 2003 | Image Processing2003，3，： | 1 |
| 12 | Efficacy, safe- ty, and pharmacokinetics of intramuscular hepatitis B im- mune globulin, Igantibe, for the prophylaxis of viral B hepatitis after liver transplantation显示文摘 | Filipponi F Franchello A Carrai P | 2010 | Dig Liver Dis2010，42，7： | 1 |
| 13 | Kinetics of Cu2+ and Cd2+ absorption by an Italian soil显示文摘 | Aringhieri R Carrai P Petruzzelli G | 1985 | Soil Science1985，139，3： | 1 |
| 14 | Prognostic value of somatosensory evoked potentials in comatose children: a systematic literature review显示文摘 | Carrai R Grippo A Lori S | 2010 | Intensive Care Med2010，36，7： | 1 |
| 15 | Neurophysiological monitoring in adult and pediatric intensive care 显示文摘 | Amantini A Carrai R Lori S | 2012 | Minerva Anestesiol2012，78，9： | 1 |
| 16 | The Impact of Everolimus on Renal Function in Maintenance Liver Transplantation显示文摘 | P. De Simone A. Precisi S. Petruccelli E. Balzano P. Carrai G. Catalano D. Campani F. Filipponi | 2009 | Transplantation Proceedings2009，，4： | 1 |
| 17 | Kinetics of Cu2 + and Cd2+ adsorption by an Italian soil显示文摘 | Aringhieri R Carrai P Petruzzelli G | 1985 | Soil Sci1985，139，： | 1 |
| 18 | Association between TAS2R38 gene polymorphisms and colorectal cancer risk:a case-control study in two independent populations of Caucasian origin显示文摘 | Carrai M Steinke V Vodicka P | | 0，，06： | 1 |
| 19 | Kineticsnof Cu2+and Cd2+adsorption by an Italian soil显示文摘 | Aringhieri R Carrai P Petruzzelli G | 1985 | Soil Science1985，139，3： | 1 |
| 20 | Association betweenTAS2R38 gene polymorphisms and colorectal cancer risk: acase 一 control study in two Independent populations ofCaucasian origin显示文摘 | Carrai M Steinke V Vodicka P | 2011 | PLoS One2011，6，20： | 1 |
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