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| 1 | Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications. | Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns | 2015 | World Journal of Gastroenterology2015，21，17： | 4 |
| 2 | Protection against lethal challenge by Ebola virus-like particles produced in insect ceils 显示文摘 | Sun Y Carrion R Jr Ye L | 2009 | Virology2009，383，1： | 1 |
| 3 | Osmoregulatory action of PRL, GH, and cortisol in the gihhead sea bream 显示文摘 | MANCERA M J CARRION R L MARTIN-DEL- PILAR M D R | 2002 | General and Comparative Endocrinology2002，129，2： | 1 |
| 4 | Rapid assembly of sensitive antigen-capture assays for Marburg virus, using in vitro selection of llama single-domain antibodies, at biosafety level4显示文摘 | Sherwood L J Osborn L E Carrion R Jr | 2007 | J Infect Dis2007，196，2： | 1 |
| 5 | Long-term efficacy of myoblast transplantation on regional structure and function after myocardial infarction显示文摘 | CARRION C SOUZA L C | 2002 | Circulation2002，106，121： | 1 |
| 6 | Successful treat- ment of pityriasis rubra pilaris with adalimumab - case re- port 显示文摘 | Bravo EA Carrion L Pauear SM | 2014 | Dermatol Online J2014，20，22： | 1 |
| 7 | Value of travel time reliabil- ity:A review of current evidence显示文摘 | CARRION C DAVID L | 2012 | Transportation Research Part A2012，46，： | 1 |
| 8 | Testing for changein the unconditional variance of financial time series显示文摘 | SansóA AragóV Carrion J L 2004 | 2004 | Revista de Economía Financiera2004，4，： | 1 |
| 9 | Testing for Change in the Uncondi tional Variance of Financial Time Series显示文摘 | SansóA ArragóV Carrion J L | 2004 | Revista de EconomiáFi nanciera2004，，4： | 1 |
| 10 | 显示文摘 | Vouagner D Carrion L Gaillard F | 2002 | Applied Surface Science2002，186，： | 1 |
| 11 | Successful treatment of pityria- sis rubra pilaris with adalimumab-case report 显示文摘 | Bravo EA Carrion L Pauear SM | 2014 | Dernmtol Online J2014，20，22： | 1 |
| 12 | Testing for Change in the Unconditional Variance of Financial Time Series显示文摘 | SANSó A ARRAGó V Carrion J L | 2004 | Revista de Economiá Financiera2004，，04： | 1 |
| 13 | Different uses of home blood pressure measure- ment in the diagnosis and monitoring of hypertension 显示文摘 | Divison JA Sanchis Domenech C carrion Valero L | 2006 | Aten Primaria2006，38，7： | 1 |
| 14 | Stress predicts brain changes in children:a pilot longitudinal study on youth stress,posttraumatic stress disorder,and the hippocampus显示文摘 | Carrion V G Weems C F Reiss A L | | 0，，03： | 1 |
| 15 | Unit root and stationarity tests wedding 显示文摘 | Carrion J L I Sanso A I | 2001 | Economics Letters2001，，1： | 1 |
| 16 | Protection against lethal chal- lenge by Ebola virus -like particles produced in insect ceils 显示文摘 | Sun Y Carrion R Jr Ye L | 2009 | Virology2009，383，1： | 1 |
| 17 | Unit root and stationarity test's wedding显示文摘 | Carrion J L I Sanso A I | 2001 | Economics Letters2001，70，1： | 1 |
| 18 | Osmoregulatory action of PRL,GH,and cortisol in the gilthead seabream (Sparus aurata)显示文摘 | Mancera J M Carrion R L Martin M P | 2002 | Gen Comp Endocrinol2002，129，： | 1 |
| 19 | Metascheduling in advance using red-black trees in heterogeneous Grids显示文摘 | TOMAS L CARRION C CAMINERO B | 2010 | IEEE International Symposium on Parallel&Distributed Processing Workshops and Phd Forum(IPDPSW)2010，18，： | 1 |
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