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| 1 | The IL-1R/TLR signaling pathway is essential for efficient CD8+ T-cell responses against hepatitis B virus in the hydrodynamic injection mouse model显示文摘The outcome of hepatitis B viral(HBV)infection is determined by the complex interactions between replicating HBV and the immune system.While the role of the adaptive immune system in the resolution of HBV infection has been studied extensively,the contribution of innate immune mechanisms remains to be defined.Here we examined the role of the interleukin-1 receptor/Toll-like receptor(IL-1R/TLR)signaling pathway in adaptive immune responses and viral clearance by exploring the HBV mouse model.Hydrodynamic injection with a replication-competent HBV genome was performed in wild-type mice(WT)and a panel of mouse strains lacking specific innate immunity component expression.We found higher levels of HBV protein production and replication in Tlr2^(−/−),Tlr23479^(−/−),3d/Tlr24^(−/−),Myd88/Trif^(−/−)and Irak4^(−/−)mice,which was associated with reduced HBV-specific CD8+T-cell responses in these mice.Importantly,HBV clearance was delayed for more than 2 weeks in 3d/Tlr24^(−/−),Myd88/Trif^(−/−)and Irak4^(−/−)mice compared to WT mice.HBV-specific CD8+T-cell responses were functionally impaired for producing the cytokines IFN-γ,TNF-αand IL-2 in TLR signaling-deficient mice compared to WT mice.In conclusion,the IL-1R/TLR signaling pathway might contribute to controlling HBV infection by augmenting HBV-specific CD8+T-cell responses. | Zhiyong Ma Jia Liu Weimin Wu Ejuan Zhang Xiaoyong Zhang Qian Li Gennadiy Zelinskyy Jan Buer Ulf Dittmer Carsten J Kirschning Mengji Lu | 2017 | Cellular & Molecular Immunology2017，14，12： | 6 |
| 2 | The use of adenosine deaminase and interferon-gamma as diagnostic tools for tuberculous pericarditis 显示文摘 | Burgess J Reuter H Carstens ME | 2002 | Chest2002，122，3： | 1 |
| 3 | A new fast and reliable radioimmunoassay of brain natriuretic peptide in human plasm显示文摘 | Jesen K T Carstens J Ivarsen N | 1997 | Scand J Clin Lab Invest1997，57，： | 1 |
| 4 | Perfusion MRI of brain tumours: a comparative study of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast imaging显示文摘 | Hanna J?rnum Elena G. Steffensen Linda Knutsson Ernst-Torben Fründ Carsten Wiberg Simonsen S?ren Lundbye-Christensen Ajit Shankaranarayanan David C. Alsop Finn Taageh?j Jensen Elna-Marie Larsson | 2010 | Neuroradiology2010，，4： | 1 |
| 5 | Mapping QTL confer- ring resistance in maize to gray leaf spot disease caused by Cerco- spora zeina显示文摘 | Berger D K Carstens M Korsman J N | 2014 | BMC Genet2014，15，： | 1 |
| 6 | Separation ofazeotropic mixtures using hyperbranched polymers or i-onic liquids显示文摘 | CARSTEN J ASIMINA K WOLFGANG A | 2004 | AIChE Journal2004，50，10： | 1 |
| 7 | Anaerobic ammonium oxidation in a tropical freshwater system ( Lake Tanganyika) 显示文摘 | Carsten J Schubert C J Durisch-Kaiser E | 2006 | Environmental Microbiology2006，8，10： | 1 |
| 8 | Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses(2012)显示文摘 | ADAMS M J CARSTENS E B | 2012 | Arch Virol2012，157，： | 1 |
| 9 | 查看详情显示文摘 | J Liu J P Raymond S Carsten | | 0，，24： | 1 |
| 10 | Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate 显示文摘 | Deutschman D H Carstens J S Klepper R L | 2003 | Am Heart J2003，146，： | 1 |
| 11 | Advanced driver assistance systems:Objective and subjective performance evaluation显示文摘 | Auckland R A Manning W J Carsten O | | 0，，1： | 1 |
| 12 | In Vivo Abdominal Magnetic Resonance Elastography for the Assessment of Portal Hypertension Before and After Transjugular Intrahepatic Portosystemic Shunt Implantation显示文摘 | Jing Guo Carsten Büning Eckart Schott Thomas Kr?ncke Jürgen Braun Ingolf Sack Christian Althoff | 2015 | Investigative Radiology2015，，： | 1 |
| 13 | Serum concentrations of antibodies against vaccine toxoids in children显示文摘 | CARSTEN H ESBEN B J FLEMMING N | | 0，，10： | 1 |
| 14 | Enzymatic hydrolysis of Ovomucin and effect on foaming properties显示文摘 | HAMMERSHOJ M NEBELA C CARSTENS J | 2008 | Food Research International2008，41，5： | 1 |
| 15 | Low toxic neoadjuvant cisplatin, 5-fluorouracil and folinic acid in locally advanced gastric cancer yields high R-0 resection rate显示文摘 | Markus Menges Carsten Schmidt Werner Lindemann Karsten Ridwelski Werner Pueschel Bernhard Jüngling Gernot Feifel Martin Schilling Andreas Stallmach Martin Zeitz | 2003 | Journal of Cancer Research and Clinical Oncology2003，，7： | 1 |
| 16 | Ex- ploring Social Constructions of Followership: A Qualitative Study显示文摘 | CARSTEN K UHL-BIEN M WEST J | 2010 | Leadership Quarterly2010，21，3： | 1 |
| 17 | Factors affecting the catalytic activity of Pd/ZrO2 for the combustion of methane显示文摘 | Carstens J N Su S C Bell A T | 1998 | Jour-hal of Catalysis1998，176，1： | 1 |
| 18 | Tunable inverted-microstrip phase shifter device using nematic liquid crystals显示文摘 | Carsten W Georg L Rolf J | 2002 | Microwave Symposium Digest2002，1，： | 1 |
| 19 | Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition显示文摘 | Stefan B Carsten J Kirschning M | 2001 | PNAS2001，98，16： | 1 |
| 20 | Boundary shear stress in unsteady turbulent pipe flow显示文摘 | CARSTENS M R ROLLER J E | 1959 | Journal of the Hydraulics Division1959，85，2： | 1 |
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