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| 1 | Isolated intestinal neurofibromatous proliferations in the absence of associated systemic syndromes显示文摘Gastrointestinal tract involvement by neurofi bromatous lesions is rare and occurs most frequently as one of the systemic manifestations of generalized neurofibromatosis type 1 (NF1). In this setting, the lesions may manifest as focal scattered neurofi bromas or as an extensive diffuse neural hyperplasia designated ganglioneuromatosis. Occasionally, such lesions may be the initial sign of NF1 in patients without any other clinical manifestations of the disease. Rarely, cases of isolated neurofi bromatosis of the large bowel with no prior or subsequent evidence of generalized neurofi bromatosis have been documented. We present the case of a 52 year-old female with abdominal pain and alternating bowel habits. Colonoscopic evaluation revealed multiple small polyps in the cecum and the presence of nodular mucosa in the colon and rectum. Pathologic evaluation of the biopsies from the cecum, descending colon, sigmoid colon, and rectum revealed tangled fascicles of spindle cells expanding the lamina propia leading to separation of the intestinal crypts. Immunohistochemical stains helped confirm the diagnosis of diffuse intestinal neurofibromatosis. A thorough clinical evaluation failed to reveal any stigmata of generalized neurofibromatosis. This case represents a rare presentation of isolated intestinal neurofi bromatosis in a patient without classic systemic manifestations of generalized neurofibromatosis and highlights the need in such cases for close clinical follow-up to exclude neurofibromatosis type Ⅰ or multiple endocrine neoplasia type Ⅱ. | J Elliot Carter Javier A Laurini | 2008 | World Journal of Gastroenterology2008，14，42： | 9 |
| 2 | 机械响应干细胞在颌骨再生中获得神经嵴命运的机制显示文摘Ransom RC,Carter AC,Salhotra A,et a1.Mechanoresponsive stem cells acquire neural crestfate in jaw regeneration.Nature,2018Oct 24.在胚胎发育和成体组织再生期间.由主转录因子驱动的染色质结构的变化导致刺激响应性转录程序。彻底了解骨骼中的干细胞如何响应机械刺激并实现再生.将揭示在再生过程中力如何转换到细胞核中。在这里.作者开发了一种遗传上可分析的下颌骨牵引成骨小鼠模型:这是一种用于矫正人类小下颌的手术.包括手术分离颌骨,从而在间隙中触发新的骨骼生长。使用该模型显示新形成的骨的区域源自存在于骨架中的干细胞。染色质和转录分析显示.这些干细胞群在黏着斑激酶(FAK)信号通路内获得活性.并且抑制FAK消除新骨形成。在牵张期间.通过FAK在骨骼干细胞中的机械转导,激活基因调节程序和发育过程中原始神经嵴细胞中激活的反转录转座子。骨骼干细胞从原始神经嵴细胞中产生。这种向发育状态的逆转是促进成体骨骼组织基于干细胞再生的强大组织生长基础。 | Ransom RC Carter AC Salhotra A 赵泽亮 | 2018 | 中国口腔颌面外科杂志2018，16，6： | 9 |
| 3 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 4 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 5 | Green tea extract:A potential cause of acute liver failure显示文摘The use of herbal products has increased significantly in recent years.Because these products are not subject to regulation by the Food and Drug Administration and are often used without supervision by a healthcare provider,the indication for and consumption of these supplements is quite variable.Moreover,their use is generally regarded as safe and natural by the lay-public.Unfortunately,there has been an increase in the number of reported adverse events occurring with the use of herbal products.We present a case of acute impending liver failure in an adolescent male using a weightloss product containing green tea extract.Our case adds to the growing concern surrounding the ingestion of green tea extract and serves to heighten healthcare provider awareness of a potential green tea extract hepatotoxicity.Despite the generally touted benefits of green tea as a whole,clinical concern regarding its use is emerging and has been linked to its concentration in multiple herbal supplements.Interestingly,the suspected harmful compounds are those previously proposed to be advantageous for weight-loss,cancer remedy,and anti-inflammatory purposes.Yet,we emphasize the need to be aware of not just green tea extract,but the importance of monitoring patient use of all dietary supplements and herbal products. | Shreena S Patel Stacey Beer Debra L Kearney Garrett Phillips Beth A Carter | 2013 | World Journal of Gastroenterology2013，19，31： | 3 |
| 6 | Overexpression of the proto-oncogene/translation factor 4E in breast-carcinoma cell lines显示文摘 | Anthony B Carter P De Benedetti A | 1996 | Int J Cancer1996，65，： | 2 |
| 7 | Hydroxyurea treatment of sickle cell anemia in hospital - based practices 显示文摘 | Ferguson RP Arun A Carter C | 2002 | Am J Hematol2002，70，： | 1 |
| 8 | Rapamycin eluting stent:the onset of a new era in the interventional cardiology显示文摘 | REGAR E CARTER A J | 2002 | Heart2002，87，： | 1 |
| 9 | Lubricantderived tribochemical films-an infra-red spectroscopic study显示文摘 | Carter R O Boulos E N | 1992 | Tribology International1992，36，： | 1 |
| 10 | Quadratic-based computation of four-impulse optimal rendezvous near circular orbit 显示文摘 | Carter T E Alvarez S A | 2000 | Journal of Guidance Control and Dynamics2000，23，1： | 1 |
| 11 | Understanding Mesozoic accretion in southeast Asia: Significance of Triassic thermotectonism (Indosinian orogen) in Vietnam显示文摘 | Carter A Roques D Bristow C | 2001 | Geology2001，29，3： | 1 |
| 12 | VEGF polymor-phisms are associated with severity of diabetic retinopathy显示文摘 | Churchill A J Carter J G Rasmden C | 2008 | Invest Ophthalmol Vis Sci2008，49，8： | 1 |
| 13 | Pathology of acute and chronic coronary stenting in humans显示文摘 | Farb A Sangiorgi G Carter AJ | 1999 | Circulation1999，99，： | 1 |
| 14 | Campath- 1H and fludarabine in combination are highly active in refractory chronic lymphocytic leukemia显示文摘 | Kennedy B Rawstron A Carter C | 2002 | Blood2002，99，6： | 1 |
| 15 | Evidence that physiLologic levels of circulating estrogens and neonatal sex-imprinting modify postpubertal hepatic microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase acivity显示文摘 | Carlson S E Mitchell A D Carter M L | 1980 | Biochem Biophys Acta1980，633，： | 1 |
| 16 | Angiotensin lorverting enzyme insertion/aesetion polymorphism and cardio - vascular disease显示文摘 | CATrO A CARTER A M BARRETT J H | 1996 | Stroke1996，27，3： | 1 |
| 17 | Acta Mater显示文摘 | Carling K M Carter E A | 2007 | 2007,55: 27912007，55，： | 1 |
| 18 | Polarization- insensitive wavelength conversion by FWM in a highly nonlinear PCF of polarization-scrambled 10-Gb/s RZ-OOK and RZ-DPSK signals 显示文摘 | ASTAR W LENIHAN A S CARTER G M | 2007 | IEEE Photonics Technology Letters2007，19，20： | 1 |
| 19 | Freezing effects on aggregate stability affected by texture, mineralogy, and organic matter显示文摘 | Lehrsch G A Sojka R E Carter D L | 1991 | Soil Science Society of America Journal1991，55，： | 1 |
| 20 | A brief behavioral sleep intervention for family caregivers of persons with cancer显示文摘 | Carter P A | | 0，，02： | 1 |
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