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| 1 | Isolated intestinal neurofibromatous proliferations in the absence of associated systemic syndromes显示文摘Gastrointestinal tract involvement by neurofi bromatous lesions is rare and occurs most frequently as one of the systemic manifestations of generalized neurofibromatosis type 1 (NF1). In this setting, the lesions may manifest as focal scattered neurofi bromas or as an extensive diffuse neural hyperplasia designated ganglioneuromatosis. Occasionally, such lesions may be the initial sign of NF1 in patients without any other clinical manifestations of the disease. Rarely, cases of isolated neurofi bromatosis of the large bowel with no prior or subsequent evidence of generalized neurofi bromatosis have been documented. We present the case of a 52 year-old female with abdominal pain and alternating bowel habits. Colonoscopic evaluation revealed multiple small polyps in the cecum and the presence of nodular mucosa in the colon and rectum. Pathologic evaluation of the biopsies from the cecum, descending colon, sigmoid colon, and rectum revealed tangled fascicles of spindle cells expanding the lamina propia leading to separation of the intestinal crypts. Immunohistochemical stains helped confirm the diagnosis of diffuse intestinal neurofibromatosis. A thorough clinical evaluation failed to reveal any stigmata of generalized neurofibromatosis. This case represents a rare presentation of isolated intestinal neurofi bromatosis in a patient without classic systemic manifestations of generalized neurofibromatosis and highlights the need in such cases for close clinical follow-up to exclude neurofibromatosis type Ⅰ or multiple endocrine neoplasia type Ⅱ. | J Elliot Carter Javier A Laurini | 2008 | World Journal of Gastroenterology2008，14，42： | 9 |
| 2 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 3 | Driven pile in clay the effect of installation and subsequent consolidation显示文摘 | Randolph M F Carter J P Wroth C P | 1979 | Geotechnique1979，29，4： | 2 |
| 4 | Prognostically relevant gene signatures of high-grade serous ovarian carcinoma显示文摘 | Verhaak Roel G W Tamayo Pablo Yang Ji-Yeon Hubbard Diana Zhang Hailei Creighton Chad J Fereday Sian Lawrence Michael Carter Scott L Mermel Craig H Kostic Aleksandar D Etemadmoghadam Dariush Saksena Gordon Cibulskis Kristian Duraisamy Sekhar | 2013 | Journal of Clinical Investigation2013，，1： | 2 |
| 5 | Folate and vitamin B12 in idiopathic male infertility显示文摘尽管 methylenetetrahydrofolate reductase,叶酸的酶基因,与自发的男不孕被联系了,很少研究检验了另外的叶酸相关的代谢物和基因。我们调查了自发的男不孕是否与变体被联系在叶酸,维生素 B 12(B12 ) 和全部的 homocysteine (tHcy ) 联系了基因并且在血测量了这些代谢物。我们进行了与自发的不孕和在生育力中心和胎儿的照顾中心招募的 184 肥沃的男控制包括了 153 个人的盒子控制研究,大学医院, Malmö并且 Lund,瑞典。浆液叶酸的、红房间叶酸(RCF ) ,浆液 B12,血浆 tHcy 和精液质量被测量。题目是为在与 folate/B12/homocysteine 新陈代谢有关的 12 基因的 20 普通变体的 genotyped。代谢物集中和遗传型分布为 covariates 与调整用线性、逻辑的回归在案例和控制之间被作比较。phosphatidylethanolamine N-methyltransferase (PEMT ) M175V 和 TCblR rs173665 多型性显著地与不孕被联系(P=0.01 和 P=0.009,分别地) ,然而并非与精液质量。在补充的非用户之中,有的不肥沃的人降低浆液叶酸的集中比肥沃的人(12.89 对 14.73 nmol l −1 ;P=0.02 ) ,但是在 RCF, B12 或 tHcy 没有重要差别。叶酸, B12 和 tHcy 集中没与任何精液参数被相关。这研究几乎不提供小支持为低叶酸或在自发的男不孕的致病的 B12 地位。尽管另外的数据被需要证实这些起始的调查结果,我们的结果建议那 PEMT 和 TCblR,基因在胆碱和 B12 新陈代谢包含了,在自发的男不孕应得进一步的调查。 | Laurel E Murphy James L Mills Anne M Molloy Cong Qian Tonia C Carter Helena Strevens Dag Wide-Swensson Aleksander Giwercman Richard J Levine | 2011 | Asian Journal of Andrology2011，13，6： | 2 |
| 6 | An inexpensive and simple method for DNA purifications on silica particles 显示文摘 | Carter M J Milton I D | 1993 | Nucleic Acids Res1993，21，4： | 2 |
| 7 | Driven Piles in clay - the effects of installation and subsequent consolidation显示文摘 | RANDOLPH M F CARTER J P WROTH C P | 1979 | Geotechnique1979，29，4： | 1 |
| 8 | Rapamycin eluting stent:the onset of a new era in the interventional cardiology显示文摘 | REGAR E CARTER A J | 2002 | Heart2002，87，： | 1 |
| 9 | Interpretation of drilling parameters for ground characterization in exploration and development of quarries显示文摘 | Scoble M J Carter M | 1987 | Transactions of the Institution of Mining and Metallurgy1987，96，： | 1 |
| 10 | The transformation of the nuclear power industry显示文摘 | CARTER J P | 2006 | IEEE Power and Energy Magazine2006，4，6： | 1 |
| 11 | A theory of finite elastic consolidation显示文摘 | CARTER J P SMALL J C BOOKER J R | 1977 | International Journal of Solids and Structures1977，13，5： | 1 |
| 12 | Epidemiology of hospitalizations and death from heat illness in soldiers显示文摘 | Carter R 3rd Cheuvront S N Williams J O | 2005 | Med Sci Sports Exerc2005，37，4： | 1 |
| 13 | Deep penetration of strip and circular footings into layered clays显示文摘 | WANG C X CARTER J P | 2002 | International Journal of Geomechanics2002，2，2： | 1 |
| 14 | Genetic base of 651Chinese soybean eultivars released during 1923 to 1995 显示文摘 | Cui Z L Thomas E Carter J Burton J W | 2000 | Crop Science2000，40，： | 1 |
| 15 | Driven piles in clay-the effects of installation and sub- sequent consolidation显示文摘 | RANDOLPH M F CARTER J P & WROTH C P | 1979 | Geotechnique1979，29，4： | 1 |
| 16 | VEGF polymor-phisms are associated with severity of diabetic retinopathy显示文摘 | Churchill A J Carter J G Rasmden C | 2008 | Invest Ophthalmol Vis Sci2008，49，8： | 1 |
| 17 | PD-1 : PD-L inhibitory pathway affects both CD4^+ and CD8^+ T cells and is overcomed by IL-2显示文摘 | Carter L Fouser LA Jussif J | 2002 | Eur J Immunol2002，32，： | 1 |
| 18 | Maternal health factors and early pediatric antiretroviral therapy influence the rate of perinatal HIV-1 disease progression in children显示文摘 | Abrams EJ Wiener J Carter R | 2003 | AIDS2003，17，： | 1 |
| 19 | Toward the production of bispecific antibody fragments for clinical applications显示文摘 | Carter P Ridgway J Zhu Z | 1995 | J Hematother1995，4，5： | 1 |
| 20 | 显示文摘 | Carter G M Hryniewicz J V Thakur M K | 1986 | Appl Phys Lett1986，48，： | 1 |
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