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| 1 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 2 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 3 | Green tea extract:A potential cause of acute liver failure显示文摘The use of herbal products has increased significantly in recent years.Because these products are not subject to regulation by the Food and Drug Administration and are often used without supervision by a healthcare provider,the indication for and consumption of these supplements is quite variable.Moreover,their use is generally regarded as safe and natural by the lay-public.Unfortunately,there has been an increase in the number of reported adverse events occurring with the use of herbal products.We present a case of acute impending liver failure in an adolescent male using a weightloss product containing green tea extract.Our case adds to the growing concern surrounding the ingestion of green tea extract and serves to heighten healthcare provider awareness of a potential green tea extract hepatotoxicity.Despite the generally touted benefits of green tea as a whole,clinical concern regarding its use is emerging and has been linked to its concentration in multiple herbal supplements.Interestingly,the suspected harmful compounds are those previously proposed to be advantageous for weight-loss,cancer remedy,and anti-inflammatory purposes.Yet,we emphasize the need to be aware of not just green tea extract,but the importance of monitoring patient use of all dietary supplements and herbal products. | Shreena S Patel Stacey Beer Debra L Kearney Garrett Phillips Beth A Carter | 2013 | World Journal of Gastroenterology2013，19，31： | 3 |
| 4 | Modulation of statin- activated shedding of Alzheimer APP ectodomain by ROCK 显示文摘 | Pedrini S Carter TL Prendergast G | 2005 | PLoS Med2005，2，1： | 1 |
| 5 | Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism 显示文摘 | Jacob S Brune CW Carter CS | 2007 | Neurosci Lett2007，417，1： | 1 |
| 6 | Quadratic-based computation of four-impulse optimal rendezvous near circular orbit 显示文摘 | Carter T E Alvarez S A | 2000 | Journal of Guidance Control and Dynamics2000，23，1： | 1 |
| 7 | Epidemiology of hospitalizations and death from heat illness in soldiers显示文摘 | Carter R 3rd Cheuvront S N Williams J O | 2005 | Med Sci Sports Exerc2005，37，4： | 1 |
| 8 | Evidence that physiLologic levels of circulating estrogens and neonatal sex-imprinting modify postpubertal hepatic microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase acivity显示文摘 | Carlson S E Mitchell A D Carter M L | 1980 | Biochem Biophys Acta1980，633，： | 1 |
| 9 | Isokinetic evaluation of anterior cruciate ligment reconstruction: hamstring versus patellar tendon显示文摘 | Carter TR Edinger S | 1999 | Arthros copy1999，15，2： | 1 |
| 10 | A prospective, randomized, multicentered controlled trial to compare the annual glycemic and quality outcomes of patients with diabetes mellitus monitored with weekly fructosamine testing versus usual care显示文摘 | Lindsey CC Carter AW Mangum S | 2004 | Diabetes Technol Ther2004，6，3： | 1 |
| 11 | Association of Cervical Cytology and HPV DNA Status During Pregnancy With Placental Abnormal- ities and Preterm Birth显示文摘 | Zuo Z Goel S Carter JE | 2011 | American Journal of Clinical Pathology2011，136，2： | 1 |
| 12 | The First Five Years of the Peking Union Medical Col lege显示文摘 | Carter W S | 1926 | The China Medical Journal1926，40，8： | 1 |
| 13 | The Asian lower eyelid:a comparative anatomic study using high-resolution magnetic resonance imaging显示文摘 | CARTER S R SEIFF S R GRANT P E | 1998 | Ophthal Plast Reconstr Surg1998，14，4： | 1 |
| 14 | Polarization- insensitive wavelength conversion by FWM in a highly nonlinear PCF of polarization-scrambled 10-Gb/s RZ-OOK and RZ-DPSK signals 显示文摘 | ASTAR W LENIHAN A S CARTER G M | 2007 | IEEE Photonics Technology Letters2007，19，20： | 1 |
| 15 | Sudden productivity collapse associated with the triassic- jurassic boundary mass extinction显示文摘 | Ward P D Haggart J W Carter E S | 2001 | Science2001，292，： | 1 |
| 16 | Development of subscales from the symptom/Problem and effect of kidney disease scales of kidney disease quality of life instrument显示文摘 | Rao S Carter W B Mapes D L | 2000 | Clin Ther2000，22，： | 1 |
| 17 | Reflexivity, defectiveness, and mental health in BBC-TV production teams 显示文摘 | CARTER S WEST M A | 1998 | Small Group Re- search1998，，29： | 1 |
| 18 | Clinieal efficacy of two hypocaloric diets that vary in overweight patients with type 2 diabetes: comparison of moderate fat versus carbohydrate reductions显示文摘 | McLaughlin T Carter S Lamendola C | 2007 | Diabetes Care2007，30，7： | 1 |
| 19 | Hydrologic model development of the Sacramento River Watershed to support TMDL development显示文摘 | CARTER S DENTON D SIEVERS M | 2005 | Proceedings of the Water En- vironment Federation2005，29，： | 1 |
| 20 | Prevalence and impact of gastroesophageal reflux in adolescents with asthma: a population-based study 显示文摘 | Debley J S Carter E R Redding G J | 2006 | Pediatr Pulmonol2006，41，5： | 1 |
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