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| 1 | Bcl-2 with loss of apoptosis allows accumulation of genetic alterations: a pathway to metastatic progression in human breast cancer显示文摘 | Sierra A Castellsague X Eseobedo A | 2000 | Int J Cancer2000，89，2： | 1 |
| 2 | Synergistic cooperation between c-myc and Bcl-2 in lymph node progression of T1 human breast carcinoma显示文摘 | Sierra A Castellsague A Escobedo A | 1999 | Breast Cancer Research and Treatment1999，54，： | 1 |
| 3 | A cohort study on the risk of acute liver injury among users of ketoconazole and other antifungal drugs 显示文摘 | Garcia Rodriguez LA Duque A Castellsague J | 1999 | Br J Clin Pharmacol1999，48，6： | 1 |
| 4 | A cohort study on the risk of acute liver injury among users of ketoconszole and other antifungal drugs显示文摘 | Garcia Bodriguez LA Duque A Castellsague J | 1999 | Br J Clin Pharmacol1999，48，6： | 1 |
| 5 | Efficacy and safety of prophylactic vaccines,against cervical HPV infection and diseases among women:a systematic review&meta-analysis显示文摘 | Lu B Kumar A Castellsague X | 2011 | BMC Infect Dis2011，11，1： | 1 |
| 6 | HPV vaccination against cervical cancer in women above 25 years of age: key considerations and current perspectives 显示文摘 | Castellsague X Schneider A Kanfmann AM | 2009 | Gyne- col Oncol2009，115，3： | 1 |
| 7 | A cohort study on the risk of acute liver injury amomg users of ketocon- azole and other antifungal drugs 显示文摘 | Garcia Rodriguez LA Duque A Castellsague J | 1999 | Br J Clin Pharmacol1999，48，6： | 1 |
| 8 | A cohort study on the risk of acute liver injury among users of keteconazole and other antifungal dross显示文摘 | Garcia Rodriguez LA Duque A Castellsague J | 1999 | Br J Clin Pharmacol1999，48，6： | 1 |
| 9 | Expres- sion of adhesion molecules in 113 patients with B-cell chronic lymphocytic leukemia: relationship with clinico-prognostic fea- tures显示文摘 | Domingo A Gonzalez-Barca E Castellsague X | 1997 | Leuk Res1997，21，1： | 1 |
| 10 | Efficacy and safety of prophylactic vaccines against cervical HPV infection and diseases among women: asystematic review &meta - analysis显示文摘 | Lu B Kumar A Castellsague X | 2011 | BMC Infect Dis2011，11，： | 1 |
| 11 | Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomised controlled trial显示文摘 | Jorma Paavonen David Jenkins F Xavier Bosch Paulo Naud Jorge Salmerón Cosette M Wheeler Song-Nan Chow Dan L Apter Henry C Kitchener Xavier Castellsague Newton S de Carvalho S Rachel Skinner Diane M Harper James A Hedrick Unnop Jaisamrarn Genara AM Limson | 2007 | The Lancet2007，，9580： | 1 |
| 12 | A cohort study on the risk of acute liver injury among users of ketoconazole and other antifungal drugs显示文摘 | Garcia Rodriguez LA Duque A Castellsague J | 1999 | Br J Clin Pharmacol1999，48，6： | 1 |
| 13 | A cohort study on the risk of acute liver injury amomg users of ketoconazole and other antifungal drugs显示文摘 | Garcia Rodriguez LA Duque A Castellsague J | 1999 | Br J Clin Pharmacol1999，48，6： | 1 |
| 14 | Chapter 1:HPV in the etiology of human cancer显示文摘 | Mu oz N Castellsagu X De Gonz lez A B | 2006 | Vaccine2006，24，3： | 1 |
| 15 | A cohort study on the risk of acute liver injury among users of ketoconazole and other antifungal drugs显示文摘 | Garcia Rodriguez LA Duque A Castellsague J | 1999 | BrJ Clin Pharmacol1999，48，6： | 1 |
| 16 | Human papillomavirus genotype attribution in invasive cervical cancer:a retrospective cross-sectional worldwide study显示文摘 | de Sanjose S Quint WG Alemany L Geraets DT Klaustermeier JE Lloveras B Tous S Felix A Bravo LE Shin HR Vallejos CS de Ruiz PA Lima MA Guimera N Clavero O Alejo M Llombart-Bosch A Cheng-Yang C Tatti SA Kasamatsu E Iljazovic E Odida M Prado R Seoud M Grce M Usubutun A Jain A Suarez GA Lombardi LE Banjo A Menéndez C Domingo EJ Velasco J Nessa A Chichareon SC Qiao YL Lerma E Garland SM Sasagawa T Ferrera A Hammouda D Mariani L Pelayo A Steiner I Oliva E Meijer CJ AlJassar WF Cruz E Wright TC Puras A Llave CL Tzardi M Agorastos T Garcia-Barriola V Clavel C Ordi J Andújar M Castellsagué X Sánchez GI Nowakowsld AM Bornstein J Mu(n)oz N Bosch FX Retrospective International Survey and HPV Time Trends Study Group | 2010 | Lancet Oncol2010，11，11： | 1 |
| 17 | 人乳头瘤病毒16/18型AS04佐剂疫苗预防肿瘤基因型HPV引起的宫颈感染和癌前病变的效应(PATRICIA):一项在年轻女性中进行的双盲、随机研究的最终分析显示文摘背景在年轻成人中进行的Ⅲ期随机、双盲对照PATRICIA试验(PApilloma TRial)的事件驱动期中分析显示,人乳头瘤病毒(HPV)16/18AS04佐剂疫苗具有免疫原性,且总体耐受性良好,对HPV16或HPV18感染及相关的癌前病变具有预防效应。本文作者旨在评估最终事件驱动分析中的疫苗效应。方法将在基线、1个月和6个月接种疫苗的15~25岁女性分类为符合方案的效应队列(ATP-E队列;疫苗组8093例,对照组8069例)、总接种队列(TVC;包括至少接种1剂疫苗的所有女性,而不考虑其基线HPV状态;代表普遍的年轻女性人群,包括性活跃者;疫苗组9319例,对照组9325例)和TVC-naive(无证据表明基线时存在肿瘤基因型HPV感染;代表无性行为女性;疫苗组5822例,对照组5819例)。主要终点是。在基线时血清和DNA均为阴性且在6个月时为相应类型(ATP-E队列)的女性中,评估疫苗对HPV16或HPV18相关性宫颈上皮内瘤变≥2级(CIN2+)的预防效应。该试验在ClinicalTrial.gov上的注册编码为NCT00122681.结果第3剂疫苗接种后平均随访34.9个月(s=6.4)。在主要分析中疫苗对HPV16/18相关性CIN2+的预防效应为92.9%(96.1%CI79.9%~98.3%),在对可能因多种肿瘤基因型HPV引起的病变(ATP-E队列)的分析中,其预防效应为98.1%(96.1%CI88.4%~100%)。不考虑病变HPVDNA时,疫苗对CIN2+的预防效应在TVC中为30.4%(96.1%CI16.4%~42.1%),在TVC-naive中为70.2%(96.1%CI54.7%~80.9%);而对CIN3+的相应效应在TVC中为33.4%(96.1%CI9.1%~51.5%).在TVC-naive中为87.0%(96.1%CI54.9%~97.7%).在预防12种非疫苗肿瘤基因型HPv相关性CIN2+的效应为54.0%(96.1%CI34.0%~68.4%:ATP-E队列)。在TVC中可见对HPV31、33和45相关性CIN2+的个体交叉保护效应。结论HPV16/18 AS04佐剂疫苗表现出对HPV16/18和非疫苗肿瘤基因型HPV相关性CIN2+较强的预防效应,而要获得整体预防效应就需要在更广泛的人群中进行大面积强化免疫计划。基金 葛兰素史克。 | J Paavonen P Naud J Salmeron C M Wheeler S-N Chow D Apter H Kitchener X Castellsague J C Teixeira S R Skinner J Hedrick U Jaisamrarn G Limson S Garland A Szarewski B Romanowski F Y Aoki T F Schwarz W A J Poppe F X Bosch D Jenkins K Hardt T Zahaf D Descamps F Struyf M Lehtinen G Dubin 周彩虹(译) | 2009 | 世界临床医学2009，，12： | 1 |
| 18 | HPV in the etiology of human cancer显示文摘 | Munoz N Castellsagué X de Gonzdlez A B etal | 2006 | Vaccine2006，24，： | 1 |
| 19 | Eurogin Roadmap' comparative epidemiology of HPV infection and associated cancers of the head and neck and cervix显示文摘 | Gillison ML Castellsague X Chaturvedi A | 2014 | Int J Cancer2014，134，3： | 1 |
| 20 | HPV in the etiology of human cancer 显示文摘 | MUNOZ N CASTELLSAGUE X de GONZALEZ A B | 2006 | Vaccine2006，24，： | 1 |
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