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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Recommendations on use of direct oral anticoagulants in the perioperative period显示文摘 | Llau JV Ferrandis R Castillo J | 2012 | Med Clin (Barc)2012，1392，： | 1 |
| 3 | A blast of gas in the latest Paleocene: simulation first-order effects of massive dissociation of oceanic methane hydrate显示文摘 | Castillo M M Walker J G C | 1997 | Geology1997，25，： | 1 |
| 4 | Structural, optical and electrical characterization of In/CdS/glass thermally annealed system 显示文摘 | Mendoza-Galvan A Ramirez-Bon R | 2000 | Thin Solid Films2000，373，： | 1 |
| 5 | Interactive effects of ozone and drought stress on pigments and activities of antioxidantive enzymes in Pinus halepensis 显示文摘 | Alonso R Elvira S Castillo F J | 2001 | Plant Cell Environ2001，24，： | 1 |
| 6 | Neurological deterioration in acute lacunar infarctions:The role of excitatory and inhibyory neurotransmitters显示文摘 | Serend J Leira R Castillo J | 2001 | Stroke2001，32，： | 1 |
| 7 | Nitric oxide-related braindamage in acute ischemic stroke 显示文摘 | Castillo J Rama R Ddvalos A | | Stroke^00031 (4):852 -8570，，4： | 1 |
| 8 | 查看详情显示文摘 | H?pfl H Farfán N Castillo D Santillan R Gutierrez A Daran J C | | 0，，： | 1 |
| 9 | Geochemistry of late Paleo- zoic mafic igneous rocks from the kuerti area,Xinjiang,northwest China;Impplications for back arc mantle evolution显示文摘 | Xu J F Castillo P R Chen F R | 2002 | Chemical Ge- ology2002，193，12： | 1 |
| 10 | Neuroprotective effect of aspirin in patients with acute cerebral infarction显示文摘 | Castillo J Leira R Moro MA | | 0，，03： | 1 |
| 11 | Blood pressure decrease during the acute phase of ischemic stroke is associated with brain injury and poor stroke outcome显示文摘 | Castillo J Leira R Garcia MM | 2004 | Stroke2004，35，2： | 1 |
| 12 | Blood pressure decreaseduring the acute phase of ischemic stroke is associated with braininjury and poor stroke outcome 显示文摘 | Castillo J Leira R Gareia MM | 2004 | Stroke2004，35，2： | 1 |
| 13 | Development and use of a multiplex real-time quantitative polymerase chain reaction assay for detection and differentiation of porcine circovirus-2 genotypes 2a and 2b in an epidemiological survey显示文摘 | Gagnon C A Del Castillo J R Music N | 2008 | J Vet Diagn Invest2008，20，5： | 1 |
| 14 | Fuzzy granular gravitational clustering algorithm for multivariate data显示文摘 | SANCHEZ M A CASTILLO O CASTRO J R | 2014 | Information Sci- ences2014，279，2： | 1 |
| 15 | Crystallization kinetics and morphology of biodegrad- able of double crystalline PLLA-b-PCL Diblock Co- polymers显示文摘 | CASTILLO R V O MULLER A J RAQUEZ J M | 2010 | Macromolecules2010，43，： | 1 |
| 16 | Isolation of bovine ovarian inhibin,its immunoneutralization in vitro and immunolocalization in bovine ovary显示文摘 | Knight P G Castillo R J Glencross R G | 1990 | Domest Anim Endocrinol1990，7，3： | 1 |
| 17 | Molecular markers of malignant middle cerebral atery infarction显示文摘 | Castillo J Serena J Leira R | 2002 | Cerebrovasc Dis2002，13，1： | 1 |
| 18 | Kinetic modeling of fluoride adsorption from aqueous solution onto bone char 显示文摘 | LEYVA-RAMOS R RIVERA-UTRILLA J MEDELL1N- CASTILLO N A SANCHEZ-POLO M | 2010 | Chemical Engineering Journal2010，158，3： | 1 |
| 19 | In situ Preparation of a Cholesterol Biosensor显示文摘 | Vidal J C Garcia E Castillo J R | 1999 | Anal Chim Acta1999，385，13： | 1 |
| 20 | Nitric oxide - related brain damage in acute ischemic stroke显示文摘 | Castillo J Rama R Davalos A | 2000 | Stroke2000，31，85： | 1 |
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