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| 1 | Targeting matrix metalloproteinases in cancer:Bringing new life to old ideas显示文摘Since the identification of matrix metalloproteinases(MMPs),a family of zincdependent endopeptidases,as being a driving factor for cancer progression and patient prognosis,MMPs have been studied extensively.Although early programs targeting MMPs were largely unsuccessful in clinical trials,they remain a viable and highly desirable therapeutic target based on preclinical studies and their role in disease progression.As information regarding the structure and function of these proteinases is compiled and biotechnology evolves,tools to develop better inhibitors are within our grasp.Improved methods for high throughput screening and in silico drug design programs have identified compounds which are highly potent,have high binding affinities,and exhibit favorable pharmacokinetic profiles.More recently,advances in drug delivery methods or compounds which bind outside the active site have brought new light to the field.In this review,we highlight the role of MMPs in cancer,clinical trials for MMP inhibitors,and novel approaches to targeting MMPs in cancer. | Jillian Cathcart Ashleigh Pulkoski-Gross Jian Cao | 2015 | Genes & Diseases2015，2，1： | 18 |
| 2 | Duodenal gangliocytic paraganglioma with lymph node metastases: a case report and comparative review of 31 cases显示文摘Gangliocytic paraganglioma(GP) is a rare tumor of uncertain origin most often located in the second portion of the duodenum. It is composed of three cellular components: Epithelioid endocrine cells, spindlelike/sustentacular cells, and ganglion-like cells. While this tumor most often behaves in a benign manner, cases with metastasis are reported. We describe the case of a 62-year-old male with a periampullary GP with metastases to two regional lymph nodes who was successfully treated with pancreaticoduodenectomy. Using Pub Med, EMBASE, EBSCOhost MEDLINE and CINAHL, and Google Scholar, we searched the literature for cases of GP with regional lymph node metastasis and evaluated the varying presentations, diagnostic workup, and disease management of identified cases. Thirty-one cases of GP with metastasis were compiled(30 with at least lymph node metastases and one with only distant metastasis to bone), with age at diagnosis ranging from 16 to 74 years. Ratio of males to females was 19:12. The most common presenting symptoms were abdominal pain(55%) and gastrointestinal bleeding or sequelae(42%). Twenty-five patients underwent pancreaticoduodenectomy. Five patients were treated with local resection alone. One patient died secondary to metastatic disease, and one died secondary to perioperative decompensation. The remainder did well, with no evidence of disease at follow-up from the most recent procedure(except two in which residual disease was deliberately left behind). Of the 26 cases with sufficient histological description, 16 described a primary tumor that infiltrated deep to the submucosa, and 3 described lymphovascular invasion. Of the specific immunohistochemistry staining patterns studied, synaptophysin(SYN) stained all epithelioid endocrine cells(18/18). Neuron specific enolase(NSE) and SYN stained most ganglion-like cells(7/8 and 13/18 respectively), and S-100 stained all spindle-like/sustentacular cells(21/21). Our literature review of published cases of GP with lymph node metastasis underscores the excellent prognosis of GP regardless of specific treatment modality. We question the necessity of aggressive surgical intervention in select patients, and argue that local resection of the mass and metastasis may be adequate. We also emphasize the importance of pre-surgical assessment with imaging studies, as well as post-surgical follow-up surveillance for disease recurrence. | Sahara J Cathcart Aaron R Sasson Jessica A Kozel Jennifer M Oliveto Quan P Ly | 2017 | World Journal of Clinical Cases2017，5，6： | 9 |
| 3 | Cyclooxygenasez-linked attenuation of hypoxia-induced pulmonary hypertension and intravascular thrombosis 显示文摘 | Cathcart M C Tamosiuniene R Chen G | 2008 | Pharmacol Exp Ther2008，326，1： | 1 |
| 4 | Regulation of superoxide anion production by NADPH oxides in monocytes/macrophages: contributions to atheroselerosis显示文摘 | Cathcart MK | 2004 | Arterioscler Thromb Vasc Biol2004，24，： | 1 |
| 5 | Uric acid provides anantioxidant defense in humans against oxidant- and radi-cal-caused aging and cancer: a hypothesis显示文摘 | Ames BN Cathcart R Schwiers E | 1981 | Proc Natl AcadSci U S A1981，78，11： | 1 |
| 6 | Regulation of superoxide anion production by NADPH oxides in monocytes/macrophages: Contribu- tions to atherosclerosis显示文摘 | Cathcart M K | 2004 | Artefioscler Thromb Vasc Biol2004，24，1： | 1 |
| 7 | Improve- ment of in vitro mitogen proliferative responses in non- Hodgkin's lymphoma patients exposed to fractionated to- tal body irradiation显示文摘 | Yonkosky DM Feldman MI Cathcart ES | 1978 | Cancer1978，42，3： | 1 |
| 8 | Incidence of primary and recurrent acute urinary retention between 1998 and 2003 in England显示文摘 | Cathcart P van der Meulen J Armitage J Emberton M | 2006 | J Urol2006，176，1： | 1 |
| 9 | Purification and partial amino acid sequence of plantaricin S ,a bacteriocin produced by Lactobacillus plantarum LPCO10,the activity of which depends on the complementary action of two peptides显示文摘 | Jimenez-Diaz R Ruiz-Barba J L Cathcart D P | 1995 | App1 Environ Microbiol1995，61，： | 1 |
| 10 | Effect of 2 weeks of sprint interval training on health-related outcomes in sedentary overweight/obese men显示文摘 | W-byte LI Gill JM Cathcart AJ | 2010 | Metabolism2010，59，： | 1 |
| 11 | Mortality in men admitted to hospital with acute urinary retention : database analysis 显示文摘 | Armitage JN Sibanda N Cathcart PJ | 2007 | BMJ2007，335，7631： | 1 |
| 12 | Beneficial effects of methyprednisolone 'pulse' therapy in diffuse proliferative lupus nephritis显示文摘 | Cathcart ES Idelson BA | 1976 | Lancet1976，7，： | 1 |
| 13 | Regulation of superoxide anion production by NADPH oxidase in monocytes/macrophages:contributions to atherosclerosis 显示文摘 | Cathcart M K | 2004 | Arterioscler Thromb Vasc Biol2004，24，1： | 1 |
| 14 | The attending nurse: an evolving model for integrating nursing ed- ucation and practice显示文摘 | Terry Fulmer Eloise Cathcart Kimberly Glassman | 2011 | Open Nuts J2011，5，： | 1 |
| 15 | Regulation of superoxide anion production by NAD-PH oxidase in monocytes/macrophages contributions to atheroscl-erosis显示文摘 | | 2004 | Arterioscler Thromb Vasc Biol2004，24，1： | 1 |
| 16 | The Oxidation ofZircaloy-4 at 900 and 1100℃ in High Pressure Steam显示文摘 | Pawel R E Cathcart JV Cambell J J | 1979 | Journal of Nuclear Materials1979，82，： | 1 |
| 17 | Uric acid provides an antioxidant defense in humans against oxidant and radical caused aging and cancer a hypothesis显示文摘 | Ames BN Cathcart R Schwiers E | | 0，，： | 1 |
| 18 | Purification and partial amino acid sequence of plantaricin S,a bacteriocin produced by Lactobacillus plantarum LPCO10,the activity of which depends on the complementary action of two peptides显示文摘 | Jimenez-Diaz R Ruiz-Barba J L Cathcart D P | | 0，，12： | 1 |
| 19 | Cystatin C as a risk factor for Alzheimer disease显示文摘 | Cathcart HM Huang R Lanham IS | 2005 | Neurology2005，64，： | 1 |
| 20 | Semi-analytical pricing of defaultable bonds in a signaling jump-default model 显示文摘 | CATHCART L E1-JAHEL L | 2003 | Journal of computational finance2003，6，3： | 1 |
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