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| 1 | 2,3-Diaryl-3H-imidazo[4,5-b]pyridine derivatives as potential anticancer and anti-inflammatory agents显示文摘In this study we examined the suitability of the 3H-imidazo[4,5-b]pyridine ring system in developing novel anticancer and anti-inflammatory agents incorporating a diaryl pharmacophore. Eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives retrieved from our in-house database were evaluated for their cytotoxic activity against nine cancer cell lines. The results indicated that the compounds showed moderate cytotoxic activity against MCF-7, MDA-MB-468, K562 and SaOS2 cells, with K562 being the most sensitive among the four cancer cell lines. The eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives were also evaluated for their COX-1 and COX-2 inhibitory activity in vitro. The results showed that compound 3f exhibited 2-fold selectivity with IC_(50) values of 9.2 and 21.8 mmol/L against COX-2 and COX-1, respectively. Molecular docking studies on the most active compound 3f revealed a binding mode similar to that of celecoxib in the active site of the COX-2 enzyme. | Erin Marie Kirwen Tarun Batra Chandrabose Karthikeyan Girdhar Singh Deora Vandana Rathore Chaitanya Mulakayala Naveen Mulakayala Amy Catherine Nusbaum Joel Chen Haneen Amawi Kyle Mc Intosh Sahabjada Neelam Shivnath Deepak Chowarsia Nisha Sharma Md Arshad Piyush Trivedi Amit KTiwari | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 3 |
| 2 | Nutritional effects on blood pressure 显示文摘 | Valefie HM Catherine MC | 2007 | Current Opinion in Lipidology2007，18，1： | 1 |
| 3 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 4 | Anger expression and sleep quality in patients with coronary heart disease: findings from the heart and soul study 显示文摘 | Catherine MC Bethany EH Michelle HW | 2009 | Psychosomat Med2009，71，3： | 1 |
| 5 | Dietary intakes associated with successful weight loss and maintenance during the Weight Loss Maintenance trial显示文摘 | Catherine MC Stephanie TB Laura DM | | 0，，12： | 1 |
| 6 | Nutritional effects on blood pressure 显示文摘 | Valerie HM Catherine MC | 2007 | Current Opinion in Lipidology2007，18，： | 1 |
| 7 | The variation of cage motor losses with skew显示文摘 | Catherine I Mc Clay Stephen Williamson | 2000 | IEEE Transactions on Industry Applications2000，36，6： | 1 |
| 8 | Nutritional effects on blood pressure显示文摘 | Valerie HM Catherine MC | 2007 | Current Opinion in Lipidology2007，18，： | 1 |
| 9 | Which outcome measure is the best? Evaluating responsiveness of the disabilities of the arm, shoulder, and hand questionnaire, the michigan hand questionnaire and the patient-specific functional scale following hand and wrist surgery显示文摘 | Catherine R Mc M Paul AB | 2009 | Hand2009，4，3： | 1 |
| 10 | Changes in neighbourhood food store enviroment,food behavior and bodymass index,1981-1990显示文摘 | WANG MC CATHERINE C DAVE A | | 0，，09： | 1 |
| 11 | A systematic review of oral fungal infections in patients receiving cancer thera- py显示文摘 | Lalla RV Latortue MC Catherine H | 2010 | Support Care Cancer2010，18，8： | 1 |
| 12 | One-year outcomes in survivors of the acute respiratory distress syndrome显示文摘 | Margaret SH Angela MC Catherine MT | 2003 | N Engl J Med2003，348，8： | 1 |
| 13 | Understanding chinese devel- opmental dyslexia:morphological awareness as a core cognitive con- struct 显示文摘 | Hua BS Catherine MC Sina W | 2006 | Journal of Educational Psychology2006，98，1： | 1 |
| 14 | Large and growing environmental reservoirs of Deca-BDE present an emerging health risk for fish and marine mammals显示文摘 | Peter SR Catherine MC Michael GI | 2009 | Mar Pollut Bull2009，58，： | 1 |
| 15 | Use of pentoxifylline in nembranous nephropathy 显示文摘 | Didier D Catherine BV Jean MC | 2001 | The Lancet2001，357，： | 1 |
| 16 | Nurses' views of fundamental relational skills used in clinical practice: a cross-sectional pilot study显示文摘Objective:Effective communication skills are one of the core competencies of nursing curricula internationally.Nurses are generally regarded as proficient.Despite our complete trust in the profession,deficiencies and gaps exist.However,it is not clear to which extent nurses use key communication skills in practice,and whether or not confident in using these skills compounds environmental issues that occur.This study explored nurse’s confidence and application of relational skills competencies in nursing practice.Methods:A 13-item online survey was used to collect data.Results:Being self-aware on key areas where there was more uncertainty.Nurses also lacked confidence in exploring the impact of their personal feelings and values on their interactions.Nurses were also less confident on responding appropriately to instances of unsafe or unprofessional practice and using information and communication systems and technology.Conclusions:Given the potential impact of poor relational skills on quality client care,an increased emphasis on caring and compassion,and the ever-expanding use of communication technologies,there is a need to explore the need for reflective practice to enhance continuous professional development for nurses to enhance their relational skills. | Fiona Timmins Jan M.A.de Vries Yvonne Muldowney Catherine Mc Cabe Jacqueline Whelan Sinead Buckley Sandra McCarthy | 2021 | Frontiers of Nursing2021，8，3： | 0 |
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