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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Acute pancreatitis in aging animals:Loss of pancreatitis-associated protein protection?显示文摘AIM:To investigate the effect of age on severity of acute pancreatitis(AP) using biochemical markers,histology and expression of the protective pancreatitisassociated proteins(PAPs).METHODS:AP was induced via intraductal injection of 4% sodium taurocholate in young and old rats.Sera and pancreata were assayed at 24 h for the parameters listed above;we also employed a novel molecular technique to assess bacterial infiltration using polymerase chain reaction to measure bacterial genomic ribosomal RNA.RESULTS:At 24 h after induction of AP,the pancreata of older animals had less edema(mean ± SE histologic score of young vs old:3.11 ± 0.16 vs 2.50 ±-0.11,P < 0.05),decreased local inflammatory response(histologic score of stromal infiltrate:3.11 ± 0.27 vs 2.00 ± 0.17,P < 0.05) and increased bacterial infiltration(174% ± 52% increase from sham vs 377% ± 4%,P < 0.05).A decreased expression of PAP1 and PAP2 was demonstrated by Western blotting analysis and immunohistochemical staining.There were no differences in serum amylase and lipase activity,or tissue myeloperoxidase or monocyte chemotactic protein-1 levels.However,in the most-aged group,serum C-reactive protein levels were higher(young vs old:0.249 ± 0.04 mg/dL vs 2.45 ± 0.68 mg/dL,P < 0.05).CONCLUSION:In older animals,there is depressed PAP expression related to a blunted inflammatory response in AP which is associated with worsened bacterial infiltration and higher C-reactive protein level;this may explain the more aggressive clinical course. | Sophia Fu Albert Stanek Cathy M Mueller Nefertti A Brown Chongmin Huan Martin H Bluth Michael E Zenilman | 2012 | World Journal of Gastroenterology2012，18，26： | 5 |
| 3 | Gastro-duodenal disease in Africa: Literature review and clinical data from Accra, Ghana显示文摘Gastroduodenal disease(GDD)was initially thought to be uncommon in Africa.Amongst others,lack of access to optimal health infrastructure and suspicion of conventional medicine resulted in the reported prevalence of GDD being significantly lower than that in other areas of the world.Following the increasing availability of flexible upper gastro-intestinal endoscopy,it has now become apparent that GDD,especially peptic ulcer disease(PUD),is prevalent across the continent of Africa.Recognised risk factors for gastric cancer(GCA)include Helicobater pylori(H.pylori),diet,Epstein-Barr virus infection and industrial chemical exposure,while those for PUD are H.pylori,non-steroidal antiinflammatory drug(NSAID)-use,smoking and alcohol consumption.Of these,H.pylori is generally accepted to be causally related to the development of atrophic gastritis(AG),intestinal metaplasia(IM),PUD and distal GCA.Here,we perform a systematic review of the patterns of GDD across Africa obtained with endoscopy,and complement the analysis with new data obtained on premalignant gastric his-topathological lesions in Accra,Ghana which was compared with previous data from Maputo,Mozambique.As there is a general lack of structured cohort studies in Africa,we also considered endoscopy-based hospital or tertiary centre studies of symptomatic individuals.In Africa,there is considerable heterogeneity in the prevalence of PUD with no clear geographical patterns.Furthermore,there are differences in PUD within-country despite universally endemic H.pylori infection.PUD is not uncommon in Africa.Most of the African tertiary-centre studies had higher prevalence of PUD when compared with similar studies in western countries.An additional intriguing observation is a recent,ongoing decline in PUD in some African countries where H.pylori infection is still high.One possible reason for the high,sustained prevalence of PUD may be the significant use of NSAIDs in local or over-the-counter preparations.The prevalence of AG and IM,were similar or modestly higher over rates in western countries but lower than those seen in Asia..In our new data,sampling of 136 patients in Accra detected evidence of pre-malignant lesions(AG and/or IM)in 20 individuals(14.7%).Likewise,the prevalence of pre-malignant lesions,in a sample of 109 patients from Maputo,were 8.3%AG and 8.3%IM.While H.pylori is endemic in Africa,the observed prevalence for GCA is rather low.However,cancer data is drawn from country cancer registries that are not comprehensive due to considerable variation in the availability of efficient local cancer reporting systems,diagnostic health facilities and expertise.Validation of cases and their source as well as specificity of outcome definitions are not explicit in most studies further contributing to uncertainty about the precise incidence rates of GCA on the continent.We conclude that evidence is still lacking to support(or not)the African enigma theory due to inconsistencies in the data that indicate a particularly low incidence of GDD in African countries. | Timothy N Archampong Richard H Asmah Cathy J Richards Vicki J Martin Christopher D Bayliss Edília Botao Leonor David Sandra Beleza Carla Carrilho | 2019 | World Journal of Gastroenterology2019，25，26： | 3 |
| 4 | Consumer Responses to Service Failures: Influence of Procedural and lnteractional Fairness Perceptions显示文摘 | Goodwin Cathy and h an Ross | 1992 | Journal of Business Research1992，25，2： | 1 |
| 5 | Image assessment for a destination with limited comparativeadvantages显示文摘 | Cathy H C Hsua Kara Wolfeb Soo K Kang | 2004 | Tourism Management2004，25，： | 1 |
| 6 | Effects of Travel MotivationPast Expe- rience, Perceived Constraint, and Attitude on Revisit Inten- tion显示文摘 | Songs H Cathy H C H | 2009 | Journal of Travel Research2009，48，1： | 1 |
| 7 | Outbreaks of renal failure associated with melamine and cyanuric acid in dogs and cats in 2004 and 2007 显示文摘 | Cathy A Brown Kyu Shik Jeong Robert H | 2007 | Journal of Veterinary Diagnostic Investigation2007，19，5： | 1 |
| 8 | Pore system characterization in heterogeneous carbonates: An alternative approach to widely-used rock-typing methodologies显示文摘 | Cathy H Volker V Simon T | 2010 | Marine and Petroleum Geology2010，27，4： | 1 |
| 9 | Accumulation of heparan sulfate proteoglycans in cerebellar senile plaques显示文摘 | Jack H Johanneke K Cathy N M | 2002 | Neurobiol Aging2002，23，4： | 1 |
| 10 | Disulfiram, a drug widely used to control alcoholism, suppresses self-renewal of glio- blastoma and overrides resistance to temozolomide 显示文摘 | TRISCOTT J CATHY L KAIJI H | 2012 | Oncotar- get2012，3，10： | 1 |
| 11 | A model of senior tourism motivations-Anecdotes from Beijing and Shanghai显示文摘 | Cathy H Liping C Kevin W | 2007 | Tourism Management2007，，28： | 1 |
| 12 | Tourism and China's Development:Policies,Regional Economic Growth and Ecotourism显示文摘 | | 2003 | Tourism Management2003，24，3： | 1 |
| 13 | Muhifunctionality and diversity within the Plant MYB - gene family 显示文摘 | JIN H L CATHIE M | 1999 | Plant Mol Biol1999，，41： | 1 |
| 14 | Harpin, elicitor of the HR produced by the plant pathogen Erwinia amylovora 显示文摘 | WEI Z M RON J L CATHY H Z | 1992 | Science1992，257，： | 1 |
| 15 | Tourist behaviour: theme and conceptual schemes显示文摘 | Hsu Cathy H C | 2006 | Annals of Tourism Research2006，33，3： | 1 |
| 16 | Evaluation of membranes used for electroblotting of proteins for direct automated microsequencing 显示文摘 | Cathy S B Michael J D Magdi H Y | 1991 | Electrophoresis1991，12，： | 1 |
| 17 | Outbreaks of renal failure associated with melamine and cyanuricacid in dogs and cats in 2004 and 2007 显示文摘 | CATHY A B JEONG K S ROBERT H | 2007 | J Vet Diagn Invest2007，19，5： | 1 |
| 18 | The protein information resource 显示文摘 | Cathy H W Lai-Su L Yeh Hongzhan Huang | 2003 | Nucleic Acids Research2003，31，： | 1 |
| 19 | Image assessment for a destination with limited comparative advantages显示文摘 | CATHY H C HSU KARA WOLFE SOO K KANG | 2004 | Tourism management2004，25，1： | 1 |
| 20 | Multicenter Evaluation of AMPLICOR and Automated COBAS AMPLICOR CT/NG Tests for Neisseria gonorrhoeae显示文摘 | David H M Cathy Ca Barbara VDP | 2000 | J Clin Microbiol2000，38，10： | 1 |
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