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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Fre- quency of duplications in the D-loop in patients with mi- tochondrial DNA deletions 显示文摘 | CELIA H T CLAUDIA F B MARINA C | 2002 | Biochimica et Biophysi- ca Acta (BBA) -Molecular Basis of Disease2002，1588，1： | 1 |
| 3 | Recent advances in designing supcrhydrophobic surfaces 显示文摘 | CELIA E DARMANIN T GIVENCIIY E T D AMIGONI S GU1TTARD F | 2013 | Journal of Colloid and Interface Science2013，402，： | 1 |
| 4 | Seasonal and tidal influence on the variability of nitrous oxide in the Tagus estuary 显示文摘 | CELIA G MARIA J B MARIA F C | 2010 | Portugal Scientia Marina2010，74，1： | 1 |
| 5 | Orthogonal collocation and alternating-direction procedures for unsaturated flow problems显示文摘 | Celia M A Ahuja L R Pinder G F | 1987 | Advances in Water Resources1987，10，4： | 1 |
| 6 | The Functional As-sessment of Cancer Therapy Scale: Development and Vali-dation of the General Measure显示文摘 | Celia D F Tulsky D S Gray G | 1993 | J Clin Oncol1993，11，3： | 1 |
| 7 | Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon显示文摘 | Celia M Jarrossay D Facchetti F | 1999 | Nature1999，5，8： | 1 |
| 8 | The functional assessment of cancer therapy scale:development and validation of the general measure显示文摘 | Celia D F Tulsky D S Gray G | 1993 | J Clin Oncal1993，11，3： | 1 |
| 9 | Reliability and validity of the functional assessment of cancer therapy--breast qualityof-life instrument显示文摘 | Brade M J Celia D F Mo F | 1997 | J Clin Oncol1997，15，3： | 1 |
| 10 | Characterization of wood plastic composites made from landfill-derived plastic and sawdust~ Volatile compounds end olfactometric analysis显示文摘 | Juliana S F Celia D Cristina N | 2013 | Waste Manag2013，33，3： | 1 |
| 11 | Noisy speech enhancement based on an adaptive threshold and a modified hard thresholding function in wavelet packet domain 显示文摘 | TAHS1NA F S CELIA S | 2013 | Digital Signal Processing2013，23，3： | 1 |
| 12 | Multifocal contacts make headway显示文摘 | Celia F | | 0，，： | 1 |
| 13 | The Funetional As- sessment of Cancer Therapy Scale: Development and Vali- dation of the General Measure显示文摘 | Celia D F Tulsky D S Gray G | 1993 | Am J Clin Oneol1993，11，3： | 1 |
| 14 | Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent THI polarization 显示文摘 | Celia M Facchetti F Lanzavecchia A | 2000 | Nat Immunol2000，1，4： | 1 |
| 15 | Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon显示文摘 | Celia M Jarrossay D Facchetti F | 1999 | Nat Med1999，5，8： | 1 |
| 16 | Reliability and validity of the functional assessment of cancer therapy-Breast quality - of-life instrument 显示文摘 | Brade MJ Celia DF Mo F | 1997 | Journal of Clinical Oncology1997，15，3： | 1 |
| 17 | Quality of life: Concepts and definition显示文摘 | Celia D F | 1994 | J Pain Symptom Manag1994，9，3： | 1 |
| 18 | Glycated haemoglobin reduction and fixed ratio combinations of analogue basal insulin and glucagon-like peptide-1 receptor agonists:A systematic review显示文摘BACKGROUND Fixed ratio combinations(FRCs)of analogue basal insulin and glucagon-like peptide-1 receptor agonists are a newer addition to the therapeutic armamentarium for the management of type 2 diabetes mellitus.They reduce treatment complexity by combining two injectables in a single daily injectable,thus potentially improving adherence and persistence.Clinicians wanting to use FRCs would need to choose between members of the class.AIM To describe and contrast the glycated haemoglobin reduction of two FRCs of analogue basal insulin and glucagon like peptide-1 receptor agonist in adults with type 2 diabetes mellitus.METHODS The following Population,Intervention,Comparison,Outcome question was used for the primary analysis:Among adult patients with type 2 diabetes mellitus[P],what is the effect of iGlarLixi[I]compared to IDegLira[C]for bringing about glycaemic control(as measured by reduction in glycosylated haemoglobin)[O]?The Prisma Statement was used as a guideline for framing this systematic review.We searched PubMed,EMBASE and Cochrane library databases and Clinicaltrials.gov using various keywords and medical search headings related to type 2 diabetes mellitus,iGlarlixi,IDegLira and glycated haemoglobin A1c.RESULTS All 14 studies identified by the systematic search met the primary efficacy endpoint of reduction in glycated haemoglobin.There were no head-to-head studies between the FRCs of iGlarlixi and IDegLira,and we therefore did an indirect comparison based on a common comparator of insulin glargine U100.Both iGlarLixi and IDegLira effectively reduce glycated haemoglobin when compared to insulin glargine U100.However,using indirect comparisons,IDegLira had a greater haemoglobin A1c reducing ability(0.6%vs 0.3%).The indirect comparison is limited by the differences between the studies;the fasting blood glucose targets were slightly higher for iGlarLixi studies when compared to the IDegLira studies(4.0-5.0 mmol/L and 4.4-5.6 mmol/L),and the IDegLira study used a greater average dose of insulin glargine when compared to the iGlarLixi studies(66 U/d vs 40 U/d).CONCLUSION Both iGlarLixi and IDegLira effectively reduce glycated haemoglobin.Indirect comparisons,using insulin glargine as the common comparator,suggest that IDegLira reduces glycated haemoglobin to a greater extent than iGlarLixi.However,given the limitations of indirect comparisons,robust head to head studies and real-world data would better inform clinician choice and clinical practice guidelines. | Poobalan Naidoo Celia Bouharati Virendra Rambiritch Sumanth Karamchand Barbara A Tafuto Rory F Leisegang | 2021 | World Journal of Meta-Analysis2021，9，3： | 1 |
| 19 | Origin, maturation and antigen presenting function oof dendritic cells显示文摘 | Celia M Sallusto F Lanzavecchia A | 1996 | Curr Opin Immunol1996，9，： | 1 |
| 20 | Plasma markers of endothelial dysfunction in pulmonary hypertension 显示文摘 | Celia G Bellotto F Tona F | 2001 | Chest2001，120，4： | 1 |
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