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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Autophagy is increased in cryptorchid testis resulting in abnormal spermatozoa显示文摘Autophagy is invoIved in spermatogenesis by regulating germ cell maturation.This catabolic process increases with hyperthermic conditions to prevent the accumulation of damaged organelles.Cryptorchidism is associated with impairment of germ cell maturation revealed by the presence of immature forms of sperm cells in ejaculates.The aim of the present study was to evaluate the status of autophagy in sperm cells from cryptorchid patients.Semen samples of cryptorchid patients and normozoospermic controls were analyzed by immuno cytochemistry and electron microscopy.Autophagy protei ns,autophagy-related protein 9(ATG9)and microtubule-associated protein,lA/lB-light chain 3(LC3)were localized by immunocytochemistry on the acrosome and on the equatorial segment of sperm cells.LC3 was also detected in the midpiece of cryptorchid sperm tail.Autophagy substrate p62 protein was present in the acrosome and in the postequatorial segment of sperm in control samples,but not in the cryptorchid ones.Transmission electron microscopy revealed double-membrane-limited autophagosomes in postequatorial part of spermatozoa head and midpiece in cryptorchid samples.Partly degraded mitochondria were frequently discerned in autophagic vacuoles.In conclusion,autophagy is increased in sperm cells from patients with cryptorchid history comparatively to control.Our work provides insights into the role of autophagy in the maturation and survival of human male gametes in pathological conditions.Thus,regulating autophagy could represent a potential way to improve sperm quality in cryptorchid men. | Marina G Yefimova Antoine Buschiazzo Agnes Burel Marie-Therese Lavault Celine Pimentel Guilhem Jouve Sylvie Jaillard Bernard Jegou Nicolas Bourmeyster Celia Ravel | 2019 | Asian Journal of Andrology2019，21，6： | 2 |
| 3 | Robotic-assisted rehabilitation of the upper limb after acute stroke显示文摘 | Masiero S Celia A Rosati G | 2007 | Arch Phys Med Rehabil2007，88，2： | 1 |
| 4 | Robotic -assisted rehabilitation of upper limp after acute stroke显示文摘 | Masiero S Celia A Rosati G | 2007 | Archives of Physical Medicine and re- habilitation2007，88，2： | 1 |
| 5 | Pathogenetic and Pathogenitic Features of Lacunar Transient Ischaemic Attack Syndromes显示文摘 | Landi G Motto C Celia E | 1993 | J Neurol Neurosurg Psychiatry(S0022 -- 3050)1993，56，： | 1 |
| 6 | Safe storage of CO2 in deep saline aquifers 显示文摘 | Bruant R G Guswa A J Celia M A | 2002 | Environmental Science & Technology2002，36，11： | 1 |
| 7 | The functional assessment of cancer therapy scale: Development and validation of the general measure显示文摘 | Celia DF Tulsky DS Gray G | 1993 | J Clin Onco11993，11，3： | 1 |
| 8 | Robotic-assisted rehabilitation of the upper limb after acute stroke显示文摘 | Masiero S Celia A Rosati G | 2007 | Arch Phys Med Rehabil2007，88，2： | 1 |
| 9 | Plasma markers ofendothelial dysfunction in chronic obstructive pulmonarydisease显示文摘 | Celia G Sbarai A Mazzaro G | 2001 | Clin Appl Thromb Hemost2001，7，3： | 1 |
| 10 | The Functional Assessment of Cancer Therapy scale:development and validation of the general measure 显示文摘 | Celia DE Tulsky DS Gray G | 1993 | J Clin Onco11993，11，3： | 1 |
| 11 | Seasonal and tidal influence on the variability of nitrous oxide in the Tagus estuary 显示文摘 | CELIA G MARIA J B MARIA F C | 2010 | Portugal Scientia Marina2010，74，1： | 1 |
| 12 | AHR drives the de- velopment of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch显示文摘 | Lee J S Celia M McDonald K G | 2011 | Nat Immunol2011，13，2： | 1 |
| 13 | Placental growth factor is a potent vasodilator of rat and human resistance arte6es 显示文摘 | Osol G Celia G Gokina N | 2008 | Am J Physiol Heart Circ Physiol2008，294，3： | 1 |
| 14 | The functional assessment of cancer therapy scale: Development and validation of the general measure显示文摘 | Celia DF Tulsky DS Gray G | 1993 | J Clin Oncoi1993，11，3： | 1 |
| 15 | Impact of cancer related fatigue on the lives of patients:New findings from the Fatigue Coalition 显示文摘 | Curt G Bteitbart W Celia D | 2000 | Oncologist2000，5，5： | 1 |
| 16 | Orthogonal collocation and alternating-direction procedures for unsaturated flow problems显示文摘 | Celia M A Ahuja L R Pinder G F | 1987 | Advances in Water Resources1987，10，4： | 1 |
| 17 | Sulfur dioxide fumigation alone or in combination with CO2 - enriched atmosphere extends the market life of highbush blueberry fruit显示文摘 | CELIA M C IOANNIS S M VLASIOS G | 2012 | Postharvest Biology and Technology2012，，67： | 1 |
| 18 | The Functional As-sessment of Cancer Therapy Scale: Development and Vali-dation of the General Measure显示文摘 | Celia D F Tulsky D S Gray G | 1993 | J Clin Oncol1993，11，3： | 1 |
| 19 | Stearidonic acid as a supplemental source of ω-3 polyunsaturated fatty acids to enhance status for improved human health显示文摘 | Celia G W Susan A J Philip C C | 2013 | Nutrition2013，29，2： | 1 |
| 20 | The functional assessment of cancer therapy scale: development and validation of the general measure 显示文摘 | Celia DF Tulsky DS Gray G | 1993 | J Clin Oncol1993，11，3： | 1 |
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