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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients显示文摘 | Manuel Romero-Gómez Maria Del Mar Viloria Raúl J. Andrade Javier Salmerón Moisés Diago Conrado M. Fernández-Rodríguez Raquel Corpas Marina Cruz Lourdes Grande Luis Vázquez Paloma Mu?oz-de-Rueda Pilar López-Serrano Ana Gila María L. Gutiérrez Celia Pérez A | 2005 | Gastroenterology2005，，3： | 2 |
| 3 | Inflammatory stimuli induce accumulation of MHC class Ⅱ complexes on dendritic cells显示文摘 | Celia M Engering A Pinet V | 1997 | Nature1997，388，6644： | 1 |
| 4 | Laparoscopic nephron sparing surgery: a multiinstitutional European survey of 592 cases显示文摘 | Celia A Zeccolini G Guazzoni G Pansadoro V Disanto V Por piglia F | 2008 | Arch Ital Urol Androl2008，80，： | 1 |
| 5 | Serum 25-hydroxyvi- tamin D3 levels and vitamin D receptor variants in melanoma pa- tients from the Mediterranean area of Barcelona显示文摘 | ZIGHEREDA O LAURA V CELIA B | 2013 | BMC Med Gen- et2013，14，： | 1 |
| 6 | Nicotinic receptors in neurodegencmtion 显示文摘 | Posadas I Ltpez-Hemandez B Celia V | 2013 | Curt Neuropharmacol2013，11，3： | 1 |
| 7 | New insight in the mechanism of osteoclast activation and formation in multiple myeloma:focus on the receptor activator of NF-kappaB ligand (RANKL)显示文摘 | Giuliani N Celia S Rizzoli V | 2004 | Exp Hematol2004，32，8： | 1 |
| 8 | In vivo studies with Growth Hormone (GH)-Releasing factor and clonidine in rat pups:Ontogenetic developments of their effect on GH release and synthesis 显示文摘 | Celia S G Locatelli V De Gennaro V | 1986 | Endocrinology1986，119，： | 1 |
| 9 | HIV-coinfection leads to a modest increase in plasma HCV-RNA load in patients with chronic HCV infection显示文摘 | Karin Neukam Silvia García-Rey Celia Cifuentes Juan Macías José A Mira María J Vázquez Manuel Parra-Sánchez José C Palomares Nicolás Merchante Federico A Di Lello Juan A Pineda | 2012 | Antiviral Research2012，，3： | 1 |
| 10 | Phase Ⅲtrial of doxoruhicin plus cisplatin with or without paclitaxel plus ill- grastin in advanced endometrial carcinoma: a gynecologic on- cology group study 显示文摘 | Fleming G F Brunetto V L Celia D | 2004 | J Clin Oncol2004，22，11： | 1 |
| 11 | Image featu- redescriptor based on shape salience points显示文摘 | GLAUCO V P MARCOS A B CELIA A Z B | 2013 | Neurocom- puting2013，120，23： | 1 |
| 12 | Production and characterization of monoclonal and polyclonal antibodies to forchlorfenuron 显示文摘 | CELIA S P MERCADER J V CONSUELO A | 2008 | Journal of Agricultural and Food Chemistry2008，56，11： | 1 |
| 13 | Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients显示文摘 | Manuel Romero-Gómez Maria Del Mar Viloria Raúl J. Andrade Javier Salmerón Moisés Diago Conrado M. Fernández-Rodríguez Raquel Corpas Marina Cruz Lourdes Grande Luis Vázquez Paloma Mu?oz-de-Rueda Pilar López-Serrano Ana Gila María L. Gutiérrez Celia Pérez A | 2005 | Gastroenterology2005，，3： | 1 |
| 14 | Image feature descriptor based on shape salience points显示文摘 | Glauco V P Marcos A B and Celia A Z B | 2013 | Neurocomputing2013，120，23： | 1 |
| 15 | Histologic evaluation during healing of hydrogel core-and-skirt keratoprostheses in the rabbit eye显示文摘 | Celia RH Traian VC | 1997 | Cornea1997，16，3： | 1 |
| 16 | Emission of PAHs from light-duty diesel vehicles exhausts 显示文摘 | Rui de Abrantes Joao V de Assuncao Celia R Pesquero | 2004 | Atmospheric Environment2004，38，： | 1 |
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