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14篇 您的检索式：作者名="Celso B"

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		题名	作者	年代	出处	被引量
	1	Use of siRNA molecular beacons to detect and attenuate mycobacterial infection in macrophages显示文摘Tuberculosis is one of the leading infectious diseases plaguing mankind and is mediated by the facultative pathogen, Mycobacterium tuberculosis(MTB). Once the pathogen enters the body, it subverts the host immune defenses and thrives for extended periods of time within the host macrophages in the lung granulomas, a condition called latent tuberculosis(LTB). Persons with LTB are prone to reactivation of the disease when the body's immunity is compromised. Currently there are no reliable and effective diagnosis and treatment options for LTB, which necessitates new research in this area. The mycobacterial proteins and genes mediating the adaptive responses inside the macrophage is largely yet to be determined. Recently, it has been shown that the mce operon genes are critical for host cell invasion by the mycobacterium and for establishing a persistent infection in both in vitro and in mouse models of tuberculosis. The Yrb E and Mce proteins which are encoded by the MTB mce operons display high degrees of homology to the permeases and the surface binding protein of the ABC transports, respectively. Similarities in structure and cell surface location impute a role in cell invasion at cholesterol rich regions and immunomodulation. The mce4 operon is also thought to encode a cholesterol transport system that enables the mycobacterium to derive both energy and carbon from the host membrane lipids and possibly generating virulence mediating metabolites, thus enabling the bacteria in its long term survival within the granuloma. Various deletion mutation studies involving individual or whole mce operon genes have shown to be conferring varying degrees of attenuation of infectivity or at times hypervirulence to the host MTB, with the deletion of mce4 A operon gene conferring the greatest degree of attenuation of virulence. Antisense technology using synthetic si RNAs has been used in knocking down genes in bacteria and over the years this has evolvedinto a powerful tool for elucidating the roles of various genes mediating infectivity and survival in mycobacteria. Molecular beacons are a newer class of antisense RNA tagged with a fluorophore/quencher pair and their use for in vivo detection and knockdown of mR NA is rapidly gaining popularity.	Remo George Renata Cavalcante Celso Carvalho Jr Elyana Marques Jonathan B Waugh M Tino Unlap	2015	World Journal of Experimental Medicine2015，5，3：	2
	2	Lansoprazole quantification in human plasma by liquid chromatography-electrospray tandem mass spectrometry显示文摘	Celso H O Rafael E B A Eduardo A	2003	J Chromatogr B2003，783，：	1
	3	Incorporation of Bifidobacteria into cheeses: challenges and rewards显示文摘	TERRI D BOYLSTON CELSO G VINDEROLA HAMID B GHODDUSI	2004	International Dairy Journal2004，，14：	1
	4	Hardwood pulping in Brazil显示文摘	CELSO E B FOELKEL CESLAVAS ZVINAKEVICIUS	1980	Tappi1980，63，：	1
	5	Spray forming high speedsteel~properties and processing 显示文摘	RAFAEL A M CELSO A B	2004	Materials Science andEngineering A2004，383，1：	1
	6	Chemical composition and free radical scavenging activity of pollen stinglcss bee melipona ducke显示文摘	TANIA M S S CELSO A CAMARA B ct al	2006	Food Composition and Analysis2006，19，11：	1
	7	Spray forming high speed steel-properties and processing 显示文摘	Rafael A M Celso A B	2004	Materials Science and Engineering: A2004，383，1：	1
	8	A systematic review and meta-analysis comparing outcome of severely injured patients treated in trauma centers following the establishment of trauma systems显示文摘	Celso B Tepas J Langland-Orban B	2005	J T2005，60，2：	1
	9	Hardwood pulping in Brazil显示文摘	Celso E B Foelkel Ceslavas Zvinakevicius	1980	Tappi1980，，63：	1
	10	Tassinari,Petrogenesis of the early Createous Valle Chico igneous complex (SE Uruguay):Relationships with Parana-Etendeka magmatism显示文摘	Michele Lustrino Leone Melluso Pietro Brotzu Celso B Gomes Lucio Morbidelli Rossana Muzio Excelso Ruberti Colombo C G	2005	Lithos2005，82，：	1
	11	Lanso-prazole quantification in human plasma by liquid chromatography-electrospray tandem mass spectrometry显示文摘	CELSO H O RAFAEL E B EDUARDO A	2003	J Chromatogra B2003，78，3：	1
	12	Characterization of pore systems in seal rocks using Nitrogen Gas Adsorption combined with Mercury Injection Capillary Pressure techniques显示文摘	MAYKA S CELSO P F JOS(E) A B		0，，：	1
	13	Spray forming high speed steel-properties and processing显示文摘	RAFAEL A CELSO A B	2004	Materials Science and Engineering2004，383，：	1
	14	Chemical composition and free radical scavenging activity of pollen stingless bee melipona ducke显示文摘	TANIA M S S CELSO A CAMAR A B	2006	Journal of Food Composition and Analysis2006，19，11：	1

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