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| 1 | Apoptotic cell death and its relationship to gastric carcinogenesis显示文摘AIM: To investigate the apoptotic process of cells with in the intestinal metaplasia areas co-localizing with chronic gastritis and gastric carcinomas and to analyze the involvement of proteins regulating apoptosis in the process of intestinal metaplasia related gastric carcinogenesis. METHODS: Forty-two gastric carcinoma and seventeen chronic gastritis cases were included in this study. All cases were examined for the existence of intestinal metaplasia. Ten cases randomly selected from each group were processed for TUNEL assay. TUNEL positive cells within the intestinal metaplasia areas, co-localizing either to gastric carcinoma or chronic gastritis, were counted and converted to apoptotic indices. In addition, p53, bcl-2 and bax expression patterns within these tissues were analyzed on the basis of immunohistochemistry. RESULTS: Twenty-eight of the cases were intestinal and 14 of the cases were diffuse type adenocarcinomas. 64% (27/42) of the gastric carcinoma cases had intestinal metaplasia. Intestinal metaplasia co-localized more with intestinal type carcinomas compared with diffuse type carcinomas [75% (21/28) vs 42% (6/14), respectively; P ≤0.05]. The mean apoptotic index in tumor cells was 0.70±0.08. The mean apoptotic index in intestinal metaplasias co-localizing to tumors was significantly higher than that of intestinal metaplasias co-localizing to chronic gastritis (0.70±0.03 vs 0.09±0.01, respectively; P≤0.05). p53 positivity was not observed in areas of intestinal metaplasia adjacent to tumors or chronic gastritis. Intestinal metaplasia areas adjacent to tumors showed lower cytoplasmic bcl-2 positivity compared to intestinal metaplasia areas adjacent to chronic gastritis [55.5% (15/27) vs 70.5% (12/17), respectively]. On the other hand, intestinal metaplasia areas adjacent to tumors showed significantly higher cytoplasmic bax positivity compared to intestinal metaplasia areas adjacent to chronic gastritis [44.4% (12/27) vs 11.7% (2/17), respectively; P ≤0.05]. CONCLUSION: Existence of apoptotic cells on the basis of TUNEL positivity is shown in intestinal metaplasias co-localizing to both diffuse and intestinal type gastric cancers in this study. Our results also suggested bax expression dependent induction of apoptosis especially in intestinal metaplasia areas adjacent to tumors. These findings strongly support the involvement of apoptotic mechanisms in the process of gastric carcinogenesis especially in the transition from intestinal metaplasia to gastric cancer. It may be suggested that induction of apoptosis in intestinal metaplasia areas adjacent to tumors may involve different mechanisms than induction by chronic inflammation. | Ferda Bir Nese Calli-Demirkan A Cevik Tufan Metin Akbulut N Lale Satiroglu-Tufan | 2007 | World Journal of Gastroenterology2007，13，23： | 2 |
| 2 | The effects of abdominal compartMent syndrome on the summ urea and creatinine levels J 显示文摘 | Kucuk HF Cevik a Kurt N | 2002 | Ulus Travma Derg2002，8，1： | 1 |
| 3 | Assessment of natural radioactivity and mass attenuation coefficients of brick and roofing tile used in Turkey显示文摘 | Damla N Cevik U Kobya AI | 2011 | Radiation Measurements2011，46，： | 1 |
| 4 | Myo- cyte enhancer factor 2B is involved in the inducible expres- sion of NOX1/NADPH oxidase, a vascular superoxide-pro- ducing enzyme 显示文摘 | Katsuyama M Ozgur Cevik M Arakawa N | 2007 | FEBS J2007，274，19： | 1 |
| 5 | A new coated bipolar coagulat- or:technical note显示文摘 | CEVIKER N KESKIL S K | 1998 | Acta Neurochirurgica1998，140，6： | 1 |
| 6 | A new coated bipolar coagulator: technicalnote 显示文摘 | CEVIKER N KESKIL S BAYKANER K | 1998 | Acta Neurochirurgica1998，140，6： | 1 |
| 7 | Nonvascular complications in pediatric liver recipients:multidetector computed tomography evaluation显示文摘 | Tutar N Coskun M Cevik B | 2006 | Transplant Proc2006，38，2： | 1 |
| 8 | Radiation dose estimation and mass attenuation coefficients of marble used in Turkey显示文摘 | Cevik U Damla N Kobya AI | | 0，，12： | 1 |
| 9 | Fuzzy multi-criteria evaluation of industrial robotic systems显示文摘 | KAHRAMAN C CEVIK S YASIN N | 2007 | Computers and Industrial Engineering2007，52，4： | 1 |
| 10 | Comparing the efficacy of intravenous tenoxicam, lornoxicam, and dexketoprofen trometamol for the treatment of renal colic 显示文摘 | Cevik E Cinar 0 Salman N | 2012 | Am J Emerg Med2012，30，8： | 1 |
| 11 | Melatonin prevents methotrexateinduced hepatorenal oxidative injury in rats 显示文摘 | Jahovic N Cevik H Sehirli AO | 2003 | J Pineal Res2003，34，4： | 1 |
| 12 | Head trauma and leukocytosis显示文摘 | Keskil S Baykaner MK Ceviker N | 1994 | Acta Neurochir1994，131，： | 1 |
| 13 | Head trauma and leukocytosis显示文摘 | Keskil S Baykarer MK Ceviker N | 1994 | Acta Neurochir1994，3，： | 1 |
| 14 | Risk factors for ICU-acquired methicillin-resistant staphylococcus aureus infections显示文摘 | Oztoprak N Cevik MA Akinci E | 2006 | Am J Infect Control2006，34，1： | 1 |
| 15 | Risk factors for ICU-ac- quired methicillin-resistant Staphylococcus aureus infections Am 显示文摘 | Oztoprak N Cevik MA AkinE et 81 | 2006 | Infect Control2006，34，： | 1 |
| 16 | Effect of paravalvular mitral regurgitation on left atrial thrombus formation in patients with mechanical mitral valves显示文摘 | Kaymaz C Ozdemir N Cevik C | 2003 | Am J Cardiol2003，92，1： | 1 |
| 17 | Molecular cloning of ATR5Emoy2 from Hyaloperrmospora arabidopsidis, an avirulence determinant that triggers RPPS-mediated defense in Arabidopsis 显示文摘 | Bailey K Cevik V Holton N | 2011 | Molecular Plant-Microbe Interactions2011，24，7： | 1 |
| 18 | Effects of Selenium with Vitamin E and Melatonin on Cadmium-Induced Oxidative Damage in Rat Liver and Kidneys显示文摘 | Haki Kara Ayd?n Cevik Vahit Konar Alpaslan Dayangac Kadir Servi | 2008 | Biological Trace Element Research2008，，3： | 1 |
| 19 | Head trauma and leueoeytosis显示文摘 | Keskil S Baykaner MK Ceviker N | 1994 | Aeta Neurochir(Wien)1994，131，34： | 1 |
| 20 | Biomonitoring of heavy metals by epiphytic lichen species in Black Sea region of Turkey显示文摘 | Koz B Celik N Cevik U | 2010 | Ecological Indicators2010，10，： | 1 |
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