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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | Thermal analysis of the chip formation in austenitic stainless steel显示文摘 | Chagas G M P Barbosa P A Barbosa C A | 2013 | 14th CIRP Conference on Modeling of Machining Operations2013，8，： | 1 |
| 3 | Ion-exchanging e- quilibria with aluminum pectinates显示文摘 | FRANCO C R CHAGAS A P JORGE R A | 2002 | Coll Surf A:Physico- chemical Engineering Aspects2002，204，13： | 1 |
| 4 | Characterization of earbapenem- resistant Acinctobaeter bau- naanii in Brazil (2008 -2011 ) : eount'vdde spread of OXA -23 - producing clones( CC15 and CC79 ) 显示文摘 | CHAGAS T P CARVALHO K R DE OL1VEIRA SANTOS 1 C | 2014 | Diagn Microbiol Infect Dis2014，79，4： | 1 |
| 5 | Respiratory effects of lipopolysaccharide - induced inflammatory lung injury in mice显示文摘 | FAFFE D S SEIDL V R CHAGAS P S | 2000 | EurRespirJ2000，15，1： | 1 |
| 6 | Laurifolin, a novel acetogenin from Rollinia laurifolia leaves显示文摘 | Lu cia P Santos Pimcnta Francisco Chagas do Nascimento Angela Cristina S Assun etal | 2001 | Tetrahedron Letters2001，42，48： | 1 |
| 7 | Association of pineapple mealybug wilt with closterovirus-like particles and dsRNA in Bahia, Brazil显示文摘 | Nickel O Chagas C M Vasconcelos A P A | 2000 | Fitopatologia Brasileira2000，25，2： | 1 |
| 8 | Cell Biochemistry and Function显示文摘 | Chaga G M Campello A P | 1995 | 13(4) :267 - 2711995，13，4： | 1 |
| 9 | Value of Electro‐Vectorcardiogram in Hypertrophic Cardiomyopathy显示文摘 | Andrés Ricardo Pérez‐Riera Augusto Armando Lucca Raimundo Barbosa‐Barros Frank G. Yanowitz Silvia Fortunato Cano Manuel Nicolás Cano Ant?nio Carlos Palandri‐Chagas | 2013 | Annals of Noninvasive Electrocardiology2013，，4： | 1 |
| 10 | Respiratory effects of lipopolysaccharide-induced inflammatory injury in mice显示文摘 | Faffe D S Seidl V R Chagas P S | 2000 | Eur Respir J2000，15，： | 1 |
| 11 | Exchange coupling behavior in birnagnetic CoFez 04/CoFe2 nanocomposite显示文摘 | LEITE G C P CHAGAS E F PEREIRA R | 2012 | Journal of Magnetism and Magnetic Materials2012，324，： | 1 |
| 12 | Alterations induced by citrinin in cultured kidney cells显示文摘 | Chagas G M Kluppel M L Campello Ade P | 1994 | Cell Struct Funct1994，19，2： | 1 |
| 13 | Citrininaffects the oxidative metabolism of BHK-21 cells显示文摘 | Chagas G M Campello A P Kluppel M L | 1995 | Cell Biochem- Funct1995，13，1： | 1 |
| 14 | Ion-exchange equilibria with aluminum pectinates显示文摘 | Franco C R Chagas A P Jorge R A | 2002 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2002，204，1： | 1 |
| 15 | Acaricidal action of destruxins produced by a marine-de- rived Beauveria felina on the bovine tick Rhipicephalus (Boophilus) microplus 显示文摘 | Morais-Urano R P Chagas A C S Berlinck R G S | 2012 | Experimental Parasitology2012，132，3： | 1 |
| 16 | A novel hydrofobic niobium oxyhydroxide as catalyst: selective cyclohexene oxidation to epoxide 显示文摘 | Chagas P Oliveira H S Mambrini R | 2013 | Applied Catalysis A: General2013，454，： | 1 |
| 17 | Immobilized metal ion affinity chromatography on Co^2+ - carboxymethylaspartate- agarose Superflow, as demonslrated by one-step purification of lactate dehydrogenase from chicken breast muscle 显示文摘 | Chaga G Hopp J Nelson P | 1999 | Biotechnol Appl Bloc1999，29，： | 1 |
| 18 | Multiresistance,beta-lactamase-encoding genes and bacterial diversity in hospital wastewater in Rio de Janeiro,Brazil显示文摘 | Chagas T P G Seki L M Cury J C | 2011 | Journal of Applied Microbiology2011，111，3： | 1 |
| 19 | Synthesis of hybrid mesoporous spheres using the chitos as template显示文摘 | Braga T P E C Chagas Gomes A F Sousa | 2009 | Journal of Non-Crystalline Solids2009，355，1415： | 1 |
| 20 | Decolorizvtion of ago dyes by phanerochaete chrysosporium and pleurotus saiorcaju 显示文摘 | Chagas E P Durrant L R | 2001 | Enzyme and Microbial Technology2001，29，： | 1 |
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