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| 1 | Early calcium dysregulation in Alzheimer's disease:setting the stage for synaptic dysfunction显示文摘Alzheimer's disease(AD) is an irreversible and progressive neurodegenerative disorder with no known cure or clear understanding of the mechanisms involved in the disease process.Amyloid plaques,neurofibrillary tangles and neuronal loss,though characteristic of AD,are late stage markers whose impact on the most devastating aspect of AD,namely memory loss and cognitive deficits,are still unclear.Recent studies demonstrate that structural and functional breakdown of synapses may be the underlying factor in AD-linked cognitive decline.One common element that presents with several features of AD is disrupted neuronal calcium signaling.Increased intracellular calcium levels are functionally linked to presenilin mutations,ApoE4 expression,amyloid plaques,tau tangles and synaptic dysfunction.In this review,we discuss the role of AD-linked calcium signaling alterations in neurons and how this may be linked to synaptic dysfunctions at both early and late stages of the disease. | Shreaya CHAKROBORTY Grace E.STUTZMANN | 2011 | Science China(Life Sciences)2011，54，8： | 6 |
| 2 | Seismic demand of plan-asymmetric structures:a revisit显示文摘In view of the recognition of the importance of the interdependent behavior of strength and stiffness of walltype structural elements,the seismic demand of plan-asymmetric systems is revisited.Useful strength distribution strategies,i.e.,'Center of Strength-Center of Mass(CV-CM) coinciding' and 'Balanced Center of Strength-Center of Resistance(CVCR)' are adopted.Design charts for the seismic demand of classical uni-directionally and bi-directionally asymmetric systems are developed in a simple unified format.A conceptual framework is also outlined to conveniently apply the design charts.Illustrations are included to explain the use of the current recommendations in practical design.The study also highlights the relative performance of 'CV-CM coinciding' and 'Balanced CV-CR' criteria. | Rana Roy Suvonkar Chakroborty | 2013 | Earthquake Engineering and Engineering Vibration2013，12，1： | 4 |
| 3 | Dynamic simulation of activated sludge based wastewater treatment processes: Case studies with Titagarh Sewage Treatment Plant, India显示文摘 | Ujjaini Sarkar Dwaipayan Dasgupta Trina Bhattacharya Sandip Pal Tamaghna Chakroborty | 2009 | Desalination2009，，1： | 1 |
| 4 | Exploring the behavior of LWR continuum models of traffic flow in pres- ence of shock waves显示文摘 | Durgesh Vikram Partha Chakroborty Sanjay Mittal | 2013 | Procedia-Social and Behavioral Sciences2013，104，： | 1 |
| 5 | Models of vehicular traffic: an engineering perspective 显示文摘 | Chakroborty P | 2006 | Physica A2006，372，1： | 1 |
| 6 | Microscopic modeling of driver behavior in uninterrupted显示文摘 | Chakroborty P Agrawal S Vasishtha K | 2004 | Journal of Transportation Engi- neering2004，130，4： | 1 |
| 7 | Car Fo Ilowing Model Based on A Fuzzy Infercnce System显示文摘 | Kikuchi&Chakroborty | 1992 | Transportation Research Record1992，30，： | 1 |
| 8 | Optimal Scheduling of Urban Transit Systems Using Genetic Algorithms 显示文摘 | Partha Chakroborty Kalyanmoy Deb P S Subrahmanyam | 1995 | Journal of Transportation Engineering1995，121，6： | 1 |
| 9 | Car following model based on a fuzzy in- ference system 显示文摘 | Kikuchi C Chakroborty P | 1992 | Transportation Research Record1992，1365，： | 1 |
| 10 | Network-Wide Optimal Scheduling of Transit Systems Using Genetic Algorithms 显示文摘 | Partha Chakroborty Kalyanmoy Deb B Srinivas | 1998 | Computer-Aided Civil and Infrastructure Engineering1998，13，： | 1 |
| 11 | Meaning,Unmeaning the Po- etics of L = A = N = G = U = A = G = E显示文摘 | Chakroborty Suman | 2008 | Irwle2008，，： | 1 |
| 12 | Models of Vehicular Traffic:An Engineering Perspective 显示文摘 | CHAKROBORTY P | 2006 | Physica A: Statistical Mechanics and Its Applications2006，372，1： | 1 |
| 13 | Optimum Assignment of Trains to Platforms under Partial Schedule Compliance显示文摘 | PARTHA Chakroborty Durgesh Vikram | 2008 | Transportation Research Part B2008，42，2： | 1 |
| 14 | Genetic Algorithms for Optimal Urban Transit Network Design Computer Aided Civil and Infrastructure Engineering显示文摘 | Chakroborty P | 2003 | 18(3): 18-202003，18，3： | 1 |
| 15 | Dopamine regulatesendothelial progenitor cell mobilization from mouse bone marrow in tumorvascularization显示文摘 | Chakroborty D Chowdhury U R Sarkar C | 2008 | J Clin Invest2008，118，4： | 1 |
| 16 | Tissue adhesive in ophthalmology显示文摘 | Shaw C Islam MN Chakroborty S | 2010 | J Indian Med Assoc2010，108，： | 1 |
| 17 | Feature selection using singular value decomposition and QR factorization with column pivoting for text-independent speaker identification 显示文摘 | CHAKROBORTY S SAHA G | 2010 | Speech Communication2010，52，9： | 1 |
| 18 | Cutting Edge: Stimulation of dopamine D4 receptors induce T cell quies- cence by up-regulating Kruppel-like factor-2 expression through inhibition of ERK1/ERK2 phosphorylation 显示文摘 | Sarkar C Das S Chakroborty D | 2006 | J Immunol2006，177，： | 1 |
| 19 | Optimum assignment of trains to platforms under partial schedule compliance显示文摘 | CHAKROBORTY P VIKRAM D | 2008 | Transportation Research Part B2008，42，： | 1 |
| 20 | Genetic algorithms for optimal urban transit network design 显示文摘 | CHAKROBORTY P | 2003 | Computer-Aided Civil and Infrastructure Engineering2003，18，3： | 1 |
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