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| 1 | Isolation of circulating tumor cells in non-small-cell-lung-cancer patients using a multi-flow microfluidic channel显示文摘Circulating tumor cells(CTCs)carry a wealth of information on primary and metastatic tumors critical for precise cancer detection,monitoring,and treatment.Numerous microfluidic platforms have been developed in the past few years to capture these rare cells in patient bloodstream for deciphering the critical information needed.However,the practical need for a high-quality method of CTC isolation remains to be met.Herein,we demonstrate a novel multi-flow microfluidic device that is able to sensitively provide high purity(>87%)of separation outcome without labeling.Our device is constructed and configured based on the phenomenal effect of size-dependent inertial migration.The recovery rate of>93%has been achieved using spiked cancer cells at clinically relevant concentrations(10 cells per 5 mL and above).We have also successfully detected CTCs from 6 out of 8 non-small-cell-lung-cancer(NSCLC)patients,while none for 5 healthy control subjects.With these results,we envision our approach is a promising alternative for reliable CTC capture,and thus for facilitating the progress of extracting information from CTCs to personalize treatment strategies for solid tumor patients. | Jian Zhou Arutha Kulasinghe Amanda Bogseth Ken O’Byrne Chamindie Punyadeera Ian Papautsky | 2019 | Microsystems & Nanoengineering2019，5，1： | 9 |
| 2 | A review of potential biomarkers for assessing physical and psychological trauma in paediatric burns显示文摘Biological markers that evaluate physical healing as well as psychological impact of a burn are essential for effective treatment of paediatric burns.The objective of this review is to summarize the evidence supporting the use of biomarkers in children with burns.An extensive review of the literature was performed using PubMed.A total of 59 biomarkers were identified relating to burn presence,specifically relating to processes involved in inflammation,wound healing,growth and metabolism.In addition,biomarkers involved in the stress response cascade following a burn trauma were also identified.Although many biomarkers have been identified that are potentially associated with burn-related physical and psychological trauma,an understanding of burn biology is still lacking in children.We propose that future research in the field of children’s burns should be conducted using broad screening methods for identifying potential biomarkers,examine the biological interactions of different biomarkers,utilize child-appropriate biological fluids such as urine or saliva,and include a range of different severity burns.Through further research,the biological response to burn injury may be fully realized and clinically relevant diagnostic tests and treatment therapies utilizing these biomarkers could be developed,for the improvement of healing outcomes in paediatric burn patients. | Morgan Carlton Joanne Voisey Tony J.Parker Chamindie Punyadeera Leila Cuttle | 2021 | Burns & Trauma2021，9，1： | 2 |
| 3 | Identification of salivary N‐glycoproteins and measurement of glycosylation site occupancy by boronate glycoprotein enrichment and liquid chromatography/electrospray ionization tandem mass spectrometry显示文摘 | Ying Xu Ulla‐Maja Bailey Chamindie Punyadeera Benjamin L. Schulz | 2014 | Mass Spectrom2014，，5： | 1 |
| 4 | The effect of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle显示文摘 | Chamindie Punyadeera Antoine HG Zorenc etal | 2005 | European Journal Of Endocrinology2005，152，14： | 1 |
| 5 | A novel saliva-based miRNA profile to diagnose and predict oral cancer显示文摘Oral cancer (OC) is the most common form of head and neck cancer. Despite the high incidence and unfavourable patient outcomes, currently, there are no biomarkers for the early detection of OC. This study aims to discover, develop, and validate a novel saliva-based microRNA signature for early diagnosis and prediction of OC risk in oral potentially malignant disorders (OPMD).The Cancer Genome Atlas (TCGA) miRNA sequencing data and small RNA sequencing data of saliva samples were used to discover differentially expressed miRNAs. Identified miRNAs were validated in saliva samples of OC (n=50), OPMD (n=52), and controls(n=60) using quantitative real-time PCR. Eight differentially expressed miRNAs (miR-7-5p, miR-10b-5p, miR-182-5p, miR-215-5p,miR-431-5p, miR-486-3p, miR-3614-5p, and miR-4707-3p) were identified in the discovery phase and were validated. The efficiency of our eight-miRNA signature to discriminate OC and controls was:area under curve (AUC):0.954, sensitivity:86%, specificity:90%,positive predictive value (PPV):87.8%and negative predictive value (NPV):88.5%whereas between OC and OPMD was:AUC:0.911,sensitivity:90%, specificity:82.7%, PPV:74.2%and NPV:89.6%. We have developed a risk probability score to predict the presence or risk of OC in OPMD patients. We established a salivary miRNA signature that can aid in diagnosing and predicting OC,revolutionising the management of patients with OPMD. Together, our results shed new light on the management of OC by salivary miRNAs to the clinical utility of using miRNAs derived from saliva samples. | Jaikrishna Balakittnen Chameera Ekanayake Weeramange Daniel F.Wallace Pascal H.G.Duijf Alexandre S.Cristino Gunter Hartel Roberto A.Barrero Touraj Taheri Liz Kenny Sarju Vasani Martin Batstone Omar Breik Chamindie Punyadeera | 2024 | International Journal of Oral Science2024，16，1： | 0 |
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