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| 1 | Response to endoscopic therapy for biliary anastomotic strictures in deceased versus living donor liver transplantation显示文摘BACKGROUND:Endoscopic therapy has been successful in the management of biliary complications after both deceased donor liver transplantation(DDLT) and living donor liver transplantation(LDLT).LDLT is thought to be associated with higher rates of biliary complications,but there are few studies comparing the success of endoscopic management of anastomotic strictures between the two groups.This study aims to compare our experience in the endoscopic management of anastomotic strictures in DDLT versus LDLT.METHODS:This is a retrospective database review of all liver transplant patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) after liver transplantation.The frequency of anastomotic stricture and the time to develop and to resolve anastomotic stricture were compared between DDLT and LDLT.The response of anastomotic stricture to endoscopic therapy was also analyzed.RESULTS:A total of 362 patients underwent liver transplantation between 2003 and 2011,with 125 requiring ERCP to manage biliary complications.Thirty-three(9.9%) cases of DDLT and 8(27.6%) of LDLT(P=0.01) were found to have anastomotic stricture.When comparing DDLT and LDLT,there was no difference in the mean time to the development of anastomotic strictures(98±17 vs 172±65 days,P=0.11),likelihood of response to ERCP [22(66.7%) vs 6(75.0%),P=0.69],mean time to the resolution of anastomotic strictures(268±77 vs 125±37 days,P=0.34),and the number of ERCPs required to achieve resolution(3.9±0.4 vs 4.7±0.9,P=0.38).CONCLUSIONS:Endoscopic therapy is effective in the majority of biliary complications relating to liver transplantation.Anastomotic strictures occur more frequently in LDLT compared with DDLT,with equivalent endoscopic treatment response and outcomes for both groups. | Calvin HY Chan Fergal Donnellan Michael F Byrne Alan Coss Mazhar Haque Holly Wiesenger Charles H Scudamore Urs P Steinbrecher Alan A Weiss Eric M Yoshida | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 7 |
| 2 | TSC1-mTOR-PLK轴以阶段特异性方式调节从施旺细胞增殖到髓鞘形成的内稳态开关显示文摘恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和髓鞘稳态,建立了雪旺细胞谱系进展和髓鞘形成的阶段依赖性程序。小鼠雪旺细胞祖细胞中TSC1的解离导致mTOR信号通路激活,继而导致雪旺细胞过量增殖,分化受阻,髓鞘形成减少。转录组分析显示,TSC1突变体中的mTOR活化使得polo样激酶(PLK)依赖性通路和细胞周期调节剂上调。弱化mTOR或者对PLK进行药理抑制部分挽救了因TSC1缺失导致的外周神经发育过程中的髓鞘形成减少。相较之下,成年小鼠成熟雪旺细胞中TSC1缺失可导致髓鞘的过度增殖和过度生长。本文的发现提示了TSC1-mTOR-PLK信号轴在控制雪旺细胞的发育过程中,从增殖到分化和髓鞘内稳态中起到的阶段特异性功能。 | Jiang M Rao R Wang J Wang J1 Xu L Wu LM Chan JR Wang H Lu QR 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，5： | 2 |
| 3 | Response of nanocomposite pyroelectric detectors 显示文摘 | CHEN Y CHAN W L H HUI N M | 1998 | Sensors and Actuators A1998，69，1： | 2 |
| 4 | The 40-50 day oscillation and El Nino/Southern Oscillation:A new perspective显示文摘 | Lau K M Chan P H | 1986 | Bull Amer Meteor Soc1986，67，5： | 2 |
| 5 | A probabilistic reasoning-based decision support system for selecting remediation technologies for petroleum-contaminated sites 显示文摘 | HE L CHAN C W HUANG G H ZENG G M | 2006 | Expert Systems with Applications2006，30，4： | 1 |
| 6 | Damage-based formability analysis for TWBs显示文摘 | Cheng C H Jie M | 2005 | International Journal of Damage Mechanics2005，14，1： | 1 |
| 7 | On the training of radial basis function classifiers 显示文摘 | Musavi M T Ahmed W Chan K H | 1992 | Neural Networks1992，，5： | 1 |
| 8 | The water-soluble ionic composition of PM25 in Shanghai and Beijing,China显示文摘 | YAO X H CHAN C K FANG M | 2002 | Atmos Environ2002，36，26： | 1 |
| 9 | Temporal and spatial trends of mercury in fish collected in the English-Wabigoon river system in Ontario, Canada显示文摘 | Kinghorn A Solomon P Chan H M | 2007 | Science of the Total Environment2007，372，2： | 1 |
| 10 | The effect of excimer laser surface treatment on the pitting corrosion fatigue behaviour of alnminium alloy 7075 显示文摘 | Chan C P Yue T M Man H C | 2003 | Journal of Materials Science2003，15，12： | 1 |
| 11 | Effects of chronic cysteamine treatment on growth enhancement and insulin-like growth factor I and II mRNA levels in common carp tissues显示文摘 | TSE M C CHENG C H CHAN K M | 2006 | Br J Nutr2006，96，： | 1 |
| 12 | A hybridized displacement discontinuity and indirect boundary element method to model fracture propagation显示文摘 | CHAN H C M LI V EINSTEIN H H | 1990 | International Journal of Fracture1990，45，4： | 1 |
| 13 | Preferred risk allocation in target cost contracts in con- struction显示文摘 | Joseph H L Chan Daniel W M Chan Patrick T I Lam | 2011 | Facilities2011，29，1314： | 1 |
| 14 | Celecoxib suppres- ses hepatoma stemness and progression by up-regulating PTEN显示文摘 | Chu T H Chan H H Kuo H M | 2014 | Oncotarget2014，5，6： | 1 |
| 15 | Temporal and spatial trends of mercury in fish collected in the English-Wabigoon river system in Ontario, Canada 显示文摘 | Kinghorn A Solomon P Chan H M | 2007 | Science of the Total Environment2007，372，23： | 1 |
| 16 | Oxide film formation and oxygen adsorption on copper in aqueous media as probed by surface-enhanced Raman spectroscopy显示文摘 | Chan H Y H Takoudis C G Weaver M J | 1999 | Journal of Physical Chemistry B1999，103，2： | 1 |
| 17 | Agrobacterium-mediated production of transgenic rice plants expressing a chimeric α-amylase promoter β-glucuronidase gene显示文摘 | CHAN M T CHANG H H HO S L | 1993 | Plant Mol Biol1993，22，： | 1 |
| 18 | Tissue distribution of Epstein-Ban:virus genotypes显示文摘 | Chen H L Lung M L Chan K H | 1996 | J Viral1996，70，10： | 1 |
| 19 | Determination of antibacterial reagents by liquid chromatography-elec- trospray-mass spectrometry显示文摘 | Fuh M R S Chan S A Wang H L | 2000 | Talanta2000，52，1： | 1 |
| 20 | High prevalence of human papillomavirus type 58 in Chinese women with cervical cancer and precancerous lesions显示文摘 | Chan P K Li W H Chan M Y | 1999 | J Med Viral1999，59，2： | 1 |
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