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| 1 | Effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy显示文摘AIM: To determine the effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy.METHODS: Consecutive patients who underwent capsule endoscopy du ring the 16-mo study period were either given 250 mg oral erythromycin, 1 h prior to swallowing the capsule endoscope or nothing. The gastric and small bowel transit time, and the small bowel image quality were compared.RESULTS: Twenty-four patients received oral erythromycin whereas 14 patients were not given any prokinetic agent.Patients who received erythromycin had a significantly lower gastric transit time than control (16 min vs70 min, P= 0.005),whereas the small bowel transit time was comparable between the two groups (227 min vs183 min, P = 0.18).Incomplete small bowel examination was found in three patients of the control group and in one patient of the erythromycin group. There was no significant difference in the overall quality of small bowel images between the two groups. A marked reduction in gastric transit time was noted in two patients who had repeat capsule endoscopy after oral erythromycin.CONCLUSION: Use of oral erythromycin significantly reduces the gastric transit time of capsule endoscopy. | Wai K Leung Francis KL Chan Sara SL Fung Mei-Yin Wong Joseph JY Sung | 2005 | World Journal of Gastroenterology2005，11，31： | 16 |
| 2 | Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC. | Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 3 | Prognostic factors and survival in 1396patients with uterine leiomyosarcomas:emphasis on impact of lymphadenectomy and oophorectomy显示文摘 | Kapp DS Shin JY Chan JK | 2008 | Cancer2008，112，4： | 3 |
| 4 | Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn 显示文摘 | Chan JY Lee-Pmdhoe JE Jorgensen B | 2001 | J Biol Chem2001，276，： | 1 |
| 5 | Chromosomal localization of the human NF-E2 family of bZIP transcription factors by fluorescence in situ hybridization显示文摘 | Chan JY Cheung MC Moi P | | 0，，03： | 1 |
| 6 | Extracorporeal shockwave for hip necrosis in systemic lupus erythematosus显示文摘 | Wang CJ Ko JY Chan YS | 2009 | Lupus2009，18，12： | 1 |
| 7 | Diagnostic value of procalcitonin forbacterial infection in elderly patients-a systemic review and meta-a-nalysis显示文摘 | Lee SH Chan RC Wu JY | 2013 | Int J Clin Pract2013，67，12： | 1 |
| 8 | Prone table stereotactic breast biopsy显示文摘 | Hui JY Chan LK Chan Rl | 2002 | Hong Kong Med J2002，8，6： | 1 |
| 9 | Biventricular pacing in patients with bradyeardia and normal ejection fraction显示文摘 | Yu CM Chan JY Zhang Q | 2009 | N Engl J Med2009，361，22： | 1 |
| 10 | Prevalence and Clinical Characteristics of Simple RenalCyst显示文摘 | Chang CC Kuo JY Chan WL | 2007 | J Chin MedAssoe2007，70，11： | 1 |
| 11 | Clopidogrel versus aspirin and esomeprazole to prevent recurrentulcer bleeding显示文摘 | Chan FK Ching JY Hung LC | 2005 | N Engl J med2005，352，3： | 1 |
| 12 | CD164--a novel sialomucin on CD34( + ) cells显示文摘 | Watt SM Chan JY | 2000 | Leuk Lymphoma2000，37，： | 1 |
| 13 | The value of admission HbA (lc) level in diabetic patients with acute coronary syndrome显示文摘 | Chan CY Li R Chan JY | 2011 | Clin Cardiol2011，34，8： | 1 |
| 14 | Clopidogrel versus aspirin and esomeprasole to prevent recurrent ulcer bleeding 显示文摘 | Chan FK Ching JY Hung LC | 2005 | N Engl J Med2005，352，3： | 1 |
| 15 | Diagnostic value ofprocalcitonin for bacterial infection in elderly patients-a systemic review and meta- analysis显示文摘 | Lee SH Chan RC Wu JY | 2013 | Int J Clin Pratt2013，67，12： | 1 |
| 16 | The contribution of medializing calcaneal osteotomy on hindfoot alignment in the reconstruction of the stage 11 adult acquired fiat- foot deformity 显示文摘 | Chan JY Williams BR Nair P | 2013 | Foot Ankle Int2013，34，2： | 1 |
| 17 | Biventrieular pacing in patients with bradycardia and normal ejection fraction显示文摘 | Yu CM Chan JY Zhang Q | 2009 | N Engl J Med2009，361，22： | 1 |
| 18 | Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding显示文摘 | Chan FK Ching JY Hung LC | 2005 | N Engl J Med2005，352，： | 1 |
| 19 | Differential expression of the suppressor PML and Ki-67 identifies three subtypes of human nasopharyngeal carcinoma显示文摘 | Chan JY Meng CL To KF | 2002 | Eur J Cancer2002，38，12： | 1 |
| 20 | Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in beta-cell gene expression and progression to diabetes显示文摘 | Chan JY Luzuriaga J Laybutt DR | 2013 | Diabetes2013，62，： | 1 |
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