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| 1 | 膳食中钠(盐)与血压的关系及其他膳食因素可能的调节作用显示文摘现有资料表明,膳食钠(盐)与血压直接相关。以往大多数研究结果来自缺乏膳食数据的研究;因此,这种钠-血压关系是否受其他膳食因素调节尚不清楚。国际宏量/微量营养素和血压研究(international study on macro/micronutrients and blood pressure,INTERMAP)结果显示,在控制多种非膳食因素情况下,年龄40~59岁的男性和女性4680人(中国、日本、英国和美国的17个人口样本)的血压与24h尿钠排泄和尿钠/钾直接相关。 | 刘莉 叶鹏 Stamler J Chan Q Daviglus ML Dyer AR Van Horn L Garside DB Miura K Wu Y Ueshima H Zhao L Elliott P INTERMAP Research Group | 2018 | 中华高血压杂志2018，26，4： | 8 |
| 2 | TSC1-mTOR-PLK轴以阶段特异性方式调节从施旺细胞增殖到髓鞘形成的内稳态开关显示文摘恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和髓鞘稳态,建立了雪旺细胞谱系进展和髓鞘形成的阶段依赖性程序。小鼠雪旺细胞祖细胞中TSC1的解离导致mTOR信号通路激活,继而导致雪旺细胞过量增殖,分化受阻,髓鞘形成减少。转录组分析显示,TSC1突变体中的mTOR活化使得polo样激酶(PLK)依赖性通路和细胞周期调节剂上调。弱化mTOR或者对PLK进行药理抑制部分挽救了因TSC1缺失导致的外周神经发育过程中的髓鞘形成减少。相较之下,成年小鼠成熟雪旺细胞中TSC1缺失可导致髓鞘的过度增殖和过度生长。本文的发现提示了TSC1-mTOR-PLK信号轴在控制雪旺细胞的发育过程中,从增殖到分化和髓鞘内稳态中起到的阶段特异性功能。 | Jiang M Rao R Wang J Wang J1 Xu L Wu LM Chan JR Wang H Lu QR 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，5： | 2 |
| 3 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 4 | Vehicle axle loads identification using finite element method 显示文摘 | Law S S Bu J Q Zhu X Q Chan S L | 2004 | Journal of Engineering Structures2004，26，： | 1 |
| 5 | Poisoning effect of nitrogen compounds on the performance of CoMoS/ Al2O3 catalyst in the hydrodesulfurization of dibeuzothiophene,4-methyldibenzothiophene,and 4,6-dimethyldibenzothiophene显示文摘 | CHAN K JUNG J L JUN S B | 2001 | Applied Catalysis B:Environmental2001，35，1： | 1 |
| 6 | How strong ENSO events affect tropical storm activity over the western North Pacific显示文摘 | WANG B CHAN J C L | 2002 | J Climate2002，15，： | 1 |
| 7 | The Sorption of acid dye onto chitosan nanoparticles显示文摘 | Hu Z G Zhang J Chan W L | 2006 | Polymer2006，47，16： | 1 |
| 8 | Comment on 'Changes in Tropical Cyclone Number, Duration, and Intensity in a Warming Environment'显示文摘 | Chan J C L | 2006 | Science2006，311，5768： | 1 |
| 9 | Enhanced plasticity by phase separation in CuZrAl bulk metallic glass with micro-addition of Fe 显示文摘 | PAN J LIU L CHAN K C | 2009 | Scripta Mater2009，60，9： | 1 |
| 10 | Tropical cyclone movement and sur- rounding flow relationship 显示文摘 | Chan J C L G ray W M | 1982 | Mon Wea Rev1982，110，9： | 1 |
| 11 | Six month radiologieal and physiological outcomes in severe acute respiratory syndrome(SARS) survivors 显示文摘 | Ng C K Chan J W Kwan T L | 2004 | Thorax2004，59，： | 1 |
| 12 | Removal of heavy metals from anaerobically digested sewage sludge by isolated indigenous iron-oxidizing bacteria显示文摘 | Xiang L Chan L C Wong J W C | 2000 | Chemosphere2000，41，： | 1 |
| 13 | The conversion of procyanidins and prodelphinidins to cuaniding and delphinidin显示文摘 | Porter L J Hrstich L N Chan B G | 1986 | Phytochemistry1986，25，： | 1 |
| 14 | Tropical cyclone movement and surrounding flow relationship显示文摘 | CHAN J C L GRAY W M | 1982 | Mon Wea Rev1982，110，9： | 1 |
| 15 | Spatial distribution of ciguatericfish in the Republic of Kiribati显示文摘 | CHAN W H MAK Y L WU J J | 2011 | Chemosphere2011，84，： | 1 |
| 16 | Hydrogen sulfide-based therapeutics and gastrointestinal diseases : translating physiology to treatments显示文摘 | Chan M V Wallace J L | 2013 | Am J Physial Gastrointest Liver Physiol2013，305，7： | 1 |
| 17 | Experimental Study on the Shearing Behaviour of Fine--blanking Versus Bar Cropping显示文摘 | Chan L C Lee T C Wu B J | 1998 | Journal of Materials Processing Technology1998，80，8： | 1 |
| 18 | lmmunolgical aspects of premure ovarian failure associated with idiopathic Addison' s disease显示文摘 | Chan M W Scarth L | 1968 | Lancet1968，2，： | 1 |
| 19 | Improved Temporal Basis Function for Time Domain Electric Field Integral Equation Method显示文摘 | Chan C H | 1999 | Electronics Letters1999，35，11： | 1 |
| 20 | Lafora progressiveMyoclonus Epilepsy mutation database-EPM2A andNHLRC1(EPM2B)genes显示文摘 | Ianzano L Zhang J Chan EM | 2005 | Hum Mutat2005，26，4： | 1 |
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