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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 3 | Mutations of PIK3CA in gastric adenocarcinoma显示文摘 | Li V S Wong C W Chan T L | 2005 | BMC Cancer2005，5，： | 1 |
| 4 | Sliding mode controller for linear systems with mismatched time-varying uncertainties 显示文摘 | TAO C W LEE T T | 2000 | Journal of Franklin Institute2000，337，： | 1 |
| 5 | Colloidal behaviour of materials with ionizable group surfaces显示文摘 | HEALY T W CHAN D WHITE L R | 1980 | Pure Appl Chem1980，52，5： | 1 |
| 6 | A multiphase level set framework for image segmentation using the Mumford and Shah model 显示文摘 | Vese L Chan T | 2002 | International Journal of Computer Vision2002，50，： | 1 |
| 7 | Maintenance of Continuously Monitored Degrading Systems 显示文摘 | Liao H T Elsayed E A Chan L Y | 2006 | European Journal of Operational Research2006，175，2： | 1 |
| 8 | Six month radiologieal and physiological outcomes in severe acute respiratory syndrome(SARS) survivors 显示文摘 | Ng C K Chan J W Kwan T L | 2004 | Thorax2004，59，： | 1 |
| 9 | Active contours without edges 显示文摘 | T Chan L Vese | 2001 | IEEE Transactions on Image Processing2001，10，2： | 1 |
| 10 | Active contours without edges 显示文摘 | Chan T Vese L A | 2001 | IEEE Transactions on Image Processing2001，，10： | 1 |
| 11 | Active contours without edges 显示文摘 | CHAN T VESE L | 2001 | IEEE Trans on Imag Proc2001，10，2： | 1 |
| 12 | Active contours without edges显示文摘 | Chan T F Vese L A | 2001 | IEEE Transactions on Image Processing2001，10，2： | 1 |
| 13 | Real-time frequency and harmonic evaluation using artificial neural networks显示文摘 | LAI L L TSE C T CHAN W L | 1999 | IEEE Transactions on Power Delivery1999，14，1： | 1 |
| 14 | A multiphase level set framework for image segmentation using the Mumford and Shah model显示文摘 | VESE L A CHAN T F | 2002 | International Journal of Computer Vision2002，50，3： | 1 |
| 15 | Preferred risk allocation in target cost contracts in con- struction显示文摘 | Joseph H L Chan Daniel W M Chan Patrick T I Lam | 2011 | Facilities2011，29，1314： | 1 |
| 16 | A multiphase level set frame work for image segmentation using the Mumford and Shah model 显示文摘 | Vese L Chan T F | 2002 | Interna- tional Journal of Computer Vision2002，50，3： | 1 |
| 17 | The Effects of Firm-initiated Clawback Provisions on Earnings Quality and Au- ditor Behavior显示文摘 | Chan L H Chen K C W Chen T Y Yu Y X | 2012 | Journal of Accounting and Economics2012，，54： | 1 |
| 18 | Obstctric outcomes aftercervical ripening by multiple doses of vaginal prostaglandin E2 显示文摘 | CHAN L Y FU L LEUNG T N | 2004 | Acta Obstet Gynecol Scand2004，83，1： | 1 |
| 19 | Experimental Study on the Shearing Behaviour of Fine--blanking Versus Bar Cropping显示文摘 | Chan L C Lee T C Wu B J | 1998 | Journal of Materials Processing Technology1998，80，8： | 1 |
| 20 | Active contours without edges, IEEE Trans显示文摘 | Chan T F Vese L A | 2001 | Image Processing2001，10，2： | 1 |
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