|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 八角茴香挥发油超声辅助提取及抗氧化性研究显示文摘目的:研究超声波辅助法提取八角茴香挥发油的最佳工艺参数及体外抗氧化活性。方法:选取八角茴香为原料,以料液比、粉碎粒径、超声时间作为考察因素,采用单因素试验和正交试验,对超声波辅助提取八角茴香油的工艺参数进行了研究,同时以维生素C标准品作为对照,通过测定其对羟自由基、超氧阴离子自由基及DPPH自由基的清除能力考察其体外抗氧化活性。结论:3个考察因素影响超声波辅助提取法的程度依次为料液比>粉碎粒径>超声时间;提取工艺的最佳条件是料液比1∶15、粉碎粒径60目、超声时间30min、提取率(28.438±0.11)%。八角茴香挥发油对羟自由基、超氧阴离子自由基、DPPH自由基均有较强的清除能力,但均低于维生素C标准品;在一定浓度范围内清除能力随着浓度增加而增大,其半数清除率(IC50)分别为4.9422,7.8492,6.1980mg/mL。 | 谢志新 陈琳琳 张文州 William Chandler | 2018 | 中国调味品2018，43，4： | 21 |
| 2 | 影响青贮玉米营养价值的因素及其评价方法显示文摘 | Paul Chandler 于旭华 | 2001 | 国外畜牧科技2001，28，4： | 14 |
| 3 | Surgical decompression in acute spinal cord injury: A review of clinical evidence, animal model studies, and potential future directions of investigation显示文摘为在尖锐针的绳索损害(SCI ) 的治疗的目标是减少第二等的损坏的程度并且便于神经新生和功能的恢复。尽管多重研究为尖锐 SCI 的治疗调查了潜在的新治疗,结果和管理协议在病人在改善瞄准了神经损害仍然保持无效。更最近的临床、基本的科学研究显示了外科的干预是为治疗的一种潜在地珍贵的形式;然而,角色并且外科的解压缩预定除了最佳的外科的干预,仍然是与尖锐 SCI 的外科的治疗相关的最争论的话题之一。当越来越多的潜在的治疗形式出现,动物模型为调查它的临床的申请和翻译进人的审判是枢轴的。这评论极其估价可得到的文学让临床、基本的科学研究加亮调查的程度考虑的那发生的、特定的治疗,和为未来研究的潜在的区域。 | Yiping LI Chandler L. WALKER Yi Ping ZHANG Christopher B. SHIELDS Xiao-Ming XU | 2014 | Frontiers in Biology2014，9，2： | 14 |
| 4 | 人HCN4通道的滞后现象:影响窦房结起搏的潜在决定因素(英文)显示文摘超极化活化环核苷酸门控(hyperpolarization-activated cyclic-nucleotide-gated,HCN)通道参与调制心脏跳动的节律和速率。与HCN1和HCN2有所不同,慢通道HCN4可能不存在电压依赖的滞后现象。本研究采用单细胞膜片钳方法,在稳定转染hHCN4的HEK293细胞上进行电生理记录,观察hHCN4通道是否存在滞后现象,以及cAMP对其的调制作用;同时采用实时定量RT-PCR方法检测窦房结和心房组织中HCNs的表达。电压钳实验结果显示hHCN4电流(Ih)激活随着保持电位超极化的变化而向去极化方向移动。三角电位变化钳(triangular ramp)和动作电位钳的结果也显示了hHCN4的滞后现象。cAMP增加Ih电流幅度,且使电流激活向去极化方向移动,从而改变内源性hHCN4滞后行为。RT-PCR结果显示,人窦房结组织主要表达HCN4,占75%,HCN1占21%,HCN2占3%,HCN3占0.7%。以上结果提示,人窦房结组织主要表达HCN4亚型,hHCN4的Ih存在电压依赖性的滞后现象,且受cAMP调制。由此推断,hHCN4通道的滞后现象可能在窦房结起搏活动中起到了关键作用。 | 萧永福 Natalie Chandler Halina Dobrzynski Eric S.Richardson Erica M.TenBroek Joshua J.Wilhelm Vinod Sharma Anthony Varghese Mark R.Boyett Paul A.Iaizzo Daniel C.Sigg | 2010 | 生理学报2010，62，1： | 10 |
| 5 | Characterization of Gibberellin Receptor Mutants of Barley (Hordeum vulgare L.)显示文摘Gid1 的顺序(为赤霉素(GA ) 的基因从米饭的受体) 被用来从大麦识别通常认为的 orthologue。这在 E 被表示。coli,并且生产了能与结构的特性和 saturability 在 vitro 绑 GA 的蛋白质。它在 GA 回答的潜在的角色与减少的 GA 敏感(gse1 异种) 用大麦异种被调查。十六不同 gse1 异种各在这个序列带了唯一的核苷酸替换。在里面几乎一个案例,这些变化导致了单个氨基酸替换,并且,为留下的异种,在 mRNA 的 5 untranslated 区域的替换被建议防碍翻译开始。在分离有完美的连接在新变异的等位基因和 gse1 显型之间的人口,导致在大麦的通常认为的 GID1 GA 受体顺序对应于 Gse1 地点的结论。在异种之一的内长的 GA 内容的决心揭示了 C20 GA 先锋的 bioactive GA1,和赤字的提高的累积。所有在通常正在浸透的集中 gse1 异种把敏感归结为外长的 GA3,并且到 AC94377 (GA 类似物) ,,但是,在高得多的集中,经常有可观的回答。在大麦和米饭异种之间的比较揭示这之间的有趣的差别在 GA 的二谷物种神经质的生理学。 | Peter M. Chandler Carol A. Harding Anthony R. Ashton Mark D. Mulcair Nicholas E. Dixonb Lewis N. Manderb | 2008 | Molecular Plant2008，1，2： | 10 |
| 6 | PTEN/PI3K and MAPK signaling in protection and pathology following CNS injuries显示文摘大脑和针的绳索损害开始普遍时间、空间的 neurodegeneration,通过坏死、规划的房间死亡机制。发炎,反应氧化, excitotoxicity 和新陈代谢的过程的房间特定的 dysregulation 被创伤的侮辱怂恿并且是到这累积损坏的主要贡献者。成功的处理依靠混乱的大小的预防或减小,并且通过表明串联的调整防碍有害细胞的回答是一条有效途径。二细胞内部的发信号小径,磷酸酶和 tensin 相当或相同的事物(PTEN )/phosphatidylinositol 3-kinase (PI3K ) 和表明串联的 mitogenactivated 蛋白质 kinase (MAPK ) 在正常、病理学的条件下面起各种各样的细胞的作用。两条小径的激活能在多重 CNS 混乱影响解剖、功能的结果。然而,一些机制涉及禁止或提高一条小径或其它,或,在宣传特定的下游的效果。尽管许多细胞内部的机制贡献房间回答侮辱,这评论检验探索在病理, neuroprotection,和修理上表明影响的 PTEN/PI3K 和 MAPK 的证据并且这些小径怎么可以为推进知识并且在对大脑和针的绳索的损害以后改进神经病学的结果被指向。 | Chandler L. WALKER | 2013 | Frontiers in Biology2013，8，4： | 9 |
| 7 | Diabetes inhibits corneal epithelial cell migration and tight junction formation in mice and human via increasing ROS and impairing Akt signaling显示文摘Corneal wounds usually heal quickly;but diabetic patients have more fragile corneas and experience delayed and painful healing. In the present study, we compared the healing capacity of corneal epithelial cells (CECs) between normal and diabetic conditions and the potential mechanisms. Primary murine CEC derived from wild-type and diabetic (db/db) mice, as well as primary human CEC were prepared. Human CEC were exposed to high glucose (30 mM) to mimic diabetic conditions. Cell migration and proliferation were assessed using Scratch test and MTT assays, respectively. Reactive oxygen species (ROS) production in the cells was measured using dichlorofluorescein reagent. Western blot was used to evaluate the expression levels of Akt. Transepithelial electrical resistance (TEER) and zonula occludens-1 (ZO-1) expression were used to determine tight junction integrity. We found that the diabetic CEC displayed significantly slower cell proliferation and migration compared with the normal CEC from both mice and humans. Furthermore, ROS production was markedly increased in CEC grown under diabetic conditions. Treatment with an antioxidant N-acetyl cysteine (NAC, 100 μM) significantly decreased ROS production and increased wound healing in diabetic CEC. Barrier function was significantly reduced in both diabetic mouse and human CEC, while NAC treatment mitigated these effects. We further showed that Akt signaling was impaired in diabetic CEC, which was partially improved by NAC treatment. These results show that diabetic conditions lead to delayed wound-healing capacity of CEC and impaired tight junction formation in both mice and human. Increased ROS production and inhibited Akt signaling may contribute to this outcome, implicating these as potential targets for treating corneal wounds in diabetic patients. | Qi-wei Jiang Denis Kaili Jonaye Freeman Chong-yang Lei Bing-chuan Geng Tao Tan Jian-feng He Zhi Shi Jian-jie Ma Yan-hong Luo Heather Chandler Hua Zhu | 2019 | Acta Pharmacologica Sinica2019，40，9： | 8 |
| 8 | The efficacy of various kinds of error feedback for improvement in the accuracy and fluency of L2 student writing显示文摘 | Jean Chandler | 2003 | Journal of Second Language Writing2003，，3： | 7 |
| 9 | Cytokines as biomarkers of inflammatory response after open versus endovascular repair of abdominal aortic aneurysms: a systematic review显示文摘一个腹的大动脉的动脉瘤(AAA ) 的修理是与有煽动性的串联的随后的激活的神经质、新陈代谢的压力相关的反应有关的一个高风险的外科的过程。与开的修理相对照(或) , endovascular 大动脉的动脉瘤修理(EVAR ) 由为更少提供广泛的切口,解剖,和织物操作似乎是手术后的压力到减少。然而,这些有益的效果可以是由代谢物在用在 endovascular 的导管的血栓的 intra 钠操作期间修理的 cytokines 和 arachidonic 酸的版本的偏移量,导致全身的煽动性的反应(先生) ,它是临床上叫的培植以后的症候群。在我们比较了的这系统的评论或与 EVAR,以 post-interventional,从改变导致传播 cytokine 的煽动性的反应铺平。我们寻求了在 EVAR 以后关于培植以后的症候群总结所有最近的证据。我们寻找了为临床的研究作为煽动性的反应的部分在 cytokines 的版本上报导在以后的 Medline (PubMed ) , ClinicalTrials.gov 和 Cochrane 图书馆开 / 常规并且 AAA 的 endovascular 修理。我们鉴别 17 学习检验 cytokine 层次在以后或对 EVAR。或似乎特别地比 EVAR 与一位更大的先生被联系,由增加的 cytokine 层次证实了 IL-6 和 IL-8 而 IL-1, IL-10 和 TNF- 出现了,冲突在二之间的结果或没有差别组织。聚酯 endografts 看起来断然在 EVAR 以后与培植以后的症候群的发生被相关。未来大未来的研究被保证位于在 surgical 以后的 cytokine 相互作用下面描出的机制煽动性的反应背景。 | Diamantis I TSILIMIGRAS Fragiska SIGALA Georgios KARAOLANIS Ioannis NTANASIS-STATHOPOULOS Eleftherios SPARTALIS Michael SPARTALIS Nikolaos PATELIS Alexandros PAPALAMPROS Chandler LONG Demetrios MORIS | 2018 | Acta Pharmacologica Sinica2018，39，7： | 5 |
| 10 | Mismatch repair, minichromosome maintenance complex component 2, cyclin A, and transforming growth factor β receptor type Ⅱ as prognostic factors for colorectal cancer: results of a 10-year prospective study using tissue microarray analysis显示文摘编码涉及 colorectal 癌症的很多条病原的小径的基因的表示能潜在地作为预示的标记扮演的背景。大未来的研究被要求建立他们的关联到我们调查了的疾病 prognosis.Methods 在 790 个病人的 19 个标记的关联用 immunohistochemistry 在 5 氟尿嘧啶的大 randomised 试用注册了并且在 situ 杂交发色。在全面 10 年的幸存和标记地位之间的关系是 assessed.Results Minichromosome 维护建筑群部件 2 (MCM2 ) 并且 cyclin A 显著地与全面幸存被联系。提高的 MCM2 表示与更好的预后被联系(HR=0.63, 95%CI:0.46-0.86 ).Cyclin A 表示在上面中部预言了改进耐心的预后(HR=0.71, 95%CI:0.53-0.95 ) 。为失配修理缺乏和转变生长因素受体类型(TGFBRII ) ,在那里的 overexpression 是有更差的预后的一个边线协会(HR=0.69, 95%C/ :0.46-1.04 和 HR=2.11, 95%CI:1.02-4.40,分别地) 。没有明显的协会被作出对有利的裁决这研究识别了的另外的 markers.Conclusion 房间增长和 cyclin A 表示在 colorectal 癌症的耐心的结果的同样预示的指示物。 | ZHAO Dong-bing Ian Chandler CHEN Zheng-ming PAN Hong-chao Sanjay Popat SHAO Yong-fu Richard S Houlston | 2011 | Chinese Medical Journal2011，，4： | 4 |
| 11 | NF-κB–YY1–miR-29 Regulatory Circuitry in Skeletal Myogenesis and Rhabdomyosarcoma显示文摘 | Huating Wang Ramiro Garzon Hao Sun Katherine J. Ladner Ravi Singh Jason Dahlman Alfred Cheng Brett M. Hall Stephen J. Qualman Dawn S. Chandler Carlo M. Croce Denis C. Guttridge | 2008 | Cancer Cell2008，，5： | 4 |
| 12 | 糖尿病病人和非糖尿病的病人特别护理单位和与败血联系的医院死亡风险显示文摘 AIM:To compare mortality risks associated with known diabetic patients to hyperglycemic non-diabetic patients.METHODS:PubMed data base was searched for patients with sepsis,bacteremia,mortality and diabetes.Articles that also identified new onset hyperglycemia (NOH) (fasting blood glucose>125 mg/dL or random blood glucose>199 mg/dL) were identified and reviewed.Nine studies were evaluated with regards to hyperglycemia and hospital mortality and five of the nine were summarized with regards to intensive care unit (ICU) mortality.RESULTS:Historically hyperglycemia has been believed to be equally harmful in known diabetic patients and non-diabetics patients admitted to the hospital.Unexpectedly,having a history of diabetes when admitted to the hospital was associated with a reduced risk of hospital mortality.Approximately 17% of patients admitted to hospital have NOH and 24% have diabetes mellitus.Hospital mortality was significantly increased in all nine studies of patients with NOH as compared to known diabetic patients (26.7%±3.4% vs 12.5% ±3.4%,P<0.05;analysis of variance).Unadjusted ICU mortality was evaluated in five studies and was more than doubled for those patients with NOH as compared to known diabetic patients (25.3%±3.3% vs 12.8%±2.6%,P<0.05) despite having similar blood glucose concentrations.Most importantly,having NOH was associated with an increased ICU and a 2.7-fold increase in hospital mortality when compared to hyperglycemic diabetic patients.The mortality benefit of being diabetic is unclear but may have to do with adaptation to hyperglycemia over time.Having a history of diabetes mellitus and prior episodes of hyperglycemia may provide time for the immune system to adapt to hyperglycemia and result in a reduced mortality risk.Understanding why diabetic patients have a lower than expected hospital mortality rate even with bacteremia or acute respiratory distress syndrome needs further study.CONCLUSION:Having hyperglycemia without a history of previous diabetes mellitus is a major independent risk factor for ICU and hospital mortality. | Chandler J Tayek John A Tayek | 2012 | World Journal of Diabetes2012，3，2： | 4 |
| 13 | Excavation-induced damage studies at the Underground Research Laboratory显示文摘 | J.B. Martino N.A. Chandler | 2004 | International Journal of Rock Mechanics and Mining Sciences2004，，8： | 3 |
| 14 | Nonalcoholic Fatty Liver Disease in Lean/Nonobese and Obese Individuals:A Comprehensive Review on Prevalence,Pathogenesis,Clinical Outcomes,and Treatment显示文摘Nonalcoholic fatty liver disease(NAFLD)is the most common liver disease worldwide,with an estimated prevalence of 25% globally.NAFLD is closely associated with metabolic syndrome,which are both becoming increasingly more common with increasing rates of insulin resistance,dyslipidemia,and hypertension.Although NAFLD is strongly associated with obesity,lean or nonobese NAFLD is a relatively new phenotype and occurs in patients without increased waist circumference and with or without visceral fat.Currently,there is limited literature comparing and illustrating the differences between lean/nonobese and obese NAFLD patients with regard to risk factors,pathophysiology,and clinical outcomes.In this review,we aim to define and further delineate different phenotypes of NAFLD and present a comprehensive review on the prevalence,incidence,risk factors,genetic predisposition,and pathophysiology.Furthermore,we discuss and compare the clinical outcomes,such as insulin resistance,dyslipidemia,hypertension,coronary artery disease,mortality,and progression to nonalcoholic steatohepatitis,among lean/nonobese and obese NAFLD patients.Finally,we summarize the most up to date current management of NAFLD,including lifestyle interventions,pharmacologic therapies,and surgical options. | Ankoor H.Patel Dhiraj Peddu Sahil Amin Mohamed I.Elsaid Carlos D.Minacapelli Toni-Marie Chandler Carolyn Catalano Vinod K.Rustgi | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 3 |
| 15 | miR-328 Functions as an RNA Decoy to Modulate hnRNP E2 Regulation of mRNA Translation in Leukemic Blasts显示文摘 | Anna M. Eiring Jason G. Harb Paolo Neviani Christopher Garton Joshua J. Oaks Riccardo Spizzo Shujun Liu Sebastian Schwind Ramasamy Santhanam Christopher J. Hickey Heiko Becker Jason C. Chandler Raul Andino Jorge Cortes Peter Hokland Claudia S. Huettner Ra | 2010 | Cell2010，，5： | 2 |
| 16 | Cognitive Load Theory and the Format of Instruction显示文摘 | Paul Chandler John Sweller | 1991 | Cognition and Instruction1991，，4： | 2 |
| 17 | Rayleigh-Taylor instability experiments examining feed through growth in an incompressible convergent geometry显示文摘 | Weir S T Chandler E A Goodwin B T | 1998 | Phys Rev Lett1998，80，17： | 2 |
| 18 | Regional concentration and efficiency in Mexican manufacturing显示文摘 | Geoffrey J. Bannister Chandler Stolp | 1995 | European Journal of Operational Research1995，，3： | 2 |
| 19 | A definition of initial, fatty streak, and intermediate lesions of atherosclerosis: a report from the committee on vascular lesions of the council on arteriosclerosis, American heart association显示文摘 | Stary HC Chandler AB Glagov S | | Circulation0，1，： | 2 |
| 20 | Sarcopenia: An Undiagnosed Condition in Older Adults. Current Consensus Definition: Prevalence, Etiology, and Consequences. International Working Group on Sarcopenia显示文摘 | Roger A. Fielding Bruno Vellas William J. Evans Shalender Bhasin John E. Morley Anne B. Newman Gabor Abellan van Kan Sandrine Andrieu Juergen Bauer Denis Breuille Tommy Cederholm Julie Chandler Capucine De Meynard Lorenzo Donini Tamara Harris Aimo Kannt F | 2011 | Journal of the American Medical Directors Association2011，，4： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员