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| 1 | 儿童NTRK重排间叶源性肿瘤临床病理学观察显示文摘目的:探讨儿童NTRK重排间叶源性肿瘤临床和病理学特征,以提高对该类疾病的认识。方法:收集上海交通大学医学院附属上海儿童医学中心及新加坡KK Women′s and Children′s Hospital从2017年1月至2019年9月5例手术切除标本,采用EnVision法检测免疫组织化学表型,荧光原位杂交(FISH)检测相关基因并对NTRK基因重排进行克隆性分析。结果:该组5例患儿,3例男性,2例女性。年龄从3个月到13岁,部位包括软组织(膝、胸腔、腹壁)和肾,肿瘤大小为4.5~12.5 cm。组织学检查主要呈梭形细胞肿瘤,浸润性生长,可伴有炎性细胞。免疫表型上,肿瘤细胞阳性表达Pan-TRK,分子检测均存在NTRK基因重排,包括DCTN1-NTRK1的发现。除2例目前接受靶向药物治疗,其余均为无疾病进展病例,随访时间9~29个月。结论:NTRK重排间叶源性肿瘤,其肿瘤发生部位广泛,组织学图像多变。免疫组织化学Pan-TRK可以帮助诊断,NTRK基因检测确认其存在重排是诊断的金标准,对不能完整切除或有复发、转移病例建议靶向药物治疗。 | 殷敏智 马靖 何巧 沈萍 陈洁枫 金晓婷 张忠德 Chik Hong Kuick Chen Huiyi Eileen Hui Qi Ng Sze Jet Aw Kenneth Tou En Chang | 2020 | 中华病理学杂志2020，49，7： | 6 |
| 2 | 具有TSC2基因突变的儿童嗜酸性实性和囊性肾细胞癌临床病理学观察显示文摘目的:探讨具有TSC2基因突变的儿童嗜酸性实性和囊性肾细胞癌(ESC RCC)临床病理特征、免疫组织化学及分子遗传学特征和预后。方法:收集2017年至2018年2例ESC RCC临床资料,HE和免疫组织化学染色(EnVision)法进行形态学观察;荧光原位杂交检测TFE3、TFEB断裂重排基因;分子基因检测,PCR扩增,二代测序。结果:2例ESC RCC为男性,年龄分别9岁8个月和13岁,均发生在右肾。肿瘤大小5~7 cm,切面囊实性,灰红、灰白鱼肉样。显微镜下肿瘤具有纤维性包膜,肿瘤细胞突破胞膜。肿瘤细胞弥漫分布,圆形、多边性,胞质丰富,嗜伊红,可见大小不一的空泡,呈透明细胞样;部分区域类似乳头样结构,可见纤维轴心。细胞核圆形、泡状核,易见多核及巨核细胞,核分裂象未见;少量大小不一的囊样结构,囊壁可见单层瘤细胞被覆呈钉突样。间质见厚壁血管,灶状淋巴细胞浸润;较多嗜伊红坏死,可见钙化和胆固醇结晶。免疫组织化学阳性表达:PAX8(弥漫)、细胞角蛋白(CK)20、广谱细胞角蛋白(CKpan,局灶)、CD10(1例局灶/1例弥漫)、INI1、波形蛋白、CD68阳性,Ki-67阳性指数5%~10%。HMB45、S-100蛋白、Melan A、p53、结蛋白、TFE3、CK7、CK19、上皮细胞膜抗原(EMA)、CD56、嗜铬粒素A(CgA)、突触素、CD30、CD117、WT1、平滑肌肌动蛋白(SMA)阴性。分子遗传学检测:TFE3、TFEB断裂重排阴性。二代测序:例1,TSC2 p.Lys574Ter(0.198);例2,TSC2 p.Arg406Ter(0.355)。结论:ESC RCC儿童发病比较罕见,容易误诊,其具有独特的病理形态学特征、免疫表型和分子遗传学改变,预后较好。 | 杨文萍 Kenneth Tou En Chang 徐红艳 Chik Hong Kuick Eileen Hui Qi Ng 黄慧 熊枫 吴艳 曾松涛 樊金星 Xinyi Loh | 2020 | 中华病理学杂志2020，49，7： | 3 |
| 3 | A Novel Dimer──Heteropolytungstate with a Vanadium Atom as the Centre ──Synthesis and Structural Characterization of (H_3O)_4[VW_(12)O_(40)Na(H_2O)_4]_2显示文摘A novel dimer tungstovanadate, (H 3O) 4[VW 12 O 40 Na(H 2O) 4] 2, was hydrothermally synthesized and structurally characterized by single crystal X ray diffraction, IR spectra, TGA DSC thermal analysis and polarograpy. The yellowish crystal crystallized in the triclinic system, space group P1, a =1 464 5(3) nm, b =1 468 6(3) nm, c =1 411 1(3) nm, α=111 82(2)°, β=93 17(3)°, γ=117 47(3)°, V =2 210 6(8) nm 3, Z=1, D c=4 552 g·cm -3 , λ (Mo Kα )=0 071 073 nm, μ =31 402 mm -1 , F(000)=2 648, R =0 078 0. The title compound consists of two Keggin structure units linked together with two hydrated sodium cations to form a dimer with a porous structure with the pore dimension of 0 766 nm×0 778 5 nm. [WT5FZ] | LIU Zong rui 1,2 , XU Lin 1, WANG En bo 1,** , PENG Jun 1, HU Chang wen 1 XING Yan 3, LIN Yong hua 3 and JIA Heng qing 3 (1. Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. China 2. Inner Mongolia Teac | 2000 | Chemical Research in Chinese Universities2000，16，3： | 2 |
| 4 | Significant loss of soil inorganic carbon at the continental scale显示文摘Widespread soil acidification due to atmospheric acid deposition and agricultural fertilization may greatly accelerate soil carbonate dissolution and CO_(2) release.However,to date,few studies have addressed these processes.Here,we use meta-analysis and nationwide-survey datasets to investigate changes in soil inorganic carbon(SIC)stocks in China.We observe an overall decrease in SIC stocks in topsoil(0-30 cm)(11.33 g C m^(-2)yr^(-1))from the 1980s to the 2010s.Total SIC stocks have decreased by∼8.99±2.24%(1.37±0.37 Pg C).The average SIC losses across China(0.046 Pg C yr^(-1))and in cropland(0.016 Pg C yr^(-1))account for∼17.6%-24.0%of the terrestrial C sink and 57.1%of the soil organic carbon sink in cropland,respectively.Nitrogen deposition and climate change have profound influences on SIC cycling.We estimate that∼19.12%-19.47%of SIC stocks will be further lost by 2100.The consumption of SIC may offset a large portion of global efforts aimed at ecosystem carbon sequestration,which emphasizes the importance of achieving a better understanding of the indirect coupling mechanisms of nitrogen and carbon cycling and of effective countermeasures to minimize SIC loss. | Xiao-Dong Song Fei Yang Hua-Yong Wu Jing Zhang De-Cheng Li Feng Liu Yu-Guo Zhao Jin-Ling Yang Bing Ju Chong-Fa Cai Biao Huang Huai-Yu Long Ying Lu Yue-Yu Sui Qiu-Bing Wang Ke-Ning Wu Feng-Rong Zhang Ming-Kui Zhang Zhou Shi Wan-Zhu Ma Gang Xin Zhi-Ping Qi Qing-Rui Chang En Ci Da-Gang Yuan Yang-Zhu Zhang Jun-Ping Bai Jia-Ying Chen Jie Chen Yin-Jun Chen Yun-Zhong Dong Chun-Lan Han Ling Li Li-Ming Liu Jian-Jun Pan Fu-Peng Song Fu-Jun Sun Deng-Feng Wang Tian-Wei Wang Xiang-Hua Wei Hong-Qi Wu Xia Zhao Qing Zhou Gan-Lin Zhang | 2022 | National Science Review2022，9，2： | 2 |
| 5 | Hydrothermal Synthesis, Structural Characterization and Properties of Mixed Valent Decavanadium Oxide [Co_2Cl_8V_(10) O_(18)(H_2O)]Cl_2·6H_2O with Novel Three-dimensional Framework显示文摘Decavanadium oxide [Co 2Cl 8V 10 O 18 (H 2O)]Cl 2·6H 2O was synthesized hydrothermally with NH 4VO 3, Na 2MoO 4·2H 2O, H 3PO 4(85%), CoCl 2·6H 2O and hexamethylenetetraamine. The X ray diffraction analysis showed that [Co 2Cl 8V 10 O 18 (H 2O)]Cl 2·6H 2O crystallized in a monoclinic crystal system, the space group was C2/m with cell parameters a =1 6065(3) nm, b =2 2699(5) nm, c =1 3897(3) nm, β = 125.29(3)°, V =4 1363(14) nm 3, Z =2 and the final R =0 06, wR =0 1926. Its crystal structure is a 3 D open framework constructed by VO x polyhedra and CoCl 4 tetrahedra with channels along the crystallographic axes a, b, and c . | WU Ping song, XU Lin, WANG En bo ** and HU Chang wen Faculty of Chemistry, Northeast Normal University, Changchun 130024, P. R. China | 2003 | Chemical Research in Chinese Universities2003，19，2： | 2 |
| 6 | Cooperative problem solving in diagnostic agents for chemical processes 显示文摘 | CHANG Tae Suk SHIN Dongil YOON En Sup | 2000 | Computers and Chemical Engineering2000，24，： | 1 |
| 7 | Screening for maternal thyroid dysfunction in pregnancy: a review of the clinical evidence and current gnide- lines显示文摘 | Chang DL Pearce EN | 2013 | J Thyroid Res2013，2013，85： | 1 |
| 8 | Analysis and comparison of decline models:A field case study for the Intercampo Oil Field,Venezuela显示文摘 | Dou Hong'en Chen Changchun Chang Yuwen | 2009 | SPE Reservoir Evaluation & Engineering2009，12，1： | 1 |
| 9 | Transplantation:focus on kidney,liver and islet cells显示文摘 | Chang EN Scudamore CH Chung SW | 2004 | Can J Surg2004，47，2： | 1 |
| 10 | Effects of HNO 3 treatment of TiO 2 nanoparticles on the photovoltaic properties of dye-sensitized solar cells显示文摘 | Kyung-Hee Park En Mei Jin Hal Bon Gu Sang Eun Shim Chang Kook Hong | 2009 | Materials Letters2009，，26： | 1 |
| 11 | Effects of learning support in simulation -- based physics learning显示文摘 | Kuo - En Chang Yu- Lung Chen He- Yan Lin Yao- Ting Sung | 2008 | Computer2008，51，： | 1 |
| 12 | What kinds of knowledge do teachers share on blogs? A quantitative content analysis of teachers' knowledge sharing on blogs显示文摘 | Huei-Tse Hou Kuo En Chang Yao Ting Sung | 2010 | British Journal of Educational Technology2010，41，6： | 1 |
| 13 | Modular Design to Support Green Life-cycle Engineering显示文摘 | Hwai -En Tseng Hien-Chen Chang | 2008 | Expert Systems with Applicationa2008，，34： | 1 |
| 14 | Supernormal conduction in accessory atrioventricular connections显示文摘 | Chang MS Miles WM Prystowsky EN | 1987 | Am J Cardiol1987，59，： | 1 |
| 15 | Measurement scale of in- tellectual capital for the information service industry 显示文摘 | YU - CHUNG HUNG EN - LIN CHANG | 2006 | Interna- tional Journal of Services and Standards2006，2，2： | 1 |
| 16 | Single inci- sion laparoscopic endorectal pull-through(SILEP) for hir- schsprung disease显示文摘 | Muensterer O1 Chang A Hansen EN e al | 2010 | J Gastrointest Surg2010，14，12： | 1 |
| 17 | Primary Study on Electron Beam Surfi-Sculpt of Ti-6Al-4V显示文摘 | Wang Xi Chang Gong Shui Li Guo En Ming Zhao Hai Yan Xu Heng Dong | 2012 | Advanced Materials Research2012，，418： | 1 |
| 18 | Solution-based synthesis of chalcostibite (CuSbS2) nanobricks for solar energy conversion显示文摘 | YAN Chang SU Zhenghua GU Ening | 2012 | RSC Advances2012，2，10： | 1 |
| 19 | Genetic diversity of rhizobia associated with Vicia faba in three ecological regions of China显示文摘 | Chang F T En T W | 2007 | Arch Microbial2007，188，： | 1 |
| 20 | ACIDITY AND CATALYTIC ACTIVITY OF KEGGIM STRUCTURE HETEROPOLYACIDS ──EFFECT OF CENTRAL ATOM IN H_α XW_(12) O_(40)显示文摘ACIDITY AND CATALYTIC ACTIVITY OF KEGGIM STRUCTURE HETEROPOLYACIDS ──EFFECT OF CENTRAL ATOM IN H_α XW_(12) O_(40)ACIDITYANDCA... | Chang Wen HU Yan Yong LIU En Bo WANG (Department of Chemistry, northeast Normal University. Changchun 130024)M.HASHIMOTO T. OKUHARA M.MISONO (Department of Synthesis Chemistry. Faculty of Engineering, Tokyo University, Tokyo 113,Japan) | 1994 | Chinese Chemical Letters1994，5，6： | 1 |
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