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| 1 | Bacterial entombment by intratubular mineralization following orthograde mineral trioxide aggregate obturation: a scanning electron microscopy study显示文摘The time domain entombment of bacteria by intratubular mineralization following orthograde canal obturation with mineral trioxide aggregate(MTA) was studied by scanning electron microscopy(SEM). Single-rooted human premolars(n560) were instrumented to an apical size #50/0.06 using ProF ile and treated as follows: Group 1(n510) was filled with phosphate buffered saline(PBS); Group 2(n510) was incubated with Enterococcus faecalis for 3 weeks, and then filled with PBS; Group 3(n520) was obturated orthograde with a paste of OrthoM TA(BioM TA, Seoul, Korea) and PBS; and Group 4(n520) was incubated with E. faecalis for 3 weeks and then obturated with OrthoM TA–PBS paste. Following their treatments, the coronal openings were sealed with PBS-soaked cotton and intermediate restorative material(IRM), and the roots were then stored in PBS for 1, 2, 4, 8 or 16 weeks. After each incubation period, the roots were split and their dentin/MTA interfaces examined in both longitudinal and horizontal directions by SEM. There appeared to be an increase in intratubular mineralization over time in the OrthoM TA-filled roots(Groups 3 and 4). Furthermore, there was a gradual entombment of bacteria within the dentinal tubules in the E. faecalis inoculated MTA-filled roots(Group 4). Therefore, the orthograde obturation of root canals with OrthoM TA mixed with PBS may create a favorable environment for bacterial entombment by intratubular mineralization. | Jun Sang Yoo Seok-Woo Chang So Ram Oh Hiran Perinpanayagam Sang-Min Lim Yeon-Jee Yoo Yeo-Rok Oh Sang-Bin Woo Seung-Hyun Han Qiang Zhu Kee-Yeon Kum | 2014 | International Journal of Oral Science2014，6，4： | 5 |
| 2 | Endoscopic submucosal dissection vs endoscopic mucosal resection for colorectal polyps:A meta-analysis and metaregression with single arm analysis显示文摘BACKGROUND Endoscopic submucosal dissection(ESD)has shown to be effective in management of colorectal neoplasm in the Asian countries,while its implementation in Western countries where endoscopic mucosal resection(EMR)is preferred is still debatable.AIM To compare the surgical,histological,and oncological outcomes between ESD and EMR in the treatment of colorectal polyps,with subgroup analysis comparing the efficacy of ESD and EMR between Japan and the rest of the world.METHODS Embase and Medline databases were searched from inception to October 2020 in accordance with PRISMA guidelines for studies comparing en bloc,complete resection,margin involvement,resection time,need for additional surgery,complications,and recurrence rate of ESD with EMR.RESULTS Of 281344 colorectal polyps from 21 studies were included.When compared to EMR,the pooled analysis revealed ESD was associated with higher en bloc and complete resection rate,and lower lateral margin involvement and recurrence.ESD led to increased procedural time,need for additional surgery,and perforation risk.No significant difference in bleeding risk was found between the two groups.Meta-regression analysis suggested only right colonic polyps correlated with an increased perforation risk in ESD.Confounders including polyp size and invasion depth did not significantly influence the en bloc and complete resection rate,bleeding risk and recurrence.In subgroup analysis,Japan performed better than the rest of the world in both ESD and EMR with perforation risk of 4%and 0.0002%,respectively,as compared to perforation risk of 8%and 1%,respectively,in reports coming from rest of the world.CONCLUSION ESD resulted in better resection outcomes and lower recurrence compared to EMR.With appropriate training,ESD is preferred over EMR as the first-line therapy for resection of colorectal polyps,without restricting to lesions greater than 20 mm and those with high suspicion of submucosal invasion. | Xiong Chang Lim Kameswara Rishi Yeshayahu Nistala Cheng Han Ng Snow Yunni Lin Darren Jun Hao Tan Khek-Yu Ho Choon-Seng Chong Mark Muthiah | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 3 | A case of Clostridium difficile infection complicated by acute respiratory distress syndrome treated with fecal microbiota transplantation显示文摘Acute respiratory distress syndrome is a life-threatening disorder caused mainly by pneumonia.Clostridium difficile infection(CDI)is a common nosocomial diarrheal disease.Disruption of normal intestinal flora by antibiotics is the main risk factor for CDI.The use of broadspectrum antibiotics for serious medical conditions can make it difficult to treat CDI complicated by acute respiratory distress syndrome.Fecal microbiota transplantation is a highly effective treatment in patients with refractory CDI.Here we report on a patient with refractory CDI and acute respiratory distress syndrome caused by pneumonia who was treated with fecal microbiota transplantation. | Ji Eun Kim Tae-Geun Gweon Chang Dong Yeo Young-Seok Cho Gi Jun Kim Jae Young Kim Jong Wook Kim Hyunho Kim Hye Won Lee Taeseok Lim Hyoju Ham Hyun Jin Oh Yeongbok Lee Jaeho Byeon Sung Soo Park | 2014 | World Journal of Gastroenterology2014，20，35： | 3 |
| 4 | Intestinal endometriosis:Diagnostic ambiguities and surgical outcomes显示文摘BACKGROUND Endometriosis is a common disease for women of reproductive age. However,when it involves intestines, it is difficult to diagnose preoperatively because its symptoms overlap with other diseases and the results of evaluations can be unspecific. Thus it is important to know the clinical characteristics of intestinal endometriosis and how to exactly diagnose.AIM To analyze patients in whom intestinal endometriosis was diagnosed after surgical treatments, and to evaluate the clinical characteristics of preoperatively misdiagnosed cases.METHODS We retrospectively reviewed the pathologic reports of 30 patients diagnosed as having intestinal endometriosis based on surgical specimens between January2000 and December 2017. We reviewed their clinical characteristics and surgical outcomes.RESULTS Twenty-three(76.6%) patients showed symptoms associated with endometriosis,with dysmenorrhea being the most common(n = 9, 30.0%). Thirteen patients(43.3%) had a history of pelvic surgeries. Ten patients(33.3%) had a history of treatment for endometriosis. Only 4 patients(13.3%) had a diagnosis of endometriosis based on endoscopic biopsy findings. According to preoperative evaluations, 13 patients(43.3%) had an initial diagnosis of pelvic endometriosis and 17 patients(56.6%) were misdiagnosed as having other diseases. The most common misdiagnosis was submucosal tumor in the large intestine(n = 8, 26.7%),followed by malignancies of the colon/rectum(n = 3, 10.0%) and ovary(n = 3,10.0%). According to the Clavien-Dindo classification, 5 complications were grade I or II and 2 complications were grade IIIa. The median follow-up period was 26.9(0.6-132.1) mo, and only 1 patient had a recurrence of endometriosis.CONCLUSION Intestinal endometriosis is difficult to diagnose preoperatively because it mimics various intestinal diseases. Thus, if women of reproductive age have ambiguous symptoms and signs with nonspecific radiologic and/or endoscopic findings,intestinal endometriosis should be included in the differential diagnosis. | Jun Woo Bong Chang Sik Yu Jong Lyul Lee Chan Wook Kim Yong Sik Yoon In Ja Park Seok-Byung Lim Jin Cheon Kim | 2019 | World Journal of Clinical Cases2019，7，4： | 3 |
| 5 | 腹腔镜胃癌手术的历史与展望显示文摘胃恶性肿瘤是全世界常见且致命的恶性肿瘤之一。根据2012年数据,胃癌居全世界恶性肿瘤发病率第5位,肿瘤相关病死率第3位。胃癌是严重危及人民健康的疾病之一。腹腔镜手术不仅将手术创伤最小化,且在降低手术并发症的同时加速患者康复。因此,该技术在外科领域已逐渐取代开腹手术。笔者分析腹腔镜胃癌手术相关前瞻性、随机性研究等相关文献,结合自身临床经验及最新见解,就腹腔镜胃癌手术的历史、现状及发展趋势进行深入阐述。 | Shin-Hoo Park Amy Kim Yeongkeun Kwon Seung Hyun Lim Won Jun Seo Chang Min Lee You Jin Jang Jong-Han Kim Seong-Heum Park Sungsoo Park | 2020 | 中华消化外科杂志2020，19，5： | 2 |
| 6 | Interplay between ABA and GA Modulates the Timing of Asymmetric Cell Divisions in the Arabidopsis Root Ground Tissue显示文摘在多细胞的有机体,控制预定和不对称的细胞部门(ACD ) 的程度为正确 patterning 是关键的。在在 Arabidopsis thaliana 的 embryonic 以后根开发期间,地面织物(GT ) 成熟包含内皮的另外的 ACD,它产生二不同纸巾:内皮(内部) 并且中间的外皮(外部) 。这被报导了 abscisic 酸(骆驼毛的织物) 和赤霉素(GA ) 小径涉及中间的外皮(MC ) 形成。然而,在 GT 成熟期间位于在骆驼毛的织物和 GA 之间的相互作用下面的分子的机制仍然保持大部分未知。通过 transcriptome 分析,我们识别了一以前 uncharacterized C 2 H 2-type 锌手指基因,其表情被 GA 和骆驼毛的织物调整,因此命名的 GAZ (GA- 和骆驼毛的织物应答的锌手指) 。幼苗宫外地 overexpressing GAZ (GAZ 公牛) 在 MC 形成期间对骆驼毛的织物和 GA 敏感,而 GAZ-SRDX 和 RNAi 幼苗显示了相反的显型。另外,我们的结果显示 GAZ 涉及骆驼毛的织物和 GA 动态平衡的 transcriptional 规定。与那件骆驼毛的织物和 GA 协调控制预定 MC 形成的以前的研究一致,我们也证实了在骆驼毛的织物和 GA 之间的唯一的相互影响并且识别了在 Arabidopsis 根的 GT 成熟期间衔接二条荷尔蒙小径的因素和规章的网络。 | Shin Ae Lee Sejeong Jang Eun Kyung Yoon Jung-Ok Heo Kwang Suk Chang Ji Won Choi Souvik Dhar Gyuree Kim Jeong-Eun Choe Jae Bok Heo Chian Kwon Jae-Heung Ko Yong-Sic Hwang Jun Lim | 2016 | Molecular Plant2016，9，6： | 2 |
| 7 | Reactive blending of biodegradable polymers:PLA and starch显示文摘 | Chang Lim Jun | 2000 | Polymers and the Environment2000，8，1： | 1 |
| 8 | Human Umbilical Cord Blood-Derived Mesenchymal Stem Cell Therapy Promotes Functional Recovery of Contused Rat Spinal Cord through Enhancement of Endogenous Cell Proliferation and Oligogenesis显示文摘 | Sang In Park Jung Yeon Lim Chang Hyun Jeong Seong Muk Kim Jin Ae Jun Sin-Soo Jeun Won Il Oh Ken-ichi Isobe | 2012 | Journal of Biomedicine and Biotechnology2012，，： | 1 |
| 9 | Role of alkyl chain length and mole concentration of hydrophobic moiety in association behavior of amphiphilic polyelectrolytes in aqueous media显示文摘 | Hyung Jun Lim Eun Chul Cho Junoh Kim Ih-Seop Chang | 2006 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2006，，1： | 1 |
| 10 | Reactive blending of biodegradable polymers: PLA and starch显示文摘 | Jun Chang Lim | 2000 | J Polym Env2000，8，1： | 1 |
| 11 | Effect of ginsam, a vinegar extract from Panax ginseng, on body weight and glucose homeostasis in an obese insulin-resistant rat model显示文摘 | Soo Lim Ji Won Yoon Sung Hee Choi Bong Jun Cho Jun Tae Kim Ha Soon Chang Ho Seon Park Kyong Soo Park Hong Kyu Lee Young-Bum Kim Hak Chul Jang | 2009 | Metabolism2009，，1： | 1 |
| 12 | Effect of polymer characteristics on structure of polymer-liposome complexes显示文摘 | Eun Chul Cho Hyung Jun Lim Jongwon Shim Ju Young Park Nily Dan Junoh Kim Ih-Seop Chang | 2007 | Journal of Colloid and Interface Science2007，311，1： | 1 |
| 13 | Human Umbilical Cord Blood-Derived Mesenchymal Stem Cell Therapy Promotes Functional Recovery of Contused Rat Spinal Cord through Enhancement of Endogenous Cell Proliferation and Oligogenesis显示文摘 | Sang In Park Jung Yeon Lim Chang Hyun Jeong Seong Muk Kim Jin Ae Jun Sin-Soo Jeun Won Il Oh Ken-ichi Isobe | 2012 | Journal of Biomedicine and Biotechnology2012，，： | 1 |
| 14 | Melastatin-Type Transient Receptor Potential Channel 7 Is Required for Intestinal Pacemaking Activity显示文摘 | Byung Joo Kim Hyun–Ho Lim Dong Ki Yang Jae Yeoul Jun In Youb Chang Chul–Seung Park Insuk So Peter R. Stanfield Ki Whan Kim | 2005 | Gastroenterology2005，，5： | 1 |
| 15 | Reactive blending of biodegradable polymers: PLA and starch 显示文摘 | Chang Lim Jun | 2000 | Polymers and the Environment2000，8，1： | 1 |
| 16 | CXCR4-transfected human umbilical cord blood-derived mesenchymal stemcells exhibit enhanced migratory capacity toward gliomas显示文摘 | Soon Park Chung Ryu Seong Kim Jung Lim Sang Park Chang Jeong Jin Jun Ji Oh Sun Park Wonil Oh Sin-Soo Jeun | 2011 | International Journal of Oncology2011，，1： | 1 |
| 17 | Migration of human umbilical cord blood mesenchymal stem cells mediated by stromal cell-derived factor-1/CXCR4 axis via Akt, ERK, and p38 signal transduction pathways显示文摘 | Chung Heon Ryu Soon A Park Seong Muk Kim Jung Yeon Lim Chang Hyun Jeong Jin Ae Jun Ji Hyeon Oh Sun Hwa Park Won-il Oh Sin-Soo Jeun | 2010 | Biochemical and Biophysical Research Communications2010，，1： | 1 |
| 18 | Migration of human umbilical cord blood mesenchymal stem cells mediated by stromal cell-derived factor-1/CXCR4 axis via Akt, ERK, and p38 signal transduction pathways显示文摘 | Chung Heon Ryu Soon A Park Seong Muk Kim Jung Yeon Lim Chang Hyun Jeong Jin Ae Jun Ji Hyeon Oh Sun Hwa Park Won-il Oh Sin-Soo Jeun | 2010 | Biochemical and Biophysical Research Communications2010，，1： | 1 |
| 19 | Comparison of the rheological properties of four root canal sealers显示文摘The flowability of a root canal sealer is clinically important because it improves the penetration of the sealer into the complex root canal system. The purpose of this study was to compare the flowabilities of four root canal sealers, measured using the simple press method(ISO 6876), and their viscosities, measured using a strain-controlled rheometer. A newly developed, calcium phosphate-based root canal sealer(Capseal) and three commercial root canal sealers(AH Plus, Sealapex and Pulp Canal Sealer EWT) were used in this study.The flowabilities of the four root canal sealers were measured using the simple press method(n55) and their viscosities were measured using a strain-controlled rheometer(n55). The correlation between these two values was statistically analysed using Spearman's correlation test. The flow diameters and the viscosities of the root canal sealers were strongly negatively correlated(r520.8618). The viscosity of Pulp Canal Sealer EWT was the lowest and increased in the following order: AH Plus,Sealapex,Capseal(P,0.05). All of the tested root canal sealers showed characteristic time- and temperature-dependent changes in their rheological properties. The viscosities measured using the strain-controlled rheometer were more precise than the flowabilities measured using the simple press method, suggesting that the rheometer can accurately measure the rheological properties of root canal sealers. | Seok Woo Chang Young-Kyu Lee Qiang Zhu Won Jun Shon Woo Cheol Lee Kee Yeon Kum Seung Ho Baek In Bog Lee Bum-Soon Lim Kwang Shik Bae | 2015 | International Journal of Oral Science2015，7，1： | 0 |
| 20 | Oncometabolic surgery:Emergence and legitimacy for investigation显示文摘Studies on morbid obesity have shown remarkable improvement of diabetes in patients who have undergone bariatric operations.It was subsequently shown that these operations induce diabetes remission independent of the resultant weight loss;as a result,surgeons began to investigate whether operations for gastric cancer(GC)could have the same beneficial effect on diabetes as bariatric operations.It was then shown in multiple reports that followed that certain operations for GC were able to improve or even cure type 2 diabetes mellitus(T2 DM)in GC patients.This finding gave rise to the concept of'oncometabolic surgery',in which a patient diagnosed with both GC and T2 DM undergo a single operation with the purpose of treating both diseases.With the increasing incidence of T2 DM,oncometabolic surgery has the potential to improve the quality of life and even extend survival of many GC patients.However,because the GC patient population and the bariatric patient population are wildly different and because different GC operations have different properties,the effect of oncometabolic surgery must be carefully assessed and engineered in order to maximize benefit and avoid harm.This manuscript aims to summarize the findings made so far in the field of oncometabolic surgery and to provide an outlook regarding the possibility of oncometabolic surgery being incorporated into standard clinical practice. | Won Jun Kim Yeongkeun Kwon Chang Min Lee Seung Hyun Lim Yong Li Junjiang Wang Weixian Hu Jiabin Zheng Gang Zhao Chunchao Zhu Wei Wang Wenjun Xiong Quan Wang Mingjie Xia Sungsoo Park | 2020 | Chinese Journal of Cancer Research2020，32，2： | 0 |
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