|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Review of the anticancer activities of bee products显示文摘Bee products have long been used in traditional medicine.The raw materials,crude extracts and purified active compounds from them have been found to exhibil interesting bioactivities,such as antimicrobial,anti-inflammatory and antioxidant activities.In addition,they have been widely used in the treatment of many immune-related diseases,as well as in recent times in the treatment of tumors.Bee product peptides induce apoptotic cell death in vitro in several transformed(cancer) human cell lines,including those derived from renal,lung,liver,prostate,bladder and lymphoid cancers.These bioactive natural products may.therefore,prove to be useful as part of a novel targeted therapy for some types of cancer,such as prostate and breast cancer.This review summarizes the current knowledge regarding the in vivo and in vitro potential of selective bee products against tumor cells. | Pongsathon Premratanachai Chanpen Chanchao | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，5： | 6 |
| 2 | Morphometric and genetic variation of small dwarf honeybees Apis andreniformis Smith, 1858 in Thailand显示文摘小矮子蜜蜂,蜂 andreniformis,是稀罕、 patchily 分布式的蜂 spp。并且是本国的泰国蜜蜂之一,然而,很少对它的生物多样性被知道。三十(27 泰语并且 3 马来西亚) 并且 37 (32 泰语并且 5 马来西亚) A 的殖民地。andreniformis 分别地为 morphometric 和基因分析被取样。为 morphometric 分析, 20 个增进知识的人物被用来决定变化。在阴谋因素分数以后,一。从越过泰国的 andreniformis 被发现属于一个组,簇分析进一步支持的一个观点产生了 dendrogram。然而,在一些蜜蜂 morphometric 人物的 clinal 模式被直线回归分析揭示。蜜蜂的身体尺寸从南方增加到诺思,但是从韦斯特减少到东方,尽管这可以反映高度而非经度。遗传变异被 mitochondrial 细胞色素氧化酶子单元 b (cytb ) 的 520 bp 碎片的顺序分析决定。在从泰国的大陆的蜜蜂之中的脱氧核糖核酸多型性从 Phuket 岛和 Chiang Mai 是比那低的。尽管蜜蜂的二个主要的不同的组从加入邻居、未加权的对组方法用算术一般水准节目构造的系统树被获得,不变清地理信号是在场的。因此,当次要的组(B)从取样的唯一的岛(在南方的 Phuket )样品包含了所有时,然而并非南部的大陆殖民地,它也从 Chiang Mai 的远北的内陆地带包含了样品,哪个在专业是坚定地生根的另外的样品组织(A)。 | ATSALEK RATTANAWANNEE CHANPEN CHANCHAO SIRIWAT WONGSIRI | 2007 | Insect Science2007，14，6： | 2 |
| 3 | Propolis from Thailand:antimicrobial,antiproliferative and cytotoxic activities显示文摘 | Supawadee U Songchan P Chanpen C | 2005 | The American Journal of Chinese Medicine2005，37，9： | 1 |
| 4 | Effects of processing conditons and the use of modified starch and monoglyceride on some properties of extruded rice vermicelli 显示文摘 | Chanpen Charutigon Jintana Jitpupakdree Pimjai Namsree | 2008 | LWT2008，，： | 1 |
| 5 | Effects of processing conditions and the use of modified starch andmonoglyceride on some properties of extruded rice vermicelli显示文摘 | Chanpen Charutigon Jintana Jitpupakdree Pimjai Namsree Vilai Rungsardthong | 2008 | LWT2008，，41： | 1 |
| 6 | Studies on the pathogenesis of the local isolates of Nomuraea rileyi against Spodoptera litura显示文摘 | Pornpoj S Chanpen W Somsak P | 2005 | Science Asia2005，31，3： | 1 |
| 7 | Studies on the pathogenesis of the local isolates of Nomuraea rileyi against Spodoptera litura 显示文摘 | Pornpoj S Chanpen W Somsak P | 2005 | Science Asia2005，31，3： | 1 |
| 8 | Effects of processing conditions and the use of modified starch and monoglyceride on some properties of extruded rice vermicelli显示文摘 | Chanpen Charutigon Jintana Jitpupakdree Pimjai Namsree Vilai Rungsardthong | 2007 | LWT - Food Science and Technology2007，，4： | 1 |
| 9 | Effects of processing conditions and the use of modified starch and monoglyceride on some properties of extruded rice vermicelli显示文摘 | Chanpen C Jintana J Pimjai N | 2008 | LWT2008，41，： | 1 |
| 10 | In vitro cytotoxicity of Indonesian stingless bee products against human cancer cell lines显示文摘Objective:To screen crude extracts of propolis,bee pollen and honey from four stingless bee species[Trigona incisa(T.incisa)],Timia apicalis,Trigona fuso-baltata and Trigona filscibasis)native to East Kalimantan.Indonesia for cytotoxic activity against five human cancer cell lines(HepG2,SW620,ChaGo-1,KATO-Ⅲand BT474).Methods:All samples were extracted with methanol,and then subpartitioned with n-hexane and ethyl acetate.Each crude extract was screened at 20μg/mL for in vitro cytotoxicity against the cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.Tn addition,four previously shown bioactive components from propolis(apigenin,cafieic acid phenyl ester,kaempferol and naringenin)and two chemotherapeutic drugs(doxorubicin and 5-fluorouracil)were used to evaluate the sensitivity of the cell lines.Results:Overall,crude extracts from propolis and honey had higher cytotoxic activities than bee pollen,but the activity was dependent upon the extraction solvent,bee species and cell line.Propolis extracts from T.incisa and Tarda apicalis showed the highest and lowest cytotoxic activity,respectively.Only the HepG2 cell line was broadly sensitive to the honey extracts.For pure compounds,doxorubicin was the most cytotoxic,the four propolis compounds the least,but the ChaGo-I cell line was sensitive to kaempferol at 10μg/mL and KATO-Ⅲwas sensitive to kaempferol and apigenin at 10μg/mL,.All pure compounds were effective against the BT474 cell line.Conclusions:Propolis from f,incisa and Trigona fusco-balteata contain an in vitro cytotoxic activity against human cancer cell lines.Further study is required,including the isolation and characterization of the active antiproliferative agent(s). | Paula M.Kustiawan Songchan Puthong Enos T.Arung Chanpen Chanchao | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，7： | 1 |
| 11 | Studies on the pathogenesis of the local isolates of Nomuraea rileyi against Spodoptera litura显示文摘 | Pornpoj S Chanpen W Somsak P | 2005 | Science Asia2005，31，3： | 1 |
| 12 | Rural Parents with Urban Children:Social and Economic Imaplications of Migration for the Rural Elderly in Thailand显示文摘 | John Knodel Chanpen Saengtienchai | 2007 | Population Space and Place2007，12，： | 1 |
| 13 | Effects of processing conditions and the use of modified starch and monoglyceride on some properties of extruded rice vermicelli显示文摘 | Chanpen Charutigon Jintana Jitpupakdree Pimjai Namsree Vilai Rungsardthong | 2007 | LWT - Food Science and Technology2007，，4： | 1 |
| 14 | Studies on the pathogenesis of the local isolates of Nomuraea rileyi against Spodoptera litura显示文摘 | PORNPOJ S CHANPEN W SOMSAK P | 2005 | ScienceAsia2005，31，3： | 1 |
| 15 | Vertically aligned carbon nanotube based electrochemcial sensor for salbutamol detection 显示文摘 | Chanpen Karuwan Assawapong Sappat Kata Jaruwon- grungsee | 2010 | SensorLetters2010，8，4： | 1 |
| 16 | Purification and characterization of α-glucosidase in Apis cerana indica显示文摘 | Chanpen Chanchao Suwisa Pilalam Polkit Sangvanich | 2008 | Insect Science2008，15，3： | 0 |
| 17 | α-Mangostin and apigenin induced the necrotic death of BT474 breast cancer cells with autophagy and inflammation显示文摘Objective: To find new compounds in order to overcome the mainstay of metastatic breast cancer due to the adverse side effects from, and increasing resistance to, current chemotherapeutic agents. Methods: 毩-Mangostin and apigenin were reported in comparison to doxorubicin, a chemotherapeutic drug. Ductal carcinoma(BT474) cell line and nontumorigenic epithelial tissue from mammary gland(MCF-10 A) were used. Cell viability assessment was calculated by the standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. Cell morphology was investigated by light microscopy. By flow cytometry analysis, programmed cell death was observed using annexin observed using propidium iodide st桋 and propidium iodide staining while cell-cycle arrest wasaining. Change in transcriptional expression was evaluated by real-time quantitative reverse transcription PCR. Results: In 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, the result revealed and apigenin were more cytotoxic to BT474 cells. Longer exposure times to 毩-mangostin enin caused more floating cells and a lower density of adhered cells wi毩-mangostin and apigth more vacuoles present in the colonies in BT474 only. 毩-Mangostin and apigenin caused necrosis in BT474 cells in a 24 h exposure, but a small amount of early apoptotic cells could also be detected at 24, 48 and 72 h exposure, whereas doxorubicin caused early apoptosis to BT474 cells at 24 h. Transcript expression and activity analysis supported caspase-3 was involved in the death of BT474 cells treated by all compounds. Moreover, 毩-mangostin and apigenin arrested the cellcycle at the G1-phase, but at the G2/M-phase by doxorubicin. All three compounds induced a change in transcript expression levels of inflammation-associated, proto-oncogene, autophagyassociated and apoptosis-associated genes. Conclusions: ntial new sources of chemotherapeuti毩-Mangostin and apigenin are worth investigating as potec agents for breast cancer treatment. | Teeranai Ittiudomrak Songchan Puthong Tanapat Palaga Sittiruk Roytrakul Chanpen Chanchao | 2018 | Asian Pacific Journal of Tropical Biomedicine2018，8，11： | 0 |
| 18 | Expression and characterization of a-glucosidase III in the dwarf honeybee, Apis florea (Hymenoptera: Apoidea: Apidae)显示文摘 | CHANPEN CHANCHAO RUMPALAI PADOONGSUPALAI POLKIT SANGVANICH | 2007 | Insect Science2007，14，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员