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| 1 | Common misconceptions about 5-aminosalicylates and thiopurines in inflammatory bowel disease显示文摘Misconceptions are common in the care of patients with inflammatory bowel disease(IBD).In this paper,we state the most commonly found misconceptions in clinical practice and deal with the use of 5-aminosalicylates and thiopurines,to review the related scientificevidence,and make appropriate recommendations.Prevention of errors needs knowledge to avoid making such errors through ignorance.However,the amount of knowledge is increasing so quickly that one new danger is an overabundance of information.IBD is a model of a very complex disease and our goal with this review is to summarize the key evidence for the most common daily clinical problems.With regard to the use of 5-aminosalicylates,the best practice may to be consider abandoning the use of these drugs in patients withsmall bowel Crohn's disease.The combined approach with oral plus topical 5-aminosalicylates should be the first-line therapy in patients with active ulcerative colitis;once-daily treatment should be offered as a first choice regimen due to its better compliance and higher efficacy.With regard to thiopurines,they seem to be as effective in ulcerative colitis as in Crohn's disease.Underdosing of thiopurines is a form of undertreatment.Thiopurines should probably be continued indefinitely because their withdrawal is associated with a high risk of relapse.Mercaptopurine is a safe alternative in patients with digestive intolerance or hepatotoxicity due to azathioprine.Finally,thiopurine methyltransferase(TPMT)screening cannot substitute for regular monitoring because the majority of cases of myelotoxicity are not TPMT-related. | Javier P Gisbert María Chaparro Fernando Gomollón | 2011 | World Journal of Gastroenterology2011，17，30： | 8 |
| 2 | Long-term outcome of chronic hepatitis C patients with sustained virological response to peginterferon plus ribavirin显示文摘AIM: To assess the clinical, biochemical and virological long-term outcome in chronic hepatitis C (CHC) patients with a sustained virological response (SVR) after peginterferon (PEG-IFN) plus ribavirin combination therapy. METHODS: One hundred and fifty three patients with a SVR after treatment with PEG-IFN plus ribavirin were included in a 5-year follow-up study in a single Spanish center, based on standard clinical practice. Clinical anamnesis, biochemical analysis, hepatitis C virus RNA and alpha-fetoprotein measurement, ultrasonography and transient elastography were performed annually. RESULTS: The mean follow-up period of the 153 patients was 76 ± 13 mo after they obtained a SVR. Five patients (3.26%) presented with cirrhosis before treatment and 116 (75.8%) had genotype 1. No patient showed evidence of hepatic decompensation. One patient (0.65%) developed a hepatocellular carcinoma at month 30 after achieving SVR. There were no virological relapses during this follow-up period. Persistently elevated alanine aminotransferase was found in only one patient (0.65%). At the end of the 5-year follow-up, the mean value of transient elastography was 7 ± 4.3 kPa (F1). There were no deaths and no other tumors. CONCLUSION: The long-term outcome of 153 CHC patients with SVR to PEG-IFN plus ribavirin was good. No evidence of a virological relapse was seen. One patient (0.65%) developed a hepatocellular carcinoma. | María Trapero-Marugán Jorge Mendoza María Chaparro Leticia González-Moreno José Andrés Moreno-Monteagudo María Jesús Borque Ricardo Moreno-Otero | 2011 | World Journal of Gastroenterology2011，17，4： | 3 |
| 3 | Systematic review with meta‐analysis: the declining risk of colorectal cancer in ulcerative colitis显示文摘 | C. Casta?o‐Milla M. Chaparro J. P. Gisbert | 2014 | Aliment Pharmacol Ther2014，，7： | 2 |
| 4 | Serum proteomic changes in adults with obstructive sleep apnoea显示文摘 | BERNABEJURADO‐GAMEZ JOSE LUISGOMEZ‐CHAPARRO MARIAMU?OZ‐CALERO ANTONIOSERNA SANZ LUISMU?OZ‐CABRERA JUANLOPEZ‐BAREA DAVIDGOZAL | 2012 | Journal of Sleep Research2012，，2： | 2 |
| 5 | Genetic mapping of monoterpene composition in an interspecific eucalypt hybrid显示文摘 | Shepherd M Chaparro J X Teasdale R | 1999 | Theor Appl Genet1999，99，： | 1 |
| 6 | Stability of biocatalysts 显示文摘 | Polizzi KM Bommarius AS Broering JM Chaparro - Riggers JF | 2007 | Current Opinion in Chemical Biolo- gy2007，11，2： | 1 |
| 7 | Intensification of infliximab therapy in Crohn's disease:Efficacy and safety显示文摘 | Chaparro M Martinez-Montiel P Van Domselaar M | 2012 | J Crohn''s and Colitis2012，6，1： | 1 |
| 8 | Changes in feeding mechanisms during early ontogeny in juveniles of Crepidula fecunda (Gastropoda, Calyptraeidae)显示文摘 | Montiel Y A Chaparro O R Segura C J | 2005 | Marine Biology2005，147，： | 1 |
| 9 | Bronchiolitis obliteranssyndrome in lung transplant recipient:can thin-asction CT find-ings predict disease before its clinical appearance?显示文摘 | Konen E Gutierreez C Chaparro C et a1 | 2004 | Radiology2004，231，4： | 1 |
| 10 | Proprotein convertase substilisin/kexin type 9 antagonism reduces low- density lipoprotein cholesterol in statin-treated hyperchotesterolemic nonhuman primates 显示文摘 | Liang H Chaparro Riggers J Strop P | 2012 | J Pharmacol Exp Ther2012，340，2： | 1 |
| 11 | Bronchiolitis oblite- tans syndrome in lung transplant recipients: can thin-section CT findings predict disease before its clinical appearance?显示文摘 | Konen E Gutierrez C Chaparro C | 2004 | Radiology2004，231，2： | 1 |
| 12 | Cytomegalovirus viremia in lung transplant receiving ganciclovir and immune globulin显示文摘 | Gutierrez CA Chaparro C Krajden M | 1998 | Chest1998，113，4： | 1 |
| 13 | Voiding disfunction in prostate cancer 显示文摘 | Prieto Chaparro L | 2009 | Arch Esp Uro2009，62，10： | 1 |
| 14 | Should we monitor vitamin B<sub>12</sub> and folate levels in Crohn’s disease patients?显示文摘 | Fernando Bermejo Alicia Algaba Ivá n Guerra Marí a Chaparro Gema De-La-Poza Paz Valer Belé n Piqueras Andrea Bermejo Javier Garcí a-Alonso Marí a-José Pé rez Javier P Gisbert | 2013 | Scandinavian Journal of Gastroenterology2013，，11： | 1 |
| 15 | Adaptive Morphological Representation of Signals:Polynomial and Wavelet Methods显示文摘 | Cha Hyungtai Chaparro L F | 1997 | Multidi-mensional Systems and Signal Processing1997，8，： | 1 |
| 16 | Hippoeampal cellular loss after brief hypotension 显示文摘 | Chaparro RE Quiroga C Bosco G et at | 2013 | Springerplus2013，2，1： | 1 |
| 17 | Breakdown delay limes for subnanose- cond gas discharges at pressures below one atmosphere显示文摘 | Chaparro J Jnstis W Krompholz H | 2008 | IEEE Transactions on Plasma Science2008，36，5： | 1 |
| 18 | Cytomegalovirus viremia in lung transplant recipients receiving ganciclovir and immune globulin显示文摘 | Gutierrez CA Chaparro C Krajden M | | 0，，04： | 1 |
| 19 | Bronchiolitis obliterans syndrome in lung transplant recipients: can thin-section CT findings predict dis- ease before its clinical appearance?显示文摘 | Konen E Gutierrez C Chaparro C | 2004 | Radiology2004，231，2： | 1 |
| 20 | In vivo tricalcium phosphate,bone morphogenetic protein and autologous bone marrow biomechanical enhancement in vertebral fractures in a porcine model显示文摘 | Manrique E Chaparro D Cebrian JL | 2014 | Int Orthop2014，38，9： | 1 |
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