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| 1 | Metalloproteinase expression after desflurane preconditioning in hepatectomies:A randomized clinical trial显示文摘BACKGROUND Hepatectomy with inflow occlusion results in ischemia-reperfusion injury;however,pharmacological preconditioning can prevent such injury and optimize the postoperative recovery of hepatectomized patients.The normal inflammatory response after a hepatectomy involves increased expression of metalloproteinases,which may signal pathologic hepatic tissue reformation.AIM To investigate the effect of desflurane preconditioning on these inflammatory indices in patients with inflow occlusion undergoing hepatectomy.METHODS This is a single-center,prospective,randomized controlled trial conducted at the 4th Department of Surgery of the Medical School of Aristotle University of Thessaloniki,between August 2016 and December 2017.Forty-six patients were randomized to either the desflurane treatment group for pharmacological preconditioning(by replacement of propofol with desflurane,administered 30 min before induction of ischemia)or the control group for standard intravenous propofol.The primary endpoint of expression levels of matrix metalloproteinases and their inhibitors was determined preoperatively and at 30 min posthepatic reperfusion.The secondary endpoints of neutrophil infiltration,coagulation profile,activity of antithrombin III(AT III),protein C(PC),protein S and biochemical markers of liver function were determined for 5 d postoperatively and compared between the groups.RESULTS The desflurane treatment group showed significantly increased levels of tissue inhibitor of metalloproteinases 1 and 2,significantly decreased levels of matrix metalloproteinases 2 and 9,decreased neutrophil infiltration,and less profound changes in the coagulation profile.During the 5-d postoperative period,all patients showed significantly decreased activity of AT III,PC and protein S(vs baseline values,P<0.05).The activity of AT III and PC differed significantly between the two groups from postoperative day 1 to postoperative day 5(P<0.05),showing a moderate drop in activity of AT III and PC in the desflurane treatment group and a dramatic drop in the control group.Compared to the control group,the desflurane treatment group also had significantly lower international normalized ratio values on all postoperative days(P<0.005)and lower serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase values on postoperative days 2 and 3(P<0.05).Total length of stay was significantly less in the desflurane group(P=0.009).CONCLUSION Desflurane preconditioning can lessen the inflammatory response related to ischemia-reperfusion injury and may shorten length of hospitalization. | Eleni Koraki Ioannis Mantzoros Christos Chatzakis Anna Gkiouliava Angeliki Cheva Athina Lavrentieva Freideriki Sifaki Helena Argiriadou Isaak Kesisoglou Konstantinos Galanos-Demiris Stefanos Bitsianis Konstantinos Tsalis | 2020 | World Journal of Hepatology2020，12，11： | 4 |
| 2 | Combustion reactivity and morphological change in coal chars:Effect of pyrolysis temperature,heating rate and pressure显示文摘 | CAI H-Y GELL A J CHATZAKIS I N LIM J-Y DUGWELL D R KANDIYDT I R | 1996 | Fuel1996，75，1： | 1 |
| 3 | Co-expression of survivin, c-erbB2, and cyclooxygenase-2 (COX-2): prognostic value and survival of endometrial cancer patients显示文摘 | Maria Lambropoulou Nikolaos Papadopoulos Grigoris Tripsianis George Alexiadis Olga Pagonopoulou Anastasia Kiziridou Vassilios Liberis Stylianos Kakolyris Ekaterini Chatzaki | 2010 | Journal of Cancer Research and Clinical Oncology2010，，3： | 1 |
| 4 | Co-expression of survivin, c-erbB2, and cyclooxygenase-2 (COX-2): prognostic value and survival of endometrial cancer patients显示文摘 | Maria Lambropoulou Nikolaos Papadopoulos Grigoris Tripsianis George Alexiadis Olga Pagonopoulou Anastasia Kiziridou Vassilios Liberis Stylianos Kakolyris Ekaterini Chatzaki | 2010 | Journal of Cancer Research and Clinical Oncology2010，，3： | 1 |
| 5 | Manage- ment of malignant pleural effusion by suicide gene therapy in advanced stage lung cancer: a case series and literature review 显示文摘 | Zarogoulidis P Chatzaki E Hohenforst-Schmidt W | 2012 | Cancer gene therapy2012，19，9： | 1 |
| 6 | Combustion reac-tivity and morphological change in coal chars:Effect of pyrol-ysis temperature,heating rate and pressure显示文摘 | Cai H Y Gliell A J Chatzakis IN | 1996 | Fuel1996，75，1： | 1 |
| 7 | Voulganing a new generalized battery management system 显示文摘 | CHATZAKIS J KALAITZAKIS K NICHOLAS C | 2003 | IEEE Transactions2003，50，5： | 1 |
| 8 | Transforming growth factor betal exerts an autocrine regulatory effect on human endometrial stromal cell apoptosis, involving the FasL and Bcl-2 apoptotic pathways显示文摘 | Chatzaki E Kouimtzoglou E Margioris AN | 2003 | Mol Hum Reprod2003，9，2： | 1 |
| 9 | Combustion reactivity and morphological change in coal chars: Effect of pyrolysis temperature, heating rate and pressure显示文摘 | CAI H Y GELL A J CHATZAKIS I N | 1996 | Fuel1996，75，1： | 1 |
| 10 | The Fas/FasL apoptotic pathway is involved kappa-opioid-in- duced apoptosis of human endometrial stromal cells 显示文摘 | Chatzaki E Makrigiannakis A Margioris AN | 2001 | Mol Ham Reprod2001，7，9： | 1 |
| 11 | Immature malignant sacrococcygeal teratoma:case report and review of the literature显示文摘 | Grammatikopoulou I Kontomanolis EN Chatzaki E | 2013 | Clin Exp Obstet Gynecol2013，40，3： | 1 |
| 12 | Combustion reaetivty and morphological change in coal chars:Effect of pyrolysis temperature,heating rate and pressure显示文摘 | Cai H Y Guell A J Chatzakis I N | 1996 | Fuel1996，75，1： | 1 |
| 13 | Combustion reactivity and morphological change in coal chars:effect of pyrolysis temperature,heating rate and pressure显示文摘 | Guell A J Chatzakis I N | 1996 | Fuel1996，75，1： | 1 |
| 14 | Combustionreactivity and morphological change in coal chars : effectof pyrolysis temperature, heating rate and pressure显示文摘 | Cai H Y Guell A J Chatzakis I N | 1996 | Fuel1996，75，1： | 1 |
| 15 | Combustion reactivity and morphological change in coal chars:effect of pyrolysis temperature,heating rate and pressure显示文摘 | CAI H Y GUELL A J CHATZAKIS I N | 1996 | Fuel1996，75，1： | 1 |
| 16 | Neuropeptide and sigma receptors as novel therapeutic targets for the pharmacotherapy of depression显示文摘 | Paschos KA Veletza S Chatzaki E | 2009 | CNS Drugs2009，23，9： | 1 |
| 17 | Management of malignant pleural effusion by suicide gene therapy in advanced stage lung cancer: a case series and literature review 显示文摘 | Zarogoulidis P Chatzaki E Hohenforst-Schmidt W | 2012 | Cancer Gene Ther2012，19，9： | 1 |
| 18 | Designing a new generalized battery management system 显示文摘 | CHATZAKIS J KALAITZAKIS K NICHOLAS C | 2003 | IEEE Transac- tions on Industrial Electronics2003，50，5： | 1 |
| 19 | 'Designing a new generalized battery management system'显示文摘 | CHATZAKIS J KALAITZAKIS K VOULGARIS N C | 2003 | IEEE Transactions on Industrial Electronics2003，50，5： | 1 |
| 20 | High-pressure pyrolysis and CO2-gasification of coal maeeral concentrates: Conversions and char combustion reactivities 显示文摘 | Megaritis A Messenbock R C Chatzakis I N | 1999 | Fuel1999，78，8： | 1 |
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