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| 1 | 开心散乙醇提取物中远志皂苷的入血成分及体内代谢产物分析显示文摘目的:鉴定开心散60%乙醇提取物(KXS-60%E)及其血中移行成分中的远志皂苷类成分,分析大鼠体内远志皂苷类成分的代谢产物。方法:应用UPLC-TOF-MS技术,分析TOF-MS/MS给出的二级离子信息,结合液质联用工作站Mass Lynx v4.1分析软件及现有的文献数据库,鉴定KXS-60%E中远志皂苷类成分、灌服KXS-60%E后血清中的远志皂苷类成分及其代谢产物。结果:鉴定了KXS-60%E中14个远志皂苷类成分,主要为三萜型皂苷;鉴定了大鼠口服KXS-60%E后血中的5个原型皂苷类成分及4个代谢产物。结论:远志皂苷类成分及4个代谢产物可能是KXS-60%E潜在的活性成分及直接药效物质基础,这将有助于阐明开心散防治阿尔兹海默症的有效成分及作用机制。 | Reeju Maharjan Chiranjivi Thapa 汪娜 Ram Chaulagain 薛迪 贾永明 邓竹君 黄树明 刘学伟 | 2017 | 中国实验方剂学杂志2017，23，19： | 13 |
| 2 | UHPLC-MS法鉴定大鼠灌服开心散后血中远志糖酯类化合物及其代谢产物显示文摘本研究利用超高效液相色谱-飞行时间质谱联用技术(UHPLC-TOF/MS),借助液质联用工作站Masslynx V4.1分析软件,结合现有文献及相关数据库,鉴定了开心散60%乙醇提取物(KXS-60%E)中20个远志糖酯类成分;在此基础上,进一步指认并鉴定了灌服KXS-60%E后大鼠血中的14个远志糖酯类化合物及4个来源于远志糖酯类成分的代谢产物。以上研究结果表明,远志糖酯类化合物及其代谢产物是KXS-60%E的主要血中移行成分,原形及代谢产物可能是开心散防治AD的潜在药效物质基础。 | 汪娜 Hassan AHMAD 贾永明 薛迪 Ram CHAULAGAIN 黄树明 刘学伟 | 2017 | 药学学报2017，52，10： | 11 |
| 3 | Response reduction factor of irregular RC buildings in Kathmandu valley显示文摘Most current seismic design includes the nonlinear response of a structure through a response reduction factor(R). This allows the designer to use a linear elastic force-based approach while accounting for nonlinear behavior and deformation limits. In fact, the response reduction factor is used in modern seismic codes to scale down the elastic response of a structure. This study focuses on estimating the actual ‘R' value for engineered design/construction of reinforced concrete(RC) buildings in Kathmandu valley. The ductility and overstrength of representative RC buildings in Kathmandu are investigated. Nonlinear pushover analysis was performed on structural models in order to evaluate the seismic performance of buildings. Twelve representative engineered irregular buildings with a variety of characteristics located in the Kathmandu valley were selected and studied. Furthermore, the effects of overstrength on the ductility factor, beam column capacity ratio on the building ductility, and load path on the response reduction factor, are examined. Finally, the results are further analyzed and compared with different structural parameters of the buildings. | Hemchandra Chaulagain Hugo Rodrigues Enrico Spacone Ramesh Guragain Radhakrishna Mallik Humberto Varum | 2014 | Earthquake Engineering and Engineering Vibration2014，13，3： | 2 |
| 4 | Molecular epidemiology ofan outbreak of imipenem-resistant Acinetobacter baumannii carryingthe ISAba1-bla(OXA-51-like) genes in a Korean hospital显示文摘 | Chaulagain BP Jang SJ Ahn GY | 2012 | Jpn JInfect Dis2012，65，2： | 1 |
| 5 | Molecular epidemiology of an outbreak of imipenem-resistant Acinetobacter baumannii carrying the ISAbal-bla (OXA-51-1ike) genes in a Korean hospital 显示文摘 | Chaulagain BP Jang S J Ahn GY | 2012 | Jpn J Infect Dis2012，65，2： | 1 |
| 6 | Molecular epidemiology of an outbreak of imipenem-resistant Acinetobacter baumannii carrying the ISAbal-bla (OXA-51-1ike) genes in a Korean hospital显示文摘 | Chaulagain BP Jang S J Ahn GY | 2012 | Jpn J Infect Dis2012，65，2： | 1 |
| 7 | First radiative shock experiments on the SG-II laser显示文摘We report on the design and first results from experiments looking at the formation of radiative shocks on the ShenguangII(SG-II)laser at the Shanghai Institute of Optics and Fine Mechanics in China.Laser-heating of a two-layer CH/CH–Br foil drives a∼40 km/s shock inside a gas cell filled with argon at an initial pressure of 1 bar.The use of gas-cell targets with large(several millimetres)lateral and axial extent allows the shock to propagate freely without any wall interactions,and permits a large field of view to image single and colliding counter-propagating shocks with time-resolved,pointprojection X-ray backlighting(∼20µm source size,4.3 keV photon energy).Single shocks were imaged up to 100 ns after the onset of the laser drive,allowing to probe the growth of spatial nonuniformities in the shock apex.These results are compared with experiments looking at counter-propagating shocks,showing a symmetric drive that leads to a collision and stagnation from∼40 ns onward.We present a preliminary comparison with numerical simulations with the radiation hydrodynamics code ARWEN,which provides expected plasma parameters for the design of future experiments in this facility. | Francisco Suzuki-Vidal Thomas Clayson Chantal Stehlé Uddhab Chaulagain Jack W.D.Halliday Mingying Sun Lei Ren Ning Kang Huiya Liu Baoqiang Zhu Jianqiang Zhu Carolina De Almeida Rossi Teodora Mihailescu Pedro Velarde Manuel Cotelo John M.Foster Colin N.Danson Christopher Spindloe Jeremy P.Chittenden Carolyn Kuranz | 2021 | High Power Laser Science and Engineering2021，9，2： | 1 |
| 8 | Molecular epidemiology of an outbreak of imipenem-resistant Acinetobacter baumannii carrying the ISAba1-bla(oxA-51-like) genes in a Korean hospital显示文摘 | Chaulagain B P Jang S J Ahn G Y | 2012 | Jpn J Infect Dis2012，65，2： | 1 |
| 9 | Molecular epi- demiology of an outbreak of imipenem-resistant Aeineto- bacter baumannii carrying the ISAbal-bla (OXA-51- like)genes in a Korean hospital 显示文摘 | Chaulagain BP Jang SJ Ahn GY | 2012 | Jpn J Infection Dis2012，65，2： | 1 |
| 10 | Molecular epidemiol- ogy of an outbreak of imipenem-resistant Acinetobacter bau- rnannii carrying the ISAbal-bla (OXA-51-1ike) genes in a Ko- rean hospital显示文摘 | Chaulagain BP Jang SJ Ahn GY | 2012 | Jpn J Infect Dis2012，65，2： | 1 |
| 11 | Molecular epidemiology of an outbreak of imipenem-resistant Acinetobacter baumannii carrying the ISA bal-bla(OXA-51-like)genes in a Korean hospital显示文摘 | Chaulagain BP Jang SJ Ahn GY | 2012 | Jpn J Infect Dis2012，65，2： | 1 |
| 12 | Developmentally reg- ulated expression of intracellular Fgfl 1-13, hormone-like Fgfl 5 and canonical Fgf16,-17 and -20 mRNAs in the developing mouse mo- lar tooth 显示文摘 | Kettunen P Furmanek T Chaulagain R | 2011 | Acta Odontol Scand2011，69，6： | 1 |
| 13 | New insights and modern treatment of AL amyloidosis显示文摘 | Chaulagain CP Comenzo RL | 2013 | Curr Hematol Malig Rep2013，8，4： | 1 |
| 14 | Molecular epidemiology of an outbreak of imipenem-resistant Acinetobacter baumannii carrying the ISAbal-bla(OXA-51-1ike) genes in a Korean hospital显示文摘 | Chaulagain BP Jang SJ Ahn GY | 2012 | JJID2012，65，2： | 1 |
| 15 | New N-Heterocyclic Carbene Ligand and Its Application in Asymmetric Nickel-Catalyzed Aldehyde/Alkyne Reductive Couplings显示文摘 | Chaulagain M R Sormunen G J Montgomery J | | 0，，31： | 1 |
| 16 | Molecular epidemiology of an outbreak of imipenem-reaiatant Acinetobacter baumannii carrying the 1SA bal-bla(OXA-5l-like)genes in a Korean hospital显示文摘 | Chaulagain B P Jang S J Ahn GY | 2012 | Jpn J Infect Dis2012，65，2： | 1 |
| 17 | Molecular epidemiology of an outbreak of imipenem-resistant acinetobacter baumannii carrying the ISAba1-bla(OXA-51-like) genes in a Korean hospital显示文摘 | Chaulagain BP Jang SJ | | 0，，02： | 1 |
| 18 | Molecular epidemi- ology of an outbreak of imipenem - resistant acinetobacter baumannii canying the ISAbal -bla( OXA -51 -like) genes in a korean Hospi- tal显示文摘 | CHAULAGAIN B P JANG S J AHN G Y | 2012 | Jpn J Infect Dis2012，65，2： | 1 |
| 19 | Molecular epi- demiology of an out-break of imipenem-resistant acineto- bacter baumannii carrying the ISAbal-bla(OXA-51-1ike) genes in a Korean hospital显示文摘 | Chaulagain BP Jang SJ Ahn GY | 2012 | Jpn J Infect Dis2012，65，2： | 1 |
| 20 | Develop-mentally regulated expression of intracellular Fgf11-13,hormone-like Fgf15 and canonical Fgf16,-17 and -20 mRNAs in the developing mouse molar tooth显示文摘 | Kettunen P Furmanek T Chaulagain R | | 0，，06： | 1 |
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