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| 1 | FragAnchor: A Large-Scale Predictor of Glycosylphosphatidylinositol Anchors in Eukaryote Protein Sequences by Qualitative Scoring显示文摘A glycosylphosphatidylinositol (GPI) anchor is a common but complex C-terminal post-translational modification of extracellular proteins in eukaryotes. Here we investigate the problem of correctly annotating GPI-anchored proteins for the growing number of sequences in public databases. We developed a computa- tional system, called FragAnchor, based on the tandem use of a neural net- work (NN) and a hidden Markov model (HMM). Firstly, NN selects potential GPI-anchored proteins in a dataset, then HMM parses these potential GPI sig- nals and refines the prediction by qualitative scoring. FragAnchor correctly predicted 91% of all the GPI-anchored proteins annotated in the Swiss-Prot database. In a large-scale analysis of 29 eukaryote proteomes, FragAnchor predicted that the percentage of highly probable GPI-anchored proteins is between 0.21% and 2.01%. The distinctive feature of FragAnchor, compared with other systems, is that it targets only the C-terminus of a protein, making it less sensitive to the background noise found in databases and possible incomplete protein sequences. Moreover, FragAnchor can be used to predict GPI-anchored proteins in all eukaryotes. Finally, by using qualitative scoring, the predictions combine both sensitivity and information content. The predictor is publicly available at http://navet.ics.hawaii.edu/~fraganchor/NNHMM/NNHMM.html. | Guylaine Poisson Cedric Chauve Xin Chen Anne Bergeron | 2007 | Genomics, Proteomics & Bioinformatics2007，5，2： | 3 |
| 2 | Cellulose poly(ethylene-co-vinyl acetate) nanocomposites studied by molecular modeling and mechanical spectroscopy显示文摘 | Chauve G Heux L Arouini R | 2005 | Biomacromolecules2005，6，： | 1 |
| 3 | Nonflocculating and chiral-nematic self-ordering of cellulose microcrystals suspensions in nonpolar solvents显示文摘 | Heux L Chauve G Bonini C | 2000 | Langmuir2000，16，21： | 1 |
| 4 | 查看详情显示文摘 | Chauve G Heux L Arouini R Mazeau K | | 0，，04： | 1 |
| 5 | Bacterial taxa associated with the hematophagous mite Dermanyssus gallinaedetected by 16S rRNA PCR amplification and TTGE finger printing显示文摘 | Valiente M C Thioulouse J Chauve C | 2009 | Res Micro2009，160，1： | 1 |
| 6 | Detection of Hiltomonas nzeleagridis in turkeys caecal droppings by PCR amplification of the small subunit ribosomal DNA sequence显示文摘 | Huber K Chauve C Zenner L | 2005 | Veterinary Parasitol- ogy2005，131，： | 1 |
| 7 | Turbulent rotating disk flow with inward throughflow显示文摘 | Poncet S Chauve M P Legal P | 2005 | Journal of Fluid Mechanics2005，522，1： | 1 |
| 8 | Vectorial role of some dermanyssoid mites(Acari,Mesostigmata,Dermanyssoidea)显示文摘 | Valiente M C Chauve C Zenner L | 2005 | Parasite2005，12，： | 1 |
| 9 | Contribution a l'etude des coccidies de l'oie dans la region du sud-ouest de la France:proposition d'une cle de diagnose des differentes especes,basee sur la morpholgie de l' ookyste sporule显示文摘 | CHAUVE C M | 1988 | Avian Pathology1988，17，： | 1 |
| 10 | Turbidity Mech- anism of Water from a Karstic Spring: Example of the Ain Asserdoune Spring (BeniMellal Atlas, Mo- rocco) 显示文摘 | Bouchaou L Managin A Chauve P | 2002 | Journal of Hydrology2002，265，1： | 1 |
| 11 | In vitro activity of therapeutic drugs against Histomonas meleagridis ( Smith, 1895 ) 显示文摘 | Callait MP Granier C Chauve C | 2002 | Poultry Sci2002，81，8： | 1 |
| 12 | Detection of Histomonas meleagridis in turkeys cecal droppings by PCR amplification of the small subunit ribosomal DNA sequence显示文摘 | Huber K Chauve C Zenner L | 2005 | Vet Parasitol2005，131，34： | 1 |
| 13 | Advanced full - waveform lidar data echo detection : assessing quali- ty of derived terrain and tree height models in an alpine coniferous forest 显示文摘 | CHAUVE A V GA C DURRIEU S | 2009 | International Journal of Remote Sensing2009，30，19： | 1 |
| 14 | Batchelor versus Stew- artson flow structures in a rotor-stator cavity with throughflow 显示文摘 | Poncet S Chauve M P Schiestel R | 2005 | Physics of Fluids2005，17，7： | 1 |
| 15 | Terrain surfaces and 3 - D landcover classification from small footprint full - waveform lidar data: application to bad- lands 显示文摘 | BRETAR F CHAUVE A MALLET C | 2009 | Hydrology and Earth System Sciences2009，6，1： | 1 |
| 16 | Turbulent Rotating Disk Flow With Inward Throughfiow 显示文摘 | Poncet S Chauve M P Legal P | 2005 | Journal of Fluid Me- chanics2005，522，： | 1 |
| 17 | Batchelor Versus Stewartson Flow Structures in a Rotor-Stator Cavity With Throughflow 显示文摘 | Poncet S Chauve M P Schiestel R | 2005 | Physics of Fluids2005，17，07： | 1 |
| 18 | Velocity and Con- centration Distributions in Globally Unstable Axisymmetric Helium Jets 显示文摘 | Boujemaa Sami Amielh Muriel Chauve | 2007 | Comptes Rendus Mechique2007，335，： | 1 |
| 19 | Comparative kinetic analysis of two fungal glucosidases显示文摘 | CHAUVE M MATHIS H HUC D | 2010 | Biotechnol Biofueis2010，3，1： | 1 |
| 20 | Nonflocculating and chiral-nematic self-ordering of cellulose microcrystals suspensions in nonpolar solvents 显示文摘 | HEUX L CHAUVE G BONINI C | 2000 | Langmuir2000，16，21： | 1 |
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