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| 1 | Expression and functional analysis of the rice plasma-membrane intrinsic protein gene family显示文摘血浆膜内在的蛋白质(果仁) 是 aquaporins 的一个亚科越过膜启用水的快、控制的 translocation。在这研究,我们系统地从米饭识别了并且克隆十果仁基因。基于他们编码了的氨基酸序列的类似,这些米饭果仁基因被分类进二个组并且指定了为 OsPIP1-1 到 OsPIP1-3 和 OsPIP2-1 到在玉米跟随果仁基因的名称的 OsPIP2-7。量的 RT-PCR 分析识别了三根特定并且一叶特定的 OsPIP 基因。而且,响应盐,干旱和骆驼毛的织物处理的每 OsPIP 基因的表示侧面详细被检验。OsPIP1 (OsPIP1-1 ) 或在野类型的 Arabidopsis,腌,然而并非腌更高的集中(NaCl 的 150 公里) 的处理的显示出的提高的忍耐(NaCl 的 100 公里) 和干旱(甘露糖醇的 200 公里) 的 OsPIP2 (OsPIP2-2 ) 过去表示的转基因的植物上的分析。总起来说,这些数据响应不同压力建议每 OsPIP 基因的一个不同角色,并且应该把新层加到米饭果仁基因的生理的功能的理解。 | Lei Guo Zi Yi Wang Hong Lin Wei Er Cui Jun Chen Meihua Liu Zhang Liang Chen Li Jia Qu Hongya Gu | 2006 | Cell Research2006，16，3： | 35 |
| 2 | Non-coding RNAs:the new central dogma of cancer biology显示文摘The central dogma of molecular biology states that the functions of RNA revolve around protein translation.Until the last decade,most researches were geared towards characterization of RNAs as intermediaries in protein translation,namely,messenger RNAs(mRNAs)as temporary copies of genetic information,ribosomal RNAs(rRNAs)as a main component of ribosome,or translators of codon sequence(t RNAs).The statistical reality,however,is that these processes account for less than 2%of the genome,and insufficiently explain the functionality of 98%of transcribed RNAs.Recent discoveries have unveiled thousands of unique non-coding RNAs(ncRNAs)and shifted the perception of them from being'junk'transcriptional products to'yet to be elucidated'—and potentially monumentally important—RNAs.Most ncRNAs are now known as key regulators in various networks in which they could lead to specific cellular responses and fates.In major cancers,ncRNAs have been identified as both oncogenic drivers and tumor suppressors,indicating a complex regulatory network among these ncRNAs.Herein,we provide a comprehensive review of the various ncRNAs and their functional roles in cancer,and the pre-clinical and clinical development of nc RNA-based therapeutics.A deeper understanding of ncRNAs could facilitate better design of personalized therapeutics. | Phei Er Saw Xiaoding Xu Jianing Chen Er-Wei Song | 2021 | Science China(Life Sciences)2021，64，1： | 21 |
| 3 | Anycast service model and its QoS routing algorithm显示文摘In the Internet, a group of replicated servers is commonly used in order to improve the scalability of network service. Anycast service is a new network service that can improve network load distribution and simplify certain applications. In this paper, the authors described a simple anycast service model in the Internet without significant affecting the routing and protocol processing infrastructure that was already in place, and proposed an anycast QoS routing algorithm for this model. The algorithm used randomized method to balance network load and improve its performance. Several new techniques are proposed in the algorithm, first, theminimum hops for each node are used in the algorithm, which are used as metric for computing the probability of possible out links. The metric is pre computed for each node in the network, which can simplify the network complexity and provide the routing process with useful information. Second, randomness is used at the link level and depends dynamically on the routing configuration. This provides great flexibility for the routing process, prevents the routing process from overusing certain fixed routing paths, and adequately balances the delay of the routing path. the authors assess the quality of QoS algorithm in terms of the acceptance ratio on anycast QoS requests, and the simulation results on a variety of network topologies and on various parameters show that the algorithm has good performances and can balance network load effectively. | WANG Jian xin, CHEN Song qiao, CHEN Jian er (College of Information Science and Engineering, Central South University, Changsha 410083, China) | 2001 | Journal of Central South University of Technology2001，8，2： | 11 |
| 4 | Protective effects of baicalin on oxygen/glucose deprivation - and NMDA -induced injuries in rat hippocampal slices显示文摘 | Lu - Ying Liu Er - Qing Wei Yan- Min Zhao Fang - Xue Chen Meng - Ling Wang Wei - Ping Zhang Zhong Chen | 2005 | 中国药理通讯2005，22，4： | 11 |
| 5 | Changes in Temporal Concentration Property of Summer Precipitation in China during 1961–2010 Based on a New Index显示文摘Based on the property of entropy,a new index Q was defined to measure the temporal concentration property of summertime daily rainfall in China,based on daily precipitation data collected at 553 observation stations in China during 1961–2010.Furthermore,changes in the temporal concentration property of summer precipitation in China were investigated.The results indicate that the regions with larger Q values were located in most parts of Northwest China and the north of the Yellow River,where daily precipitation tended to become temporally concentrated during the study period.On the contrary,smaller Q values were found in eastern Tibetan Plateau,southeastern Northwest China,and most parts of Southwest and South China.The most obvious increasing trend of Q index was found in South China and most parts of Southwest China,where precipitation showed a temporal concentration trend.However,a decreasing trend of Q index was found in Northwest China,the Tibetan Plateau,and the north of the Huaihe River.Variations of the Q index and the summer rainfall total during 1961–2010 in China both exhibited an increasing trend,implying larger temporal variability in rainfall attributes.It is illustrated that the summer precipitation in general became more temporally concentrated with more intense rainfall events and wetter days. | Hui LI Panmao ZHAI Er LU Wei ZHAO Yang CHEN Huan WANG | 2017 | Journal of Meteorological Research2017，31，2： | 9 |
| 6 | Chimeric antigen receptor T cells in solid tumors: a war against the tumor microenvironment显示文摘Chimeric antigen receptor(CAR) T cell is a novel approach, which utilizes anti-tumor immunity for cancer treatment. As compared to the traditional cell-mediated immunity, CAR-T possesses the improved specificity of tumor antigens and independent cytotoxicity from major histocompatibility complex molecules through a monoclonal antibody in addition to the Tcell receptor. CAR-T cell has proven its effectiveness, primarily in hematological malignancies, specifically where the CD19 CAR-T cells were used to treat B-cell acute lymphoblastic leukemia and B-cell lymphomas. Nevertheless, there is little progress in the treatment of solid tumors despite the fact that many CAR agents have been created to target tumor antigens such as CEA,EGFR/EGFRvIII, GD2, HER2, MSLN, MUC1, and other antigens. The main obstruction against the progress of research in solid tumors is the tumor microenvironment, in which several elements, such as poor locating ability, immunosuppressive cells,cytokines, chemokines, immunosuppressive checkpoints, inhibitory metabolic factors, tumor antigen loss, and antigen heterogeneity, could affect the potency of CAR-T cells. To overcome these hurdles, researchers have reconstructed the CAR-T cells in various ways. The purpose of this review is to summarize the current research in this field, analyze the mechanisms of the major barriers mentioned above, outline the main solutions, and discuss the outlook of this novel immunotherapeutic modality. | Zijun Zhao Xiaoyun Xiao Phei Er Saw Wei Wu Hongyan Huang Jiewen Chen Yan Nie | 2020 | Science China(Life Sciences)2020，63，2： | 7 |
| 7 | 2D IMAGE BASED SIEVING FOR PARTICLE AGGREGATE GRADATION显示文摘Acquiring the size gradation for particle aggregates is a common practice in the granule related industry,and mechanical sieving or screening has been the normal method. Among many drawbacks of this conventional means,the major ones are time-consuming,labor-intensive,and being unable to provide real-time feedback for process control. In this letter,an optical sieving approach is introduced. The two-dimensional images are used to develop methods for inferring particle volume and sieving behavior for gradation purposes. And a combination of deterministic and probabilistic methods is described to predict the sieving behaviors of the particles and to construct the gradation curves for the aggregate sample. Comparison of the optical sieving with standard mechanical sieving shows good correlation. | Chen Ken John Zaniewski Zhao Pan Yang Ren'er | 2008 | Journal of Electronics(China)2008，25，2： | 5 |
| 8 | Anal cancer in Chinese:human papillomavirus infection and altered expression of p53显示文摘AnalcancerinChinese:humanpapilomavirusinfectionandalteredexpressionofp53LAIMaoDe,LUOMinJie,YAOJianErandCHENPeiHuiSubject... | LAI MaoDe, LUO MinJie, YAO JianEr and CHEN PeiHuiKeywords anus neoplasms papillomavirus infection DNA, viral p53 gene gene expression polymerase chain reaction | 1998 | World Journal of Gastroenterology1998，4，4： | 4 |
| 9 | Cytogenetic and molecular aberrations of multiple myeloma patients: a single-center study in Singapore显示文摘 | LIM Alvin Soon Tiong LIM Tse Hui SEE Karen Hsu Shien NG Yit Jun TAN Yu Min CHO0 Natasha Swee Lian LIM Sherry Xin Er YEE Yenny LAU Lai Ching TIEN Sim Leng Kumar Sathish TAN Daryl Chen Lung | 2013 | Chinese Medical Journal2013，，10： | 4 |
| 10 | NS1-binding protein radiosensitizes esophageal squamous cell carcinoma by transcriptionally suppressing c-Myc显示文摘Background:Cisplatin-based chemotherapy with concurrent radiotherapy is a standard treatment for advanced esophageal squamous cell carcinoma(ESCC).NS1-binding protein(NS1-BP),a member of the BTB-kelch protein fam-ily,has been shown to inhibit the proliferation of Hela cells by suppressing c-Myc.In the present study,we examined the potential function role of NS1-BP expression in ESCC,and particularly,the sensitivity of ESCC to radiotherapy.Methods:NS1-BP expression was examined using immunohistochemistry in two cohorts(n=98 for the training cohort;n=46 for independent validation cohort)of ESCC patients receiving cisplatin-based chemotherapy and con-current radiotherapy.Normal esophageal mucosal tissue blocks were used as a control.We also conducted a series of in vitro and in vivo experiments to examine the potential effects of over-expressing NS1-BP on ESCC cells,and particu-larly their sensitivity to ionizing irradiation.Results:In the training cohort,NS1-BP downregulation was observed in 59%(85/144)of the ESCC specimens.NS1-BP downregulation was associated with chemoradiotherapeutic resistance and shorter disease-specific survival(DSS)in both the training and validation cohorts.Over-expressing NS1-BP in cultured ESCC cells substantially increased the cellular response to irradiation both in vitro and in vivo.NS1-BP also significantly enhanced IR-induced apoptosis,and abrogated IR-induced G2/M cell-cycle arrest and ATM/Chk1 phosphorylation.Immunoprecipitation assays indicated that NS1-BP could interact with c-Myc promoter regions to inhibit its transcription.In ESCC tissues,c-Myc expression was inversely correlated with NS1-BP levels,and was associated with a shorter DSS.Conclusions:Our findings highlight the role and importance of NS1-BP in radiosensitivity of ESCC.Targeting the NS1-BP/c-Myc pathway may provide a novel therapeutic strategy for ESCC. | Yuwen Wang Jingjing Cheng Dan Xie Xiaofeng Ding Hailing Hou Xi Chen Puchun Er Furong Zhang Lujun Zhao Zhiyong Yuan Qingsong Pang Ping Wang Dong Qian | 2018 | Cancer Communications2018，38，1： | 4 |
| 11 | A New Treatment of Depression for Drainage Network Extraction Based on DEM显示文摘Depressions in landscapes function as buffers for water and sediment. A landscape with depressions has less runoff,less erosion and more sedimentation than that without depressions. Sinks in digital elevation models (DEMs) can be considered the real features that represent depressions in actual landscapes or spurious features that result from errors in DEM creation. In many hydrological and erosion models,all sinks are considered as spurious features and,as a result,these models do not deal with the sinks that represent real depressions. Consequently,the surface runoff and erosion are overestimated due to removing the depressions. Aiming at this problem,this paper presents a new method,which deal with the sinks that represent real depressions. The drainage network is extracted without changing the original DEM. The method includes four steps:detecting pits,detecting depressions,merging depressions,and extracting drainage network. Because the elevations of grid cells are not changed,the method can also avoid producing new flat areas,which are always produced by the conventional filling methods. The proposed method was applied to the Xihanshui River basin,the upper reach of the Jialingjiang River basin,China,to automatically extract the drainage network based on DEM. The extracted drainage network agrees well with the reality and can be used for further hydrologic analysis and erosion estimation. | WANG Yan PENG Hong CUI Peng ZHANG Wanshun QIAO Fei CHEN Cai'er | 2009 | Journal of Mountain Science2009，6，4： | 3 |
| 12 | Performance Comparison and Analysis of IP and MPLS Networks显示文摘With the increasing need for Quality of Service( QoS ),the traditional IP network is becoming less competitive. In order to give readers quantitative and convictive performance comparisons between IP and MPLS network,we choose Berkeleys NS 2 simulator [1] in our research on network throughput and end to end TCP behavior. Using NS 2 simulator,we analyze the performance of a network with MPLS Traffic Engineering( MPLS TE ).Specifically,the throughput and TCP end to end delay time under two different queuing algorithms are obtained and compared between the MPLS network and traditional IP network. We find that in the IP network using SFQ queuing algorithm will help traffic balance compared to the simple FIFO scheme,but it still can not utilize the available bandwidth,which in turn leads to the poor performance as in the FIFO case.With MPLS TE , the throughput will be higher and the end to end TCP delay time remains almost the same even in heavy load case.We notice that if flows are isolated partially,using SFQ scheme will have a comparable performance as the fully isolation case using FIFO scheme in a MPLS network,and that if flows are isolated fully for FIFO and SFQ schemes,both will have the same result.Finally,we conclude that a better queuing algorithm will help reduce the label space requirement. | LIU Er wu, CAO Ming cui, CHEN Chun han, LI Feng (State Key Laboratory of Laser Technology, Huazhong University of Science and Technology, Wuhan 430074, P.R.China) | 2001 | The Journal of China Universities of Posts and Telecommunications2001，8，2： | 3 |
| 13 | The efficacy and safety of pramipexole ER versus IR in Chinese patients with Parkinson’s disease: a randomized, double-blind, double-dummy, parallel-group study显示文摘Objective:To evaluate the non-inferiority of pramipexole extended-release(ER)versus immediate-release(IR)in Chinese patients with Parkinson’s disease(PD)in a double-blind,randomized,parallel-group study.Methods:Subjects were Chinese patients with idiopathic PD with diagnosis≥2 years prior to trial,age≥30 years old at diagnosis,and Modified Hoehn and Yahr score 2-4 during‘on’-time.Subjects received treatment with pramipexole ER(n=234)or IR(n=239).Non-inferiority was based on the primary endpoint,the change from baseline to end of maintenance(week 18)in the UPDRS(Parts II+III)total score.Results:For the primary endpoint,the adjusted mean changes(standard error)of UPDRS Parts II+III at week 18 were−13.81(0.655)and−13.05(0.643)for ER and IR formulations,respectively,using ANCOVA adjusted for treatment and centre(fixed effect)and baseline(covariate).The adjusted mean between group difference was 0.8 for the 2-sided 95%CI(−1.047,2.566).Since the lower limit of the 2-sided 95%CI(−1.047)for treatment difference was higher than the non-inferiority margin of−4,non-inferiority between pramipexole ER and IR was demonstrated.The incidence of adverse events(AEs)was 68.8%in the ER arm and 73.6%in the IR arm with few severe AEs(ER:2.1%;IR:3.8%).Conclusion:Based on the UPDRS II+III score,pramipexole ER was non-inferior to pramipexole IR.The safety profiles of pramipexole ER and IR were similar.These results were based on comparable mean daily doses and durations of treatment for both formulations. | Ying Wang Shenggang Sun Suiqiang Zhu Chunfeng Liu Yiming Liu Qing Di Huifang Shang Yan Ren Changhong Lu Mark Forrest Gordon Nolwenn Juhel Shengdi Chen for the Pramipexole ER Study Team | 2014 | Translational Neurodegeneration2014，3，1： | 3 |
| 14 | Caffeic acid attenuates neuronal damage, astrogliosis and glial scar formation in mouse brain with cryoinjury显示文摘 | Zhang Lei Zhang Wei - Ping Chen Ke - Da Qian Xiao - Dong Fang San - Hua Wei Er - Qing | 2006 | 中国药理通讯2006，23，4： | 3 |
| 15 | NS1结合蛋白通过转录抑制c-Myc增强食管鳞状细胞癌的放疗敏感性显示文摘背景与目的基于顺铂的化疗联合放疗是晚期食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)的标准疗法。NS1结合蛋白(NS1-binding protein,NS1-BP)是BTB-kelch蛋白家族中的一员,已被证明可通过抑制c-Myc进而抑制HeLa细胞增殖。在本研究中,我们检测NS1-BP表达在ESCC中的潜在作用,特别是其在ESCC放疗敏感性方面的作用。方法对于两组接受基于顺铂化疗且联合放疗的ESCC患者(研究组n=98;验证组n=46),采用免疫组化方法分别检测NS1-BP表达。使用正常食管黏膜组织块作为对照。我们也进行了一系列体外和体内实验来检测过表达NS1-BP对ESCC细胞各方面的潜在影响,尤其关注的是对电离辐射的敏感性方面的影响。结果在研究组中,59%(85/144)的ESCC样本观察到了NS1-BP下调。在研究组和验证组中,NS1-BP下调与放化疗抵抗和较短的疾病特异生存期(disease-specific survival,DSS)均具有相关性。体内和体外培养条件下过表达NS1-BP均能大幅度提高ECSS细胞对放疗的敏感性。NS1-BP也显著增强IR诱导的凋亡,阻断IR诱导的G2/M细胞周期阻滞和ATM/Chk1磷酸化。免疫沉淀反应显示NS1-BP可以与c-Myc启动子区相互作用从而抑制其转录。在ESCC组织中,c-Myc表达与NS1-BP水平负相关,与较短的疾病特异生存期相关。结论我们的研究结果显示了NS1-BP在ESCC放疗敏感性中的作用和重要性。以NS1-BP/c-Myc通路为靶标有望开发一种新的ESCC治疗策略。 | Yuwen Wang Jingjing Cheng Dan Xie Xiaofeng Ding Hailing Hou Xi Chen Puchun Er Furong Zhang Lujun Zhao Zhiyong Yuan Qingsong Pang Ping Wang Dong Qian | 2019 | 癌症2019，38，2： | 2 |
| 16 | An improved network layer protocol based on mobile IPv6显示文摘The mobile IPv6 proposed by the IETF aims at providing mobility support on the next generation Internet. First, the authors described the basic principle of mobile IPv6 in brief and analyzed the advantages and disadvantages of it, presented a new idea of allocating a specific address space for mobile node (MN) and developed a new extension header and two ICMP message types for mobile IPv6. Lastly the authors proposed an optimization strategy for mobile IPv6 based on these extensions of protocol, which has the following advantages: 1) It is more convenient to manage the MNs because MN can be judged from its IP address; 2) When the correspondent node (CN) is not actively communicating with a MN, the MN and its home agent (HA) need not send Binding Update to the CN, and the CN need not send Binding Request to the MN. Only when the CN really wants to send a packet to the MN, will the CN voluntarily send a MN Discovery Request message to acquire the MN′s care of address. In this way,the transmission of Binding Update and Binding Request is greatly reduced, consequently the network overhead is also decreased; 3) While sending packets, the CN simply uses a MN Home Address Extension Header without using IPinIP encapsulation and routing header, which can reduce the redundant information in the packet and the message delay; 4) All the packets sent by the CN can be directly routed to the MN and the triangle routing can be completely avoided. By using these protocol extensions, the overhead of the network is greatly reduced and the network quality of services (QoS) is improved. | WANG Jian xin 1,HUANG Guo sheng 2,CHEN Song qiao 1,CHEN Jian er 1 (1.College of Information Science and Engineering, Central South University, Changsha 410083, China 2.Department of Physics and Electronic Engineering, Jishou University, Jisho | 2001 | Journal of Central South University of Technology2001，8，4： | 2 |
| 17 | The effect of cholinergic manipulations on the analgesic response to cobrotoxin in mice显示文摘 | Chen RZ Susan ER | 1990 | Life Sci1990，47，： | 2 |
| 18 | Tetrahydrofuran Ring Opening with Acyl Chlorides or Anhydrides Catalyzed by Gallium Triiodides: A Novel and Facile Method for the Preparation of Iodo Esters显示文摘Tetrahydrofuran ring can be opened with acyl chlorides or anhydrides catalyzed by gallium triiodides to afford iodo esters under mild conditions in good yields. | Hua Yue WU Ren Er CHEN Yong Min ZHANG | 2000 | Chinese Chemical Letters2000，11，3： | 2 |
| 19 | Study on Sensitivity Improving of Fiber Bragg Grating Based pH Sensor显示文摘在基于 FBG 的 pH 传感器中的敏感的关键因素详细被分析。胶化的 multi-thin-layer 结构涂的盖子与一个特殊过程被建议并且实现。有 420 m, 500 m,和 580 m 的涂的厚度的传感器分别地被建立。相应光谱 0.08 nm, 0.13 nm,和 0.22 nm 的移动被检测 pH 传感器是否在 39 的 pH 价值被浸泡。同时,有 580 m 的胶化层厚度的传感器在最佳测量时间时期被测量, pH 价值从 312 变化,在哪个 52 pm/pH 的检测敏感在 612 的 pH 范围被完成。 | Xiongchang Liang Shun’er Chen Hongbin Huang Weiping Liu | 2014 | Photonic Sensors2014，4，1： | 2 |
| 20 | An epidemic of enterovirus 71 infection in Taiwan显示文摘 | Ho M Chen ER Hsu KH | 1999 | N Engl J Med1999，341，13： | 1 |
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