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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Linking atmospheric pollution to cryospheric change in the Third Pole region: current progress and future prospects显示文摘The Tibetan Plateau and its surroundings are known as the Third Pole(TP). This region is noted for its high rates of glacier melt and the associated hydrological shifts that affect water supplies in Asia. Atmospheric pollutants contribute to climatic and cryospheric changes through their effects on solar radiation and the albedos of snow and ice surfaces; moreover, the behavior and fates within the cryosphere and environmental impacts of environmental pollutants are topics of increasing concern. In this review, we introduce a coordinated monitoring and research framework and network to link atmospheric pollution and cryospheric changes(APCC) within the TP region. We then provide an up-to-date summary of progress and achievements related to the APCC research framework, including aspects of atmospheric pollution’s composition and concentration, spatial and temporal variations, trans-boundary transport pathways and mechanisms, and effects on the warming of atmosphere and changing in Indian monsoon, as well as melting of glacier and snow cover. We highlight that exogenous air pollutants can enter into the TP’s environments and cause great impacts on regional climatic and environmental changes. At last, we propose future research priorities and map out an extended program at the global scale. The ongoing monitoring activities and research facilitate comprehensive studies of atmosphere–cryosphere interactions, represent one of China’s key research expeditions to the TP and the polar regions and contribute to the global perspective of earth system science. | Shichang Kang Qianggong Zhang Yun Qian Zhenming Ji Chaoliu Li Zhiyuan Cong Yulan Zhang Junming Guo Wentao Du Jie Huang Qinglong You Arnico K.Panday Maheswar Rupakheti Deliang Chen Orjan Gustafsson Mark H.Thiemens Dahe Qin | 2019 | National Science Review2019，6，4： | 35 |
| 3 | Recent advances in biodegradation controls over Mg alloys for bone fracture management: A review显示文摘Magnesium(Mg) alloys possess comparable physical and mechanical properties to bone, making them an outstanding candidate of implant materials for bone fracture treatment. In addition to the excellent biocompatibility, and bioactivity, the engagement of Mg alloys is key for a number of biological functionalities in the human body. The unique biodegradation nature of Mg alloy implants implies that it may not require a secondary removal procedure when the expected supporting tasks accomplish, as they may simply and safely 'disappear' over time. Nonetheless, the demonstrated drawback of potentially rapid degradation, is an issue that must be addressed appropriately for Mg implants and is consequently given unique attention in this review article. Herein, the critical criteria and the state-of-the-art strategies for controlling the degradation process of Mg alloys are reported. Furthermore, future developments of biodegradable Mg and its alloys systems with satisfactory specifications for clinical trials and deployment,are discussed. This review aims to provide information to materials scientists and clinical practitioners in the context of developing practical biodegradable Mg alloys. | Ming-Shi Song Rong-Chang Zeng Yun-Fei Ding Rachel W.Li Mark Easton Ivan Cole Nick Birbilis Xiao-Bo Chen | 2019 | Journal of Materials Science & Technology2019，35，4： | 26 |
| 4 | 移动时代的阅读 发展中国家移动阅读研究显示文摘序
几个世纪以来,文本获取渠道的限制一直是提高识字能力的障碍。阅读需要书籍,离开了书籍,扫盲依旧是遥不可及的。
不过在今天,得益于廉价移动技术的普及,这种障碍正在被克服。手机提供了一种新的、可负担的、易于使用的阅读材料获取门户。 | Mark West Han Ei Chen 沈浠琳 薛玉贞 王晨宇 李超平 | 2015 | 图书馆论坛2015，35，9： | 17 |
| 5 | Analysis of Autopilot Disengagements Occurring During Autonomous Vehicle Testing显示文摘In present-day highly-automated vehicles, there are occasions when the driving system disengages and the human driver is required to take-over. This is of great importance to a vehicle's safety and ride comfort. In the U.S state of California, the Autonomous Vehicle Testing Regulations require every manufacturer testing autonomous vehicles on public roads to submit an annual report summarizing the disengagements of the technology experienced during testing. On 1 January 2016,seven manufacturers submitted their first disengagement reports:Bosch, Delphi, Google, Nissan, Mercedes-Benz, Volkswagen, and Tesla Motors. This work analyses the data from these disengagement reports with the aim of gaining abetter understanding of the situations in which a driver is required to takeover, as this is potentially useful in improving the Society of Automotive Engineers(SAE) Level 2 and Level 3 automation technologies.Disengagement events from testing are classified into different groups based on attributes and the causes of disengagement are investigated and compared in detail. The mechanisms and time taken for take-over transition occurred in disengagements are studied. Finally, recommendations for OEMs, manufacturers, and government organizations are also discussed. | Chen Lv Dongpu Cao Yifan Zhao Daniel J. Auger Mark Sullman Huaji Wang Laura Millen Dutka Lee Skrypchuk Alexandros Mouzakitis | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，1： | 15 |
| 6 | Calcium phosphate cements for bone engineering and their biological properties显示文摘Calcium phosphate cements(CPCs) are frequently used to repair bone defects. Since their discovery in the 1980 s, extensive research has been conducted to improve their properties, and emerging evidence supports their increased application in bone tissue engineering. Much effort has been made to enhance the biological performance of CPCs, including their biocompatibility, osteoconductivity, osteoinductivity, biodegradability,bioactivity, and interactions with cells. This review article focuses on the major recent developments in CPCs,including 3 D printing, injectability, stem cell delivery, growth factor and drug delivery, and prevascularization of CPC scaffolds via co-culture and tri-culture techniques to enhance angiogenesis and osteogenesis. | Hockin HK Xu Ping Wang Lin Wang Chongyun Bao Qianming Chen Michael D Weir Laurence C Chow Liang Zhao Xuedong Zhou Mark A Reynolds | 2017 | Bone Research2017，5，4： | 14 |
| 7 | Chemical vapor deposition growth of large-scale hexagonal boron nitride with controllable orientation显示文摘有一致厚度的大域的六角形的硼氮化物(h-BN ) 的化学蒸汽免职(CVD ) 合成是很挑战性的,主要由于这材料的极其高的成核密度。此处,我们报导晶片规模的成功的生长,有大单人赛水晶的领域尺寸的高质量的 h-BN 单层电影,吗直到~ 72 ??????????????????????????慮潮档湡敮獬???????慮潮畴敢??洠獥灯牯???? ?? | Xiuju Song Junfeng Gao Yufeng Nie Teng Gao Jingyu Sun Donglin Ma Qiucheng Li Yubin Chen Chuanhong Jin Alicja Bachmatiuk Mark H. Rummeli Feng Ding Yanfeng Zhang Zhongfan Liu | 2015 | Nano Research2015，8，10： | 12 |
| 8 | Meeting 24-h movement guidelines: Prevalence, correlates, and the relationships with overweight and obesity among Chinese children and adolescents显示文摘Background:Meeting 24-h movement guidelines by children and adolescents has been associated with improved indicators of health,although it has been under-studied in China.Hence,this study aimed to investigate the prevalence of meeting the 24-h movement guidelines,its correlates,and its relationships with body mass index in children and adolescents in China.Methods:Cross-sectional data from the 2017 Youth Study in China of 114,072 children and adolescents(mean age=13.75 years,49.18%boys)were used.Meeting 24-h movement guidelines(60 min of daily moderate-to-vigorous physical activity,2 h of daily leisure screen time,911 h and 810 h nightly sleep duration for 613-year-olds and 1417-year-olds,respectively)and height and weight of all participants were assessed.The prevalence of meeting the 24-h movement guidelines and World Health Organization weight status categories were determined.Generalized linear models were used to determine the correlates of meeting the 24-h movement guidelines and the relationships of meeting the 24-h movement guidelines with overweight(OW)and obesity(OB).Results:Only 5.12%of Chinese children and adolescents met the 24-h movement guidelines,and 22.44%were classified as OW/OB.Older children and adolescents were less likely to meet the 24-h movement guidelines.Parental education level and family income were positively related to meeting the 24-h movement guidelines.Children and adolescents meeting the 24-h movement guidelines showed lower odds ratios for OW/OB.Compared with participants meeting the 24-h movement guidelines,boys in 4th6th grades met none of the recommendations(OR=1.22,95%CI:1.061.40),met the screen time recommendation only(OR=1.13,95%CI:1.011.28),met the nightly sleep duration recommendation only(OR=1.14,95%CI:1.031.28),and had significantly higher odds ratios for OW/OB.Similar trends were observed for girls in 4th6th grades:meeting none of the guidelines(OR=1.35,95%CI:1.141.59),meeting sleep duration guidelines only(OR=1.23,95%CI:1.081.39),and meeting moderate-to-vigorous physical activity+nightly sleep duration guidelines(OR=1.24,95%CI:1.011.54).For girls in 7th9th grades,the following trend was observed:meeting none of the guidelines(OR=1.30,95%CI:1.011.67).Conclusion:Very few Chinese children and adolescents met the 24-h movement guidelines.Age(negatively correlated),parental education level,and family income(both positively correlated)were correlates of meeting the 24-h movement guidelines.Children and adolescents meeting the 24-h movement guidelines were more likely to have lower risks for OW/OB,especially in the youngest age group(Grades 46);and girls in the middle age group(Grades 79)were also more likely to have lower risks for OW/OB.Further research studies should explore additional correlates and determinants for meeting the 24-h movement guidelines.Also,future studies should use longitudinal or interventional designs to determine the relationships between meeting the 24-h movement guidelines and OW/OB and other health indicators,while taking sex and age differences into account. | Si-Tong Chen Yang Liu Mark S.Tremblay Jin-Tao Hong Yan Tang Zhen-Bo Cao Jie Zhuang Zheng Zhu Xueping Wu Lijuan Wang Yujun Cai Peijie Chen | 2021 | Journal of Sport and Health Science2021，10，3： | 12 |
| 9 | Lessons in bridge damage learned from the Wenchuan earthquake显示文摘A strong earthquake occurred in Wenchuan County,Sichuan Province,China,on May 12,2008.Shortly after the earthquake,the Turner-Fairbank Highway Research Center of the Federal Highway Administration,in partnership with the Research Institute of Highways,the Ministry of Communication of China,led a reconnaissance team to conduct a post-earthquake bridge performance investigation of the transportation system in the earthquake affected areas.The U.S.transportation system reconnaissance team visited the area during July 20-24,2008.This paper presents the fi ndings and lessons learned by the team. | W. Phillip Yen Genda Chen Mark Yashinski Youssef Hashash Curtis Holu Wang Kehai GuoXiaodong | 2009 | Earthquake Engineering and Engineering Vibration2009，8，2： | 11 |
| 10 | Repression of the Arabidopsis thaliana Jasmonic Acid/Ethylene-Induced Defense Pathway by TGA-Interacting Glutaredoxins Depends on Their C-Terminal ALWL Motif显示文摘Glutaredoxins 是小热马厩 oxidoreductases 从谷胱甘肽(GSH ) 的转移电子到氧化半胱氨酸残余,从而贡献蛋白质正直和规定。在 Arabidopsis thaliana,花的 glutaredoxins ROXY1 和 ROXY2 和导致病原体的 ROXY19/GRX480 与 TGACG (TGA ) 主题绑定家庭的 bZIP 抄写因素交往。ROXY1, ROXY2,和 TGA 因素 PERIANTHIA, TGA9,和 TGA10 在花的开发起必要作用。相反,宫外地否定地表示了 ROXY19/GRX480 调整 /ethylene (et ) 导致了的 jasmonic 酸(JA ) 的表示通过要求 clade II 抄写因素 TGA2, TGA5,或 TGA6 的未知机制的防卫基因。这里,我们报导 21 中的至少 17 个打编码为 Arabidopsis 染色体的植物特定的 glutaredoxins 在一个 yeast-two-hybrid 系统与 TGA2 交往。调查他们的能力防碍 JA/ET-induced 基因的表示,我们开发了一个短暂表示系统。ORA59 (OCTADECANOID 应答的 ARABIDOPSIS AP2/ERF-domain 蛋白质 59 ) 的激活由抄写因素 EIN3 (乙烯 INSENSITVE 3 ) 的倡导者被共同表示的 ROXY19/GRX480 镇压。抑制在 ROXY19/GRX480 的 C 终点取决于 L **LL 主题。这个通常认为的蛋白质相互作用领域最近被描述为为 TGA/ROXY 相互作用是必要的。17 测试 ROXY 蛋白质中的十个压制了 ORA59 倡导者活动,它与 C 终端 ALWL 主题的存在相关,它为在花开发的 ROXY1 功能是必要的。ROXY19/GRX480-mediated 压抑取决于 GSH 有约束力的地点,建议 TGA 因素或迄今为止未知的目标蛋白质的那氧化还原作用修正为 ORA59 的抑制是重要的倡导者活动。 | Mark Zander Shuxia Chen Julia Imkampe Corinna Thurow Christiane Gatz | 2012 | Molecular Plant2012，5，4： | 11 |
| 11 | Effect of driving conditions and suspension parameters on dynamic load-sharing of longitudinal-connected air suspensions显示文摘The objective of this research was to investigate the effects of driving conditions and suspension parameters on dynamic load-sharing of longitudinal-connected air suspensions of a tri-axle semi-trailer.A novel nonlinear model of a multi-axle semi-trailer with longitudinal-connected air suspension was formulated based on fluid mechanics and thermodynamics and was validated through test results.The effects of driving conditions and suspension parameters on dynamic load-sharing and road-friendliness of the semi-trailer were analyzed.Simulation results indicate that the road-friendliness metric-DLC(dynamic load coefficient) is not always in accordance with the load-sharing metric-DLSC(dynamic load-sharing coefficient).The effect of employing larger air lines and connectors on the DLSC optimization ratio gives varying results as road roughness increases and as driving speed increases.When the vehicle load reduces,or the static pressure increases,the DLSC optimization ratio declines monotonically.The results also indicate that if the air line diameter is always assumed to be larger than the connector diameter,the influence of air line diameter on load-sharing is more significant than that of the connector. | CHEN YiKai HE Jie KING Mark CHEN WuWei ZHANG WeiHua | 2013 | Chinese Science Bulletin2013，58，7： | 10 |
| 12 | Central Asian aridification during the late Eocene to early Miocene inferred from preliminary study of shallow marine-eolian sedimentary rocks from northeastern Tajik Basin显示文摘The tempo-spatial development of the Cenozoic Asian aridification across the Eocene-Oligocene and its controlling factors are important scientific topics in Earth Sciences, which are pertinent to regional and global tectonic and climatic events. However, sedimentary rocks preserving the record of aridification during this time from central Asia(ACA) are rare. Here we present a preliminary analysis of sedimentary facies of the lower Paleogene in the northeastern Tajik Basin, which reveals that: the lower part of the studied section is dominated by shallow marine deposits of the Paratethys, the middle part is typical of alternations of eolian dune and fluvial deposits, the upper part is represented by eolian loess-sandy loess(L&SL) like facies, and the top exhibits alternations of fluvial-lacustrine and loess like facies. Based on a chronological framework derived from preliminary magnetostratigraphy, published U-Pb dating of a volcanic ash, and regional litho-stratigraphic correlations, we determine that eolian and L&SL facies accumulated in the northeastern Tajik Basin during the Late Eocene and through most of the Oligocene. These sedimentary units indicate that semi-arid to arid environments of ACA had developed at least since the late Eocene. This initial aridification is closely linked to the westward retreat of the Paratethys that was likely driven by a combination of tectonic activity and sea level changes. | WANG Xin Brian KRAATZ Jin MENG Barbara CARRAPA Peter DECELLES Mark CLEMENTZ Sherzod ABDULOV CHEN FaHu | 2016 | Science China Earth Sciences2016，59，6： | 9 |
| 13 | Measuring the resilience of an airport network显示文摘Resilience is the ability of a system to withstand and stay operational in the face of an unexpected disturbance or unpredicted changes. Recent studies on air transport system resilience focus on topology characteristics after the disturbance and measure the robustness of the network with respect to connectivity. The dynamic processes occurring at the node and link levels are often ignored. Here we analyze airport network resilience by considering both structural and dynamical aspects. We develop a simulation model to study the operational performance of the air transport system when airports operate at degraded capacity rather than completely shutting down. Our analyses show that the system deteriorates soon after disruptive events occur but returns to an acceptable level after a period of time. Static resilience of the airport network is captured by a phase transition in which a small change to airport capacity will result in a sharp change in system punctuality. After the phase transition point, decreasing airport capacity has little impact on system performance. Critical airports which have significant influence on the performance of whole system are identified, and we find that some of these cannot be detected based on the analysis of network structural indicators alone. Our work shows that air transport system’s resilience can be well understood by combining network science and operational dynamics. | Yanjun WANG Jianming ZHAN Xinhua XU Lishuai LI Ping CHEN Mark HANSEN | 2019 | Chinese Journal of Aeronautics2019，32，12： | 8 |
| 14 | INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To characterize the efficacy of the dual FXR/TGR5 receptor agonist INT-767 upon histological endpoints in a rodent model of diet-induced and biopsy-confirmed non-alcoholic steatohepatitis(NASH).METHODS The effects of INT-767 on histological features of NASH were assessed in two studies using Lep^(ob/ob)(ob/ob) NASH mice fed the AMLN diet(high fat with transfat, cholesterol and fructose). In a proof-of-conceptstudy, Lep^(ob/ob)(ob/ob) NASH mice were first dosed with INT-767(3 or 10 mg/kg for 8 wk). A second ob/ob NASH study compared INT-767(3 and 10 mg/kg) to obeticholic acid(OCA)(10 or 30 mg/kg; 16 wk). Primary histological endpoints included qualitative and quantitative assessments of NASH. Other metabolic and plasma endpoints were also assessed. A comparative assessment of INT-767 and OCA effects on drug distribution and hepatic gene expression was performed in C57 Bl/6 mice on standard chow. C57 Bl/6 mice were orally dosed with INT-767 or OCA(1-30 mg/kg) for 2 wk, and expression levels of candidate genes were assessed by RNA sequencing and tissue drug levels were measured by liquid chromatography tandem-mass spectrometry.RESULTS INT-767 dose-dependently(3 and 10 mg/kg, PO, QD, 8 wk) improved qualitative morphometric scores on steatohepatitis severity, inflammatory infiltrates and fibrosis stage. Quantitative morphometric analyses revealed that INT-767 reduced parenchymal collagen area, collagen fiber density, inflammation(assessed by Galectin-3 immunohistochemistry) and hepatocyte lipid droplet area following INT-767 treatment. In a comparative study(16 wk), the FXR agonists OCA(10 and 30 mg/kg) and INT-767(3 and 10 mg/kg) both improved NASH histopathology, with INT-767 exerting greater therapeutic potency and efficacy than OCA. Mechanistic studies suggest that both drugs accumulate similarly within the liver and ileum, however, the effects of INT-767 may be driven by enhanced hepatic, but not ileal, FXR function. CONCLUSION These findings confirm the potential utility of FXR and dual FXR/TGR5 activation as disease intervention strategies in NASH. | Jonathan D Roth Michael Feigh Sanne S Veidal Louise KD Fensholdt Kristoffer T Rigbolt Henrik H Hansen Li C Chen Mathieu Petitjean Weslyn Friley Niels Vrang Jacob Jelsing Mark Young | 2018 | World Journal of Gastroenterology2018，24，2： | 7 |
| 15 | Population-level economic burden of lung cancer in China:Provisional prevalence-based estimations,2017-2030显示文摘Objective:Population-level economic burden is essential for prioritizing healthcare resources and healthcare budget making in the future.However,little is known about the economic burden of lung cancer in China.Methods:A prevalence-based approach was adopted to estimate the economic burden of lung cancer,including direct expenditure(medical and non-medical)and indirect cost(disability and premature death).Data on direct expenditure and work-loss days per patient in each year post-diagnosis were obtained from two primary surveys.Other parameters were obtained from literatures and official reports.Projections were conducted based on varying parameters.All expenditure data were reported in United States dollars(USD)using 2017 value(exchange rate:1 USD=6.760 CNY),with the discount rate of 3%.Results:The total economic burden of lung cancer was estimated to be 25,069 million USD in China in 2017(0.121%of gross domestic productivity,GDP).The estimated direct expenditure was 11,098 million USD,up to1.43%of total healthcare expenditure for China,covering 10,303 million USD and 795 million USD for medical and non-medical expenditure,respectively.The estimated indirect cost was 13,971 million,including 1,517 million USD due to disability and 12,454 million USD due to premature death.Under current assumptions,the projected total economic burden would increase to 30.1 billion USD,40.4 billion USD,and 53.4 billion USD in 2020,2025,and 2030,accounting for 0.121%,0.131%,and 0.146%of China's GDP,respectively.However,if China meets the United Nation sustainable development goal of reducing premature death from non-communicable diseases by one-third by 2030,the total economic burden in 2030 would be 31.9 billion USD,0.087%of China's GDP.Conclusions:The economic burden of lung cancer in China in 2017 is substantial and more likely to increase significantly in the future.Policy makers need to take urgent actions in budget making for health systems.The economic burden could be alleviated by reducing the disease burden of lung cancer via effective control and prevention actions. | Chengcheng Liu Jufang Shi Hong Wang Xinxin Yan Le Wang Jiansong Ren Mark Parascandola Wanqing Chen Alin Dai | 2021 | Chinese Journal of Cancer Research2021，33，1： | 6 |
| 16 | Predicting defect behavior in B2 intermetallics by merging ab initio modeling and machine learning显示文摘We present a combination of machine learning and high throughput calculations to predict the points defects behavior in binary intermetallic(A–B)compounds,using as an example systems with the cubic B2 crystal structure(with equiatomic AB stoichiometry).To the best of our knowledge,this work is the first application of machine learning-models for point defect properties.High throughput first principles density functional calculations have been employed to compute intrinsic point defect energies in 100 B2 intermetallic compounds.The systems are classified into two groups:(i)those for which the intrinsic defects are antisites for both A and B rich compositions,and(ii)those for which vacancies are the dominant defect for either or both composition ranges.The data was analyzed by machine learning-techniques using decision tree,and full and reduced multiple additive regression tree(MART)models.Among these three schemes,a reduced MART(r-MART)model using six descriptors(formation energy,minimum and difference of electron densities at the Wigner–Seitz cell boundary,atomic radius difference,maximal atomic number and maximal electronegativity)presents the highest fit(98%)and predictive(75%)accuracy.This model is used to predict the defect behavior of other B2 compounds,and it is found that 45%of the compounds considered feature vacancies as dominant defects for either A or B rich compositions(or both).The ability to predict dominant defect types is important for the modeling of thermodynamic and kinetic properties of intermetallic compounds,and the present results illustrate how this information can be derived using modern tools combining high throughput calculations and data analytics. | Bharat Medasani Anthony Gamst Hong Ding Wei Chen Kristin A Persson Mark Asta Andrew Canning Maciej Haranczyk | 2016 | npj Computational Materials2016，，1： | 6 |
| 17 | Human adenovirus(HAdV)infection in children with acute respiratory tract infections in Guangzhou,China,2010–2021:a molecular epidemiology study显示文摘Background Human adenovirus(HAdV)infection can cause a variety of diseases.It is a major pathogen of pediatric acute respiratory tract infections(ARIs)and can be life-threatening in younger children.We described the epidemiology and subtypes shifting of HAdV among children with ARI in Guangzhou,China.Methods We conducted a retrospective study of 161,079 children diagnosed with acute respiratory illness at the Guangzhou Women and Children’s Medical Center between 2010 and 2021.HAdV specimens were detected by real-time PCR and the hexon gene was used for phylogenetic analysis.Results Before the COVID-19 outbreak in Guangzhou,the annual frequency of adenovirus infection detected during this period ranged from 3.92%to 13.58%,with an epidemic peak every four to fve years.HAdV demonstrated a clear seasonal distribution,with the lowest positivity in March and peaking during summer(July or August)every year.A signifcant increase in HAdV cases was recorded for 2018 and 2019,which coincided with a shift in the dominant HAdV subtype from HAdV-3 to HAdV-7.The latter was associated with a more severe disease compared to HAdV-3.The average mortality proportion for children infected with HAdV from 2016 to 2019 was 0.38%but increased to 20%in severe cases.After COVID-19 emerged,HAdV cases dropped to 2.68%,suggesting that non-pharmaceutical interventions probably reduced the transmission of HAdV in the community.Conclusion Our study provides the foundation for the understanding of the epidemiology of HAdV and its associated risks in children in Southern China. | Yi Chen Tao Lin Chang‑Bing Wang Wan‑Li Liang Guang‑Wan Lian Mark Zanin Sook‑San Wong Xin‑Gui Tian Jia‑Yu Zhong Ying‑Ying Zhang Jia‑Hui Xie Ling‑Ling Zheng Fei‑Yan Chen Run Dang Ming‑Qi Zhao Yi‑Yu Yang Rong Zhou Bing Zhu | 2022 | World Journal of Pediatrics2022，18，8： | 5 |
| 18 | Source apportionment of atmospheric particulate carbon in Las Vegas,Nevada,USA显示文摘研究被进行确定到在在拉斯维加斯山谷的四个城市的地点的碳的 PM2.5 的来源类型的冬贡献,在西南的美国的最快成长的城市的区域之一。24 个小时平均的周围的样品为质量,离子,元素,器官的碳(OC ) ,元素的碳(EC ) ,和踪迹被收集器官的标记分析。另外的大小被做决定日报在轻吸收的黑碳(BC ) 的模式作为为燃烧来源的一个标记。在道路上汽油车辆,在道路上柴油机车辆,和越野的柴油机引擎的碳的下午来源与他们的化学侧面,以及基于燃料的排放因素被描绘,用一个在里面羽毛采样系统。有效变化化学集体平衡(EV-CMB ) 来源分配模型被用于收集的周围的样品,用在象从另外的相关研究的侧面一样的这研究开发的来源侧面。四主要来源在拉斯维加斯山谷以内贡献了 PM2.5 碳:(1 ) 铺了道路灰尘,(2 ) 在道路上汽油车辆,(3 ) 居住木头燃烧,并且(4 ) 在道路上柴油机车辆。CMB 估计在道路上混合了舰队汽油车辆根本是为 OC 和 EC 的最大的来源这些地点。到 OC 和 EC 的铺的道路灰尘的贡献在四个地点是 510% 。在道路上柴油机车辆在城市中心附近在一个地点贡献 22% OC 和 34% EC,它被定位一条主要马路立即顺风。居住木头燃烧比为二个居住邻居地点的在道路上柴油机车辆是更重要的来源。这些结果与我们的概念的模型一致,并且研究方法论可以被用于学习另外的城市的区域。 | Mark C.Green Judith C.Chow M.-C.Oliver Chang L.-W.Antony Chen Hampden D.Kuhns Vicken R.Etyemezian John G.Watson | 2013 | Particuology2013，11，1： | 5 |
| 19 | Divalent metal transporter, iron, and Parkinson's disease: A pathological relationship显示文摘 | Hyun-pil Lee Xiongwei Zhu Gang Liu Shu G Chen George Perry Mark A Smith Hyoung-gon Lee | 2010 | Cell Research2010，20，4： | 5 |
| 20 | Reversible phosphorylation of the 26S proteasome显示文摘在 ubiquitin-proteasome 系统(不间断电源) 的中心的 26S proteasome 是必要的为几乎优核质的所有细胞的过程。一旦做,关于 proteasome 的普通误解是那,它作为静电干扰和制服留下与为蛋白质降级的自发、组成的活动复杂。当 26S proteasome 在许多 physiopathological 条件下面经历动态、可逆的 phosphorylation,最近的发现提供了引人注目的证据到这样程度支持准确反面。在这评论,我们总结历史和 proteasome phosphorylation 的当前的理解,并且倡导为几个人的临床的干预作为新策略指向 proteasome kinases/phosphatases 的想法疾病。 | Xing Guo Xiuliang Huang Mark J. Chen | 2017 | Protein & Cell2017，8，4： | 4 |
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