|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clostridium perfringens bacteremia caused by choledocholithiasis in the absence of gallbladder stones显示文摘A 67-years-old male presented with periumbilical abdominal pain, fever and jaundice. His anaerobic blood culture was positive for clostridium perfringens. Computed tomogram scan of the abdomen and abdominal ultrasound showed normal gallbladder and common bile duct (CBD). Subsequently magnetic resonance cholangiopancreaticogram showed choledocholithiasis. Endoscopic retrograde cholangiopancreaticogram-with sphincterotomy and CBD stone extraction was performed. The patient progressively improved with antibiotic therapy Choledocholithiasis should be considered as a source of clostridium perfringens bacteremia especially in the setting of elevated liver enzymes with cholestatic pattern. | Antwan Atia Tejas Raiyani Pranav Patel Robert Patton Mark Young | 2012 | World Journal of Gastroenterology2012，18，39： | 11 |
| 2 | INT-767 improves histopathological features in a dietinduced ob/ob mouse model of biopsy-confirmed nonalcoholic steatohepatitis显示文摘AIM To characterize the efficacy of the dual FXR/TGR5 receptor agonist INT-767 upon histological endpoints in a rodent model of diet-induced and biopsy-confirmed non-alcoholic steatohepatitis(NASH).METHODS The effects of INT-767 on histological features of NASH were assessed in two studies using Lep^(ob/ob)(ob/ob) NASH mice fed the AMLN diet(high fat with transfat, cholesterol and fructose). In a proof-of-conceptstudy, Lep^(ob/ob)(ob/ob) NASH mice were first dosed with INT-767(3 or 10 mg/kg for 8 wk). A second ob/ob NASH study compared INT-767(3 and 10 mg/kg) to obeticholic acid(OCA)(10 or 30 mg/kg; 16 wk). Primary histological endpoints included qualitative and quantitative assessments of NASH. Other metabolic and plasma endpoints were also assessed. A comparative assessment of INT-767 and OCA effects on drug distribution and hepatic gene expression was performed in C57 Bl/6 mice on standard chow. C57 Bl/6 mice were orally dosed with INT-767 or OCA(1-30 mg/kg) for 2 wk, and expression levels of candidate genes were assessed by RNA sequencing and tissue drug levels were measured by liquid chromatography tandem-mass spectrometry.RESULTS INT-767 dose-dependently(3 and 10 mg/kg, PO, QD, 8 wk) improved qualitative morphometric scores on steatohepatitis severity, inflammatory infiltrates and fibrosis stage. Quantitative morphometric analyses revealed that INT-767 reduced parenchymal collagen area, collagen fiber density, inflammation(assessed by Galectin-3 immunohistochemistry) and hepatocyte lipid droplet area following INT-767 treatment. In a comparative study(16 wk), the FXR agonists OCA(10 and 30 mg/kg) and INT-767(3 and 10 mg/kg) both improved NASH histopathology, with INT-767 exerting greater therapeutic potency and efficacy than OCA. Mechanistic studies suggest that both drugs accumulate similarly within the liver and ileum, however, the effects of INT-767 may be driven by enhanced hepatic, but not ileal, FXR function. CONCLUSION These findings confirm the potential utility of FXR and dual FXR/TGR5 activation as disease intervention strategies in NASH. | Jonathan D Roth Michael Feigh Sanne S Veidal Louise KD Fensholdt Kristoffer T Rigbolt Henrik H Hansen Li C Chen Mathieu Petitjean Weslyn Friley Niels Vrang Jacob Jelsing Mark Young | 2018 | World Journal of Gastroenterology2018，24，2： | 7 |
| 3 | High Prevalence of Sessile Serrated Adenomas With BRAF Mutations: A Prospective Study of Patients Undergoing Colonoscopy显示文摘 | Kevin J. Spring Zhen Zhen Zhao Rozemary Karamatic Michael D. Walsh Vicki L.J. Whitehall Tanya Pike Lisa A. Simms Joanne Young Michael James Grant W. Montgomery Mark Appleyard David Hewett Kazutomo Togashi Jeremy R. Jass Barbara A. Leggett | 2006 | Gastroenterology2006，，5： | 3 |
| 4 | 试井新技术及其应用显示文摘自1926年首次进行中途测试以来,试井技术有了长足的发展。试井的范围也从简单地在钻柱上安装封隔器和阀门发展到了一系列先进的井下和地面技术。 | Hani Aghar Mark Carie Hani Elshahawi Jaime Ricardo Gomez Jawaid Saeedi Clay Young Keith Swainson Elie Takla Bertrand Theuveny | 2008 | 国外测井技术2008，23，4： | 2 |
| 5 | A Comparison of Clinical Outcomes with Retrievable and Permanent Inferior Vena Cava Filters显示文摘 | Hyun S. Kim Mark J. Young Anand K. Narayan Kelvin Hong Robert P. Liddell Michael B. Streiff | 2008 | Journal of Vascular and Interventional Radiology2008，，3： | 2 |
| 6 | 锌缺乏症:最适当的干预措施是什么?显示文摘锌缺乏症在发展中国家很常见,有很高的死亡率在发展中国家,规律地补充锌可大大降低婴儿的发病率补锌还是一种有效治疗腹泻病的辅助方法锌缺乏症常与其他微量营养素缺乏症并存,包括铁缺乏症,因此补充一种营养素是不够的直到复合微量营养素干预治疗的试验结果显示可行之后。 | Roger Shrimpton Rainer Gross Ian Darnton-Hill Mark Young 王燕飞 | 2005 | 英国医学杂志中文版2005，8，4： | 2 |
| 7 | The vascular and biochemical effects of cilostazol in patients with peripheral arterial disease显示文摘 | Mark E. O’Donnell Stephen A. Badger Mohammed A. Sharif Ian S. Young Bernard Lee Chee V. Soong | 2009 | Journal of Vascular Surgery2009，，： | 2 |
| 8 | MRI-ultrasound fu- sion for guidance of targeted prostate biopsy显示文摘 | Marks L Young S Natarajan S | 2013 | Curr Opin Urol2013，23，： | 1 |
| 9 | Safe driving in a green world: A review of driver performance benchmarks and technologies to support ‘smart’ driving显示文摘 | MARK S YOUNG STEWART A | 2011 | Applied Ergonomics2011，，42： | 1 |
| 10 | Gelcasting of Alumina显示文摘 | YOUNG A C MATETE O O MARK A | 1991 | Journal of the American Ceramic Society1991，74，3： | 1 |
| 11 | Phase II study of thalidomide and radiation in children with newly diagnosed brain stem gliomas and glioblastoma multiforme显示文摘 | Christopher D. Turner Susan Chi Karen J. Marcus Tobey MacDonald Roger J. Packer Tina Young Poussaint Sridhar Vajapeyam Nicole Ullrich Liliana C. Goumnerova R. Michael Scott Caitlin Briody Christine Chordas Mary Ann Zimmerman Mark W. Kieran | 2007 | Journal of Neuro - Oncology2007，，1： | 1 |
| 12 | Management Accounting: A Bibliographic Study显示文摘 | James W. Hesford Sung-Han (Sam) Lee Wim A. Van der Stede S. Mark Young | 2007 | Handbooks of Management Accounting Research2007，，： | 1 |
| 13 | Marcinkeviciene mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin ( BMS-477118 ) 显示文摘 | Young B Kim Lisa M Kopcho Mark S Kirby | 2006 | Arch Biochem Biophys2006，445，： | 1 |
| 14 | Intraperitoneal hyperthermic perfusion with mitomycin C for colorectal cancer with peritoneal metastases显示文摘 | Dr. Schlomo Schneebaum MD Mark W. Arnold MD Alfred Staubus PhD Donn C. Young PhD David Dumond BS Edward W. Martin MD | 1996 | Annals of Surgical Oncology1996，，1： | 1 |
| 15 | Overview of the CALIPSO Mission and CALIOP Data Processing Algorithms显示文摘 | Winker David M Vaughan Mark A Omar Ali Hu Yongxiang Powell Kathleen A Liu Zhaoyan Hunt William H Young Stuart A | 2009 | Journal of Atmospheric and Oceanic Technology2009，，11： | 1 |
| 16 | Investigation of multipotent postnatal stem cells from human periodontal ligament显示文摘 | Byoung-Moo Seo Masako Miura Stan Gronthos Peter Mark Bartold Sara Batouli Jaime Brahim Marian Young Pamela Gehron Robey Cun Yu Wang Songtao Shi | 2004 | The Lancet2004，，9429： | 1 |
| 17 | Development of the as-cast microstructure in magnesium-aluminium alloys 显示文摘 | ARNE K D YOUNG C L MARK D N | 2001 | Journal of Light Metals2001，，1： | 1 |
| 18 | Phase I Trial of Intravesical Recombinant Adenovirus Mediated Interferon-α2b Formulated in Syn3 for Bacillus Calmette-Guérin Failures in Nonmuscle Invasive Bladder Cancer显示文摘 | Colin P.N. Dinney Mark B. Fisher Neema Navai Michael A. O’Donnell David Cutler Alice Abraham Sophia Young Beth Hutchins Maria Caceres Narendra Kishnani George Sode Constance Cullen Guangcheng Zhang H. Barton Grossman Ashish M. Kamat Marshall Gonzales Mich | 2013 | The Journal of Urology2013，，： | 1 |
| 19 | Tracheopathia osteoplastica: clinical, radiologic, and pathological correlations显示文摘 | Young R H Sandstrom R E Mark G J | 1980 | J Thorac Cardiovasc Surg1980，79，4： | 1 |
| 20 | Driving automation : Learning from aviation about design philosophies显示文摘 | MARK S YOUNG NEVILLE A STANTON DON HARRIS | 2007 | Inter- national Journal of Vehicle Design2007，45，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员