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| 1 | Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis显示文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. | Yong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and Liu F designed the study, collected and analyzed the data and wrote the manuscript Li B collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and Liu F contributed equally to this work. | 2011 | World Journal of Gastroenterology2011，17，34： | 3 |
| 2 | A preliminary validation of the Brief COPE instrument for assessing coping strategies among people living with HIV in China显示文摘Background:The Brief COPE instrument has been utilized to conduct research on various populations,including people living with HIV(PLWH).However,the questionnaire constructs when applied to PLWH have not been subjected to thorough factor validation.Methods:A total of 258 PLWH were recruited from two provinces of China.They answered questions involving the scales of three instruments:the Brief COPE,the Perceived Social Support Scale,and the Perceived Discrimination Scale for PLWH.Confirmatory factor analysis(CFA)and exploratory factor analysis(EFA)were conducted.Results:The CFA found a poor goodness of fit to the data.The subsequent EFA identified six preliminary factors,forming subscales with Cronbach’s alphas,which ranged from 0.61 to 0.80.Significant correlation coefficients between the subscales and measures of perceived social support and perceived discrimination were reported,giving preliminary support to the validity of the new empirical factor structure.Conclusion:This study showed that the original factor structure of the Brief COPE instrument,when applied to PLWH in China,did not fit the data.Thus,the Brief COPE should be applied to various populations and cultures with caution.The new factor structure established by the EFA is only preliminary and requires further validation. | Xiao-you Su Joseph TF Lau Winnie WS Mak KC Choi Tie-jian Feng Xi Chen Chu-liang Liu Jun Liu De Liu Lin Chen Jun-min Song Yan Zhang Guang-lu Zhao Zhang-ping Zhu Jin-quan Cheng | 2015 | Infectious Diseases of Poverty2015，4，1： | 2 |
| 3 | Sexual knowledge, attitudes and activity of older people in Taipei, Taiwa 显示文摘 | Wang TF Lu CH Chen IJ | 2008 | Journal of Clinical Nursing2008，17，： | 1 |
| 4 | Effect of ginkgolides on beta-amyloid-suppressed acetylocholine release from rat hippocampal slices显示文摘 | Lee TF Chen CF Wang LC | 2004 | Phytother Res2004，18，7： | 1 |
| 5 | TGF-beta signaling in ehondrocytes显示文摘 | Li TF O'Keefe RJ Chen D | 2005 | Front Biosei2005，10，： | 1 |
| 6 | Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling显示文摘 | Tang DZ Hou W Zhou Q Zhang M Holz J Sheu TJ Li TF Cheng SD Shi Q Harris SE Chen D Wang YJ | 2010 | J Bone Miner Res2010，25，6： | 1 |
| 7 | Decreased plasma visfatin concentrations in women with gestational diabetes mellitus显示文摘 | Chan TF Chen YL Lee CH | 2006 | Soc Gynecol Investig2006，13，： | 1 |
| 8 | Effect of ginkgolides on beta-amyloid-suppressed acetylocholine release from rat hippocampal slices显示文摘 | Lee TF Chen CF Wang LC | 2004 | Phytother Res2004，18，： | 1 |
| 9 | The selectin:vascular adhesion molecules显示文摘 | Tedder TF Steeber DA Chen A | 1995 | FASEB J1995，9，4： | 1 |
| 10 | Hypoxia inhibits osteogenesis in human mesenchymal stem cells through direct regulation of RUNX2 by TWIST显示文摘 | Yang DC Yang MH Tsai CC Huang TF Chen YH Hung SC | | 0，，： | 1 |
| 11 | Connective tissue growth factor inhibits metastasis and acts as independent progrostie marker in colorectal cancer 显示文摘 | Lin BR Chang CC Chen TF | 2005 | Gperbal Bastrenterology2005，128，： | 1 |
| 12 | Use of evidence-based therapy for the prevention of cardiovascular events among older people显示文摘 | Castelino RL Chen TF Guddattu V | | 0，，03： | 1 |
| 13 | Suppression of endotoxin-induced proinflammatory responses by citrus pectin through blocking LPS signaling pathways显示文摘 | Chen CH Sheu MT Chen TF | 2006 | Biochemical Pharmacology2006，72，8： | 1 |
| 14 | Correlations between umbilical and maternal serum adiponectin levels and neonatal birthweights显示文摘 | Chan TF Yuan SS Chen HS | 2004 | Acta Obstet Gynecol Scan2004，83，2： | 1 |
| 15 | TGF-β signaling in chondrocytes显示文摘 | Li TF O' Keefe RJ Chen D | 2005 | Front Biosci2005，10，： | 1 |
| 16 | N -acetylcysteineimproves hemodynamics and reduces oxidative stress inthe brains of newborn piglets with hypoxia-reoxygena-tion injury 显示文摘 | Liu JQ Lee TF Chen C | 2010 | Journal of Neurotrauma2010，27，10： | 1 |
| 17 | Investigation of nontypeable Haemophilus influenzae outer membrane protein P6 as a new carrier for lipooligosaccharide conjugate vaccines显示文摘 | Wu T Chen J Murphy TF | 2005 | Vaccine2005，23，44： | 1 |
| 18 | Cognitive function in children with type 1 diabetes: a meta-analysis显示文摘 | Gaudieri PA Chen R Greer TF | 2008 | Diabetes Care2008，31，： | 1 |
| 19 | Aberrant serum adiponectin levels in women with uterine leiomyomas显示文摘 | Chen H$ Ohan TF Chung YF et aI | 2004 | Gynecol Obstet Invest2004，56，3： | 1 |
| 20 | CHRNA7 Polymorphisms and Response to Cholinesterase Inhibitors in Alzheimer's Disease显示文摘 | Weng PH Chen JH Chen TF | 2013 | PloS One2013，8，84： | 1 |
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