维普期刊资源整合服务平台（V6.5）

37篇 您的检索式：作者名="Cheng ED"

选中清除导出查看参考文献查看引证文献引用追踪共2页首页上一页第1页下一页末页 /2 跳转

	题名	作者	年代	出处	被引量
1	Extracellular histones stimulate collagen expression in vitro and promote liver fibrogenesis in a mouse model via the TLR4-MyD88 signaling pathway显示文摘BACKGROUND Liver fibrosis progressing to liver cirrhosis and hepatic carcinoma is very common and causes more than one million deaths annually.Fibrosis develops from recurrent liver injury but the molecular mechanisms are not fully understood.Recently,the TLR4-MyD88 signaling pathway has been reported to contribute to fibrosis.Extracellular histones are ligands of TLR4 but their roles in liver fibrosis have not been investigated.AIM To investigate the roles and potential mechanisms of extracellular histones in liver fibrosis.METHODS In vitro,LX2 human hepatic stellate cells(HSCs)were treated with histones in the presence or absence of non-anticoagulant heparin(NAHP)for neutralizing histones or TLR4-blocking antibody.The resultant cellular expression of collagen I was detected using western blotting and immunofluorescent staining.In vivo,the CCl4-induced liver fibrosis model was generated in male 6-week-old ICR mice and in TLR4 or MyD88 knockout and parental mice.Circulating histones were detected and the effect of NAHP was evaluated.RESULTS Extracellular histones strongly stimulated LX2 cells to produce collagen I.Histone-enhanced collagen expression was significantly reduced by NAHP and TLR4-blocking antibody.In CCl4-treated wild type mice,circulating histones were dramatically increased and maintained high levels during the duration of fibrosisinduction.Injection of NAHP not only reduced alanine aminotransferase and liver injury scores,but also significantly reduced fibrogenesis.Since the TLR4-blocking antibody reduced histone-enhanced collagen I production in HSC,the CCl4 model with TLR4 and MyD88 knockout mice was used to demonstrate the roles of the TLR4-MyD88 signaling pathway in CCl4-induced liver fibrosis.The levels of liver fibrosis were indeed significantly reduced in knockout mice compared to wild type parental mice.CONCLUSION Extracellular histones potentially enhance fibrogenesis via the TLR4–MyD88 signaling pathway and NAHP has therapeutic potential by detoxifying extracellular histones.	Zhi Wang Zhen-Xing Cheng Simon T Abrams Zi-Qi Lin ED Yates Qian Yu Wei-Ping Yu Ping-Sheng Chen Cheng-Hock Toh Guo-Zheng Wang	2020	World Journal of Gastroenterology2020，26，47：	3
2	Surgical Treatment of Hepatocellular Carcinoma with Portal Vein Tumor Thrombus显示文摘	Jie Shi MD Eric C. H. Lai MBChB MRCS(Ed) FRACS Nan Li MD Wei-Xing Guo MD Jie Xue MD Wan Yee Lau MD FRCS FACS FRACS(Hon) Meng-Chao Wu MD Shu-Qun Cheng MD	2010	Annals of Surgical Oncology2010，，8：	2
3	A Comparative Study of Antiviral Therapy After Resection of Hepatocellular Carcinoma in the Immune-Active Phase of Hepatitis B Virus Infection显示文摘	Nan Li MD Eric C. H. Lai MBChB MRCS(Ed) FRACS Jie Shi MD Wei-Xing Guo MD Jie Xue MD Bing Huang MD Wan-Yee Lau MD FRCS FACS FRACS(Hon) Meng-Chao Wu MD Shu-Qun Cheng MD	2010	Annals of Surgical Oncology2010，，1：	2
4	Review of docetaxel in the treatment of gastric cancer显示文摘	Tetzlaff ED Cheng JD Ajani JA	2008	Ther Clin Risk Manag2008，4，5：	1
5	Reducing endogenous tau ameliorates amyloid beta-in- duced deficits in an Alzheimer' s disease mouse model显示文摘	Roberson ED Scearce-Levie K Palop JJ Yan F Cheng IH Wu T	2007	Sc/- ence2007，316，5825：	1
6	Spontaneous resolution of osteonecrosis of the femoral head显示文摘	Cheng ED Ward Y Thongtrangan	2004	J Bone Joint Surg Am2004，86，：	1
7	The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex 显示文摘	Cheng KY Lowe ED Sinclair J	2003	EMBO J2003，22，21：	1
8	Morphology and reactivity characteristics of char biomass particles显示文摘	Claudio Avila Cheng Heng Pang Tao Wu Ed Lester	2011	Bioresource Technology2011，，8：	1
9	Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective显示文摘	Cheng T Liu D Griffin JH Fernandez JA Castellino F Rosen ED	2003	Nat Med2003，9，：	1
10	Cholesterol-lowering therapy may retard the progression of diabetic nephropathy 显示文摘	LAM KS CHENG IK JANUS ED	1995	Diabetologia1995，38，5：	1
11	Reducing endogenous tau ameliorates amyloid beta-in- duced deficits in an Alzheimer' s disease mouse model显示文摘	Robemon ED Scearce-Levie K Palop JJ Yan F Cheng IH Wu T	2007	Sci- ence2007，316，5825：	1
12	Ultrasound score to select subcentimeter-sized thyroid nodules requiring ultrasound guided fine needle aspiration biopsy in eastern China显示文摘	Cheng P Chen ED Zheng HM	2013	Asian Pac J Cancer Prev2013，14，：	1
13	Processability Improvement of Polyolefins Through Radiation-induced Branching 显示文摘	Song Cheng Ed Phillips Lewis Parks	2010	Radiation Physics and Chemistry2010，79，3：	1
14	Review of docetatxel in the treament of gastic cancer显示文摘	Tetzlaff ED Cheng JD Ajani JA	2008	Ther Clin Risk Manag2008，4，5：	1
15	Specificity determinants of recruitment peptides bound to phospho-CDK2/Cyclin A显示文摘	Lowe ED Tews I Cheng KY Brown NR Gul S Noble ME Gamblin SJ Johnson LN	2002	Biochemistry2002，41，15：	1
16	A Comparative Study of Antiviral Therapy After Resection of Hepatocellular Carcinoma in the Immune-Active Phase of Hepatitis B Virus Infection显示文摘	Nan Li MD Eric C. H. Lai MBChB MRCS(Ed) FRACS Jie Shi MD Wei-Xing Guo MD Jie Xue MD Bing Huang MD Wan-Yee Lau MD FRCS FACS FRACS(Hon) Meng-Chao Wu MD Shu-Qun Cheng MD	2010	Annals of Surgical Oncology2010，，1：	1
17	Ultrasound score to select subcentimeter-sized thyroid nodules requiring ultrasound-guided fine needle aspiration biopsy in eastern China显示文摘	Cheng P Chen ED Zheng HM	2013	Asian Pac J Cancer Prev2013，14，8：	1
18	Review of docetaxel in the treatment of gastric cancer 显示文摘	Tetzlaff ED Cheng JD Ajani JA	2008	Ther Clin Risk Man- ag2008，4，5：	1
19	Papillary thyroid microcar- cinoma with synchronous asymptomatic advanced esophageal squa- mous cell carcinoma: a case report and review of the literature 显示文摘	Cheng P Xiang YY Chen ED	2015	Oneol Lett2015，9，2：	1
20	Cholesterol-lowering therapy may retard the progression of diabetic nephropa thy显示文摘	Cheng IKP Janus ED	1995	Diabetologia1995，38，：	1

返回顶部每页显示：

共2页首页上一页第1页下一页末页 /2 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示