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| 1 | Humanized mice are susceptible to Salmonella typhi infection显示文摘Salmonella enterica serovar Typhi is a pathogen that only infects humans.Currently,there is no animal model for studying this pathogen.Recently,alymphoid RAG2^(-/-)/γc^(-/-) mice engrafted with human leukocytes,known as humanized mice,have been successfully utilized to develop experimental models for several human-specific viral infections,including HIV,human-like dengue fever and hepatitis C virus.Little is known about the usefulness and feasibility of the humanized mouse model for the study of human-specific bacterial pathogens,such as S.typhi.The aim of this study was to determine if Salmonella enterica serovar Typhi could establish productive infection in humanized mice.Here we report that intravenous inoculation of S.typhi into humanized mice,but not controls,established S.typhi infections.High bacterial loads were found in the liver,spleen,blood and bone marrow of mice reconstituted with human leukocytes,but not in the unreconstituted control mice.Importantly,S.typhi-infected humanized mice lost significant body weight,and some of the infected mice displayed neurological symptoms.Our data suggest,for the first time,that humanized mice are susceptible to S.typhi challenge and that this model can be utilized to study the pathogenesis of S.typhito develop novel therapeutic strategies. | M Firoz Mian Elisabeth A Pek Meghan J Chenoweth Ali A Ashkar | 2011 | Cellular & Molecular Immunology2011，8，1： | 2 |
| 2 | Assessing freshwater use in LCA:Part I-inventory modelling and characterization factors for the main impact pathways显示文摘 | MLACANALS L CHENOWETH A CHAPAGAIN S | 2008 | International Journal of Life Cycle Assessment2008，14，： | 1 |
| 3 | Self-management and symptom monitoring among older adults with chronic obstructive pulmonary disease显示文摘 | Warwick M Gallagher R Chenoweth L | 2010 | Journal of Advanced Nursing2010，66，4： | 1 |
| 4 | Rethinking the economic contribution of tourism: case study from a Mediterranean Island显示文摘 | HADJIKAKOU M CHENOWETH J MILLER G | 2014 | Journal of Travel Research2014，53，： | 1 |
| 5 | Multiple independent emer- gences of type 2 vaccine-derived polioviruses during a large outbreak in northern Nigeria显示文摘 | Burns C C Shaw J Jorba J Bukbuk D Adu F Gumede N Pate M A Abanida E A Gasasira A Iber J Chen Q Vincent A Chenoweth P Henderson E Wannemuehler K Naeem A Umarni R N Nishimura Y Shimizu H Baba M Adeniji A Williams A J Kil- patrick D R Oberste M S Wassilak S G Tomori O Pallansch M A Kew O | 2013 | J Virol2013，87，9： | 1 |
| 6 | Self-management and symptom monitoring among older adults with ehronic obstructive pulmonary disease 显示文摘 | Warwick M Gallagher R Chenoweth L | 2010 | J Adv Nurs2010，66，4： | 1 |
| 7 | Effects of inspiratory muscle training on exercise responses in norrnoxia and hypoxia显示文摘 | Downey A E Chenoweth L M Townsend D K | 2007 | Respir Physiol Nettrobiol2007，156，2： | 1 |
| 8 | Achromobacte xylosoxidans bacteremia:report of four cases and review of the literature显示文摘 | Duggan J M Goldstein S J Chenoweth C E | 1996 | Clink Infect Dis1996，23，3： | 1 |
| 9 | Final report of the HTRI/ TEMA joint committee to review the fouling section of the TEMA Standards 显示文摘 | JAMES M CHENOWETH | 1990 | Heat Transfer Engineering1990，11，1： | 1 |
| 10 | Natural Selection and the Reinforcement of Mate Recognition显示文摘 | Higgie M Chenoweth SF Blow MW | 2000 | Science2000，290，： | 1 |
| 11 | The karst lands of Trinidad and Tobago, their land use and conservation 显示文摘 | Michael J Day M Sean Chenoweth | 2004 | The Geographical Journal2004，170，3： | 1 |
| 12 | Self-man- agement and symptom monitoring among older adults with chronic obstructive pulmonary disease显示文摘 | Warwick M Gallagher R Chenoweth L | 2010 | J Adv Nurs2010，66，4： | 1 |
| 13 | Natural selection and the reinforcement of mate recognition 显示文摘 | Higgie M Chenoweth S Blow MW | 2000 | Science2000，290，5491： | 1 |
| 14 | Self-management and symptom monitoring among older adults with chronic obstructive pulmonary disease显示文摘 | Warwick M Gallagher R Chenoweth L | 2010 | Journal of Advanced Nursing2010，66，4： | 1 |
| 15 | As- sessment of estrus detection by visual observation and elec- tronic detection methods and characterization of factors asso- ciated with estrus and pregnancy in beef heifers 显示文摘 | RAE D O CHENOWETH P J GIANGRECO M A | 1999 | Theri- ogenology1999，51，6： | 1 |
| 16 | The karstlands of Trinidad and Tobago,their land use and conservation显示文摘 | MICHAEL J CHENOWETH M | 2004 | The Geographical Journal2004，170，3： | 1 |
| 17 | Influence of seminal plasma and processing on cold-stored stallion spermatozoa 显示文摘 | Todd P Arns M J Chenoweth P et ol | 2001 | Anim Reprod Sci2001，68，： | 1 |
| 18 | Self-management and symptom monitoring among older adults with chronic obstructive pulmonary disease显示文摘 | Warwick M Gallagher R Chenoweth L | 2010 | J Adv Nurs2010，66，4： | 1 |
| 19 | Influence of seminal plasma and processing on cold-stored stallion spermatozoa 显示文摘 | Todd P Ams M J Chenoweth P et d | 2001 | Anim Reprod Sci2001，68，： | 1 |
| 20 | Metabolism of t rimet hylamines in kelp bass and marine and freshwater pink salmon显示文摘 | Charest RP Chenoweth M Duna A | 1988 | J Comp Physiol1988，158，5： | 1 |
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