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| 1 | Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice显示文摘 | Chiamulera C Epping-Jordan MP Zocchi A | | 0，，09： | 1 |
| 2 | Reinforcing and locomotor stimulant effects of cocaine are absent in m GluR5 null mutant mice显示文摘 | Chiamulera C Epping-Jordan MP Zocchi A Marcon C Cottiny C Tacconi S | 2001 | Nat Neurosci2001，4，9： | 1 |
| 3 | Post-retrieval extinction as recon- solidation interference: methodological issues or boundary conditions'? 显示文摘 | Auber A Tedesco V Jones CE Monfils MH Chiamulera C | 2013 | Psychopharmacology (Bed)2013，226，4： | 1 |
| 4 | Expression ofsmall-conductance calcium-activated Potassium channels(SK3)in skeletal muscle:regulation by muscle activity显示文摘 | Favero M Jiang DJ Chiamulera C | 2008 | J Physiol2008，586，19： | 1 |
| 5 | Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice显示文摘 | Chiamulera C Epping- Jordan MP Zocchi A | 2001 | NatureNeurosci2001，4，： | 1 |
| 6 | Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice显示文摘 | Chiamulera C Epping - Jordan MP Zocchi A | 2001 | Nat Neurosci2001，4，9： | 1 |
| 7 | 神经对大鼠骨骼肌小电导钙激活钾通道(SK3)表达的影响显示文摘目的小电导钙激活的钾通道(SK3)介导了动作电位后的后超极化电位的产生,在调节可兴奋细胞的膜电位中起关键作用。使去神经支配和肌强直营养不良患者骨骼肌SK3表达显著上调。本实验拟观察神经对骨骼肌SK3钾通道表达的调节作用。方法在Wistar大鼠,分别通过切断坐骨神经和局部注射河豚毒素(TTX)建立比目鱼肌去神经支配模型,和通过钳夹损伤比目鱼肌神经建立比目鱼肌去神经后神经再支配模型。在体给予去神经比目鱼肌频率为30Hz的电刺激(100脉冲/100 s)。实验结束后,免疫荧光法测定比目鱼肌中SK3钾通道的表达和定位;提取比目鱼肌组织总mRNA和蛋白,逆转录PCR和Western Blot分别检测SK3 mRNA和蛋白水平。结果切断坐骨神经能显著上调比目鱼肌SK3 mRNA和蛋白表达,且分别在术后第6 d和第9 d到达稳定。TTX诱导肌肉瘫痪也能显著上调比目鱼肌SK3 mRNA和蛋白表达。钳夹比目鱼肌神经所造成的暂时神经损伤能诱导SK3蛋白表达上调,而随着神经功能的恢复SK3蛋白表达也随之显著下调。在切断除坐骨神经术后6 d,在体给予电刺激6 d能显著下调比目鱼肌SK3的高表达;而且,在去除坐骨神经的同时给予电刺激则能阻止比目鱼肌SK3表达的上调。结论神经对骨骼肌SK3钾通道表达具有抑制作用,其作用与唤起肌肉活性密切相关。在体电刺激能抑制和防止去神经诱导的骨骼肌SK3蛋白表达上调,可能是改善神经损伤后或相关疾病所致的肌强直症状的有效手段之一。 | 姜德建 Morgana Favero Christian Chiamulera Alberto Cangiano Guido Francesco Fumagalli | 2007 | 中南药学2007，5，1： | 0 |
| 8 | The effects of oral smokeless tobacco administration on endurance performance显示文摘Background: Smokeless tobacco is widely used by athletes to enhance performance. Nicotine is a central nervous system stimulant and acts on cardiocirculatory and metabolic systems, involving tissue blood flow and circulatory vasoreactivity. The aim of this study was to investigate the effects of the oral smokeless tobacco(Swedish snus(SS)) on the perception of fatigue and time to exhaustion(TTE) during moderate-intensity aerobic exercise.Methods: Fourteen healthy non-tobacco male users were recruited for a double-blind, controlled crossover design(SS vs. snus placebo(SP)).Subjects were tested for 3 sessions: experimental session 1(Exp1) consisted of an incremental test to determine the maximal aerobic power output(Wmax), whereas Exp2 and Exp3 consisted of exercising at 65%Wmaxuntil exhaustion in SS or SP conditions. During Exp2 and Exp3, muscle and cerebral oxygenation was assessed by means of near-infrared spectroscopy, and the rating of perceived exertion(RPE) was recorded.Results: Comparing SS with SP tests, significant differences(p < 0.05) were found in the values of cerebral(~3%) and muscular tissues oxygenation(~4%) in the first 30 min of exercise. The RPE values were not significantly different between the 2 conditions(SS vs. SP). No significant difference was found in TTE(SS: 54.25 § 21.84 min; SP: 50.01 § 17.03 min).Conclusion: This study showed that muscular and cerebral oxygenation increased significantly with snus administration during an endurance exercise until exhaustion, but this did not affect fatigue perception and TTE. The results showed that snus could not be considered an ergogenic substance in non-tobacco users. | thomas zandonai enrico tam paolo bruseghini fabio pizzolato loretta franceschi massimo baraldo carlo capelli paola cesari cristiano chiamulera | 2018 | Journal of Sport and Health Science2018，7，4： | 0 |
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