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| 1 | Histotype-based prognostic classification of gastric cancer显示文摘AIM:To test the efficiency of a recently proposed histotype-based grading system in a consecutive series of gastric cancers.METHODS:Two hundred advanced gastric cancers operated upon in 1980-1987 and followed for a median 159 mo were investigated on hematoxylin-eosinstained sections to identify low-grade [muconodular,well differentiated tubular,diffuse desmoplastic and high lymphoid response (HLR)],high-grade (anaplastic and mucinous invasive) and intermediate-grade (ordinary cohesive,diffuse and mucinous) cancers,in parallel with a previously investigated series of 292 cases.In addition,immunohistochemical analyses for CD8,CD11 and HLA-DR antigens,pancytokeratin and podoplanin,as well as immunohistochemical and molecular tests for microsatellite DNA instability and in situ hybridization for the Epstein-Barr virus (EBV) EBER1 gene were performed.Patient survival was assessed with death rates per 100 person-years and with Kaplan-Meier or Cox model estimates.RESULTS:Collectively,the four low-grade histotypes accounted for 22% and the two high-grade histotypes for 7% of the consecutive cancers investigated,while the remaining 71% of cases were intermediate-grade cancers,with highly significant,stage-independent,survival differences among the three tumor grades (P=0.004 for grade 1 vs 2 and P=0.0019 for grade 2 vs grade 3),thus confirming the results in the original series.A combined analysis of 492 cases showed an improved prognostic value of histotype-based grading compared with the Lauren classification.In addition,it allowed better characterization of rare histotypes,particularly the three subsets of prognostically different mucinous neoplasms,of which 10 ordinary mucinous cancers showed stage-inclusive survival worse than that of 20 muconodular (P=0.037) and better than that of 21 high-grade (P<0.001) cases.Tumors with high-level microsatellite DNA instability (MSI-H) or EBV infection,together with a third subset negative for both conditions,formed the T8 cell-rich HLR group,the largest group among low-grade histotypes.Coexisting HLR proved to be a factor in improved prognosis in tumors with microsatellite instability (P=0.0015 vs HLR-/MSI-H tumors) or DR type human leukocyte antigen expression (P=0.033 vs HLR/HLA-DR+ tumors).CONCLUSION:Identification of lowand high-grade histotypes can improve the prognostic assessment of a substantial proportion of gastric cancers in routine diagnostic practice. | Anna Maria Chiaravalli Catherine Klersy Alessandro Vanoli Andrea Ferretti Carlo Capella Enrico Solcia | 2012 | World Journal of Gastroenterology2012，18，9： | 3 |
| 2 | Gastrointestimd stromal tumors frequency, malignancy, and new prognostic factors : the experi- ence of a single institution 显示文摘 | Bertolini V Chiaravalli AM Klersy C | 2008 | Pathol Res Pract2008，204，4： | 1 |
| 3 | Inhibition of NF-kap- pa B activation by peptides targeting NF-kappa B essential modulator(nemo) oligomerization显示文摘 | Agou F Courtois G Chiaravalli J | 2004 | J Biol Chem2004，279，54： | 1 |
| 4 | Immunohistochemical pattern of hMSH2/hMLH1 in familial and sporadic colorectal ,gastric,endometrial and ovarian carcinomas with instability in micro~tellite sequences显示文摘 | Chiaravalli AM Furlan D Facco C | 2001 | Virchows Arch2001，438，： | 1 |
| 5 | Gastrointestinalstromal tumors-frequency,malignancy,and new prognosticfactors:the experience of a single institution显示文摘 | Bertolini V Chiaravalli AM Klersy C | 2008 | Pathol ResPract2008，204，4： | 1 |
| 6 | Immunohistochemical pattern of hMSH2/hMLH1 in familial and sporadic colorectal, gastric, endometrial and ovarian carcinomas with instability in microsatellite sequences显示文摘 | Chiaravalli Furlan Facco | 2001 | Virchows - Arch2001，438，1： | 1 |
| 7 | Gastrointestinal stromal tumors-frequency, malignancy, and new prognostic fac- tors: the experience of a single institution 显示文摘 | Bertolini V Chiaravalli AM Klersy C | 2008 | Pathol Res Pratt2008，204，4： | 1 |
| 8 | Immunohistochemical pattern of hMLHI/hMSH2 in familial and sporadic colorectal,gastric,endometrial and ovarian carcinomas with instability in microsatellite sequences显示文摘 | Chiaravalli AM Furlan D Facco C | 2001 | Virchows Arch2001，438，1： | 1 |
| 9 | Immunohistochemical pattern of hMSH2/hMLH1 in familial and sporadic colorectal, gastric, endometrial and ovarian carcinomas with instability in microsatellite sequences显示文摘 | Chiaravalli AM Furlan D Facco C | 2001 | Virchows Arch2001，438，1： | 1 |
| 10 | Gastrointestinal mesenchymal tumors-immunophenotypic classification and survival analysis显示文摘 | Rudolph P Chiaravalli AM Pauser U | 2002 | Virchows Arch2002，441，3： | 1 |
| 11 | Gastrointestinal stromal tumors - frequency, malignancy, and new prognostic factors : The experience of a single institution 显示文摘 | Bertolini V Chiaravalli AM Klersy C | 2008 | Pathol Res Pract2008，204，4： | 1 |
| 12 | Intratumour T cells, their activation status and survival in gastric carcinomas characterised for microsatellite instability and Epstein - Barr virus infection 显示文摘 | Chiaravalli AM Feltri M Bertolini V | 2006 | Virchows Arch2006，448，3： | 1 |
| 13 | Immunohistochemical pattern of h MSH2/h MLH1 in familial and sporadic colorectal,gastric,endometrial and ovarian carcinomas with instability in microsatellite sequences显示文摘 | Chiaravalli A M Furlan D Facco C | 2001 | Virchows Arch2001，438，： | 1 |
| 14 | Gastrointestinalstromal tumors-frequency,malignancy,and new prognosticfactors:the experience of a single institution显示文摘 | Bertolini V Chiaravalli AM Klersy C | 2008 | Pathol ResPract2008，204，4： | 1 |
| 15 | Polycystin-1 Binds Par3/aPKC and Controls Convergent Extension Daring Renal Tubular Morphogenesis显示文摘 | Castelli M Boca M Chiaravalli M | 2013 | Nat Commun2013，4，： | 1 |
| 16 | Gastrointestinal stromaltumors-frequency, malignancy,and new prognostic factors : the expe-rience of a single institution显示文摘 | Bertolini V Chiaravalli AM Klersy C | 2008 | Pathol Res Pract2008，204，4： | 1 |
| 17 | Gastrointestinal stroreal tumors-fiequency, malignancy,and new prognostie factors: The experience of a sinsle institution 显示文摘 | Bertolini V Chiaravalli AM Klersy C | 2008 | Pathol Res Pract2008，204，4： | 1 |
| 18 | Gastroin-testinal stromal tumors-frequency,malignancy,and new prognostic factors:the experience of a single institution显示文摘 | Bertolini V Chiaravalli AM Klemy C | 2008 | Pathol Res Pract2008，204，4： | 1 |
| 19 | Gastrointestinal mesenchymal turmors-immunophenotypic classification and survival analysis显示文摘 | Rudolph P Chiaravalli AM Pauser U | 2002 | Virchows Arch2002，441，3： | 1 |
| 20 | Gastrointestinal stromal tumors-frequency, malignancy, and new prognostic factors: the experience of a single institutian显示文摘 | BERTOLINI V CHIARAVALLI AM KLERSY C | 2008 | Palhol Res Pract2008，204，4： | 1 |
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