|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Anticancer activity of Mahonia leschenaultii methanolic root extract and berberine on Dalton’s ascitic lymphoma in mice显示文摘Objective: To evaluate the effects of methanol root extract of Mahonia leschenaultii and berberine of Mahonia leschenaultii on Dalton’s ascitic lymphoma in Swiss Albino mice. Methods: The methanol root extracts of Mahonia leschenaultii(200 and 400 mg/kg) were given orally, and berberines(10 and 20 mg/kg) were injected intra-peritoneally for 14 successive days in tumor bearing mice. Hematological parameters(white and red blood cells, haemoglobin level, granulocytes, and agranulocytes), lipid parameters(total cholesterol and triglycerides), serum enzymes(serum glutamate pyruvate transaminases, serum glutamate oxaloacetate transaminases, and alkaline phosphatise) and mean survival and solid tumor growth were determined and compared with untreated mice. 5-fluorouracil(20 mg/kg) was used as a reference standard drug. Results: Mahonia leschenaultii and berberine reduced the hematocrit significantly. Furthermore, Mahonia leschenaultii and berberine improved the survival of mice significantly and restored the affected hematological and lipid parameters similar to the normal levels. Conclusions: These observations show a strong anticancer effect of methanol root extract of Mahonia leschenaultii and berberine in suppressing Dalton’s ascitic lymphoma cancer cell growth in a mouse model by controlling haematological, lipid, serum enzymes, and other derived parameters effectively. | R Latha TM Chozhavel Rajanathan Ameer Khusro N Chidambaranathan Paul Agastian Sankaranarayanan Nagarajan | 2019 | Asian Pacific Journal of Tropical Medicine2019，12，6： | 1 |
| 2 | Per- sistent trigeminal artery: A rare cause o{ trigeminal neuralgia - MR imaging 显示文摘 | Chidambaranathan N Ahmed-Sayeed Z Sunder K | 2006 | Neuroimage2006，54，2： | 1 |
| 3 | Value of dynamic MRI imaging in pituitary adenomas显示文摘 | Indrajit IK Chidambaranathan N Sundar K | 2001 | Neuroradiology2001，11，4： | 1 |
| 4 | Value of dynamic MRI imaging in pituitary adenomas显示文摘 | Indrajit IK Chidambaranathan N Sundar K | 2001 | Neuroradiology2001，11，： | 1 |
| 5 | Value of dy namic MRI imaging in pituitary adenomas显示文摘 | Indrajit IK Chidambaranathan N Sundar K | 2001 | Neuroradiol2001，11，1： | 1 |
| 6 | Persistent tri- geminal artery: a rare cause of trigeminal neuralgia-MR imaging 显示文摘 | Chidambaranathan N Sayeed ZA Sunder K | 2006 | Neurol India2006，54，2： | 1 |
| 7 | Persistent trigeminal artery:A rare cause of trigeminal neuralgia-MR imaging显示文摘 | Chidambaranathan N Ahmed-Sayeed Z Sunder K | 2006 | Neuroimage2006，54，： | 1 |
| 8 | Persistent trigeminal artery:a rare cause of trigeminal neuralgia-MR imaging显示文摘 | Chidambaranathan N Sayeed Z A Sunder K | | 0，，02： | 1 |
| 9 | Persistent trigeminal artery: A rare cause of trigeminaI neuralgia MR imaging显示文摘 | Chidambaranathan N Sayeed ZA Sunder K | 2006 | Neuroimage2006，54，2： | 1 |
| 10 | Identification, quantification and agerelated changes of human trabecular meshwork stem cells显示文摘Background:Loss of cells in the human trabecular meshwork(TM)has been reported with ageing and in glaucoma.This study aims to identify,quantify and determine the age-related changes of human TM stem cells(TMSCs).Methods:Isolation of TM cells/paraffin sectioning was carried out using human corneoscleral rings and whole globes.The TM cells/sections were immunostained for the stem cell markers ATP-binding cassette protein G2(ABCG2),nerve growth factor receptor p75 and AnkyrinG(AnkG).Images were acquired using Leica SP8 confocal microscope.The isolated cells were analyzed for two parameters-ABCG2 expression and nucleus to cytoplasmic ratio(N/C ratio).The total number of TM cells and those positive for ABCG2 and p75 in each section were quantified.Spearman rank order correlation was used to determine the association between age and the cell counts.Results:The TMSCs were identified based on two parameters-high ABCG2 expression and high N/C ratio>0.7.These stem cells were also positive for p75 and AnkG.The TMSC content based on the two parameters was 21.0±1.4%in<30 years age group,12.6±6.6%in 30–60 years and 4.0±3.5%in>60 years.The stem cells with high ABCG2 and p75 expression were restricted to the Schwalbe’s line region of the TM.A significant correlation was observed between the reduction in TMSC content and TM cell count during ageing.Conclusion:The human TMSCs were identified and quantified based on two parameter analysis.This study established a significant association between age-related reduction in TMSC content and TM cell loss. | Yogapriya Sundaresan Muthukkaruppan Veerappan Krishnadas Subbiah Ramasamy Gowri Priya Chidambaranathan | 2019 | Eye and Vision2019，6，1： | 1 |
| 11 | Photodynamic therapy of oral leukoplakia and orallichen planus using methylene blue:A pilot study显示文摘Premalignant lesions like oral lichen planus(OLP),oral leukoplakia(OL)has a fair probability of transforming into malignancy and they are perverse toward conventional therapies.Photody-namic therapy(PDT)has been considered as an alternative/complimentary therapeutic mo-dality for the management of premalignant lesions.In this study,methylene blue mediated photodynamic therapy(MB-PDT)was used as a possible alternative method for the treatment of OLP and OL.A total of 15 OLP lesions and 13 OL lesions were enrolled in the study.The patients were irradiated 1using metal halide lamp filtered at 630土10nm,with a light exposure dose of 120 J/cm^(2) per stting.For the OLP lesions,MB-PDT was performed once a week for four weeks and for the OL lesions,MB-PDT was performed twice a week for three weeks.Lesions were evaluated pre-and post-and at follow-u sessions by changes in sign and symptom scores,and size of lesions.We have observed a 53.3%of complete reduction in the treated OLP lesions and their decrease in size,sign and symptom score after treatment and at follow-up session was statistially signifcant.We have also observed complete response for one OL lesion of the 13 treated lesions.The result indicates that MB-PDT is an effective modality in management of OLP and OL.Among the two types of premalignancies treated with MB-PDT,OLP lesions responded much better than that of OL. | Savarimuthu Wilfred Prasanna Ekta Ingle Prakasa Rao Aruna Chidambaranathan Pravada Dornadula Koteeswaran S.Ganesan | 2015 | Journal of Innovative Optical Health Sciences2015，8，1： | 1 |
| 12 | Persiatent trigeminal artery:a rare cause of trigeminal neuralgiaMR imaging显示文摘 | Chidambaranathan N Sayeed ZA Sunder K | 2006 | Neurology India2006，54，2： | 1 |
| 13 | Persistent trigeminal artery: A rare cause of trigeminal neuralgia - MR imaging显示文摘 | Chidambaranathan N Sayeed ZA Sunder K | 2006 | Neurology India2006，54，2： | 1 |
| 14 | Antitumor activity of Vitex negundo Linn against daltons ascitic lymphoma 显示文摘 | Dewade D R Christinal A J M Chidambaranathan N | 2010 | Int J Pharm Tech Res2010，2，2： | 1 |
| 15 | Rice(Oryza sativa L.)plant protection using dual biological control and plant growth-promoting agents:Current scenarios and future prospects显示文摘Various microorganisms live in association with different parts of plants and can be harmful,neutral,or beneficial to plant health.Some microbial inhabitants of plants can control plant diseases by contesting with,predating on,or antagonizing plant pathogens and by inducing systems for plant defense.A range of methods,including plant growth-promoting microorganisms(PGPMs)as biological control agents(BCAs)(BCA-PGPMs)are used for the biological management and control of plant pathogens.Some BCAs interact with plants by inducing resistance or priming plants without direct interaction with the pathogen.Other BCAs operate via nutrient competition or other mechanisms to modulate the growth conditions for the pathogen.Generally,PGPMs can be applied alone or together with other chemicals or carriers to control various crop diseases.This review highlights the effective types of BCA-PGPMs and their applications,roles,carrier based-formulations,and responses to rice(Oryza sativa L.)pathogens.Future plant disease management prospects are promising,and growers’increasing demand for BCA-PGPM products can be exploited as an effective approach to the management of plant diseases,as well as to improve yield,environmental protection,biological resources,and agricultural system sustainability. | Debasis MITRA Sergio DE LOS SANTOS-VILLALOBOS Fannie Isela PARRA-COTA Ana María Garcia MONTELONGO Erika Lorena BLANCO Vanessa L.LIRA Adeyemi N.OLATUNBOSUN Bahman KHOSHRU Rittick MONDAL Parameswaran CHIDAMBARANATHAN Periyasamy PANNEERSELVAM Pradeep K.DAS MOHAPATRA | 2023 | Pedosphere2023，33，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员