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| 1 | Driving vascular endothelial cell fate of human multipotent Isl1 heart progenitors with VEGF modified mRNA显示文摘multipotent 心祖先的不同家庭在哺乳动物的 cardiogenesis 期间在多样的心脏的、光滑的肌肉和 endothelial 房间系的产生起一个中央作用。驾驶这些 multipotent 祖先的房间命运决定的精确 paracrine 信号的鉴定,和小说的开发来临在 vivo 交付这些信号,是向开他们的再生治疗学的潜力的关键步。此处,我们识别了位于早人的胎儿的心(OFT-ECs ) 的流出道的人的心脏的 endothelial 中介的一个家庭,由 Isl1 和 CD144/vWF 的 coexpression 描绘了。由比较人的 OFT-ECs 和非心脏的 EC 表示的 angiocrine 因素,脉管的 endothelial 生长因素( VEGF ) A 作为最富有地表示的因素被识别,并且同种细胞的试金记录了它的能力驱使人的胚胎的干细胞(转换字符)的 endothelial 说明以一种 VEGF 受体依赖者方式导出 Isl1 +祖先。人的 Isl1-ECs (区分开来与导出 hESC 的 ISL1 + 祖先的 endothelial 房间) 以心脏的 endothelial 祖先的表示类似于 OFT-ECs -- 并且 endocardial 房间特定的基因,证实他们的机关特性。决定是否 VEGF -- A 可能是服务一在里面为人的导出转换字符的 Isl1-ECs 的 vivo 房间命运开关,我们证实化学上使用的一条新奇途径作为一个平台修改了 mRNA 为短暂,还在心血管的祖先的 paracrine 因素的高度有效的表示。VEGF 的 Overexpression -- A 支持在 vivo 的人的 Isl1 + 祖先的不仅 endothelial 说明而且嫁接,增长和幸存(减少的 apoptosis ) 。从人的 pluripotent 干细胞的心脏特定的人的 Isl1-ECs 的大规模推导,结合了能力驾驶跟随移植的 endothelial 说明,嫁接,和幸存,在心为脉管的新生建议新奇策略。 | Kathy O Lui Llor Lang Eduardo A Silva Lei Bu Makoto Sahara Ronald A Li David J Mooney Kenneth R Chien | 2013 | Cell Research2013，23，10： | 6 |
| 2 | Application of artificial intelligence-driven endoscopic screening and diagnosis of gastric cancer显示文摘The landscape of gastrointestinal endoscopy continues to evolve as new technologies and techniques become available.The advent of image-enhanced and magnifying endoscopies has highlighted the step toward perfecting endoscopic screening and diagnosis of gastric lesions.Simultaneously,with the development of convolutional neural network,artificial intelligence(AI)has made unprecedented breakthroughs in medical imaging,including the ongoing trials of computer-aided detection of colorectal polyps and gastrointestinal bleeding.In the past demi-decade,applications of AI systems in gastric cancer have also emerged.With AI’s efficient computational power and learning capacities,endoscopists can improve their diagnostic accuracies and avoid the missing or mischaracterization of gastric neoplastic changes.So far,several AI systems that incorporated both traditional and novel endoscopy technologies have been developed for various purposes,with most systems achieving an accuracy of more than 80%.However,their feasibility,effectiveness,and safety in clinical practice remain to be seen as there have been no clinical trials yet.Nonetheless,AI-assisted endoscopies shed light on more accurate and sensitive ways for early detection,treatment guidance and prognosis prediction of gastric lesions.This review summarizes the current status of various AI applications in gastric cancer and pinpoints directions for future research and clinical practice implementation from a clinical perspective. | Yu-Jer Hsiao Yuan-Chih Wen Wei-Yi Lai Yi-Ying Lin Yi-Ping Yang Yueh Chien Aliaksandr A Yarmishyn De-Kuang Hwang Tai-Chi Lin Yun-Chia Chang Ting-Yi Lin Kao-Jung Chang Shih-Hwa Chiou Ying-Chun Jheng | 2021 | World Journal of Gastroenterology2021，27，22： | 2 |
| 3 | Patient-specific hemodynamic analysis of small internal carotid artery-ophthalmic artery aneurysms显示文摘 | Chien A Tateshima S Sayre J | 2009 | Surg Neurol2009，72，5： | 1 |
| 4 | Isolation and characterization of an immunomodulatory protein (APP) from the Jew's Ear mushroom Auricularia polytricha显示文摘 | SHEU F CHIENP J CHIEN A L | 2004 | Food Chemistry2004，87，4： | 1 |
| 5 | Oral cancer plasma tumor marker identified with bead-based affinity-fractionated proteomic technology 显示文摘 | Cheng A J Chen LC Chien KY | 2005 | Clin Chem2005，51，： | 1 |
| 6 | Entropia: Ar-chitecture and Performance of An Enterprise DesktopGrid System 显示文摘 | CHIEN A CALDER B ELBERT S et ol | 2003 | Journal of Parallel and Distributed Com-puting2003，63，5： | 1 |
| 7 | Planar-adaptive routing:low-cost adaptive networks for multiprocessors显示文摘 | Chien A Kim J H | 1995 | Journal of The ACM1995，42，1： | 1 |
| 8 | Needs of families with a relative in a critical care unit in HongKong显示文摘 | Lee I Y Chien W T Mackenzie A E | 2000 | J Clin Nurs2000，9，1： | 1 |
| 9 | Calcium site mutations in cadherin: impact on adhesion and evidence of cooperativity 显示文摘 | Prakasam A Chien YH Maruthamuthu V | 2006 | Biochemistry2006，45，22： | 1 |
| 10 | Mineral scaling mitigation in cooling systems using tertiary-treated municipal wastewater显示文摘 | LIU W CHIEN S H DZOMBAK D A | 2012 | Water Research2012，46，14： | 1 |
| 11 | Identification of underexpressed genes in early-and late-stage primary ovarian tumours by suppression subtraction hybridization显示文摘 | Shridhar V Sen A Chien J | 2002 | Cancer Res2002，62，1： | 1 |
| 12 | Hypoaesthesia occurs with sensory hypersensitivity in chronic whiplash:further evidence of a neuro- pathic condition显示文摘 | Chien A Eliav E Sterling M | 2009 | Man Ther2009，14，2： | 1 |
| 13 | Needs of Chinese families with a relative in a critical care unit显示文摘 | Lee I Y Mackenzie A E Chien W T | 1999 | J Clin Nurs1999，8，6： | 1 |
| 14 | α-Solanine inhibits human melanoma cell migration and invasion by reducing matrix metalloproteinase-2/9 activities 显示文摘 | Ming-Kun LU a Yuan-Wei SHIH b Tzu-Tsung CHANG CHIEN | 2010 | Biol Pharm Bull2010，33，10： | 1 |
| 15 | Emerging techniques for evaluation of the hemodynamics of intracranial vascular pathology 显示文摘 | Chang W Huang M Chien A | 2015 | Neuroradiol J2015，28，： | 1 |
| 16 | Pullout strength of thoracic pedicle screws improved with cortical bone ratio: a eadaveric study显示文摘 | Chou WK Chien A Wang JL | 2014 | J Orthop Sei2014，19，6： | 1 |
| 17 | Met5-enkephalin protects isolated adult rabbit cardiomyocytes via delta-opioid receptor显示文摘 | TAKASAKI Y WOLFF R A CHIEN G L | 1999 | Am J Physiol1999，277，62： | 1 |
| 18 | Multilineage differentiation activity by cells isolated from umbilical cord blood: expression of bone, fat and neural markers显示文摘 | Goodwin H Bicknese A Chien S | 2001 | Biol Blood Marrow Transplant2001，7，11： | 1 |
| 19 | A gradient technique for general buffer storage design in a production line显示文摘 | Ho Y C Eyler M A Chien T T | 1979 | Int J of Production Research1979，17，6： | 1 |
| 20 | DGMonitor: A Performance Monitoring Tool for Sandbox- Based Desktop Grid Platforms 显示文摘 | Cicotti P Taufer M Chien A A | 2005 | The Journal of Supercomputing2005，34，： | 1 |
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